PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM21	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
TRIM5	4	UBC	7	enzymatic study	Pertel T (2011)	1
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
HUWE1	22	UBA1	1	affinity chromatography technology	Thompson JW (2014)	1
UBE2D2	0	RNF4	1	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013), Erker Y (2013), Banka PA (2015), DiBello A (2016)	6
SMURF1	4	UBE2D2	0	pull down, pull down	Kristariyanto YA (2015), Andrews PS (2010)	2
RNF2	1	UBE2D2	0	enzymatic study, two hybrid, pull down	Lee SJ (2001), Markson G (2009), Dou H (2012)	3
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
NEDD4	2	RBX1	2	affinity chromatography technology	Liu J (2014)	1
TRIM21	0	TRIM5	4	pull down	Li X (2006)	1
UBC	7	RNF25	1	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	MIB1	5	affinity chromatography technology	Matsumoto M (2005)	1
MARCH5	0	UBE2D2	0	pull down, pull down, pull down	Yonashiro R (2012), Yonashiro R (2009), Sugiura A (2013)	3
DTX3L	1	RNF111	2	two hybrid	Woodsmith J (2012)	1
MID2	1	UBE2D2	0	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
UBR5	13	RNF2	1	imaging technique	Sanchez A (2016)	1
UBE2D2	0	STUB1	4	pull down, pull down, biochemical, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down	Demand J (2001), Soss SE (2011), Shimura H (2004), Esser C (2005), Kalia LV (2011), Xie P (2009), Grelle G (2006), Westhoff B (2005), Hatakeyama S (2004), Dolan PJ (2010), Tsukahara F (2010), Chen Z (2013), Dreiseidler M (2012), Zhang H (2015), Liu X (2017), Liu X (2017), Blessing NA (2017)	17
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
CBLC	1	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AMFR	2	UBC	7	pull down, pull down, imaging technique, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Zhong X (2004), Yang H (2010), Ying Z (2009), Jo Y (2011), Ye Y (2003), Xu Y (2012), Liu S (2012), Liu S (2012), Xu Y (2012), Morito D (2008), Flierman D (2006), Liu W (2014), Fang S (2001)	13
ANAPC11	0	UBE2D2	0	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Chang TS (2004), Townsend K (2009), Van Voorhis VA (2014), ODonovan KJ (2010), Tang Z (2001), Tang Z (2001), Vodermaier HC (2003), Shoji S (2014), Brown NG (2014), Brown NG (2015)	10
BRCA1	7	NFYA	2	affinity chromatography technology	Fan W (2002)	1
RBX1	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Pick E (2007), Lan L (2012), Tsai WB (2010), Hrecka K (2007), Okuda H (2001), Tai T (2006), Ahn J (2011), Gong B (2010), Lu Y (2012), Ohta A (2013), da Silva Almeida AC (2013), Delucia M (2013), Scott DC (2014), Camp ND (2012), Kim S (2014), Theurillat JP (2014), Kigoshi Y (2011), Pashkova N (2010), Beck J (2013), Pierce WK (2015), Wu K (2016), Parameswaran B (2015), Simo S (2013), Groisman R (2006), Marzahn MR (2016), Courtheoux T (2016), Hasanov E (2017), Ferretti LP (2016), Zhou X (2017), Kroenke J (2014), Mulvaney KM (2016)	31
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
TRAF6	0	MARCH5	0	affinity chromatography technology	Shi HX (2011)	1
FSD1	3	MIB1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
NKD2	1	UBE2D2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
PRKN	1	FBXO7	1	affinity chromatography technology, pull down, pull down	Burchell VS (2013), Burchell VS (2013), Burchell VS (2013)	3
UBE3A	4	MDM2	2	enzymatic study	Sionov RV (2001)	1
UBE2D2	0	RFWD3	5	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
RAG1	1	UBC	7	enzymatic study	Yurchenko V (2003)	1
FBXO7	1	HUWE1	22	affinity chromatography technology	Teixeira FR (2016)	1
AMFR	2	RNF5	0	affinity chromatography technology	Morito D (2008)	1
MDM4	0	UBC	7	enzymatic study	Egorova O (2014)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
TRIM11	1	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
RCHY1	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Corcoran CA (2009), Wang L (2011), Wang L (2011), Corcoran CA (2009)	4
