PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBA6	4	UCHL3	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HERC6	0	HERC3	0	affinity chromatography technology	Hochrainer K (2008)	1
BRCA1	7	DAZAP1	1	affinity chromatography technology	Goina E (2008)	1
BAG3	4	ACAT2	1	affinity chromatography technology	Chen Y (2013)	1
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
BRCA1	7	ARIH1	3	affinity chromatography technology	Ertych N (2016)	1
USP34	7	UFM1	0	biochemical	Havugimana PC (2012)	1
TRIM25	5	HSPA4	3	affinity chromatography technology	Choudhury NR (2017)	1
ACAT2	1	UBE2L3	1	biochemical	Wan C (2015)	1
UBE2V2	0	USP34	7	biochemical	Havugimana PC (2012)	1
PJA1	1	UBE2L3	1	pull down	Zoabi M (2011)	1
ELAVL1	0	MAPK6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HUWE1	22	UBA1	1	affinity chromatography technology	Thompson JW (2014)	1
AURKA	1	TRIM28	1	affinity chromatography technology	Fogeron ML (2013)	1
SKP2	2	TRIM21	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006)	5
SMURF1	4	UBE2D2	0	pull down, pull down	Kristariyanto YA (2015), Andrews PS (2010)	2
RNF2	1	UBE2D2	0	enzymatic study, two hybrid, pull down	Lee SJ (2001), Markson G (2009), Dou H (2012)	3
MAPK6	1	STUB1	4	affinity chromatography technology	Rodriguez J (2016)	1
SOD1	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Choi JS (2004), Choi JS (2004), Urushitani M (2004), Ganesan S (2008), Malty RH (2017)	5
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
NEDD4	2	RBX1	2	affinity chromatography technology	Liu J (2014)	1
UBE2L3	1	RNF144B	0	two hybrid, affinity chromatography technology	Markson G (2009), Huang J (2006)	2
RBX1	2	SKP2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Ohta T (2001), Saiga T (2009), Rodier G (2008), Zhou W (2014), Zhou W (2014)	6
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
TSNAXIP1	3	UBE2L3	1	biochemical	Havugimana PC (2012)	1
TP53BP1	3	UBE2L3	1	affinity chromatography technology	Han X (2014)	1
UBA1	1	UBE2B	3	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Wauer T (2015), Kumar B (2010), Huguenin-Dezot N (2016)	5
HUWE1	22	PSMA5	0	affinity chromatography technology	Thompson JW (2014)	1
HSPE1	0	UFM1	0	biochemical	Wan C (2015)	1
CACNA1A	21	UBE2L3	1	affinity chromatography technology	Gandini MA (2014)	1
UBC	7	UBASH3A	3	pull down, pull down, pull down	Kowanetz K (2004), Ikeda F (2007), Hoeller D (2006)	3
OTUB1	0	UBE2V2	0	pull down	Sato Y (2012)	1
UBE2V2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
DAZAP1	1	SNX12	0	biochemical	Wan C (2015)	1
TRAF6	0	HSPA4	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Chen H (2006), Pridgeon JW (2004), Chen H (2006)	3
UBE4B	5	UCHL3	1	biochemical	Havugimana PC (2012)	1
HERC4	0	UBE2L3	1	pull down	Zhang W (2016)	1
DNM1L	3	TRIM28	1	affinity chromatography technology	Malty RH (2017)	1
HACE1	2	UBE2L3	1	pull down, pull down, pull down, pull down	Castillo-Lluva S (2012), Liu Z (2014), Zhang W (2016), Huang S (2016)	4
UBR5	13	RNF2	1	imaging technique	Sanchez A (2016)	1
BRCA1	7	5430	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Krum SA (2003), Scully R (1997), Scully R (1997), Chiba N (2001), Chiba N (2001), Krum SA (2003), Starita LM (2005), Woods NT (2012), Bennett CB (2008), Hill SJ (2014), Winton CE (2016)	11
ELAVL1	0	SNX3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	USP34	7	affinity chromatography technology	Choudhury NR (2017)	1
NDFIP1	0	PTEN	24	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay	Mund T (2010), Howitt J (2012), Howitt J (2012), Li Y (2014)	4
PSMD2	2	UBE2L3	1	biochemical	Havugimana PC (2012)	1
UBE2D2	0	STUB1	4	pull down, pull down, biochemical, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down	Demand J (2001), Soss SE (2011), Shimura H (2004), Esser C (2005), Kalia LV (2011), Xie P (2009), Grelle G (2006), Westhoff B (2005), Hatakeyama S (2004), Dolan PJ (2010), Tsukahara F (2010), Chen Z (2013), Dreiseidler M (2012), Zhang H (2015), Liu X (2017), Liu X (2017), Blessing NA (2017)	17
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
UBXN7	3	USP9X	15	biochemical	Havugimana PC (2012)	1
NFKBIA	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
AHCYL1	2	STUB1	4	biochemical	Havugimana PC (2012)	1
UBR5	13	UBE2L3	1	pull down, pull down	Honda Y (2002), Flack JE (2017)	2
RELA	1	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMAD7	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lallemand F (2005), Lallemand F (2005), Al-Salihi MA (2012), Gen Y (2017), Gen Y (2017)	5
TRIM25	5	TSNAXIP1	3	affinity chromatography technology	Choudhury NR (2017)	1
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
AHCYL1	2	UBE2B	3	biochemical	Havugimana PC (2012)	1
TRAF6	0	WWP1	3	affinity chromatography technology	Lin XW (2013)	1
BRCA1	7	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lu Y (2012), Lu Y (2012), Parameswaran B (2015)	3
TRIM25	5	MYC	2	affinity chromatography technology	Choudhury NR (2017)	1
UBE2L3	1	NFKBIA	0	enzymatic study	Gonen H (1999)	1
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
SOD1	0	ELAVL1	0	affinity chromatography technology	Malty RH (2017)	1
TRIM25	5	RNF216	2	affinity chromatography technology	Choudhury NR (2017)	1
UBXN1	0	HUWE1	22	affinity chromatography technology	Alexandru G (2008)	1
NDUFA7	0	SUGP1	2	biochemical	Havugimana PC (2012)	1
UBE2L3	1	FOS	0	enzymatic study	Stancovski I (1995)	1
WWP2	7	DAZAP1	1	affinity chromatography technology	Chaudhary N (2014)	1
UBE2D2	0	RNF103	1	two hybrid	van Wijk SJ (2009)	1
TRIP12	20	MYC	2	pull down, affinity chromatography technology	Chen D (2010), Chen D (2010)	2
CBL	7	HSPA4	3	affinity chromatography technology	Valiya Veettil M (2011)	1
ELAVL1	0	PTEN	24	affinity chromatography technology	Abdelmohsen K (2009)	1
RBX1	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Pick E (2007), Lan L (2012), Tsai WB (2010), Hrecka K (2007), Okuda H (2001), Tai T (2006), Ahn J (2011), Gong B (2010), Lu Y (2012), Ohta A (2013), da Silva Almeida AC (2013), Delucia M (2013), Scott DC (2014), Camp ND (2012), Kim S (2014), Theurillat JP (2014), Kigoshi Y (2011), Pashkova N (2010), Beck J (2013), Pierce WK (2015), Wu K (2016), Parameswaran B (2015), Simo S (2013), Groisman R (2006), Marzahn MR (2016), Courtheoux T (2016), Hasanov E (2017), Ferretti LP (2016), Zhou X (2017), Kroenke J (2014), Mulvaney KM (2016)	31
HUWE1	22	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down	Pandya RK (2010), Parsons JL (2009), Schwarz SE (1998), Kristariyanto YA (2015), Choe KN (2016), Kurokawa M (2013)	6
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
UBE2L3	1	ZPR1	1	biochemical	Havugimana PC (2012)	1
DNM1L	3	HSPA4	3	affinity chromatography technology	Malty RH (2017)	1
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
NDFIP1	0	SMURF1	4	affinity chromatography technology	Wang Y (2012)	1
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
HUWE1	22	TRIM28	1	affinity chromatography technology	Thompson JW (2014)	1
ZNF598	6	TRIM21	0	affinity chromatography technology	Garzia A (2017)	1
UBA6	4	UBE2L3	1	pull down, enzymatic study	Jin J (2007), Huang DT (2009)	2
UBE2V2	0	XIAP	0	two hybrid	Markson G (2009)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
NCOA1	6	UBR5	13	affinity chromatography technology	Jung SY (2005)	1
UBE3A	4	MDM2	2	enzymatic study	Sionov RV (2001)	1
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
UBE4B	5	UFM1	0	biochemical	Havugimana PC (2012)	1
STUB1	4	UBE2L3	1	pull down	Hampe C (2006)	1
UBE2L3	1	TRIM39	0	two hybrid	Markson G (2009)	1
UBE2L3	1	DTX3	4	two hybrid	Markson G (2009)	1
