PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF41	2	UBE2D3	1	pull down, pull down	Yu F (2008), Qiu XB (2004)	2
TRIM5	4	UBC	7	enzymatic study	Pertel T (2011)	1
MID2	1	UBE2D3	1	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
BMI1	0	KDM1B	4	genetic interference	Wong AS (2016)	1
UBTD1	0	UBE2D3	1	two hybrid, biochemical, affinity chromatography technology	Uhler JP (2013), Uhler JP (2013), Uhler JP (2013)	3
HUWE1	22	UBA1	1	affinity chromatography technology	Thompson JW (2014)	1
UBE2D3	1	RNF125	0	affinity chromatography technology, two hybrid	Arimoto K (2008), Markson G (2009)	2
TRIM11	1	UBE2D3	1	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
BMI1	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
NEDD4	2	RBX1	2	affinity chromatography technology	Liu J (2014)	1
UBC	7	RNF25	1	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	MIB1	5	affinity chromatography technology	Matsumoto M (2005)	1
DTX3L	1	RNF111	2	two hybrid	Woodsmith J (2012)	1
RNF115	1	NFKBIA	0	enzymatic study	Colomer-Lluch M (2017)	1
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
NFKBIA	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
AMFR	2	UBC	7	pull down, pull down, imaging technique, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Zhong X (2004), Yang H (2010), Ying Z (2009), Jo Y (2011), Ye Y (2003), Xu Y (2012), Liu S (2012), Liu S (2012), Xu Y (2012), Morito D (2008), Flierman D (2006), Liu W (2014), Fang S (2001)	13
CDC34	3	SIAH1	2	two hybrid	Rolland T (2014)	1
UBE2D3	1	TRIM27	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
PRKN	1	FBXO7	1	affinity chromatography technology, pull down, pull down	Burchell VS (2013), Burchell VS (2013), Burchell VS (2013)	3
UBE3A	4	MDM2	2	enzymatic study	Sionov RV (2001)	1
RBX1	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down	Ohta T (2001), Sung CK (2011), DAngiolella V (2010), Kaur M (2012), Amir RE (2004), Tan M (2010), Lan L (2012), Banks D (2006), Saha A (2008), Furukawa M (2000), Gallegos JR (2008), Duan S (2011), He F (2013), Cui Y (2011), Teixeira FR (2013), Vinas-Castells R (2013), Chen Y (2009), Oda H (2010), Pick E (2007), Morimoto M (2003), Kim K (2013), Zhao D (2010), Jiang H (2005), Furukawa M (2005), Thirunavukarasou A (2015), Antonioli M (2014), Li D (2015), Watanabe K (2015), Niikura Y (2015), Zha Z (2015), Walter D (2016), Han XR (2016), Yi J (2015), Kim JH (2015), Moghe S (2012), Xu X (2008), Kuang P (2016), Kuang P (2016), Kuang P (2016), Kuchay S (2017), Xiao J (2015), McGourty CA (2016)	42
MARCH7	0	UBE2D3	1	two hybrid, pull down	Flach K (2014), Flach K (2014)	2
UBE2D3	1	MIB1	5	two hybrid, pull down	van Wijk SJ (2009), Wang J (2013)	2
TERT	7	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down	Oh W (2010), Oh W (2010), Oh W (2010), Oh W (2010), Hu C (2015), Hu C (2015)	6
ITCH	1	CDC34	3	pull down	Sheng Y (2012)	1
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
FBXO7	1	HUWE1	22	affinity chromatography technology	Teixeira FR (2016)	1
NEDD4L	3	CDC34	3	pull down	Sheng Y (2012)	1
AMFR	2	RNF5	0	affinity chromatography technology	Morito D (2008)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
UBA1	1	UBE2D3	1	enzymatic study, pull down, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Song AX (2014), Huguenin-Dezot N (2016)	4
STUB1	4	TERT	7	pull down, affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010), Lee JH (2010)	3
TRIM37	7	UBE2D3	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
UBE2D3	1	SIAH1	2	two hybrid, two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Liu M (2012), Mei Y (2007), Kim SY (2009)	5
