PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PML	7	DAXX	5	two hybrid, two hybrid, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Ishov AM (1999), Li H (2000), Li H (2000), Li H (2000), Lehembre F (2001), Zhong S (2000), Cuchet-Lourenco D (2011), Chu Y (2011), Meinecke I (2007), Jang MS (2002), Chang CC (2011), Wethkamp N (2011), Ferguson BJ (2007), Delbarre E (2013), Delbarre E (2013), Sahin U (2014), Lin DY (2006), Lin DY (2006), Lin DY (2006), Lin DY (2006), Torii S (1999)	21
UBA2	0	SAE1	0	two hybrid, affinity chromatography technology, enzymatic study, pull down, pull down, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Gong L (1999), Desterro JM (1999), Okuma T (1999), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	10
SATB1	1	PIAS1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, enzymatic study	Tan JA (2010), Tan JA (2010), Tan JA (2010), Tan JA (2010), Tan JA (2010), Tan JA (2008), Tan JA (2008)	7
CDKN2A	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, imaging technique	He L (2008), He L (2008), He L (2008)	3
TRIM28	1	DNMT3A	17	affinity chromatography technology	Quenneville S (2011)	1
BRCA1	7	AR	3	pull down, pull down, two hybrid	Park JJ (2000), Yeh S (2000), Yeh S (2000)	3
SATB1	1	UBE2I	0	two hybrid, two hybrid, two hybrid, enzymatic study	Rual JF (2005), Tan JA (2010), Tan JA (2008), Gocke CB (2005)	4
CREBBP	29	ELK1	2	far western blotting	Janknecht R (1996)	1
BRCA1	7	RANGAP1	4	affinity chromatography technology	Ertych N (2016)	1
SUMO1	0	HIPK2	0	two hybrid, imaging technique, pull down	Lee BH (2003), de la Vega L (2011), de la Vega L (2011)	3
RANGAP1	4	RANBP2	9	pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, biochemical	Gilbreth RN (2011), Werner A (2012), Gareau JR (2012), Saitoh H (2002), Zhang H (2002), Wan C (2015)	6
SP100	4	SUMO2	0	two hybrid, two hybrid, pull down	Wang J (2011), Hecker CM (2006), Hecker CM (2006)	3
SUMO2	0	ZHX1	1	two hybrid	Hecker CM (2006)	1
CREBBP	29	DAXX	5	two hybrid, affinity chromatography technology	Kuo HY (2005), Kuo HY (2005)	2
DAXX	5	SUMO1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, two hybrid, x-ray crystallography, two hybrid	Lin DY (2002), Ryu SW (2000), Ryu SW (2000), Ryu SW (2000), Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Naik MT (2011), Chang CC (2011), Chang CC (2011), Chen A (2006), Chen A (2006), Saul VV (2014), Ullmann R (2012), Lin DY (2006), Lin DY (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Naik MT (2011), Li C (2017)	20
ZHX1	1	PIAS4	5	two hybrid	Goehler H (2004)	1
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
SMAD4	9	DAXX	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Chang CC (2005), Chang CC (2005), Chang CC (2005)	3
SUMO2	0	UBA2	0	affinity chromatography technology	Li T (2006)	1
PML	7	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Matsuzaki K (2003), Doucas V (1999), Doucas V (1999), Zhong S (1999), Chen Y (2015)	7
FAS	2	TRAF3	1	pull down	Mosialos G (1995)	1
TP63	0	DAXX	5	two hybrid, affinity chromatography technology, two hybrid, pull down	Kim EJ (2003), Kim EJ (2003), Gostissa M (2004), Gostissa M (2004)	4
DAXX	5	TP53	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, unspecified method	Tang J (2006), Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Wethkamp N (2011), Zhao LY (2004), Zhao LY (2004), Zhao LY (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Zhao LY (2004), Zhao LY (2004), Zhang H (2013), Zhang H (2013), Chen TC (2014), Li Z (2017)	23