UBE2L3	1	UBE3A	4	enzymatic study, x-ray crystallography, enzymatic study, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, two hybrid, pull down, pull down, pull down, pull down, enzymatic study, two hybrid, two hybrid, affinity chromatography technology	Anan T (1998), Huang L (1999), Huang L (1999), Shimura H (2001), Sammond DW (2010), Sammond DW (2007), Eletr ZM (2007), Eletr ZM (2007), Huang L (1999), Kumar S (1999), Shimoji T (2009), Kim HC (2009), Zaaroor-Regev D (2010), Nuber U (1998), Mishra A (2009), Schwarz SE (1998), Nasu J (2010), Nakagawa S (2000), Nuber U (1996), Nuber U (1996), Ronchi VP (2012), Kumar S (1997), Kumar S (1997), Yang Y (2007), Mortensen F (2015), Cooper EM (2004), Cooper EM (2004), Cooper EM (2004), Schimmack G (2017), Grimaldo L (2017)	30
UBE2L3	1	RNF125	0	two hybrid	Markson G (2009)	1
RNF19B	0	UBE2L3	1	affinity chromatography technology	Fortier JM (2006)	1
MDH2	0	UBE2L3	1	biochemical	Wan C (2015)	1
CUL9	5	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pei XH (2011), Pei XH (2011), Skaar JR (2007), Skaar JR (2007), Skaar JR (2007)	5
UBE2L3	1	USP34	7	biochemical	Havugimana PC (2012)	1
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
UBE2D2	0	RNF125	0	two hybrid	Markson G (2009)	1
UBR5	13	UBE2B	3	pull down	Honda Y (2002)	1
ELAVL1	0	RNF144B	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SOD1	0	UFM1	0	biochemical	Wan C (2015)	1
MRPL53	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
PRKN	1	VDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okatsu K (2012), Sun Y (2012), Sarraf SA (2013)	3
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
RELA	1	HERC3	0	affinity chromatography technology, affinity chromatography technology	Hochrainer K (2015), Hochrainer K (2015)	2
ZNF598	6	TRIM28	1	affinity chromatography technology	Garzia A (2017)	1
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
BAG3	4	UCHL3	1	affinity chromatography technology	Chen Y (2013)	1
UBXN7	3	BIRC2	1	affinity chromatography technology	Alexandru G (2008)	1
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
UBE2L3	1	RBCK1	0	two hybrid, pull down, pull down	Markson G (2009), Tatematsu K (2008), Kirisako T (2006)	3
ELAVL1	0	MID1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
YAP1	0	PSMD2	2	affinity chromatography technology	Enzo E (2015)	1
UBE3A	4	MAPK6	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Martinez-Noel G (2012), Martinez-Noel G (2012), Rodriguez J (2016), Rodriguez J (2016)	4
HERC4	0	UBC	7	enzymatic study	Sheng Y (2012)	1
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
BRCA1	7	RELA	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Benezra M (2003), Benezra M (2003), Benezra M (2003), Volcic M (2012)	4
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
UBE4B	5	UBE2D2	0	pull down, pull down, pull down	Benirschke RC (2010), Wu H (2011), Buetow L (2015)	3
SMURF2	3	UBE2L3	1	pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Wiesner S (2007), Ogunjimi AA (2005), Kim S (2010), Ogunjimi AA (2005), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016)	7
STUB1	4	NR3C1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Connell P (2001), Schuelke JP (2010), Mata-Greenwood E (2013), Connell P (2001)	4
HERC6	0	HERC4	0	affinity chromatography technology	Hochrainer K (2008)	1
BAG3	4	UBE2L3	1	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
CBLC	1	UBE2D2	0	pull down, pull down	Ryan PE (2010), Kim M (2004)	2
UBE2L3	1	ATXN3	2	pull down	Durcan TM (2011)	1
UBA6	4	UBE4B	5	biochemical	Havugimana PC (2012)	1
PRKN	1	UBASH3A	3	pull down	Ikeda F (2007)	1
NFKBIA	0	5430	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYC	2	TRIM21	0	affinity chromatography technology	Agrawal P (2010)	1
WWP1	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
BRCA1	7	MDH2	0	affinity chromatography technology	Ertych N (2016)	1
BAG3	4	STUB1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Hein MY (2015)	4
PIR	0	ACAT2	1	biochemical	Wan C (2015)	1
MAPK6	1	5430	0	affinity chromatography technology	Rodriguez J (2016)	1
CCNB1IP1	0	UBE2L3	1	two hybrid, pull down	Toby GG (2003), Toby GG (2003)	2
TRAF6	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
UCHL3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
UFM1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
UBXN7	3	UBR5	13	affinity chromatography technology	Alexandru G (2008)	1
BRCA1	7	UBE2D2	0	two hybrid, two hybrid, x-ray crystallography, pull down	Dynek JN (2010), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
SF1	9	MKRN3	2	two hybrid	Rolland T (2014)	1
UBE2A	0	UBE2B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong JH (2015), Hong JH (2015), Huttlin EL (2017)	3
TRIM25	5	SKP2	2	affinity chromatography technology	Choudhury NR (2017)	1
SOD1	0	USP9X	15	affinity chromatography technology	Hein MY (2015)	1
UBXN1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
RNF2	1	RELA	1	affinity chromatography technology	Cao Q (2014)	1
UBC	7	PJA1	1	affinity chromatography technology	Matsumoto M (2005)	1
UBE2L3	1	MKRN3	2	two hybrid	Markson G (2009)	1
MAPK6	1	UBC	7	affinity chromatography technology	Rodriguez J (2016)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
PSMA5	0	5430	0	biochemical	Wan C (2015)	1
BIRC2	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
UBE2V2	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
RC3H1	6	UBE2A	0	pull down	Zhang Q (2015)	1
UBE2A	0	UBE2L3	1	biochemical	Wan C (2015)	1
RELA	1	UBC	7	affinity chromatography technology	Schweitzer K (2015)	1
UBE2L3	1	MID1	1	two hybrid	Markson G (2009)	1
PRKN	1	PSMD2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Um JW (2010), Sarraf SA (2013), Sarraf SA (2013)	3
MAPK6	1	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Rodriguez J (2016), Rodriguez J (2016)	2
UBXN7	3	UCHL3	1	biochemical	Havugimana PC (2012)	1
TRIM25	5	DAZAP1	1	affinity chromatography technology	Choudhury NR (2017)	1
PIR	0	HSPE1	0	biochemical	Wan C (2015)	1
UBE2V2	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
RC3H1	6	UBE2B	3	pull down	Zhang Q (2015)	1
DAZAP1	1	PIR	0	biochemical	Wan C (2015)	1
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
SMAD7	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Seo SR (2004), Al-Salihi MA (2012)	4
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
MAPK6	1	VDAC2	1	affinity chromatography technology	Rodriguez J (2016)	1
MDM2	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2005), Wang C (2005), Wang C (2005), Gilmore-Hebert M (2010), Okamoto K (2006), Okamoto K (2006), Okamoto K (2006)	7
ARIH1	3	UBE2L3	1	two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Tan NG (2003), Moynihan TP (1999), Moynihan TP (1999), Ardley HC (2001), Duda DM (2013), Kelsall IR (2013), Wenzel DM (2011), Moynihan TP (1999), Kelsall IR (2013), Huttlin EL (2017), Dove KK (2017), Dove KK (2017)	12
FN1	17	RAB10	1	affinity chromatography technology	Humphries JD (2009)	1
DNM1L	3	MDH2	0	affinity chromatography technology	Malty RH (2017)	1
ELAVL1	0	YAP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BRCA1	7	UBE3A	4	pull down	Wu-Baer F (2003)	1
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
PRKN	1	DNM1L	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang H (2011), Wang H (2011), Wang H (2011), Wang H (2011)	4
TRIM25	5	RAB10	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
UBXN1	0	UFM1	0	biochemical	Havugimana PC (2012)	1
MUL1	1	DNM1L	3	enzymatic study	Braschi E (2009)	1
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
AURKA	1	MDM2	2	affinity chromatography technology, enzymatic study	Sehdev V (2013), Sehdev V (2013)	2
NDFIP1	0	NEDD4L	3	affinity chromatography technology	Howitt J (2012)	1
SRPRB	0	UBE3A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
MDM2	2	RNF2	1	affinity chromatography technology, affinity chromatography technology	Wen W (2013), Wen W (2013)	2
UBE2V2	0	RNF144A	1	two hybrid	Markson G (2009)	1