SPRY2	4	CBL	7	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wong ES (2001), Wong ES (2001), Wong ES (2001), Wong ES (2002), Wong ES (2002), Ng C (2008), Ng C (2008), Chandramouli S (2008), Visser GD (2005), Hall AB (2003), Hall AB (2003), Rubin C (2003), Rubin C (2003), Rubin C (2003), Egan JE (2002), Miraoui H (2010), Mayer CE (2010), Sun Q (2010), Severe N (2011), Haglund K (2005), Lao DH (2007), Lao DH (2007), Fong CW (2003), Fong CW (2003), Mason JM (2004), DaSilva J (2006), Lao DH (2006)	27
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
RNF11	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
UBE4B	5	UBE2D2	0	pull down, pull down, pull down	Benirschke RC (2010), Wu H (2011), Buetow L (2015)	3
THAP8	0	UBE2D2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
CBLC	1	UBE2D2	0	pull down, pull down	Ryan PE (2010), Kim M (2004)	2
UBA6	4	UBE4B	5	biochemical	Havugimana PC (2012)	1
TRIM5	4	SQSTM1	0	affinity chromatography technology	OConnor C (2010)	1
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
BRCA1	7	UBE2D2	0	two hybrid, two hybrid, x-ray crystallography, pull down	Dynek JN (2010), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
RNF181	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
SIAH2	0	UBE2D2	0	pull down, pull down, pull down	Szargel R (2009), Avraham E (2005), Rott R (2011)	3
UBE2D2	0	RNF111	2	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Wright JD (2016), Birkou M (2017), Birkou M (2017)	6
SPRY2	4	SIAH2	0	pull down	Nadeau RJ (2007)	1
MDM4	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
UBC	7	PJA1	1	affinity chromatography technology	Matsumoto M (2005)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
RNF181	0	UBC	7	enzymatic study	Pedersen SM (2015)	1
UBE2D2	0	RNF126	2	two hybrid, pull down, pull down, pull down	Markson G (2009), Hou X (2012), Smith CJ (2013), Delker RK (2013)	4
UBE2D2	0	CNOT4	4	two hybrid, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Dominguez C (2004), Winkler GS (2004), Winkler GS (2004), Albert TK (2002), Albert TK (2002), Albert TK (2002), Winkler GS (2004), Albert TK (2002), Zhang L (2015)	10
TRIM8	6	RNF111	2	two hybrid	Woodsmith J (2012)	1
SMURF1	4	RNF114	0	enzymatic study	Andrews PS (2010)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
UBE2D2	0	RNF7	0	two hybrid, pull down	Markson G (2009), Kershaw NJ (2014)	2
FSD1	3	UBE2D2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM62	4	UBE2D2	0	pull down, pull down	Cao Z (2015), Leshchiner ES (2017)	2
LNX1	7	UBE2D2	0	pull down, pull down, pull down	Nie J (2002), Nie J (2004), Guo Z (2012)	3
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
CBLC	1	CHFR	5	two hybrid	Woodsmith J (2012)	1
MDM4	0	MDM2	2	pull down, two hybrid, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, two hybrid, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Kadakia M (2002), Tanimura S (1999), Badciong JC (2002), Tanimura S (1999), Tanimura S (1999), Linke K (2008), Okamoto K (2005), Pan Y (2003), Kashuba E (2011), Kashuba E (2011), Ohtsubo C (2009), Singh RK (2007), Zhu Y (2009), Zhu Y (2009), Allende-Vega N (2010), Okamoto K (2009), Okamoto K (2009), Li X (2011), Nie J (2010), Nie J (2010), Li M (2011), Li M (2011), Singh RK (2007), de Graaf P (2003), Wade M (2012), Uldrijan S (2007), Wade M (2012), Stad R (2000), Dolezelova P (2012), Kulikov R (2005), Kawai H (2007), Kawai H (2007), Miller KR (2010), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Li C (2002), Wu S (2012), Ranaweera RS (2013), Woodsmith J (2012), Wang J (2011), Egorova O (2014), Chang YS (2013), Malbert-Colas L (2014), Yasuhara T (2014), Yasuhara T (2014), Iyappan S (2010), Stad R (2001), Marcar L (2015), Ling X (2014), Leslie PL (2015), Jacob AG (2014), Jacob AG (2014), Tournillon AS (2015), Tournillon AS (2015), Tournillon AS (2015), Zhang H (2015), Chen L (2015), Pellegrino M (2015), Pellegrino M (2015), Pellegrino M (2015), Medina-Medina I (2016), Medina-Medina I (2016), Moscetti I (2016), Liu T (2017), Liu T (2017), Liu T (2017), Huttlin EL (2017), Wu W (2015), Ivanov AA (2017), Mancini F (2016), Mancini F (2016)	74
BRCA1	7	UBE3A	4	pull down	Wu-Baer F (2003)	1
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
MDM2	2	RNF2	1	affinity chromatography technology, affinity chromatography technology	Wen W (2013), Wen W (2013)	2
TRIM27	2	SIAH1	2	two hybrid	Rolland T (2014)	1