RANBP2	9	SP100	4	enzymatic study, enzymatic study	Tatham MH (2005), Pichler A (2002)	2
AR	3	HDAC4	10	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Franco PJ (2003), Yang Y (2011), Yang Y (2011), Yang Y (2011), Yang Y (2011), Yang Y (2011)	6
PARP1	3	UBE2I	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, enzymatic study, pull down, enzymatic study	Masson M (1997), Masson M (1997), Masson M (1997), Zilio N (2013), Matafora V (2009), Zilio N (2013), Gocke CB (2005)	7
SUMO3	0	PIAS1	4	pull down	Hecker CM (2006)	1
FAS	2	DAXX	5	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down	Ko YG (2001), Kim YY (2003), Cermak L (2002), Yang X (1997), Yang X (1997), Yang X (1997), Charette SJ (2000), Chen TC (2014), Chang HY (1999)	9
RANBP2	9	MDM2	2	enzymatic study	Miyauchi Y (2002)	1
SUMO3	0	UBA2	0	affinity chromatography technology	Li T (2006)	1
SAE1	0	RANGAP1	4	biochemical	Kristensen AR (2012)	1
ZNF451	3	PIAS2	2	two hybrid	Karvonen U (2008)	1
PARP1	3	PIAS4	5	affinity chromatography technology, pull down, pull down, enzymatic study	Martin N (2009), Martin N (2009), Martin N (2009), Ryu H (2010)	4
BRCA1	7	UBE2K	0	two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011), Shabbeer S (2013)	6
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
SUMO1	0	PIAS2	2	two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid	Lee BH (2003), Stehmeier P (2009), Wang J (2011), Hecker CM (2006), Hecker CM (2006), Rolland T (2014)	6
HIPK2	0	SP100	4	affinity chromatography technology	Moeller A (2003)	1
RANBP2	9	UBA2	0	affinity chromatography technology	Sarkar K (2015)	1
SUMO2	0	PIAS4	5	pull down, two hybrid, two hybrid, pull down, pull down	Goehler H (2004), Goehler H (2004), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
AR	3	UBE2I	0	two hybrid, affinity chromatography technology, genetic interference, enzymatic study	Poukka H (1999), Poukka H (1999), Poukka H (1999), Ogawa H (2009)	4
UBE2I	0	UBE2I	0	two hybrid, two hybrid, enzymatic study, two hybrid, two hybrid, pull down, two hybrid, pull down	Kovalenko OV (1996), Bandyopadhyay S (2010), Gruenwald M (2011), Jiang W (1996), Wright DA (1996), Wright DA (1996), Wang J (2011), David Y (2010)	8
DAXX	5	TRAF3	1	two hybrid	Wang J (2011)	1
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
SUMO1	0	RANBP2	9	two hybrid, pull down, pull down, affinity chromatography technology	Hecker CM (2006), Martin SF (2008), Ullmann R (2012), Ullmann R (2012)	4
MDM2	2	SUMO1	0	enzymatic study	Xirodimas DP (2002)	1
DAXX	5	SUMO3	0	pull down	Chang CC (2011)	1
UBE2I	0	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Rizos H (2005), Wang S (2015), Ivanschitz L (2015), Ivanschitz L (2015), Ivanschitz L (2015)	5
RANBP2	9	HDAC4	10	enzymatic study	Kirsh O (2002)	1
PIAS2	2	SMAD4	9	pull down	Li X (2006)	1
SP100	4	SUMO1	0	two hybrid, two hybrid, pull down, two hybrid	Rual JF (2005), Hecker CM (2006), Hecker CM (2006), Rolland T (2014)	4
MDM2	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2005), Wang C (2005), Wang C (2005), Gilmore-Hebert M (2010), Okamoto K (2006), Okamoto K (2006), Okamoto K (2006)	7
CREBBP	29	MDM2	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Inoue Y (2011), Wang X (2004), Sanchez M (2012)	3
TRIM28	1	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Neo SH (2015), Neo SH (2015), Neo SH (2015), Neo SH (2015)	4