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
SMURF2	3	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Kim S (2010), Nie J (2010), Lu K (2011), Maspero E (2013), Kristariyanto YA (2015), Mari S (2014), Emanuelli A (2017)	7
TRIM25	5	SH3RF1	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM55	2	OTUB1	0	enzymatic study	Loch CM (2012)	1
UBE2D3	1	CHFR	5	two hybrid, pull down, pull down	Markson G (2009), Chaturvedi P (2002), Liu C (2013)	3
UBE2D3	1	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
UBE2D3	1	WWP2	7	pull down, pull down, pull down	Maspero E (2013), Lv Y (2014), Kristariyanto YA (2015)	3
TRAF6	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	ZNRF1	1	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
TRIM5	4	SQSTM1	0	affinity chromatography technology	OConnor C (2010)	1
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
MSL2	3	UBE2D3	1	pull down, pull down	Wu L (2011), Wu L (2014)	2
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
UBE2D3	1	UHRF2	1	two hybrid, affinity chromatography technology	van Wijk SJ (2009), Lai M (2016)	2
TOPORS	6	UBC	7	enzymatic study	Rajendra R (2004)	1
UBC	7	PJA1	1	affinity chromatography technology	Matsumoto M (2005)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
RNF181	0	UBC	7	enzymatic study	Pedersen SM (2015)	1
UBE2D3	1	TOPORS	6	two hybrid, pull down	van Wijk SJ (2009), Rajendra R (2004)	2
UBE2D3	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
SQSTM1	0	UBE2D3	1	two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
PJA1	1	UBE2D3	1	pull down, pull down	Loch CM (2012), Loch CM (2011)	2
SMURF1	4	RNF114	0	enzymatic study	Andrews PS (2010)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
UBE2D3	1	TRIM10	3	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
CDC34	3	FBXO7	1	enzymatic study, pull down	Cenciarelli C (1999), Vingill S (2016)	2
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
BRCA1	7	UBE3A	4	pull down	Wu-Baer F (2003)	1
UBE2D3	1	MUL1	1	two hybrid, pull down, pull down	van Wijk SJ (2009), Jung JH (2011), Ni G (2017)	3
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
MDM2	2	RNF2	1	affinity chromatography technology, affinity chromatography technology	Wen W (2013), Wen W (2013)	2
TRIM27	2	SIAH1	2	two hybrid	Rolland T (2014)	1
BARD1	4	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Wu W (2007), David Y (2011), Kentsis A (2002), Kleiman FE (2005), Wenzel DM (2011), Chen A (2002), Wu-Baer F (2010)	7
RNF8	2	UBE2D3	1	pull down, pull down, pull down, two hybrid	Mallette FA (2012), Zhang S (2008), Zhang S (2013), Schimmack G (2017)	4
TRIM55	2	SQSTM1	0	affinity chromatography technology, two hybrid	Lange S (2005), Witt CC (2008)	2
RNF26	2	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Jongsma ML (2016), Jongsma ML (2016), Jongsma ML (2016)	3
RNF111	2	MARCH7	0	two hybrid	Woodsmith J (2012)	1
RNF8	2	BARD1	4	affinity chromatography technology	Yang Q (2016)	1
MID1	1	UBTD1	0	two hybrid	Rolland T (2014)	1
UBE2D3	1	PJA2	4	two hybrid, pull down	van Wijk SJ (2009), Lignitto L (2011)	2
MARCH7	0	UBC	7	enzymatic study	Flierman D (2006)	1
UBE2D3	1	RNF185	1	two hybrid, pull down	Markson G (2009), El Khouri E (2013)	2
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
UBE2D3	1	RNF111	2	two hybrid, two hybrid, pull down, two hybrid	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Rolland T (2014)	4
TRIM32	2	RNF41	2	two hybrid	Woodsmith J (2012)	1