UBE2D2	0	RNF130	0	two hybrid, pull down	van Wijk SJ (2009), Guais A (2006)	2
RNF26	2	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Jongsma ML (2016), Jongsma ML (2016), Jongsma ML (2016)	3
CBL	7	TRIM8	6	two hybrid	Woodsmith J (2012)	1
ITCH	1	UBA6	4	affinity chromatography technology	OConnor HF (2015)	1
BIRC7	0	UBC	7	x-ray crystallography	Dou H (2012)	1
MID1	1	UBTD1	0	two hybrid	Rolland T (2014)	1
BIRC3	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	MUL1	1	two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Braschi E (2009), Li W (2008), Ni G (2017)	4
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
UBR5	13	UBC	7	pull down, x-ray crystallography, pull down	Kozlov G (2007), Kozlov G (2007), Zhang X (2017)	3
UBE2D2	0	TRIM10	3	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
UBB	4	UBE3A	4	two hybrid	Rolland T (2014)	1
MDM4	0	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
TRIM25	5	AMFR	2	enzymatic study, pull down	Wang Y (2014), Wang Y (2014)	2
RAG1	1	RBX1	2	affinity chromatography technology	Kassmeier MD (2011)	1
UBE2D2	0	RNF10	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017)	3
TRIM31	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
MDM2	2	NEDD4	2	unspecified method, enzymatic study, affinity chromatography technology	Burch LR (2004), Xu C (2014), Xu C (2014)	3
LNX1	7	MID1	1	affinity chromatography technology, affinity chromatography technology	Lenihan JA (2017), Lenihan JA (2017)	2
FBXO7	1	UBR5	13	affinity chromatography technology	Teixeira FR (2016)	1
OTUB1	0	RNF126	2	two hybrid	Hayes SD (2012)	1
UBE2D2	0	ACOX1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
SQSTM1	0	TRIM11	1	affinity chromatography technology, affinity chromatography technology	Liu T (2016), Liu T (2016)	2
ANAPC11	0	NKD2	1	two hybrid	Wang J (2011)	1
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
ANAPC11	0	RNF111	2	two hybrid	Woodsmith J (2012)	1
TRIM27	2	MDM2	2	affinity chromatography technology, enzymatic study	Chu Y (2011), Chu Y (2011)	2
MDM2	2	RNF10	0	two hybrid	Woodsmith J (2012)	1
TRIM21	0	TRIM39	0	two hybrid, two hybrid	Woodsmith J (2012), Rolland T (2014)	2
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
TRIM37	7	UBE2D2	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
LNX1	7	DZIP3	6	affinity chromatography technology	Lenihan JA (2017)	1
TRIM25	5	CHFR	5	affinity chromatography technology	Choudhury NR (2017)	1
UBE3C	5	UBE2D2	0	pull down, pull down	Wu PY (2003), Kristariyanto YA (2015)	2
RNF126	2	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
TRIM8	6	RNF7	0	two hybrid	Woodsmith J (2012)	1
RNF2	1	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
TRIM25	5	FBXO2	0	affinity chromatography technology	Choudhury NR (2017)	1
NKD2	1	RCHY1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
UBE2D2	0	LTN1	8	two hybrid, pull down	van Wijk SJ (2009), Chu J (2009)	2
UBC	7	RNF126	2	affinity chromatography technology, enzymatic study, pull down	Matsumoto M (2005), Hou X (2012), Lee NS (2017)	3
MDM2	2	XIAP	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Gu L (2009), Huang X (2013), Huang X (2013), Huang X (2013), Liu T (2015)	5
HUWE1	22	UBB	4	affinity chromatography technology	Thompson JW (2014)	1
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
UBE2D2	0	TRIM8	6	two hybrid, pull down	Markson G (2009), Li Q (2011)	2
RNF11	0	SMURF1	4	two hybrid	Colland F (2004)	1
TRIM25	5	HUWE1	22	affinity chromatography technology	Choudhury NR (2017)	1
RNF2	1	RCHY1	0	affinity chromatography technology	Cao Q (2014)	1
SPRY2	4	UBE2D2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC7	0	BIRC2	1	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Dynek JN (2010), Oberoi-Khanuja TK (2012), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	5
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
UBE2D2	0	TRIM17	5	two hybrid, two hybrid, pull down	Markson G (2009), Napolitano LM (2011), Woodsmith J (2012)	3
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
DZIP3	6	RNF38	4	two hybrid	Woodsmith J (2012)	1
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
BIRC2	1	RNF181	0	two hybrid	Woodsmith J (2012)	1
TRIM23	3	UBE2D2	0	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