TRIM28	1	CREBBP	29	affinity chromatography technology	Seki Y (2010)	1
SUMO1	0	RANGAP1	4	pull down	Tatham MH (2003)	1
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
PML	7	TP63	0	affinity chromatography technology, pull down	Bernassola F (2005), Bernassola F (2005)	2
CDKN2A	1	PIAS2	2	affinity chromatography technology, affinity chromatography technology	Herkert B (2010), Herkert B (2010)	2
PIAS1	4	PML	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Rabellino A (2012), Rabellino A (2012), Rabellino A (2012)	3
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
TRIM28	1	PARP1	3	affinity chromatography technology	Quenet D (2008)	1
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
TP53	0	PIAS2	2	pull down, pull down, two hybrid, enzymatic study, enzymatic study, imaging technique	Schmidt D (2002), Schmidt D (2002), Wang J (2008), Wu SY (2009), Schmidt D (2002), Chen TC (2014)	6
SUMO1	0	UBA2	0	pull down, pull down, pull down, two hybrid, pull down	Tatham MH (2003), Gong L (1999), Hemelaar J (2004), Rolland T (2014), Okuma T (1999)	5
ZNF451	3	PML	7	enzymatic study	Koidl S (2016)	1
SUMO2	0	TRIM28	1	pull down	Ouyang J (2009)	1
SUMO2	0	PIAS1	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Gocke CB (2008), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ullmann R (2012), Ouyang J (2009)	9
TRPS1	5	SUMO1	0	two hybrid	Kaiser FJ (2007)	1
SMAD4	9	UBE2I	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Chang CC (2005), Lin X (2003), Colland F (2004), Wang J (2011), Wang J (2011)	6
SUMO1	0	TP53	0	two hybrid	Minty A (2000)	1
HIPK2	0	DAXX	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofmann TG (2003), Hofmann TG (2003), McDonough H (2009), Kumar N (2013)	4
PML	7	TOP2B	9	affinity chromatography technology	McNamara S (2008)	1
BRCA1	7	PIAS4	5	imaging technique, enzymatic study, imaging technique	Galanty Y (2009), Morris JR (2009), Morris JR (2009)	3
BRCA1	7	SUMO1	0	fluorescent resonance energy transfe, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Park MA (2008), Park MA (2008), Park MA (2008), Ertych N (2016)	5
UBE2K	0	PIAS4	5	two hybrid	Goehler H (2004)	1
FAS	2	UBE2I	0	affinity chromatography technology, two hybrid, pull down, two hybrid	Becker K (1997), Wright DA (1996), Wright DA (1996), Wright DA (1996)	4
UBE2I	0	MDM2	2	pull down, affinity chromatography technology, enzymatic study, unspecified method	Buschmann T (2001), Buschmann T (2001), Buschmann T (2001), Buschmann T (2001)	4
HIPK2	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Di Stefano V (2005), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), He Y (2013)	5
PML	7	SUMO1	0	two hybrid, imaging technique, fluorescent resonance energy transfe, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down	Lin DY (2002), Cuchet-Lourenco D (2011), Percherancier Y (2009), Cuchet-Lourenco D (2012), Stehmeier P (2009), Duprez E (1999), Shen TH (2006), Shen TH (2006), Saether T (2007), Cappadocia L (2015), Cappadocia L (2015), Cappadocia L (2015), Li C (2017), Li C (2017)	14
PML	7	SP100	4	imaging technique, imaging technique, imaging technique, imaging technique, two hybrid, imaging technique	Cuchet-Lourenco D (2011), Cuchet-Lourenco D (2011), Cuchet D (2011), Negorev D (2001), Sternsdorf T (1997), Sahin U (2014)	6
PML	7	FAS	2	affinity chromatography technology	Tao RH (2011)	1
TP63	0	HIPK2	0	two hybrid	Kim EJ (2002)	1