BRCA1	7	UBE2D3	1	two hybrid, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down	Dynek JN (2010), Polanowska J (2006), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Calvo V (2011), Wu-Baer F (2010), Yu X (2006), Starita LM (2005), Sato K (2012), Starita LM (2004), Wei L (2011), Wu W (2007), David Y (2011), Kentsis A (2002), Kleiman FE (2005), Zhao GY (2007), Wenzel DM (2011), Wenzel DM (2011), McGinty RK (2014), Chen A (2002), Shabbeer S (2013), Ando K (2017)	23
TRIM25	5	AMFR	2	enzymatic study, pull down	Wang Y (2014), Wang Y (2014)	2
UBE4B	5	UBE2D3	1	x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down	Nordquist KA (2010), Benirschke RC (2010), Benirschke RC (2010), Okumura F (2004), Nordquist KA (2010), Soss SE (2013)	6
RNF8	2	UBC	7	enzymatic study, enzymatic study, enzymatic study	Feng L (2012), Hodge CD (2015), Ho YK (2015)	3
TRIM31	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
BMI1	0	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
ZNF598	6	UBE2D3	1	affinity chromatography technology, biochemical	Garzia A (2017), Garzia A (2017)	2
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
SIAH1	2	SH3RF1	1	affinity chromatography technology, affinity chromatography technology	Xu Z (2006), Xu Z (2006)	2
MDM2	2	NEDD4	2	unspecified method, enzymatic study, affinity chromatography technology	Burch LR (2004), Xu C (2014), Xu C (2014)	3
RNF5	0	RNF185	1	two hybrid	Rolland T (2014)	1
OTUB1	0	RNF126	2	two hybrid	Hayes SD (2012)	1
UBE2D3	1	UBE4A	2	two hybrid, pull down	van Wijk SJ (2009), Spinette S (2004)	2
TRIM33	4	UBE2D3	1	pull down, pull down	Agricola E (2011), Weng L (2014)	2
BMI1	0	RNF2	1	biochemical, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Cao R (2005), Ben-Saadon R (2006), Li Z (2006), Maertens GN (2009), Wei J (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Pan MR (2011), Pan MR (2011), Voncken JW (2005), Woodsmith J (2012), Voncken JW (2003), Woodsmith J (2012), Li Z (2006), Li Z (2006), McGinty RK (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Balasubramanian S (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Abdouh M (2016), Sanchez A (2016), Wheaton K (2017), Hauri S (2016), Hauri S (2016)	30
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
CDC34	3	NFKBIA	0	enzymatic study	Wu K (2010)	1
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
SQSTM1	0	TRIM11	1	affinity chromatography technology, affinity chromatography technology	Liu T (2016), Liu T (2016)	2
NHLRC1	3	UBE2D3	1	pull down, pull down	Sharma J (2012), Gentry MS (2005)	2
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
UBE2D3	1	NFKBIA	0	enzymatic study, enzymatic study	Gonen H (1999), Wu K (2010)	2
TRIM27	2	MDM2	2	affinity chromatography technology, enzymatic study	Chu Y (2011), Chu Y (2011)	2
UBE2D3	1	ITCH	1	pull down, pull down	Maspero E (2013), Kristariyanto YA (2015)	2
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
UBE2D3	1	TRIM17	5	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
RNF31	3	UBE2D3	1	pull down, pull down, pull down	Inn KS (2011), Tokunaga F (2011), Kirisako T (2006)	3
TRIM27	2	UHRF2	1	two hybrid	Woodsmith J (2012)	1
TRIM27	2	BMI1	0	two hybrid	Woodsmith J (2012)	1
TRIM25	5	CHFR	5	affinity chromatography technology	Choudhury NR (2017)	1
HUWE1	22	UBE2D3	1	pull down, pull down	Yang Y (2010), Kristariyanto YA (2015)	2
RNF126	2	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
CDC34	3	UBE2D3	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
RNF185	1	UBC	7	affinity chromatography technology	Iioka H (2007)	1
RNF2	1	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