TRIM21	0	RBCK1	0	two hybrid	Woodsmith J (2012)	1
PITPNA	1	UBE2L3	1	biochemical	Wan C (2015)	1
AURKA	1	MAPK6	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Rodriguez J (2016)	2
MRPL53	0	SNX3	1	biochemical	Havugimana PC (2012)	1
HSPE1	0	HSPA4	3	biochemical	Wan C (2015)	1
ITCH	1	UBA6	4	affinity chromatography technology	OConnor HF (2015)	1
MCM2	3	PSMD2	2	affinity chromatography technology	Drissi R (2015)	1
UBE2D2	0	RELA	1	enzymatic study	Ryo A (2003)	1
ELAVL1	0	DAZAP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SMURF1	4	UBXN7	3	enzymatic study	Andrews PS (2010)	1
PSMD2	2	MDM2	2	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Jin Y (2008), Jin Y (2008), Kulikov R (2010), Kulikov R (2010)	4
UBE4B	5	ZPR1	1	biochemical	Havugimana PC (2012)	1
UBC	7	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Hong JH (2015)	2
UCHL3	1	YAP1	0	biochemical	Havugimana PC (2012)	1
HECW2	13	TRIM25	5	affinity chromatography technology	Lu L (2013)	1
DNM1L	3	UBA1	1	affinity chromatography technology	Malty RH (2017)	1
AHCYL1	2	UCHL3	1	biochemical	Havugimana PC (2012)	1
UBE2D2	0	MUL1	1	two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Braschi E (2009), Li W (2008), Ni G (2017)	4
ATXN3	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Chhangani D (2014), Chhangani D (2014)	2
YAP1	0	PSMA5	0	affinity chromatography technology	Enzo E (2015)	1
ZNF598	6	PSMA5	0	affinity chromatography technology	Garzia A (2017)	1
SOD1	0	HSPE1	0	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
MUL1	1	UBE2V2	0	pull down	Ni G (2017)	1
MAP1LC3B	1	UBC	7	imaging technique	Liu X (2017)	1
DUSP4	1	UBE2L3	1	affinity chromatography technology	Li X (2016)	1
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
MYC	2	FN1	17	affinity chromatography technology	Agrawal P (2010)	1
UBA7	2	UBE2L3	1	enzymatic study	Huang DT (2009)	1
UBR5	13	UBC	7	pull down, x-ray crystallography, pull down	Kozlov G (2007), Kozlov G (2007), Zhang X (2017)	3
5430	0	RELA	1	imaging technique	Freaney JE (2013)	1
UBE2D2	0	ARIH2	4	two hybrid	Markson G (2009)	1
TRIM25	5	TRAF7	11	affinity chromatography technology	Choudhury NR (2017)	1
NEDD4L	3	UBE2L3	1	pull down, pull down, pull down, pull down, pull down	Bruce MC (2008), Schwarz SE (1998), Wauer T (2015), Michel MA (2015), Zhang W (2016)	5
FN1	17	SF1	9	affinity chromatography technology	Humphries JD (2009)	1
PSMA5	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
DAZAP1	1	SNX3	1	biochemical	Wan C (2015)	1
HECW2	13	ELAVL1	0	affinity chromatography technology	Lu L (2013)	1
MDM2	2	MSI2	1	affinity chromatography technology	Sheng W (2017)	1
ITCH	1	SF1	9	pull down	Ingham RJ (2005)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
SUGP1	2	SRPRB	0	biochemical	Havugimana PC (2012)	1
PRKN	1	MDH2	0	affinity chromatography technology	Sarraf SA (2013)	1
HUWE1	22	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Bewley MA (2011), Thompson JW (2014)	2
NR3C1	2	UBE2L3	1	two hybrid, affinity chromatography technology	Garside H (2006), Garside H (2006)	2
XIAP	0	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
MYC	2	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
DUSP8	0	UBE2L3	1	affinity chromatography technology	Li X (2016)	1
UBE2D2	0	TRAF7	11	two hybrid	Markson G (2009)	1
TP53BP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Matsuoka S (2007), Wang B (2002), Bohgaki T (2011), Ertych N (2016)	4
BRCA1	7	SNX3	1	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
PRKN	1	UBE2L3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down	Shimura H (2001), Imai Y (2000), Ramsey CP (2010), Sato S (2006), Chaugule VK (2011), Um JW (2012), Choi P (2003), Uchiki T (2009), Joch M (2007), Li Y (2011), Shin JH (2011), Chung KK (2001), Sato S (2006), Hampe C (2006), Um JW (2006), Chaugule VK (2011), Wang H (2011), Imam SZ (2011), Duda DM (2013), Wauer T (2013), Rankin CA (2014), Shimura H (2000), Durcan TM (2011), Wenzel DM (2011), Romani-Aumedes J (2014), Caulfield TR (2014), Koyano F (2014), Kurup PK (2015), Wauer T (2015), Song P (2016), Kumar A (2015), Lee SB (2015), Lee SB (2015), Song P (2016), Kazlauskaite A (2015), Veeriah S (2010), Park S (2017), Park S (2017), Kumar A (2017), Klosowiak JL (2016), Gersch M (2017), Tang MY (2017), Kazlauskaite A (2014), Sul JW (2013)	44
ELAVL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Abdelmohsen K (2009), Durie D (2011), Durie D (2011), Durie D (2011)	4
TRIM28	1	UBE2D2	0	pull down	Doyle JM (2010)	1
MDM2	2	NEDD4	2	unspecified method, enzymatic study, affinity chromatography technology	Burch LR (2004), Xu C (2014), Xu C (2014)	3
MDM2	2	RELA	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Heyne K (2013), Heyne K (2013), Heyne K (2013)	4
SMURF1	4	PSMD2	2	affinity chromatography technology	Xie Y (2013)	1
NCOA1	6	ITCH	1	affinity chromatography technology	Jung SY (2005)	1
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
BIRC2	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
MAPK6	1	UBR5	13	affinity chromatography technology	Rodriguez J (2016)	1
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
NCOA1	6	BRCA1	7	pull down, affinity chromatography technology, affinity chromatography technology	Nakuci E (2006), Nakuci E (2006), Nakuci E (2006)	3
TRIM21	0	TRIM39	0	two hybrid, two hybrid	Woodsmith J (2012), Rolland T (2014)	2
TRIM25	5	HERC4	0	affinity chromatography technology	Choudhury NR (2017)	1
RNF2	1	DAZAP1	1	affinity chromatography technology	Cao Q (2014)	1
UBXN7	3	RBX1	2	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bandau S (2012)	2
PTEN	24	UBE2L3	1	affinity chromatography technology	Waite KA (2003)	1
SMURF1	4	ATXN3	2	enzymatic study	Andrews PS (2010)	1
NEDD4	2	PTEN	24	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wang X (2008), Wang X (2008), Yim EK (2009), Chung S (2011), Wu Y (2013), Hong SW (2013), Hong SW (2013), Li N (2015), Li Z (2014), Chen Z (2016), Ahn Y (2008)	11
UBE3C	5	UBE2D2	0	pull down, pull down	Wu PY (2003), Kristariyanto YA (2015)	2
HEBP1	0	SNX3	1	biochemical	Wan C (2015)	1
MRPL53	0	SUGP1	2	biochemical	Havugimana PC (2012)	1
UBA1	1	UBE2L3	1	enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Ronchi VP (2012), Jin J (2007), Liu Z (2014), Nuber U (1996), Huang DT (2009), Kang D (2002), Wauer T (2015), Huguenin-Dezot N (2016)	9
TRIM25	5	MDH2	0	affinity chromatography technology	Choudhury NR (2017)	1
AREL1	1	UBC	7	enzymatic study, enzymatic study, enzymatic study	Michel MA (2015), Kristariyanto YA (2015), Michel MA (2017)	3
MYC	2	STUB1	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paul I (2012), Paul I (2012), Paul I (2012), Huang H (2017)	4
RNF2	1	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
UBC	7	TRIM28	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Doyle JM (2010)	2
UBE2L3	1	CUL9	5	two hybrid, pull down	Moynihan TP (1999), Nikolaev AY (2003)	2
UBE2V2	0	RNF2	1	two hybrid	Markson G (2009)	1
HUWE1	22	MCM2	3	affinity chromatography technology	Thompson JW (2014)	1
RC3H1	6	UBE2D2	0	pull down	Zhang Q (2015)	1
UBASH3A	3	UBE2L3	1	fluorescent resonance energy transfe	Hoeller D (2007)	1
SOD1	0	MDH2	0	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
SMAD7	1	CBL	7	affinity chromatography technology, affinity chromatography technology, pull down	Ha Thi HT (2015), Ha Thi HT (2015), Ha Thi HT (2015)	3
ZNF598	6	UBE2L3	1	affinity chromatography technology	Garzia A (2017)	1
ATXN3	2	STUB1	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Scaglione KM (2011), Scaglione KM (2011), Scaglione KM (2011), Todi SV (2010), Todi SV (2010), Gao XC (2011), Todi SV (2009), Kristensen LV (2018), Kristensen LV (2018)	9
RNF2	1	MSI2	1	affinity chromatography technology	Cao Q (2014)	1
TRIM25	5	FBXO2	0	affinity chromatography technology	Choudhury NR (2017)	1