UBE2I	0	UBA2	0	affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Knipscheer P (2008), Tatham MH (2003), Tatham MH (2003), Huang DT (2009), Gilbreth RN (2011), Okuma T (1999), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	10
SUMO2	0	TOP2B	9	pull down	Ouyang J (2009)	1
DNMT3A	17	SP100	4	two hybrid	Rolland T (2014)	1
DAXX	5	SUMO2	0	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid	Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Chen A (2006), Chen A (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Ouyang J (2009), Li C (2017)	9
AR	3	PIAS1	4	two hybrid, affinity chromatography technology	Kotaja N (2000), Toropainen S (2015)	2
RANBP2	9	TOP2B	9	affinity chromatography technology, enzymatic study	Dawlaty MM (2008), Dawlaty MM (2008)	2
UBE2I	0	ZHX1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Chen S (2013), Chen S (2013), Chen S (2013)	4
SATB1	1	SUMO1	0	two hybrid	Tan JA (2008)	1
SUMO3	0	SP100	4	pull down	Hecker CM (2006)	1
TP53	0	HIPK2	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Kim EJ (2002), Sung KS (2005), Li Q (2011), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), Lee MG (2014), Mancini F (2016)	12
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
ZNF451	3	PIAS1	4	two hybrid, imaging technique	Karvonen U (2008), Karvonen U (2008)	2
TP53	0	TOP2B	9	affinity chromatography technology, pull down	Cowell IG (2000), Cowell IG (2000)	2
SUMO3	0	PIAS2	2	pull down, unspecified method	Hecker CM (2006), Banani SF (2016)	2
SUMO3	0	HIPK2	0	pull down	de la Vega L (2011)	1
CDKN2A	1	TP63	0	affinity chromatography technology, pull down	Calabro V (2004), Calabro V (2004)	2
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
UBE2I	0	ELK1	2	enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study	Yang SH (2006), Yang SH (2006), Yang SH (2006), Yang SH (2003), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013)	7
UBE2K	0	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay	Bae Y (2013), Bae Y (2013), Bae Y (2013)	3
CDKN2A	1	DAXX	5	pull down, affinity chromatography technology, affinity chromatography technology	Ivanchuk SM (2008), Ivanchuk SM (2008), Ivanchuk SM (2008)	3
UBE2I	0	SP100	4	enzymatic study, pull down, two hybrid, enzymatic study, enzymatic study, enzymatic study	Knipscheer P (2008), Knipscheer P (2008), Bandyopadhyay S (2010), Pelisch F (2010), Meulmeester E (2008), Knipscheer P (2007)	6
UBE2I	0	SAE1	0	affinity chromatography technology, enzymatic study, pull down, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Tatham MH (2003), Huang DT (2009), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
UBE2I	0	PCGF2	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2008), Zhang J (2008), Ju WN (2009), Jo S (2016), Jo S (2016)	5
PARP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, genetic interference, affinity chromatography technology	Hu Y (2014), Hu Y (2014), Hu Y (2014), Shen JP (2017), Srivas R (2016), Ertych N (2016)	6
TP63	0	MDM2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zdzalik M (2010), Zdzalik M (2010), Galli F (2010), Calabro V (2002), Calabro V (2002), Stindt MH (2015)	6
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
BRCA1	7	TRIM28	1	affinity chromatography technology	Ertych N (2016)	1
SAE1	0	SUMO3	0	affinity chromatography technology, biochemical	Ewing RM (2007), Wan C (2015)	2
PARP1	3	TOP2B	9	affinity chromatography technology	Ju BG (2006)	1
KMT5A	2	TP53	0	enzymatic study	Shi X (2007)	1