UBC	7	RNF126	2	affinity chromatography technology, enzymatic study, pull down	Matsumoto M (2005), Hou X (2012), Lee NS (2017)	3
MDM2	2	XIAP	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Gu L (2009), Huang X (2013), Huang X (2013), Huang X (2013), Liu T (2015)	5
TRIM55	2	TRIM27	2	two hybrid	Woodsmith J (2012)	1
BIRC3	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down, pull down	Hu S (2003), Dynek JN (2010), Darding M (2011), Hu S (2003)	4
RNF11	0	SMURF1	4	two hybrid	Colland F (2004)	1
TRIM25	5	HUWE1	22	affinity chromatography technology	Choudhury NR (2017)	1
SMURF2	3	RNF111	2	two hybrid	Colland F (2004)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
WWP2	7	CDC34	3	pull down	Sheng Y (2012)	1
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
BIRC2	1	RNF181	0	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	RFWD3	5	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
ZNF598	6	MID1	1	affinity chromatography technology	Garzia A (2017)	1
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM23	3	SIAH1	2	two hybrid	Rolland T (2014)	1
UBE2D3	1	RNF181	0	two hybrid, pull down	van Wijk SJ (2009), Pedersen SM (2015)	2
MDM2	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	BFAR	0	two hybrid, pull down	Markson G (2009), Rong J (2011)	2
UBE2D3	1	RNF25	1	two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Huttlin EL (2017)	3
NEDD4	2	RBCK1	0	pull down	Persaud A (2009)	1
RNF11	0	NEDD4L	3	two hybrid	Colland F (2004)	1
RNF11	0	SMURF2	3	pull down, affinity chromatography technology, two hybrid, two hybrid	Subramaniam V (2003), Santonico E (2010), Colland F (2004), Colland F (2004)	4
RBCK1	0	UHRF2	1	two hybrid	Woodsmith J (2012)	1
MID2	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
PRKN	1	RBCK1	0	two hybrid	Corominas R (2014)	1
UBE2D3	1	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
TRIM32	2	MID2	1	two hybrid	Reymond A (2001)	1
MDM2	2	RNF8	2	two hybrid	Woodsmith J (2012)	1
PRKN	1	CDC34	3	pull down	Kazlauskaite A (2014)	1
UBE2D3	1	OTUB1	0	two hybrid, enzymatic study, pull down, affinity chromatography technology	Rolland T (2014), Li Y (2014), Li Y (2014), Scholz CC (2016)	4
TRIM23	3	UBC	7	enzymatic study	Dawidziak DM (2017)	1
RNF11	0	NEDD4	2	affinity chromatography technology, enzymatic study, two hybrid	Santonico E (2010), Persaud A (2009), Colland F (2004)	3
TRIM32	2	UBE2D3	1	affinity chromatography technology, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Mokhonova EI (2015)	4
UBE4B	5	CBL	7	x-ray crystallography	Benirschke RC (2010)	1
OTUB1	0	UBTD1	0	affinity chromatography technology	Scholz CC (2016)	1
DTX3L	1	ITCH	1	affinity chromatography technology, pull down, pull down	Holleman J (2014), Holleman J (2014), Holleman J (2014)	3
FBXO7	1	RNF181	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	MEX3B	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
TRIM32	2	TRIM27	2	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
UBE3A	4	UBC	7	enzymatic study, enzymatic study, pull down	Schwarz SE (1998), Ronchi VP (2013), Zhang X (2017)	3
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
RNF11	0	RNF168	0	two hybrid	Colland F (2004)	1
TRIM25	5	SQSTM1	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	UBE3C	5	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D3	1	TRIM55	2	two hybrid, pull down	Markson G (2009), Loch CM (2012)	2
TRIM17	5	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Woodsmith J (2012), Rolland T (2014)	3
TRIM23	3	UBOX5	4	two hybrid	Woodsmith J (2012)	1
RNF125	0	UBC	7	pull down	Giannini AL (2008)	1
TRIM63	0	UBE2D3	1	pull down, pull down, pull down	Loch CM (2012), Thom CS (2014), Rubel CE (2013)	3
