PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KIAA0368	0	KDM2A	4	affinity chromatography technology	Gorbea C (2010)	1
UBE2G2	0	CORO1A	0	affinity chromatography technology	Ewing RM (2007)	1
TMEM216	0	UBE2G2	0	bioid	Gupta GD (2015)	1
RC3H1	6	RC3H2	5	affinity chromatography technology	Murakawa Y (2015)	1
TRIM9	3	FBXW11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Shi M (2014), Shi M (2014), Shi M (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Coyaud E (2015), Huttlin EL (2017)	8
PRKN	1	HNRNPD	3	affinity chromatography technology	Zanon A (2013)	1
RFFL	0	MDM2	2	affinity chromatography technology	Yang W (2008)	1
UBE2G2	0	USP15	4	affinity chromatography technology	Ewing RM (2007)	1
AMFR	2	UBC	7	pull down, pull down, imaging technique, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Zhong X (2004), Yang H (2010), Ying Z (2009), Jo Y (2011), Ye Y (2003), Xu Y (2012), Liu S (2012), Liu S (2012), Xu Y (2012), Morito D (2008), Flierman D (2006), Liu W (2014), Fang S (2001)	13
ERLEC1	1	UBE2G2	0	affinity chromatography technology	Christianson JC (2012)	1
OTUB1	0	UBE2G2	0	affinity chromatography technology	Scholz CC (2016)	1
AMFR	2	MGRN1	4	affinity chromatography technology, affinity chromatography technology	Mukherjee R (2016), Mukherjee R (2016)	2
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
BAG3	4	SEM1	0	affinity chromatography technology	Chen Y (2013)	1
HBS1L	3	UBE2G2	0	two hybrid	Wang J (2011)	1
BAG3	4	UBE2G2	0	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
AMFR	2	RNF5	0	affinity chromatography technology	Morito D (2008)	1
RC3H2	5	UBE2G2	0	pull down	Zhang Q (2015)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
ARL14	1	UBE2G2	0	two hybrid	Wang J (2011)	1
UBE2G2	0	MGRN1	4	two hybrid	van Wijk SJ (2009)	1
KDM2A	4	UBE2G2	0	two hybrid	Wang J (2011)	1
UBE2G2	0	RNF146	4	two hybrid	van Wijk SJ (2009)	1
RNF168	0	KIAA0368	0	two hybrid	Gorbea C (2010)	1
MDM2	2	TRIM9	3	two hybrid	Woodsmith J (2012)	1
FBXW11	2	UBE2G2	0	affinity chromatography technology	Low TY (2014)	1
RC3H2	5	UBC	7	enzymatic study	Zhang Q (2015)	1
OTUB1	0	UBL4A	0	affinity chromatography technology	Scholz CC (2016)	1
RC3H1	6	UBE2G2	0	pull down	Zhang Q (2015)	1
AMFR	2	UBL4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang Q (2011), Wang Q (2011), Liu Y (2014), Liu Y (2014)	4
UBE2G2	0	RNF111	2	two hybrid	van Wijk SJ (2009)	1
UBE2G2	0	TRIM43	0	two hybrid	van Wijk SJ (2009)	1
POLR3F	1	UBE2G2	0	two hybrid	Wang J (2011)	1
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
TRIM9	3	UBE2G2	0	affinity chromatography technology	Napolitano LM (2011)	1
TRIM25	5	AMFR	2	enzymatic study, pull down	Wang Y (2014), Wang Y (2014)	2
UBA1	1	UBE2G2	0	pull down, enzymatic study, enzymatic study	Jin J (2007), Wauer T (2015), Huguenin-Dezot N (2016)	3
EGLN3	0	FARP2	1	affinity chromatography technology	Rodriguez J (2016)	1
RNF26	2	USP15	4	affinity chromatography technology, affinity chromatography technology	Jongsma ML (2016), Jongsma ML (2016)	2
FBXW11	2	HNRNPDL	1	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
UBE2G2	0	HNRNPDL	1	biochemical	Wan C (2015)	1
SEM1	0	UBE2G2	0	affinity chromatography technology	Besche HC (2014)	1
UBE2G2	0	MALT1	1	affinity chromatography technology	Ewing RM (2007)	1
SEM1	0	UBL4A	0	affinity chromatography technology	Besche HC (2014)	1