SUMO1	0	PIAS1	4	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, pull down	Lee BH (2003), Kahyo T (2001), Stehmeier P (2009), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Gocke CB (2008), Ullmann R (2012), Ledsaak M (2016)	12
UBE2I	0	UBE2K	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, biochemical	Knipscheer P (2008), Gruenwald M (2011), Pichler A (2005), Galisson F (2011), Wan C (2015)	5
CREBBP	29	SUMO1	0	x-ray crystallography, pull down	Diehl C (2016), Diehl C (2016)	2
ZNF451	3	AR	3	affinity chromatography technology, two hybrid	Karvonen U (2008), Karvonen U (2008)	2
DAXX	5	AR	3	two hybrid, pull down, affinity chromatography technology, pull down	Lin DY (2004), Lin DY (2004), Lin DY (2004), Sun S (2016)	4
TOP2B	9	UBE2I	0	two hybrid, pull down, affinity chromatography technology, enzymatic study	Mao Y (2000), Mao Y (2000), Mao Y (2000), Gocke CB (2005)	4
SUMO2	0	RANBP2	9	two hybrid	Hecker CM (2006)	1
UBE2K	0	MDM2	2	two hybrid, pull down, pull down	Bae Y (2013), Saville MK (2004), David Y (2011)	3
PIAS2	2	PIAS4	5	two hybrid	Wang J (2011)	1
HIPK2	0	PML	7	affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	de la Vega L (2011), Renner F (2010), Sung KS (2011), Sung KS (2011), Gresko E (2009), Gresko E (2009), Gresko E (2009)	7
TP63	0	UBE2I	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Huang YP (2004), Huang YP (2004), Huang YP (2004), Ghioni P (2005)	4
PIAS1	4	MDM2	2	enzymatic study	Miyauchi Y (2002)	1
CDKN2A	1	PML	7	affinity chromatography technology, affinity chromatography technology, imaging technique	Ivanschitz L (2015), Ivanschitz L (2015), Ivanschitz L (2015)	3
HIPK2	0	PARP1	3	affinity chromatography technology, pull down, affinity chromatography technology	Choi JR (2016), Choi JR (2016), Choi JR (2016)	3
DNMT3A	17	PIAS1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Ling Y (2004), Ling Y (2004), Ling Y (2004), Ling Y (2004), Liu B (2010), Liu B (2010)	6
PML	7	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bernardi R (2004), Bernardi R (2004), Zhu H (2003), Zhu H (2003), Kurki S (2003), Kurki S (2003), Wei X (2003), Wei X (2003), Wu Q (2009), Chu Y (2011), Yang Q (2013), Yang Q (2013), Bursac S (2012)	13
RANGAP1	4	PCGF2	3	affinity chromatography technology, affinity chromatography technology	Zhang J (2008), Zhang J (2008)	2
KMT5A	2	UBE2I	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Spektor TM (2011), Spektor TM (2011), Spektor TM (2011), Spektor TM (2011), Spektor TM (2011), Spektor TM (2011)	6
SUMO1	0	TP63	0	affinity chromatography technology	Huang YP (2004)	1
UBE2I	0	TRAF3	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Miliara S (2013), Miliara S (2013), Miliara S (2013), Miliara S (2013)	4
UBE2I	0	HDAC4	10	enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Knipscheer P (2008), Zhao X (2005), Zhao X (2005), Dehennaut V (2013), Tatham MH (2001), Knipscheer P (2007)	6
SUMO2	0	ZNF451	3	pull down	Ouyang J (2009)	1
RANBP2	9	TP53	0	enzymatic study	Gareau JR (2012)	1
SUMO2	0	PIAS2	2	two hybrid, two hybrid, pull down, pull down, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
DAXX	5	DNMT3A	17	affinity chromatography technology	Halder UC (2013)	1
UBE2I	0	HIPK2	0	two hybrid, two hybrid, two hybrid, pull down, two hybrid, enzymatic study	Lee BH (2003), Bandyopadhyay S (2010), Sung KS (2005), Sung KS (2005), Hofmann TG (2005), Sung KS (2005)	6