UBE3C	5	UBE2D3	1	pull down, pull down	Kristariyanto YA (2015), Okada M (2015)	2
BARD1	4	UBE3A	4	pull down	Wu-Baer F (2003)	1
ITCH	1	CBL	7	affinity chromatography technology	Azakir BA (2009)	1
UBE2D3	1	UBOX5	4	two hybrid, pull down	Markson G (2009), Hatakeyama S (2001)	2
SMURF1	4	RBCK1	0	enzymatic study	Andrews PS (2010)	1
UBE2D3	1	TRIM31	0	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
RNF2	1	OTUB1	0	affinity chromatography technology	Cao Q (2014)	1
RFWD3	5	MDM2	2	pull down, affinity chromatography technology	Fu X (2010), Fu X (2010)	2
RNF126	2	TRIM11	1	two hybrid	Woodsmith J (2012)	1
TRIM25	5	MSL2	3	affinity chromatography technology	Choudhury NR (2017)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
TRIM27	2	TRIM11	1	two hybrid	Reymond A (2001)	1
RNF2	1	SIAH1	2	affinity chromatography technology	Woodsmith J (2012)	1
UHRF2	1	BMI1	0	affinity chromatography technology	Lai M (2016)	1
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
STUB1	4	SQSTM1	0	biochemical	Villella VR (2013)	1
DTX3L	1	UBE2D3	1	affinity chromatography technology, two hybrid	Takeyama K (2003), Markson G (2009)	2
RNF5	0	UBC	7	enzymatic study	Didier C (2003)	1
RBCK1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Zenke-Kawasaki Y (2007), Yamanaka K (2003), Inn KS (2011), Kirisako T (2006)	4
STUB1	4	UBE2D3	1	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Murata S (2001), Soss SE (2011), Page RC (2012), Parsons JL (2009), Stankiewicz M (2010), Gao XC (2011), Kundrat L (2010), Kundrat L (2010), Tsukahara F (2010), Todi SV (2010), Smith MC (2013), Ronnebaum SM (2013), Seki T (2013), Heimdal K (2014), Todi SV (2009), Yuan L (2015), Kim JH (2017), Blessing NA (2017), Pakdaman Y (2017)	19
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
TRIM23	3	RNF126	2	two hybrid	Woodsmith J (2012)	1
RNF11	0	WWP2	7	two hybrid	Colland F (2004)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
MID1	1	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reymond A (2001), Reymond A (2001), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2006), Short KM (2006), Rolland T (2014), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016)	13
RBX1	2	RNF126	2	two hybrid	Woodsmith J (2012)	1
ZNRF1	1	UBC	7	enzymatic study	Hoxhaj G (2012)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
MUL1	1	UBC	7	enzymatic study	Braschi E (2009)	1
UBE2D3	1	RNF130	0	two hybrid, pull down	van Wijk SJ (2009), Guais A (2006)	2
STUB1	4	NHLRC1	3	affinity chromatography technology, affinity chromatography technology	Rao SN (2010), Sengupta S (2011)	2
PRKN	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique	Sarraf SA (2013), Song P (2016), Song P (2016), Song P (2016), Song P (2016), Hou XO (2015), Geisler S (2014)	7
MDM2	2	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2010), Nie J (2010), Nie J (2010)	3
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
UBE2D3	1	RNF2	1	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Markson G (2009), Bentley ML (2011), Li Z (2006), Pan MR (2011), Zhang Y (2014), Xia P (2014), Gearhart MD (2006), McGinty RK (2014), Cao Q (2014), Gao Z (2014)	10
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
UBE4B	5	STUB1	4	biochemical	Wan C (2015)	1
UBC	7	RNF114	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Capon F (2008), Fenner BJ (2009), Fenner BJ (2009)	4
TRIM63	0	OTUB1	0	enzymatic study	Loch CM (2012)	1
RNF115	1	UBC	7	two hybrid, pull down, protein complementation assay, pull down	Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008)	4