SOD1	0	MCM2	3	affinity chromatography technology	Malty RH (2017)	1
AICDA	0	UBE2L3	1	affinity chromatography technology	Delker RK (2013)	1
MCM2	3	UBE2D2	0	affinity chromatography technology	Drissi R (2015)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
NDFIP1	0	NEDD4	2	affinity chromatography technology	Xing LF (2016)	1
USP9X	15	YAP1	0	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kim M (2016), Kim M (2016)	3
MDM2	2	XIAP	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Gu L (2009), Huang X (2013), Huang X (2013), Huang X (2013), Liu T (2015)	5
SKP2	2	MYC	2	affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), Zhang Q (2013), Kim TA (2013), Jamal A (2015), Fujii M (2006)	9
RNF216	2	UBE2L3	1	affinity chromatography technology	Chuang TH (2004)	1
NCOA1	6	SF1	9	affinity chromatography technology	Kelly SN (2005)	1
UBE2L3	1	UBE2B	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
YAP1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
AHCYL1	2	YAP1	0	biochemical	Havugimana PC (2012)	1
RNF2	1	UBE2L3	1	pull down	Zaaroor-Regev D (2010)	1
UBE2L3	1	NCOA1	6	affinity chromatography technology	Verma S (2004)	1
SOD1	0	UBA1	1	affinity chromatography technology	Malty RH (2017)	1
UBE4B	5	USP34	7	biochemical	Havugimana PC (2012)	1
TRIM25	5	HUWE1	22	affinity chromatography technology	Choudhury NR (2017)	1
ACAT2	1	HSPE1	0	biochemical	Wan C (2015)	1
UBE2B	3	RNF20	9	pull down, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Kim J (2011), Kim J (2011), Kim J (2009), Kim J (2009), Kim J (2009), Hong JH (2015), Huttlin EL (2017), Foglizzo M (2016)	8
NDUFA7	0	SNX3	1	biochemical	Havugimana PC (2012)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
UBE4B	5	UBXN7	3	biochemical	Havugimana PC (2012)	1
WWP2	7	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down	Wiesner S (2007), Xu H (2009), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016), Chen Z (2016)	6
UBXN7	3	YAP1	0	biochemical	Havugimana PC (2012)	1
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
MUL1	1	UBE2L3	1	two hybrid	Ambivero CT (2014)	1
UBE2V2	0	MKRN3	2	two hybrid	Markson G (2009)	1
ELAVL1	0	NEDD4L	3	affinity chromatography technology	Abdelmohsen K (2009)	1
FN1	17	VDAC2	1	affinity chromatography technology	Humphries JD (2009)	1
UBE2D2	0	MKRN3	2	two hybrid	Markson G (2009)	1
WWP2	7	USP9X	15	affinity chromatography technology	Chaudhary N (2014)	1
NFKBIA	0	PIR	0	two hybrid	Dechend R (1999)	1
MAP1LC3B	1	TRIM21	0	pull down	Kimura T (2015)	1
ELAVL1	0	RAB10	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SRPRB	0	UBE4B	5	biochemical	Havugimana PC (2012)	1
ARIH2	4	UBE2L3	1	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down	Stelzl U (2005), Markson G (2009), Marteijn JA (2005), Plafker SM (2004), Pietschmann K (2012), Marteijn JA (2009), Kelsall IR (2013), Kelsall IR (2013), Ambivero CT (2014), Marteijn JA (2005), Kelsall IR (2013)	11
FN1	17	MCM2	3	affinity chromatography technology	Humphries JD (2009)	1
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
ZNF598	6	MID1	1	affinity chromatography technology	Garzia A (2017)	1
RNF2	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
TRIM25	5	PSMA5	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2B	3	UBXN7	3	biochemical	Havugimana PC (2012)	1
TRIM25	5	UBE2L3	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	SNX12	0	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	5430	0	affinity chromatography technology	Abdelmohsen K (2009)	1
WWP2	7	SMAD7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Soond SM (2011), Al-Salihi MA (2012)	4
EIF4E2	2	ZNF598	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morita M (2012), Morita M (2012), Morita M (2012), Morita M (2012), Garzia A (2017)	5
ELAVL1	0	ITCH	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ARIH1	3	UBC	7	pull down, x-ray crystallography	Dove KK (2017), Dove KK (2017)	2
RNF31	3	UBE2L3	1	pull down, pull down, pull down	Kirisako T (2006), Greenfeld H (2015), Liu J (2017)	3
LIG4	0	SNX3	1	two hybrid	Woods NT (2012)	1
UBA1	1	UBE2D2	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Choi JS (2014), Huang DT (2009), Kang D (2002), Kumar B (2010), Liu X (2017), Huguenin-Dezot N (2016)	8
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
CBLC	1	UBC	7	enzymatic study	Kim M (2004)	1
BAG3	4	HSPA4	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doong H (2003), Doong H (2003), Gentilella A (2011), Gamerdinger M (2009), Gamerdinger M (2009), Ammirante M (2010), Chen Y (2013), Chen Y (2013)	8
EIF4E2	2	UBE2L3	1	affinity chromatography technology	Tan NG (2003)	1
SOD1	0	TRIM28	1	affinity chromatography technology	Malty RH (2017)	1
NEDD4	2	RBCK1	0	pull down	Persaud A (2009)	1
CACNA1A	21	HECW1	3	two hybrid	Kahle JJ (2011)	1
RNF20	9	SMURF2	3	affinity chromatography technology, pull down	Blank M (2012), Blank M (2012)	2
MDH2	0	UFM1	0	biochemical	Wan C (2015)	1
UFM1	0	YAP1	0	biochemical	Havugimana PC (2012)	1
NR3C1	2	MDM2	2	affinity chromatography technology	Sengupta S (2001)	1
PRKN	1	RBCK1	0	two hybrid	Corominas R (2014)	1
HERC3	0	UBE2L3	1	pull down	Schwarz SE (1998)	1
TRIM25	5	UBR5	13	affinity chromatography technology	Choudhury NR (2017)	1
ITCH	1	UBE2D2	0	pull down, pull down, pull down, pull down	Sheng Y (2012), Fang S (2001), Kristariyanto YA (2015), Riling C (2015)	4
STUB1	4	RELA	1	affinity chromatography technology	Wang S (2012)	1
UBC	7	RNF20	9	affinity chromatography technology	Bish RA (2007)	1
HECW1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
PTEN	24	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBC	7	SRPRB	0	pull down	Zhang X (2017)	1
UBXN1	0	UBE3A	4	affinity chromatography technology	Alexandru G (2008)	1
SF1	9	UBE2L3	1	biochemical	Havugimana PC (2012)	1
TRIM25	5	MAPK6	1	affinity chromatography technology	Choudhury NR (2017)	1
UBE4B	5	CBL	7	x-ray crystallography	Benirschke RC (2010)	1
AHCYL1	2	SNX12	0	biochemical	Havugimana PC (2012)	1
HERC6	0	UBE2L3	1	pull down	Zhang W (2016)	1
SOD1	0	DNM1L	3	affinity chromatography technology	Malty RH (2017)	1
FN1	17	HSPE1	0	affinity chromatography technology	Humphries JD (2009)	1
RNF31	3	UBE2D2	0	pull down, x-ray crystallography, pull down	Kirisako T (2006), Lechtenberg BC (2016), Lechtenberg BC (2016)	3
BRCA1	7	MCM2	3	affinity chromatography technology	Ertych N (2016)	1
MRPL53	0	UBE4B	5	biochemical	Havugimana PC (2012)	1
SOD1	0	HUWE1	22	affinity chromatography technology	Malty RH (2017)	1
UBE3A	4	UBC	7	enzymatic study, enzymatic study, pull down	Schwarz SE (1998), Ronchi VP (2013), Zhang X (2017)	3
UBE2D2	0	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
YAP1	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Enzo E (2015)	2
WWP2	7	UBE2D2	0	pull down, pull down, pull down	Sheng Y (2012), Kristariyanto YA (2015), Chaudhary N (2014)	3
STUB1	4	UBE2V2	0	biochemical	Havugimana PC (2012)	1
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
XIAP	0	HSPA4	3	affinity chromatography technology	Hegde R (2002)	1
UBC	7	PSMD2	2	pull down	Zhang X (2017)	1
USP9X	15	PJA1	1	affinity chromatography technology	Agrawal P (2012)	1
MYC	2	UBE2L3	1	affinity chromatography technology	Shimura H (2001)	1
CACNA1B	8	UBE2L3	1	affinity chromatography technology, affinity chromatography technology	Gandini MA (2014), Gandini MA (2014)	2
YAP1	0	STUB1	4	affinity chromatography technology	Hauri S (2013)	1
TRIM25	5	UBE3C	5	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	NR3C1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBXN1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
USP9X	15	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
UBE2D2	0	CBL	7	pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Joazeiro CA (1999), Dou H (2012), Dou H (2012), Sehat B (2008), Kassenbrock CK (2004), Roxburgh P (2012), Tsukahara F (2010), Bulut GB (2013), Buetow L (2016), Conte A (2017)	10