UBE2G2	0	BIRC8	0	two hybrid	van Wijk SJ (2009)	1
HNRNPDL	1	HNRNPD	3	biochemical	Havugimana PC (2012)	1
UBC	7	UBL4A	0	affinity chromatography technology	Matsumoto M (2005)	1
PRKN	1	UBE2G2	0	pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Kazlauskaite A (2014)	5
HNRNPD	3	KIAA0368	0	affinity chromatography technology	Hein MY (2015)	1
UBE2G2	0	HNRNPAB	4	biochemical	Wan C (2015)	1
UBE2G2	0	VAMP8	0	two hybrid	Wang J (2011)	1
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
FBXW11	2	HNRNPAB	4	affinity chromatography technology	Coyaud E (2015)	1
FBXW11	2	AUP1	0	affinity chromatography technology	Low TY (2014)	1
UBE2G2	0	RNF168	0	two hybrid	van Wijk SJ (2009)	1
UBE2G2	0	RNF26	2	two hybrid	van Wijk SJ (2009)	1
UBE2G2	0	RNF157	3	two hybrid	van Wijk SJ (2009)	1
DUSP6	2	MGRN1	4	affinity chromatography technology	Li X (2016)	1
UBA6	4	UBE2G2	0	pull down	Jin J (2007)	1
UBE2G2	0	AUP1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Spandl J (2011), Klemm EJ (2011), Klemm EJ (2011), Jo Y (2013), Christianson JC (2012), Christianson JC (2012)	7
MUL1	1	UBE2G2	0	two hybrid	Ambivero CT (2014)	1
CNNM3	2	UBE2G2	0	two hybrid	Wang J (2011)	1
PTPRO	3	ERLEC1	1	affinity chromatography technology	Li X (2016)	1
PRKN	1	NDUFS4	1	affinity chromatography technology	Zanon A (2013)	1
EGFR	5	KIAA0368	0	affinity chromatography technology	Tong J (2014)	1
EGLN3	0	AUP1	0	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
EGLN3	0	UBE2G2	0	affinity chromatography technology	Rodriguez J (2016)	1
RNF5	0	UBC	7	enzymatic study	Didier C (2003)	1
SEM1	0	UBC	7	affinity chromatography technology	Besche HC (2014)	1
FBXW11	2	RBX1	2	affinity chromatography technology	Tan P (1999)	1
PTPRO	3	AUP1	0	affinity chromatography technology	Li X (2016)	1
TRIM25	5	UBE2G2	0	affinity chromatography technology	Choudhury NR (2017)	1
EGLN3	0	HBS1L	3	affinity chromatography technology	Rodriguez J (2016)	1
DUSP6	2	UBE2G2	0	affinity chromatography technology	Li X (2016)	1
RNF5	0	UBE2G2	0	pull down	Tcherpakov M (2009)	1
EGLN3	0	USP15	4	affinity chromatography technology	Rodriguez J (2016)	1
MUL1	1	TRIM9	3	two hybrid	Rolland T (2014)	1
FBXW11	2	UBA1	1	affinity chromatography technology	Low TY (2014)	1
UBE2G2	0	UBE2G2	0	affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, pull down, enzymatic study, pull down, enzymatic study	Liu W (2014), Liu W (2014), Liu W (2014), David Y (2010), David Y (2010), Liu W (2014), Li W (2009), Liu W (2014)	8
FBXW11	2	BAG3	4	affinity chromatography technology	Low TY (2014)	1
MUL1	1	UBC	7	enzymatic study	Braschi E (2009)	1
EGLN3	0	RNF5	0	affinity chromatography technology	Rodriguez J (2016)	1
RNF139	4	UBE2G2	0	affinity chromatography technology	Jo Y (2013)	1
UBL4A	0	HNRNPAB	4	affinity chromatography technology	Xu Y (2012)	1
PRKN	1	HNRNPDL	1	affinity chromatography technology	Zanon A (2013)	1
UBL4A	0	UBE2G2	0	affinity chromatography technology	Xu Y (2012)	1
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
RFFL	0	OTUB1	0	enzymatic study	Loch CM (2012)	1
UBE2G2	0	AMFR	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, pull down	Ewing RM (2007), Cao J (2007), Chen B (2006), Chen B (2006), Chen B (2006), Li W (2009), Li W (2009), Wang Q (2011), Jo Y (2013), Morito D (2008), Das R (2013), Yan L (2014), Liu W (2014), Li W (2009), Liu W (2014), Christianson JC (2012), Liu Y (2014)	17