UBE2D3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down	Anan T (1998), Wang X (2008), Maspero E (2011), Katz M (2002), Wu K (2011), Maspero E (2013), Hong SW (2013), Zhou W (2014), Sugeno N (2014), Maspero E (2013), Miyazaki K (2003), Mari S (2014), Song F (2013), Fan CD (2013)	14
NFKBIA	0	BARD1	4	two hybrid	Dechend R (1999)	1
TRIM25	5	RNF8	2	affinity chromatography technology	Choudhury NR (2017)	1
BRCA1	7	TRIM25	5	affinity chromatography technology	Ertych N (2016)	1
NEDD4L	3	RNF7	0	pull down	Persaud A (2009)	1
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
NEDD4	2	RNF7	0	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Persaud A (2009), Zhou W (2014), Zhou W (2014), Zhou W (2014)	4
TRIM31	0	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Reymond A (2001)	2
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
UBE2D3	1	RNF4	1	two hybrid, two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013), Erker Y (2013), DiBello A (2016)	5
RBCK1	0	RNF181	0	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	UBE3A	4	enzymatic study, pull down, pull down	Anan T (1998), Sionov RV (2001), Jacobson AD (2014)	3
UBE3A	4	RNF2	1	enzymatic study, affinity chromatography technology, pull down, enzymatic study	Zaaroor-Regev D (2010), Zaaroor-Regev D (2010), Zaaroor-Regev D (2010), Mortensen F (2015)	4
TRIM23	3	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Sparrer KMJ (2017), Sparrer KMJ (2017)	2
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
RNF31	3	PRKN	1	affinity chromatography technology	Khan M (2016)	1
TRIM10	3	TRIM11	1	affinity chromatography technology	Huttlin EL (2015)	1
BRCA1	7	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Wang X (2014), Wang X (2014)	2
UBE4B	5	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Wu H (2011), Wu H (2011), Wu H (2011), Wu H (2011), Zhang Y (2014), Zhang Y (2014)	6
TRIM27	2	RBX1	2	two hybrid	Woodsmith J (2012)	1
TRAF6	0	ITCH	1	affinity chromatography technology	Shembade N (2008)	1
UBE2D3	1	RNF26	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
TRIM37	7	BMI1	0	imaging technique	Bhatnagar S (2014)	1
RNF41	2	PRKN	1	enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Yu F (2008), Zhong L (2005), Zhong L (2005), Zhong L (2005), Zhong L (2005)	5
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
RNF168	0	UBE2D3	1	pull down, pull down, two hybrid	Mallette FA (2012), Pinato S (2009), Schimmack G (2017)	3
SMURF1	4	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Nie J (2010), Nie J (2010), Fei C (2013), Wang J (2013), Cao Y (2014), Xie P (2014), Xie P (2014), Lu K (2008), Kristariyanto YA (2015), Andrews PS (2010), He S (2017), Zhang Y (2017)	12
RBX1	2	CDC34	3	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Wu K (2002), Block K (2005), Block K (2005), Chen A (2000), Cen B (2010), Cen B (2009), DAngiolella V (2010), Spruck C (2001), Shaik S (2012), Kruiswijk F (2012), Tan M (2010), Bashir T (2010), Higa LA (2003), Kanayama A (2004), Lan L (2012), Welcker M (2011), Banks D (2006), Kumar KG (2003), Higa LA (2006), Saha A (2008), Jin J (2005), Cen B (2009), Tedesco D (2002), Choi YS (2010), Duan S (2011), Li X (2003), Wang W (2003), Gallegos JR (2008), Peschiaroli A (2009), Banerjee S (2010), Duan S (2011), Wang F (2011), Chen H (2013), Rodier G (2008), Rossi M (2013), Ungermannova D (2013), Ooi LC (2013), Ziemba A (2013), Huang H (2014), Herrero-Ruiz J (2014), Kim J (2014), Min SH (2012), Watanabe M (2011), Gao D (2010), Zhou W (2014), Canettieri G (2010), Morimoto M (2003), Chen A (2002), Pashkova N (2010), Read MA (2000), Bassermann F (2005), Duda DM (2008), Enchev RI (2012), Fukushima H (2013), Tintignac LA (2005), Ungermannova D (2005), Low TY (2014), Walter D (2016), Gao J (2015), Orthwein A (2015), Wu K (2016), Wu K (2016), Nateri AS (2004), Pierce NW (2009), Kim JH (2015), Shimizu K (2017), Gschweitl M (2016), Ibarra R (2016), Kuang P (2016), Kuang P (2016), Kuang P (2016), Ferretti LP (2016), Kuchay S (2017), Gazdoiu S (2007), Dai X (2017)	75