PRKN	1	AURKA	1	affinity chromatography technology	Lee SB (2015)	1
ZNF598	6	PSMD2	2	affinity chromatography technology	Garzia A (2017)	1
UBE2D2	0	NEDD4L	3	x-ray crystallography, pull down, pull down, pull down, pull down, pull down, enzymatic study	Kamadurai HB (2009), Isasa M (2010), Sheng Y (2012), Persaud A (2009), Nazio F (2016), Todaro DR (2017), Todaro DR (2017)	7
UBE4B	5	USP9X	15	biochemical	Havugimana PC (2012)	1
RNF125	0	UBC	7	pull down	Giannini AL (2008)	1
PJA1	1	UCHL3	1	enzymatic study	Loch CM (2012)	1
RNF19A	3	UBE2L3	1	affinity chromatography technology, pull down, pull down	Niwa J (2001), Niwa J (2002), Ito T (2003)	3
UBE2L3	1	SMAD7	1	unspecified method	Ogunjimi AA (2005)	1
UBXN1	0	UBE4B	5	affinity chromatography technology	Alexandru G (2008)	1
CBL	7	PTEN	24	affinity chromatography technology, affinity chromatography technology	Rodriguez S (2013), Rodriguez S (2013)	2
UBC	7	PSMA5	0	affinity chromatography technology	Matsumoto M (2005)	1
YAP1	0	ITCH	1	affinity chromatography technology	Levy D (2007)	1
TRIP12	20	UBC	7	affinity chromatography technology	Park Y (2009)	1
OTUB1	0	UBE2D2	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Nakada S (2010), Juang YC (2012), Ernst A (2013), Juang YC (2012), Huttlin EL (2015), Scholz CC (2016), Huttlin EL (2017)	8
ITCH	1	CBL	7	affinity chromatography technology	Azakir BA (2009)	1
SMAD7	1	NEDD4L	3	affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Al-Salihi MA (2012), Aragon E (2012), Aragon E (2012), Aragon E (2012)	4
HEBP1	0	UBE2L3	1	biochemical	Wan C (2015)	1
ELAVL1	0	VDAC2	1	biochemical	Havugimana PC (2012)	1
MCM2	3	USP9X	15	affinity chromatography technology	Drissi R (2015)	1
SMURF1	4	TRIM28	1	affinity chromatography technology	Xie Y (2013)	1
UBE2D2	0	DTX3	4	two hybrid	Markson G (2009)	1
SMURF1	4	RBCK1	0	enzymatic study	Andrews PS (2010)	1
MAP1LC3B	1	NEDD4	2	affinity chromatography technology, pull down, pull down, x-ray crystallography	Sun A (2017), Sun A (2017), Qiu Y (2017), Qiu Y (2017)	4
MAPK6	1	PSMD2	2	affinity chromatography technology	Rodriguez J (2016)	1
BRCA1	7	TRIM28	1	affinity chromatography technology	Ertych N (2016)	1
RNF2	1	OTUB1	0	affinity chromatography technology	Cao Q (2014)	1
NEDD4L	3	VDAC2	1	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
ITCH	1	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down	Wiesner S (2007), Ishihara T (2011), Scialpi F (2008), Bai Y (2004), Oberst A (2007), Mouchantaf R (2006), Rossi M (2005), Zhang P (2010), Anindya R (2007), Kathania M (2015), Kristariyanto YA (2015), Riling C (2015), Riling C (2015), Zhang W (2016)	14
MDM2	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
SMURF1	4	5430	0	enzymatic study	Anindya R (2007)	1
MCM2	3	UBE2L3	1	affinity chromatography technology	Drissi R (2015)	1
UBE3A	4	HSPA4	3	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Mishra A (2009), Mishra A (2009), Mishra A (2009), Mishra A (2012)	4
CBLC	1	ITCH	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Courbard JR (2002), Courbard JR (2002), Courbard JR (2002), Courbard JR (2002)	4
ZNF598	6	VDAC2	1	affinity chromatography technology	Garzia A (2017)	1
UBA1	1	UBE2A	0	enzymatic study, pull down, enzymatic study, enzymatic study	Gavin JM (2012), Jin J (2007), Wauer T (2015), Huguenin-Dezot N (2016)	4
SF1	9	WWP2	7	two hybrid	Rual JF (2005)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
UBE2L3	1	TRAF7	11	two hybrid	Markson G (2009)	1
HUWE1	22	EIF4E2	2	affinity chromatography technology	Thompson JW (2014)	1
OTUB1	0	UBE2L3	1	affinity chromatography technology	Scholz CC (2016)	1
PRKN	1	ARIH1	3	affinity chromatography technology	Parelkar SS (2012)	1
HECW2	13	HECW1	3	affinity chromatography technology	Lu L (2013)	1
TIGAR	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
UBE2V2	0	UFM1	0	biochemical	Havugimana PC (2012)	1
HERC4	0	UBE2D2	0	pull down	Sheng Y (2012)	1
MDM2	2	HSPA4	3	affinity chromatography technology	Lu TL (2010)	1
SKP2	2	UBE2L3	1	affinity chromatography technology	Ma X (2017)	1
5430	0	YAP1	0	affinity chromatography technology	Gavva NR (1997)	1
5430	0	MCM2	3	biochemical	Yankulov K (1999)	1
UFM1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
HUWE1	22	MYC	2	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Adhikary S (2005), Adhikary S (2005), Adhikary S (2005), Koch HB (2007), Fan L (2015), Zhao X (2008)	6
NR3C1	2	NCOA1	6	pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Zilliacus J (2001), Kucera T (2002), Windahl SH (1999), Fryer CJ (1998), Needham M (2000), Li G (2006), Lempiaeinen JK (2017)	7
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
DAZAP1	1	MDH2	0	biochemical	Wan C (2015)	1
UBXN1	0	TRIM39	0	two hybrid	Rolland T (2014)	1
ELAVL1	0	SKP2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HECW1	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
WWP1	3	UBE2L3	1	pull down, pull down, pull down, pull down, pull down	Peschiaroli A (2010), Anindya R (2007), Kristariyanto YA (2015), Courivaud T (2015), Zhang W (2016)	5
MMACHC	0	UBE2L3	1	biochemical	Wan C (2015)	1
UBE2L3	1	RAB10	1	biochemical	Wan C (2015)	1
AHCYL1	2	USP34	7	biochemical	Havugimana PC (2012)	1
UBE2A	0	ELAVL1	0	affinity chromatography technology	An H (2017)	1
NEDD4L	3	AICDA	0	enzymatic study	Persaud A (2009)	1
HECW2	13	USP9X	15	affinity chromatography technology	Lu L (2013)	1
PSMD2	2	UBE3C	5	pull down, affinity chromatography technology, pull down	You J (2003), Chu BW (2013), You J (2001)	3
5430	0	UBE2L3	1	pull down	Anindya R (2007)	1
UBE2L3	1	VDAC2	1	biochemical	Havugimana PC (2012)	1
UBE2L3	1	CBLC	1	two hybrid	Markson G (2009)	1
HUWE1	22	PSMD2	2	affinity chromatography technology	Thompson JW (2014)	1
ITCH	1	NDFIP1	0	affinity chromatography technology, affinity chromatography technology, pull down	Kathania M (2015), Kathania M (2015), Riling C (2015)	3
AHCYL1	2	SNX3	1	biochemical	Havugimana PC (2012)	1
5430	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ingham RJ (2005), Ingham RJ (2005), Ingham RJ (2005), OConnor HF (2015)	4
ITCH	1	DAZAP1	1	pull down	Ingham RJ (2005)	1
UBE2D2	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
MYC	2	PSMD2	2	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2
UBE2L3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2D2	0	NFKBIA	0	enzymatic study	Gonen H (1999)	1
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
NEDD4	2	UBE2D2	0	two hybrid, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hatakeyama S (1997), Anan T (1998), Sehat B (2008), Arevalo JC (2006), Woelk T (2006), Persaud A (2009), Zeng F (2009), Sarkari F (2013), Liu PY (2012), Sugeno N (2014), Bustos F (2015), Chesarino NM (2015), Sun M (2016)	13
UBE2V2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
MDH2	0	RAB10	1	biochemical	Wan C (2015)	1
DAZAP1	1	SOD1	0	biochemical	Wan C (2015)	1
AURKA	1	RAB10	1	affinity chromatography technology	Ewing RM (2007)	1
HUWE1	22	MDH2	0	affinity chromatography technology	Thompson JW (2014)	1
AURKA	1	UBE2L3	1	affinity chromatography technology	Ewing RM (2007)	1
RC3H1	6	UBE2V2	0	pull down	Zhang Q (2015)	1
UBE2L3	1	RELA	1	enzymatic study	Ryo A (2003)	1
UBE2D2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2L3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Anan T (1998), Bruce MC (2008), Wiesner S (2007), Vina-Vilaseca A (2010), Anindya R (2007), Lin Q (2010), Chung S (2011), Tofaris GK (2011), Han L (2013), Persaud A (2014), Uchiki T (2009), Miyazaki K (2003), Zhang W (2016), Zhang X (2017)	14
SF1	9	SRPRB	0	biochemical	Havugimana PC (2012)	1
UBE3C	5	UBE2L3	1	pull down, pull down, pull down, pull down	Schwarz SE (1998), Michel MA (2015), Kristariyanto YA (2015), Zhang W (2016)	4