RBX1	2	UBE2G2	0	pull down, pull down	Mallampalli RK (2013), Zou C (2011)	2
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
TRIM25	5	CNNM3	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	FARP2	1	affinity chromatography technology	Choudhury NR (2017)	1
RNF139	4	AUP1	0	affinity chromatography technology	Jo Y (2013)	1
TRIM25	5	HNRNPD	3	affinity chromatography technology	Choudhury NR (2017)	1
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
SEM1	0	KIAA0368	0	affinity chromatography technology	Besche HC (2014)	1
EGLN3	0	OTUB1	0	affinity chromatography technology	Rodriguez J (2016)	1
UBE2G2	0	KIAA0368	0	two hybrid	Gorbea C (2010)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
TRIM25	5	KDM2A	4	affinity chromatography technology	Choudhury NR (2017)	1
UBE2G2	0	RFFL	0	two hybrid	van Wijk SJ (2009)	1
FBXW11	2	MDM2	2	affinity chromatography technology	Inuzuka H (2010)	1
AMFR	2	AUP1	0	affinity chromatography technology	Jo Y (2013)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
TRIM25	5	RC3H2	5	affinity chromatography technology	Choudhury NR (2017)	1
SEM1	0	USP15	4	affinity chromatography technology	Besche HC (2014)	1
FARP2	1	UBE2G2	0	two hybrid	Wang J (2011)	1
EGFR	5	UBE2G2	0	affinity chromatography technology	Tong J (2014)	1
MDM2	2	USP15	4	pull down	Liu WT (2016)	1
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
UBE2G2	0	TRIM3	2	two hybrid	van Wijk SJ (2009)	1
UBE2G2	0	MDM2	2	two hybrid	van Wijk SJ (2009)	1
EGLN3	0	KIAA0368	0	affinity chromatography technology	Rodriguez J (2016)	1
MDM2	2	HNRNPD	3	affinity chromatography technology	Jacob AG (2014)	1
BAG3	4	UBA1	1	affinity chromatography technology	Chen Y (2013)	1
FBXW11	2	HNRNPD	3	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
NDUFS4	1	UBE2G2	0	two hybrid	Wang J (2011)	1
TMEM45B	0	UBE2G2	0	two hybrid	Wang J (2011)	1
UBE2G2	0	UBC	7	x-ray crystallography, pull down, pull down	Bocik WE (2011), Bocik WE (2011), Reyes LF (2006)	3
UBE2G2	0	HNRNPD	3	biochemical	Wan C (2015)	1
TMEM216	0	AUP1	0	bioid	Gupta GD (2015)	1
PTPRO	3	UBE2G2	0	affinity chromatography technology	Li X (2016)	1
EGLN3	0	UBL4A	0	affinity chromatography technology	Rodriguez J (2016)	1
UBL4A	0	AUP1	0	affinity chromatography technology	Xu Y (2012)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
HNRNPD	3	HNRNPAB	4	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
CPOX	1	UBE2G2	0	two hybrid	Wang J (2011)	1
TRIM25	5	RC3H1	6	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	RFFL	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2G2	0	ZNRF4	1	two hybrid	van Wijk SJ (2009)	1
TRIM25	5	HNRNPAB	4	affinity chromatography technology	Choudhury NR (2017)	1
EGLN3	0	MGRN1	4	affinity chromatography technology	Rodriguez J (2016)	1
MLLT6	2	UBE2G2	0	two hybrid	Wang J (2011)	1
ZNRF4	1	AMFR	2	affinity chromatography technology	Huttlin EL (2017)	1
UBA6	4	UBC	7	pull down, enzymatic study, unspecified method, affinity chromatography technology	Gavin JM (2012), Gavin JM (2012), Zhao B (2012), Bish RA (2007)	4
TRIM25	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pauli EK (2014), Pauli EK (2014), Pauli EK (2014), Pauli EK (2014)	4
AUP1	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5