RNF7	0	CHFR	5	two hybrid	Woodsmith J (2012)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
TRIM50	1	SQSTM1	0	affinity chromatography technology	Fusco C (2012)	1
BIRC3	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
TRIM37	7	TRAF6	0	pull down	Zapata JM (2001)	1
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
AMFR	2	SYVN1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Zhong Y (2011), Ballar P (2010), Zhang T (2015), Zhang T (2015), Zhang T (2015)	5
UBE2D3	1	NEDD4L	3	pull down, pull down, pull down	Maspero E (2013), Todaro DR (2017), Wang Z (2016)	3
TRIM25	5	RNF4	1	affinity chromatography technology	Choudhury NR (2017)	1
FBXO7	1	UBE2D3	1	pull down, pull down	Vingill S (2016), Teixeira FR (2016)	2
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
RNF25	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
CBL	7	UBE2D3	1	pull down, pull down	Tsukahara F (2010), Sigismund S (2013)	2
PJA1	1	OTUB1	0	enzymatic study	Loch CM (2012)	1
TERT	7	UBE2D3	1	two hybrid, affinity chromatography technology	Wang W (2013), Wang W (2013)	2
MID2	1	UBTD1	0	two hybrid	Rolland T (2014)	1
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
TRIM23	3	UBE2D3	1	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
UBE2D3	1	RNF126	2	two hybrid, two hybrid, pull down	Rual JF (2005), Markson G (2009), Delker RK (2013)	3
NEDD4	2	UBOX5	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
BIRC2	1	FBXO7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Chang YF (2006), Kuiken HJ (2012), Teixeira FR (2016)	3
TRIM50	1	UBE2D3	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
BFAR	0	UBC	7	enzymatic study	Rong J (2011)	1
UBE2D3	1	TRIM5	4	two hybrid, pull down, pull down	Markson G (2009), Langelier CR (2008), Yudina Z (2015)	3
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
ITCH	1	UBA1	1	affinity chromatography technology	OConnor HF (2015)	1
MDM2	2	RNF126	2	two hybrid	Woodsmith J (2012)	1
TRIM32	2	TRIM23	3	two hybrid	Reymond A (2001)	1
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
UBE2D3	1	UBE2D3	1	enzymatic study, enzymatic study, pull down	Kentsis A (2002), David Y (2010), David Y (2010)	3
CDC34	3	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, enzymatic study	Choi YS (2010), Choi YS (2010), Sheng Y (2012), Enchev RI (2012), Huang H (2014), Huang H (2014), Huang H (2014), Bish RA (2007), Chong RA (2014), Phillips AH (2013)	10
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
MID1	1	UBC	7	affinity chromatography technology, affinity chromatography technology	Trockenbacher A (2001), Trockenbacher A (2001)	2
UBE2D3	1	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
RNF125	0	CHFR	5	two hybrid	Woodsmith J (2012)	1
TRIM5	4	TRIM32	2	two hybrid	Woodsmith J (2012)	1
MDM2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kubo N (2010), Kubo N (2010), Wu H (2015), Wu H (2015)	4
RNF7	0	CDC34	3	pull down, pull down	He H (2007), Tan M (2010)	2
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
BIRC3	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
HUWE1	22	MDM2	2	affinity chromatography technology, enzymatic study	Kurokawa M (2013), Kurokawa M (2013)	2