AHCYL1	2	UBE2L3	1	biochemical	Havugimana PC (2012)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
UBE2L3	1	UBE4B	5	biochemical	Havugimana PC (2012)	1
UBE2D2	0	XIAP	0	two hybrid, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Dynek JN (2010), Nakatani Y (2012), Nakatani Y (2012), Markson G (2009), Fang S (2001), Hu S (2003), Buetow L (2015), Foglizzo M (2016), Edison N (2017)	10
USP34	7	UCHL3	1	biochemical	Havugimana PC (2012)	1
MYC	2	UBE3C	5	affinity chromatography technology	Koch HB (2007)	1
AURKA	1	USP9X	15	affinity chromatography technology	Fogeron ML (2013)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
UBXN1	0	RBX1	2	affinity chromatography technology	Hu Y (2017)	1
MUL1	1	UBC	7	enzymatic study	Braschi E (2009)	1
MYC	2	5430	0	affinity chromatography technology	Koch HB (2007)	1
TRIM28	1	NR3C1	2	affinity chromatography technology, pull down, biochemical	Chang CJ (1998), Chang CJ (1998), Kristensen AR (2012)	3
BIRC3	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
UBE2A	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
BRCA1	7	RNF216	2	two hybrid	Woods NT (2012)	1
USP34	7	UBXN1	0	biochemical	Havugimana PC (2012)	1
MDM2	2	ARIH2	4	affinity chromatography technology, affinity chromatography technology	Bae S (2012), Bae S (2012)	2
AREL1	1	UBE2L3	1	pull down, pull down, pull down	Michel MA (2015), Kristariyanto YA (2015), Lear T (2016)	3
MDM2	2	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2010), Nie J (2010), Nie J (2010)	3
FN1	17	UBC	7	affinity chromatography technology	Humphries JD (2009)	1
UBXN1	0	BRCA1	7	affinity chromatography technology, pull down	Wu-Baer F (2010), Wu-Baer F (2010)	2
MCM2	3	UBC	7	affinity chromatography technology	Drissi R (2015)	1
BIRC2	1	UBE2B	3	two hybrid	Dynek JN (2010)	1
NFKBIA	0	RELA	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Lf (2001), Kiernan R (2003), Kiernan R (2003), Spencer E (1999), Spencer E (1999), Hay DC (2001), Hansen SK (1994), Malek S (1998), Cohen L (1998), Robert I (2009), Sasaki CY (2005), Wu BY (1995), Fagan-Garcia K (2011), Livolsi A (2001), Van Antwerp DJ (1996), Van Antwerp DJ (1996), Krappmann D (1996), Chen Z (1995), Bottero V (2001), Wang H (2010), DiDonato J (1996), Carvalho G (2010), Carvalho G (2010), Suzuki H (1999), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Pringle LM (2011), Pringle LM (2011), Pringle LM (2011), DiDonato J (1996), Ryo A (2003), Ryo A (2003), Inan MS (2000), Burstein E (2005), Chu ZL (1996), Chu ZL (1996), Starokadomskyy P (2013), Wang J (2011), Arenzana-Seisdedos F (1995), Arenzana-Seisdedos F (1997), Wood KM (1998), Cockman ME (2006), Cockman ME (2006), Li JM (2013), Rodriguez MS (1999), Huttlin EL (2015), Hein MY (2015), Taura M (2015), Kim MY (2015), Schweitzer K (2016), Schweitzer K (2016), Hochrainer K (2015), Jiang GM (2017), Huttlin EL (2017), Kumar S (2012), Kumar S (2012)	56
ELAVL1	0	UBA6	4	affinity chromatography technology	Abdelmohsen K (2009)	1
BAG3	4	PSMA5	0	affinity chromatography technology	Chen Y (2013)	1
UBE2A	0	RNF20	9	pull down, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim J (2011), Wu L (2014), Kim J (2009), Kim J (2009), Kim J (2009), Hong JH (2015), An H (2017)	7
UBE4B	5	STUB1	4	biochemical	Wan C (2015)	1
ZNF598	6	USP9X	15	affinity chromatography technology	Garzia A (2017)	1
TRAF6	0	UBE2L3	1	pull down, pull down	Geetha T (2005), Babu JR (2005)	2
PSMA5	0	PSMD2	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PTRHD1	0	UBE2L3	1	biochemical	Wan C (2015)	1
UBE2L3	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
USP34	7	USP9X	15	biochemical	Havugimana PC (2012)	1
SOD1	0	STUB1	4	affinity chromatography technology, affinity chromatography technology	Choi JS (2004), Ishigaki S (2007)	2
BRCA1	7	TRIM25	5	affinity chromatography technology	Ertych N (2016)	1
DNM1L	3	PSMD2	2	affinity chromatography technology	Malty RH (2017)	1
UBOX5	4	UBE2L3	1	two hybrid, pull down, two hybrid	Pringa E (2001), Pringa E (2001), Markson G (2009)	3
MAPK6	1	HSPA4	3	affinity chromatography technology	Rodriguez J (2016)	1
USP34	7	UBXN7	3	biochemical	Havugimana PC (2012)	1
PIR	0	UBE2L3	1	biochemical	Wan C (2015)	1
AHCYL1	2	UBXN1	0	biochemical	Havugimana PC (2012)	1
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
PTEN	24	WWP2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study	Crockett DK (2005), Ahmed SF (2012), Wu Y (2013), Maddika S (2011), Maddika S (2011), Maddika S (2011), Bawa-Khalfe T (2016), Bawa-Khalfe T (2016), Bawa-Khalfe T (2016), Chen Z (2016), Chen Z (2016), Chen Z (2017)	12
MYC	2	TRIM28	1	affinity chromatography technology	Koch HB (2007)	1
TRAF6	0	EIF4E2	2	affinity chromatography technology	Ewing RM (2007)	1
UBE2L3	1	UBE2V2	0	biochemical	Havugimana PC (2012)	1
MDM2	2	UBE2L3	1	pull down, pull down	Hampe C (2006), Yamauchi T (2014)	2
MYC	2	RELA	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Chapman NR (2002), Covic M (2005), Ivanov AA (2017)	3
HSPA4	3	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Hampe C (2006), Tsai YC (2003), Morishima Y (2008), Kalia SK (2004), Kalia SK (2004), Imai Y (2003), Imai Y (2003)	8
RC3H1	6	TRIM28	1	affinity chromatography technology	Murakawa Y (2015)	1
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
MYC	2	MDM2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMURF2	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
PJA1	1	ATXN3	2	enzymatic study	Loch CM (2012)	1
SMURF1	4	USP9X	15	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Xie Y (2013), Xie Y (2013), Xie Y (2013), Xie Y (2013)	4
UBE3A	4	RNF2	1	enzymatic study, affinity chromatography technology, pull down, enzymatic study	Zaaroor-Regev D (2010), Zaaroor-Regev D (2010), Zaaroor-Regev D (2010), Mortensen F (2015)	4
UBE2L3	1	HSPE1	0	biochemical	Wan C (2015)	1
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
RNF31	3	PRKN	1	affinity chromatography technology	Khan M (2016)	1
WWP1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBXN1	0	UBR5	13	affinity chromatography technology	Alexandru G (2008)	1
SOD1	0	PSMD2	2	affinity chromatography technology	Malty RH (2017)	1
PTEN	24	WWP1	3	affinity chromatography technology, affinity chromatography technology	Li N (2015), Maddika S (2011)	2
HUWE1	22	UBE2D2	0	pull down, pull down, pull down, pull down	Warr MR (2005), Kristariyanto YA (2015), Li L (2015), Zhang W (2016)	4
UBE2L3	1	USP26	1	biochemical	Havugimana PC (2012)	1
MCM2	3	UBXN1	0	affinity chromatography technology	Drissi R (2015)	1
DNM1L	3	UBE2L3	1	affinity chromatography technology	Malty RH (2017)	1
AHCYL1	2	UFM1	0	biochemical	Havugimana PC (2012)	1
BRCA1	7	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Wang X (2014), Wang X (2014)	2
UBE4B	5	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Wu H (2011), Wu H (2011), Wu H (2011), Wu H (2011), Zhang Y (2014), Zhang Y (2014)	6
UBE2L3	1	UFM1	0	biochemical	Wan C (2015)	1
UBXN7	3	UFM1	0	biochemical	Havugimana PC (2012)	1
TRAF6	0	ITCH	1	affinity chromatography technology	Shembade N (2008)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
RNF144B	0	UBC	7	enzymatic study	Michel MA (2017)	1
AHCYL1	2	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBC	7	RNF19B	0	affinity chromatography technology	Matsumoto M (2005)	1
RNF2	1	TRIM28	1	affinity chromatography technology	Cao Q (2014)	1
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
MYC	2	MRPL53	0	affinity chromatography technology	Agrawal P (2010)	1
NCOA1	6	FOS	0	pull down, two hybrid, pull down, pull down, affinity chromatography technology	Lee SK (2000), Lee SK (1998), Lee SK (1998), Fauquier L (2008), Fauquier L (2008)	5
UBE2L3	1	UCHL3	1	biochemical	Havugimana PC (2012)	1
AURKA	1	ZNF598	6	genetic interference	Horlbeck MA (2018)	1
TRIM21	0	UBE2L3	1	pull down	Wada K (2006)	1