TP63	0	FAS	2	affinity chromatography technology	Amoresano A (2010)	1
SUMO1	0	FAS	2	two hybrid, pull down	Okura T (1996), Okura T (1996)	2
SUMO3	0	PML	7	imaging technique	Cuchet-Lourenco D (2011)	1
CREBBP	29	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Pao GM (2000), Pao GM (2000), Benezra M (2003), Fan S (2002), Fan S (2002), Neish AS (1998), Nakuci E (2006), Crowe DL (2006), Chai YL (1999)	9
SUMO2	0	SAE1	0	affinity chromatography technology, affinity chromatography technology	Li T (2006), Hein MY (2015)	2
BRCA1	7	PIAS1	4	imaging technique, enzymatic study, imaging technique	Galanty Y (2009), Morris JR (2009), Morris JR (2009)	3
SUMO1	0	ZNF451	3	pull down	Karvonen U (2008)	1
PML	7	SATB1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Kumar PP (2007), Kumar PP (2007), Kumar PP (2007), Kumar PP (2007), Tan JA (2008)	5
DAXX	5	PARP1	3	affinity chromatography technology	Hein MY (2015)	1
SUMO1	0	ZHX1	1	two hybrid	Hecker CM (2006)	1
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
CREBBP	29	PARP1	3	enzymatic study, imaging technique	Hassa PO (2005), Chen H (2014)	2
PIAS4	5	UBE2I	0	two hybrid, pull down, pull down, pull down	Wang J (2011), Yamamoto H (2003), Yin Y (2012), Ryu H (2010)	4
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
SMAD4	9	CREBBP	29	affinity chromatography technology	Yang Y (2015)	1
SMAD4	9	SUMO1	0	affinity chromatography technology	Lee PS (2003)	1
DAXX	5	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Ivanchuk SM (2008), Ivanchuk SM (2008), Tang J (2006), Tang J (2006), Tang J (2006), Song MS (2008), Zhao LY (2004), Tang J (2013), Tang J (2013), Zhao LY (2004), Zhang H (2013), Zhang H (2013), Li Z (2017)	13
TRIM28	1	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Doyle JM (2010), Gilmore-Hebert M (2010), Okamoto K (2006)	3
CREBBP	29	AR	3	two hybrid, pull down, pull down, genetic interference, affinity chromatography technology, pull down	Kim J (2005), Fronsdal K (1998), Ishitani K (2003), Aarnisalo P (1998), Andersen RJ (2010), Fronsdal K (1998)	6
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
PML	7	RANBP2	9	affinity chromatography technology	Satow R (2012)	1
UBE2I	0	ZNF451	3	two hybrid, two hybrid, enzymatic study, two hybrid, two hybrid	Rual JF (2005), Bandyopadhyay S (2010), Karvonen U (2008), Karvonen U (2008), Yu H (2011)	5
TP53	0	ZHX1	1	two hybrid	Goehler H (2004)	1
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
DAXX	5	TOP2B	9	affinity chromatography technology	Hein MY (2015)	1
SATB1	1	PIAS4	5	two hybrid, two hybrid	Tan JA (2010), Tan JA (2008)	2
SUMO1	0	SAE1	0	pull down	Tatham MH (2003)	1
HIPK2	0	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Hofmann TG (2002), Hofmann TG (2002)	2
SUMO2	0	HIPK2	0	pull down	de la Vega L (2011)	1
DNMT3A	17	PIAS2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Ling Y (2004), Ling Y (2004), Ling Y (2004), Ling Y (2004)	4
TP53	0	TP63	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McDade SS (2011), Lu D (2013), Chae YS (2012), Chae YS (2012), Stindt MH (2015), Wei S (2014)	6
UBE2I	0	TRIM28	1	affinity chromatography technology, pull down, enzymatic study, pull down	Liang Q (2011), Garvin AJ (2013), Ivanov AV (2007), Neo SH (2015)	4
SMAD4	9	PIAS1	4	two hybrid, two hybrid	Colland F (2004), Wang J (2011)	2
SUMO1	0	TOP2B	9	two hybrid	Mao Y (2000)	1
AR	3	PIAS4	5	pull down, pull down	Gross M (2001), Gross M (2004)	2
SUMO2	0	BRCA1	7	affinity chromatography technology	Hu X (2012)	1