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
TRIM25	5	UBE4B	5	affinity chromatography technology	Choudhury NR (2017)	1
TRIM17	5	TRAF6	0	two hybrid	Woodsmith J (2012)	1
SIAH1	2	XIAP	0	affinity chromatography technology, affinity chromatography technology	Garrison JB (2011), Garrison JB (2011)	2
BIRC3	1	OTUB1	0	affinity chromatography technology	Goncharov T (2013)	1
UBE2D3	1	RNF43	5	two hybrid, pull down	van Wijk SJ (2009), Sugiura T (2008)	2
BIRC2	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
UBE2D3	1	KDM1B	4	pull down, pull down	Yang Y (2015), Yang Y (2015)	2
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
UBA1	1	CDC34	3	enzymatic study, pull down, enzymatic study, pull down, enzymatic study	Tokgoez Z (2012), Jin J (2007), Chong RA (2014), Chong RA (2014), Wauer T (2015)	5
TRIM39	0	UBTD1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBE2D3	1	RNF115	1	two hybrid, two hybrid	van Wijk SJ (2009), Rolland T (2014)	2
NFKBIA	0	OTUB1	0	affinity chromatography technology	Huttlin EL (2015)	1
UBE2D3	1	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
BIRC2	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down	Hu S (2003), Dynek JN (2010), Hu S (2003)	3
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
RNF114	0	TRIM55	2	two hybrid	Woodsmith J (2012)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
UBE3C	5	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Wang M (2006), Wu PY (2003), Michel MA (2015), Kristariyanto YA (2015), Okada M (2015)	5
RNF146	4	UBE2D3	1	pull down, enzymatic study, x-ray crystallography	Kang HC (2011), DaRosa PA (2014), DaRosa PA (2014)	3
SYVN1	2	UBE2D3	1	pull down, pull down	Kaneko M (2010), Nadav E (2003)	2
PRKN	1	UBE2D3	1	pull down, pull down, pull down	Shin JH (2011), Wenzel DM (2011), Kazlauskaite A (2014)	3
SH3RF1	1	UBE2D3	1	pull down, pull down	Votteler J (2009), Tuvia S (2007)	2
MUL1	1	CDC34	3	pull down	Ni G (2017)	1
RNF7	0	UBE2D3	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tan M (2010), Kershaw NJ (2014), Raducu M (2016), Kuang P (2016), Kuang P (2016)	5
TRIM25	5	ZNF598	6	affinity chromatography technology	Choudhury NR (2017)	1
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
ZNRF1	1	CDC34	3	pull down	Markson G (2009)	1
TRIM25	5	TRIM33	4	affinity chromatography technology	Choudhury NR (2017)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
BMI1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Bentley ML (2011), Li Z (2006), Zhang Y (2014), Taherbhoy AM (2015)	4
SQSTM1	0	TRIM63	0	two hybrid, two hybrid	Lange S (2005), Witt CC (2008)	2
RNF41	2	RFWD3	5	affinity chromatography technology	Hein MY (2015)	1
UBE2D3	1	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Bartke T (2004), Bornstein B (2011), Damgaard RB (2013), Markson G (2009)	7
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
RNF130	0	UBC	7	enzymatic study	Guais A (2006)	1
BIRC2	1	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Goncharov T (2013), Goncharov T (2013), Goncharov T (2013)	3
FBXO7	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vingill S (2016), Teixeira FR (2016), Teixeira FR (2016)	3
TRIM17	5	UBC	7	enzymatic study	Woodsmith J (2012)	1
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5
RNF4	1	UBC	7	enzymatic study, enzymatic study	Groocock LM (2014), Branigan E (2015)	2
UBE2D3	1	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, two hybrid	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Watkins GR (2012), Du H (2014), Schweiger S (2014), Rolland T (2014)	8