BIRC2	1	CBLC	1	two hybrid	Woodsmith J (2012)	1
MAP1LC3B	1	CACNA1B	8	affinity chromatography technology, affinity chromatography technology	Gandini MA (2014), Gandini MA (2014)	2
AURKA	1	UBA1	1	biochemical	Wan C (2015)	1
UBASH3A	3	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Collingwood TS (2007), Kowanetz K (2004), Kowanetz K (2004), Feshchenko EA (2004), Feshchenko EA (2004), Feshchenko EA (2004), Hoeller D (2006)	7
PRKN	1	ATXN3	2	pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography	Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Bai JJ (2013)	7
UBA6	4	UBE2D2	0	pull down, pull down, enzymatic study, enzymatic study	Pelzer C (2007), Jin J (2007), Huang DT (2009), Liu X (2017)	4
FBXO2	0	UBE2L3	1	pull down	Nelson RF (2006)	1
MSI2	1	UBE2L3	1	biochemical	Wan C (2015)	1
XIAP	0	DTX3	4	two hybrid	Woodsmith J (2012)	1
UBE2A	0	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
HECW2	13	UBE2L3	1	pull down, pull down	Miyazaki K (2003), Zhang W (2016)	2
SUGP1	2	UBE2L3	1	biochemical	Havugimana PC (2012)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
NEDD4	2	5430	0	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Anindya R (2007), Anindya R (2007), Ingham RJ (2005), Beaudenon SL (1999)	4
ELAVL1	0	SRPRB	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BRCA1	7	PSMA5	0	affinity chromatography technology	Ertych N (2016)	1
ZNF598	6	UBE2D2	0	affinity chromatography technology	Garzia A (2017)	1
AHCYL1	2	ZPR1	1	biochemical	Havugimana PC (2012)	1
RNF144A	1	UBC	7	enzymatic study	Michel MA (2017)	1
TRIM25	5	USP9X	15	affinity chromatography technology	Choudhury NR (2017)	1
WWP2	7	MYC	2	affinity chromatography technology, affinity chromatography technology	Yu Z (2016), Yu Z (2016)	2
FN1	17	ELAVL1	0	affinity chromatography technology	Humphries JD (2009)	1
UBE2D2	0	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Watkins GR (2012), Du H (2014), Schweiger S (2014)	7
SMURF1	4	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Cao Y (2014), Xie P (2014), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016), Andrews PS (2010), He S (2017), Zhang Y (2017)	8
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
PTEN	24	STUB1	4	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ahmed SF (2012), Ahmed SF (2012), Ahmed SF (2012), Yuan L (2015)	4
UBXN7	3	PSMD2	2	affinity chromatography technology	Alexandru G (2008)	1
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
PIR	0	SOD1	0	biochemical	Wan C (2015)	1
TRIM25	5	MMACHC	0	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	UBE2L3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ATXN3	2	UBC	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, imaging technique, enzymatic study, pull down	Winborn BJ (2008), Mao Y (2005), Berke SJ (2005), Matsumoto M (2005), Bremm A (2010), Nicastro G (2010), Nicastro G (2010), Donaldson KM (2003), Chai Y (2004), Chai Y (2004), Nathan JA (2013), Seki T (2013), Yang H (2014), Yang H (2014), Blount JR (2014), Evers MM (2013), Weeks SD (2011), Donaldson KM (2003), Winborn BJ (2008), Faggiano S (2015), Wauer T (2015), Satoh T (2014), Satoh T (2014), Zhang X (2017), Toonen LJA (2017), Toonen LJA (2017), Kwasna D (2018)	27
LIG4	0	UBE2L3	1	two hybrid	Woods NT (2012)	1
TRIM25	5	TRIM28	1	affinity chromatography technology	Choudhury NR (2017)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
MAPK6	1	UBE2L3	1	two hybrid	Vinayagam A (2011)	1
OTUB1	0	HSPA4	3	affinity chromatography technology	Scholz CC (2016)	1
SMAD7	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005), Al-Salihi MA (2012)	3
RNF103	1	UBE2L3	1	two hybrid	Scheper J (2009)	1
PJA1	1	OTUB1	0	enzymatic study	Loch CM (2012)	1
ACAT2	1	UBXN1	0	biochemical	Wan C (2015)	1
TRIP12	20	UBE2L3	1	pull down	Schwarz SE (1998)	1
AURKA	1	PSMA5	0	affinity chromatography technology	Fogeron ML (2013)	1
SKP2	2	STUB1	4	affinity chromatography technology	Huang Z (2004)	1
AREL1	1	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
TRIM25	5	ARIH1	3	affinity chromatography technology	Choudhury NR (2017)	1
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
UBE2A	0	UBXN1	0	biochemical	Wan C (2015)	1
PCK2	3	UBE2L3	1	biochemical	Wan C (2015)	1
PRKN	1	PSMA5	0	affinity chromatography technology	Sarraf SA (2013)	1
BAG3	4	ATXN3	2	affinity chromatography technology	Chen Y (2013)	1
UBE2L3	1	RNF113B	1	two hybrid	Markson G (2009)	1
NEDD4	2	UBOX5	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
MYC	2	PSMA5	0	affinity chromatography technology	Koch HB (2007)	1
UBE2L3	1	UBE2L3	1	enzymatic study, pull down	David Y (2010), David Y (2010)	2
UBE2D2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
SOD1	0	UBE2L3	1	biochemical	Wan C (2015)	1
HUWE1	22	USP9X	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gomez-Bougie P (2011), Schwickart M (2010), Schwickart M (2010)	3
AHCYL1	2	USP9X	15	biochemical	Havugimana PC (2012)	1
ITCH	1	UBA1	1	affinity chromatography technology	OConnor HF (2015)	1
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
SOD1	0	UBC	7	affinity chromatography technology	Urushitani M (2004)	1
UBE2A	0	UBC	7	affinity chromatography technology	Hong JH (2015)	1
ARIH2	4	UBC	7	enzymatic study	Marteijn JA (2009)	1
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
MID1	1	UBC	7	affinity chromatography technology, affinity chromatography technology	Trockenbacher A (2001), Trockenbacher A (2001)	2
RBCK1	0	UBE2D2	0	pull down	Kirisako T (2006)	1
FN1	17	DAZAP1	1	affinity chromatography technology	Humphries JD (2009)	1
UBE2L3	1	UBXN1	0	biochemical	Havugimana PC (2012)	1
UBE2L3	1	YAP1	0	biochemical	Havugimana PC (2012)	1
PIR	0	SNX3	1	biochemical	Wan C (2015)	1
FN1	17	PSMA5	0	affinity chromatography technology	Humphries JD (2009)	1
ELAVL1	0	UFM1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2L3	1	SNX3	1	biochemical	Wan C (2015)	1
MID1	1	PSMD2	2	affinity chromatography technology	Gholkar AA (2016)	1
BIRC2	1	UBXN1	0	affinity chromatography technology, affinity chromatography technology	Wang YB (2015), Wang YB (2015)	2
NDUFA7	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
NR3C1	2	RELA	1	affinity chromatography technology, pull down, pull down	Ray A (1994), Nissen RM (2000), Caldenhoven E (1995)	3
UBXN7	3	ZPR1	1	biochemical	Havugimana PC (2012)	1
ZPR1	1	ARIH1	3	biochemical	Kristensen AR (2012)	1
UBXN1	0	UBXN7	3	affinity chromatography technology	Raman M (2015)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
ELAVL1	0	UBE4B	5	affinity chromatography technology	Abdelmohsen K (2009)	1
HECW1	3	UBE2L3	1	pull down	Kristariyanto YA (2015)	1
RNF2	1	RAB10	1	affinity chromatography technology	Cao Q (2014)	1
FN1	17	TRIM28	1	affinity chromatography technology	Humphries JD (2009)	1
MDM2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kubo N (2010), Kubo N (2010), Wu H (2015), Wu H (2015)	4
LIG4	0	TP53BP1	3	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
UFM1	0	MSI2	1	biochemical	Wan C (2015)	1
ATXN3	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
MAP1LC3B	1	UBE2L3	1	two hybrid, affinity chromatography technology	Gandini MA (2014), Gandini MA (2014)	2
RNF19A	3	SOD1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Niwa J (2007), Niwa J (2002), Niwa J (2002), Ishigaki S (2007)	4
BAG3	4	UBA1	1	affinity chromatography technology	Chen Y (2013)	1
BIRC3	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
HUWE1	22	MDM2	2	affinity chromatography technology, enzymatic study	Kurokawa M (2013), Kurokawa M (2013)	2
BRCA1	7	HSPA4	3	affinity chromatography technology	Ertych N (2016)	1
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
UBE2D2	0	UBOX5	4	two hybrid	Markson G (2009)	1
TRIM25	5	UBE4B	5	affinity chromatography technology	Choudhury NR (2017)	1