PIAS2	2	PML	7	imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	Cuchet-Lourenco D (2011), Rabellino A (2012), Rabellino A (2012), Rabellino A (2012)	4
TRPS1	5	UBE2I	0	affinity chromatography technology, two hybrid, enzymatic study, enzymatic study	Kaiser FJ (2007), Kaiser FJ (2007), Kaiser FJ (2007), Brandt M (2013)	4
AR	3	MDM2	2	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zoubeidi A (2007), Gaughan L (2005), Gaughan L (2005), Chymkowitch P (2011), Chymkowitch P (2011), Liu T (2012), Liu T (2012), Deep G (2008), Deep G (2008), Lin HK (2002), Lin HK (2002), Zhang A (2015), Kwegyir-Afful AK (2015), McClurg UL (2016), McClurg UL (2016), Liao Y (2017), Steely AM (2017), Zhai W (2016)	18
TP53	0	PIAS1	4	two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, imaging technique, pull down	Gallagher WM (1999), Kahyo T (2001), Kahyo T (2001), Schmidt D (2002), Pelisch F (2010), Schmidt D (2002), Chen TC (2014), Okubo S (2004)	8
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
AR	3	PIAS2	2	two hybrid, two hybrid, pull down, pull down	Kotaja N (2000), Moilanen AM (1999), Moilanen AM (1999), Kotaja N (2000)	4
MDM2	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Zhang Y (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Clark PA (2002), Clark PA (2002), Clark PA (2002), Pomerantz J (1998), Ivanchuk SM (2008), Wang C (2005), Wang X (2001), Midgley CA (2000), Shen J (2011), Li L (2010), Li L (2010), Li X (2011), Woods YL (2004), Bouska A (2008), Lindstroem MS (2007), Lohrum MA (2000), Wang J (2006), Wang J (2006), Wang J (2006), Drago-Ferrante R (2008), Schuster K (2007), Hogan C (2008), Rizos H (2000), Gargano B (2008), Kamijo T (1998), Wang S (2010), Jones R (2007), Stott FJ (1998), Lo D (2014), Pimkina J (2009), Blattner C (2002), Leslie PL (2015), Bothner B (2003), Ivanov AA (2017)	42
PIAS4	5	SMAD4	9	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Lee PS (2003)	5
UBE2I	0	RANBP2	9	affinity chromatography technology, pull down, two hybrid, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Zhang H (2002), Bandyopadhyay S (2010), Werner A (2012), Tatham MH (2005), Saitoh H (2002), Saitoh H (2002), Gareau JR (2012), Hein MY (2015), Sarkar K (2015), Huttlin EL (2017)	11
SUMO1	0	PIAS4	5	two hybrid	Hecker CM (2006)	1
UBE2I	0	RANGAP1	4	affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Knipscheer P (2008), Shiio Y (2003), Gruenwald M (2011), Gareau JR (2012), Lee GW (1998), Zhang J (2008), Yang SH (2006), Yang SH (2006), Wang J (2011), Meulmeester E (2008), Hsieh YL (2013), Hsieh YL (2013), Oh YH (2007), Wang J (2010), Cooper HJ (2005), Hu G (2010), Galisson F (2011), Hein MY (2015), Huttlin EL (2017), Xiong Y (2017)	22
SUMO2	0	PML	7	imaging technique, two hybrid, pull down	Cuchet-Lourenco D (2011), Li C (2017), Li C (2017)	3
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
UBE2I	0	SUMO3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Li T (2006), Boutell C (2011), Hecker CM (2006), Tatham MH (2001), Wan C (2015), Huttlin EL (2017)	7
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
DNMT3A	17	UBE2I	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Ling Y (2004), Ling Y (2004), Ling Y (2004), Ling Y (2004)	4
SMAD4	9	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002)	4
BRCA1	7	TP63	0	affinity chromatography technology, imaging technique	Buckley NE (2011), Buckley NE (2014)	2