ATXN3	2	DNM1L	3	affinity chromatography technology	Kristensen LV (2018)	1
RBX1	2	UBE2L3	1	pull down, pull down, pull down	Cui Y (2011), Liu Y (2015), Liu Y (2015)	3
NFKBIA	0	AURKA	1	pull down	Briassouli P (2006)	1
BIRC3	1	OTUB1	0	affinity chromatography technology	Goncharov T (2013)	1
SUGP1	2	SNX3	1	biochemical	Havugimana PC (2012)	1
SOD1	0	HECW1	3	affinity chromatography technology	Miyazaki K (2004)	1
SUGP1	2	VDAC2	1	biochemical	Havugimana PC (2012)	1
UBXN1	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Wang YB (2015)	2
AURKA	1	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Ouchi M (2004), Ouchi M (2004), Maxwell CA (2011), Maxwell CA (2011), Ouchi M (2004), Ouchi M (2004), Ertych N (2016)	7
AHCYL1	2	SOD1	0	biochemical	Havugimana PC (2012)	1
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
USP26	1	MDM2	2	affinity chromatography technology	Lahav-Baratz S (2017)	1
TRIM25	5	PSMD2	2	affinity chromatography technology	Choudhury NR (2017)	1
SMAD7	1	SKP2	2	affinity chromatography technology	Kim TA (2013)	1
NCOA1	6	TRIM21	0	affinity chromatography technology	Wu RC (2002)	1
PRKN	1	UBE2A	0	pull down	Kazlauskaite A (2014)	1
SNX3	1	SRPRB	0	biochemical	Havugimana PC (2012)	1
NFKBIA	0	OTUB1	0	affinity chromatography technology	Huttlin EL (2015)	1
BRCA1	7	PSMD2	2	affinity chromatography technology	Ertych N (2016)	1
BAG3	4	HERC4	0	affinity chromatography technology	Hein MY (2015)	1
UBE2B	3	USP9X	15	biochemical	Havugimana PC (2012)	1
TRIM28	1	UBE2L3	1	pull down	Doyle JM (2010)	1
TP53BP1	3	TRIM28	1	affinity chromatography technology	Lin YH (2015)	1
UBE2L3	1	RNF144A	1	two hybrid, pull down	Markson G (2009), Ho SR (2014)	2
NEDD4L	3	NR3C1	2	pull down	Almloef T (1998)	1
UBE2V2	0	UBXN1	0	biochemical	Havugimana PC (2012)	1
ATXN3	2	UBE4B	5	pull down	Matsumoto M (2004)	1
FBXO2	0	STUB1	4	affinity chromatography technology, pull down, enzymatic study	Nelson RF (2006), Nelson RF (2006), Nelson RF (2006)	3
NFKBIA	0	ATXN3	2	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
UCHL3	1	UBC	7	enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Bremm A (2010), Boudreaux D (2012), Misaghi S (2005), Misaghi S (2005), Wilkinson KD (1999), Wilkinson KD (1999), Phillips AH (2013), Larsen CN (1998), Wada H (1998), Hemelaar J (2004), Altun M (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	17
UBE3C	5	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Wang M (2006), Wu PY (2003), Michel MA (2015), Kristariyanto YA (2015), Okada M (2015)	5
DAZAP1	1	UBE2L3	1	biochemical	Wan C (2015)	1
AHCYL1	2	UBE4B	5	biochemical	Havugimana PC (2012)	1
FBXO2	0	UBE2D2	0	pull down, pull down	Yoshida Y (2002), Nelson RF (2006)	2
UBC	7	USP34	7	pull down	Kwasna D (2018)	1
NDFIP1	0	UBE2L3	1	affinity chromatography technology	Kathania M (2015)	1
TRIM21	0	UBE2D2	0	pull down, pull down, pull down, pull down	Wada K (2006), Wada K (2006), Wada K (2009), Wada K (2006)	4
UBR5	13	UBE2A	0	pull down	Honda Y (2002)	1
UCHL3	1	XIAP	0	biochemical	Havugimana PC (2012)	1
NDUFA7	0	UBE4B	5	biochemical	Havugimana PC (2012)	1
UBE2A	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lyakhovich A (2003), Chen S (2012), Chen S (2012)	3
BRCA1	7	UBE2L3	1	pull down, two hybrid, x-ray crystallography, pull down	Brzovic PS (2003), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
HSPA4	3	NR3C1	2	affinity chromatography technology	Moraes LA (2005)	1
FN1	17	UBE2L3	1	affinity chromatography technology	Humphries JD (2009)	1
UBE4B	5	TRIP12	20	pull down	Park Y (2008)	1
UBE2L3	1	HSPA4	3	enzymatic study	Pridgeon JW (2004)	1
CBLC	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRIM25	5	ZNF598	6	affinity chromatography technology	Choudhury NR (2017)	1
RC3H1	6	TRIM21	0	affinity chromatography technology	Murakawa Y (2015)	1
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
UBE2D2	0	UFM1	0	two hybrid	van Wijk SJ (2009)	1
CBL	7	TRIM21	0	affinity chromatography technology	Brehme M (2009)	1
TRIM25	5	RC3H1	6	affinity chromatography technology	Choudhury NR (2017)	1
DUSP8	0	OTUB1	0	affinity chromatography technology	Li X (2016)	1
BIRC2	1	UBR5	13	affinity chromatography technology	Goncharov T (2013)	1
UBR5	13	UBE2D2	0	pull down, pull down, pull down, enzymatic study, pull down	Maddika S (2009), Honda Y (2002), Cojocaru M (2011), Matta-Camacho E (2012), Zhang W (2016)	5
UBE2D2	0	PJA1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yu P (2002), Yu P (2002), Yu P (2002), Loch CM (2011)	4
HSPA4	3	RELA	1	affinity chromatography technology, pull down	Guzhova IV (1997), Guzhova IV (1997)	2
ELAVL1	0	AHCYL1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
UBE2L3	1	SNX12	0	biochemical	Wan C (2015)	1
WWP2	7	NDFIP1	0	affinity chromatography technology	Huttlin EL (2015)	1
UBE2B	3	MDM2	2	affinity chromatography technology	Chen S (2012)	1
AHCYL1	2	UBA6	4	biochemical	Kristensen AR (2012)	1
UBE2D2	0	UBE3A	4	enzymatic study, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down	Anan T (1998), Hatakeyama S (1997), Hatakeyama S (1997), Louria-Hayon I (2009), Jacobson AD (2014), Mortensen F (2015), Rolfe M (1995), Kuslansky Y (2016)	8
SMAD7	1	YAP1	0	two hybrid, genetic interference, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down	Ferrigno O (2002), Ferrigno O (2002), Ferrigno O (2002), Aragon E (2012), Aragon E (2012), Aragon E (2012), Schuchardt BJ (2014)	7
SRPRB	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
RNF20	9	UBE2L3	1	pull down	Liu Z (2009)	1
UBE2A	0	UCHL3	1	biochemical	Havugimana PC (2012)	1
WWP2	7	5430	0	affinity chromatography technology	Huttlin EL (2017)	1
EIF4E2	2	ARIH1	3	affinity chromatography technology, two hybrid	Tan NG (2003), Tan NG (2003)	2
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HECW2	13	RNF2	1	affinity chromatography technology	Lu L (2013)	1
BIRC2	1	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Goncharov T (2013), Goncharov T (2013), Goncharov T (2013)	3
PTEN	24	XIAP	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Van Themsche C (2009), Van Themsche C (2009), Van Themsche C (2009), Ahmed SF (2012)	4
OTUB1	0	AURKA	1	enzymatic study	Min M (2015)	1
FBXO2	0	RBX1	2	affinity chromatography technology	Glenn KA (2008)	1
RC3H1	6	UBE2L3	1	pull down	Zhang Q (2015)	1
PRKN	1	UBE2B	3	pull down	Kazlauskaite A (2014)	1
UBA1	1	UCHL3	1	biochemical	Wan C (2015)	1
PCK2	3	HSPE1	0	biochemical	Wan C (2015)	1
UBA6	4	UBC	7	pull down, enzymatic study, unspecified method, affinity chromatography technology	Gavin JM (2012), Gavin JM (2012), Zhao B (2012), Bish RA (2007)	4
HERC3	0	PSMD2	2	affinity chromatography technology	Hochrainer K (2015)	1
OTUB1	0	SRPRB	0	affinity chromatography technology	Scholz CC (2016)	1
RELA	1	FOS	0	two hybrid, genetic interference	Yang X (1999), Yang X (1999)	2
TP53BP1	3	UBC	7	affinity chromatography technology	Benada J (2015)	1
SMAD7	1	MYC	2	affinity chromatography technology, affinity chromatography technology	Kim TA (2013), Kim TA (2013)	2
CBL	7	UBE2L3	1	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Yokouchi M (1999), Zheng N (2000), Wong ES (2002), Wong ES (2002), Oved S (2006), Dominguez C (2004)	6
BAG3	4	PSMD2	2	affinity chromatography technology	Chen Y (2013)	1
ELAVL1	0	UBE3C	5	affinity chromatography technology	Abdelmohsen K (2009)	1
PRKN	1	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Caulfield TR (2014), Kazlauskaite A (2014)	6
FN1	17	MDH2	0	affinity chromatography technology	Humphries JD (2009)	1
UBE3A	4	SOD1	0	pull down	Mishra A (2012)	1
ITCH	1	USP9X	15	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Mouchantaf R (2006), Mouchantaf R (2006), Azakir BA (2009), OConnor HF (2015)	4
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1
UBC	7	HERC3	0	pull down	Cruz C (2001)	1
BIRC3	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1