UBTD1	0	UBE2D2	0	two hybrid, biochemical	Uhler JP (2013), Uhler JP (2013)	2
UBC	7	ANAPC11	0	x-ray crystallography, pull down	Brown NG (2014), Brown NG (2016)	2
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM23	3	SIAH1	2	two hybrid	Rolland T (2014)	1
UBE2D2	0	TRIM27	2	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
UBA1	1	UBE2D2	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Choi JS (2014), Huang DT (2009), Kang D (2002), Kumar B (2010), Liu X (2017), Huguenin-Dezot N (2016)	8
MDM2	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
CBLC	1	UBC	7	enzymatic study	Kim M (2004)	1
BIRC3	1	RCHY1	0	two hybrid	Wang J (2011)	1
RNF11	0	NEDD4L	3	two hybrid	Colland F (2004)	1
MID2	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
TRIM25	5	UBR5	13	affinity chromatography technology	Choudhury NR (2017)	1
ITCH	1	UBE2D2	0	pull down, pull down, pull down, pull down	Sheng Y (2012), Fang S (2001), Kristariyanto YA (2015), Riling C (2015)	4
TRIM32	2	MID2	1	two hybrid	Reymond A (2001)	1
TRIM23	3	UBC	7	enzymatic study	Dawidziak DM (2017)	1
RNF11	0	NEDD4	2	affinity chromatography technology, enzymatic study, two hybrid	Santonico E (2010), Persaud A (2009), Colland F (2004)	3
UBE4B	5	CBL	7	x-ray crystallography	Benirschke RC (2010)	1
OTUB1	0	UBTD1	0	affinity chromatography technology	Scholz CC (2016)	1
DTX3L	1	ITCH	1	affinity chromatography technology, pull down, pull down	Holleman J (2014), Holleman J (2014), Holleman J (2014)	3
FBXO7	1	RNF181	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF31	3	UBE2D2	0	pull down, x-ray crystallography, pull down	Kirisako T (2006), Lechtenberg BC (2016), Lechtenberg BC (2016)	3
TRIM32	2	TRIM27	2	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
UBE3A	4	UBC	7	enzymatic study, enzymatic study, pull down	Schwarz SE (1998), Ronchi VP (2013), Zhang X (2017)	3
UBE2D2	0	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
UBE2D2	0	AMFR	2	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Fang S (2001)	3
FBXO7	1	UBB	4	affinity chromatography technology	Teixeira FR (2016)	1
WWP2	7	UBE2D2	0	pull down, pull down, pull down	Sheng Y (2012), Kristariyanto YA (2015), Chaudhary N (2014)	3
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D2	0	FBXO7	1	enzymatic study, pull down	Cenciarelli C (1999), Teixeira FR (2016)	2
TRIM25	5	SQSTM1	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	UBE3C	5	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D2	0	CHFR	5	two hybrid, pull down, pull down, pull down	Markson G (2009), Kang D (2002), Oh YM (2009), Chaturvedi P (2002)	4
TRIM17	5	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Woodsmith J (2012), Rolland T (2014)	3
UBE2D2	0	CBL	7	pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Joazeiro CA (1999), Dou H (2012), Dou H (2012), Sehat B (2008), Kassenbrock CK (2004), Roxburgh P (2012), Tsukahara F (2010), Bulut GB (2013), Buetow L (2016), Conte A (2017)	10
UBE2D2	0	NEDD4L	3	x-ray crystallography, pull down, pull down, pull down, pull down, pull down, enzymatic study	Kamadurai HB (2009), Isasa M (2010), Sheng Y (2012), Persaud A (2009), Nazio F (2016), Todaro DR (2017), Todaro DR (2017)	7
BRCA1	7	RCHY1	0	affinity chromatography technology	Ertych N (2016)	1
UBE2D2	0	UBB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OTUB1	0	UBE2D2	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Nakada S (2010), Juang YC (2012), Ernst A (2013), Juang YC (2012), Huttlin EL (2015), Scholz CC (2016), Huttlin EL (2017)	8
NFYA	2	UBE2D2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITCH	1	CBL	7	affinity chromatography technology	Azakir BA (2009)	1
TRIM39	0	LNX1	7	two hybrid	Rolland T (2014)	1
UBE2D2	0	ZNRF1	1	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Markson G (2009)	3
UBE2D2	0	BFAR	0	two hybrid, pull down	Markson G (2009), Rong J (2011)	2
RNF2	1	OTUB1	0	affinity chromatography technology	Cao Q (2014)	1
RFWD3	5	MDM2	2	pull down, affinity chromatography technology	Fu X (2010), Fu X (2010)	2
MDM4	0	RNF115	1	two hybrid	Rolland T (2014)	1
RNF126	2	TRIM11	1	two hybrid	Woodsmith J (2012)	1
CBLC	1	ITCH	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Courbard JR (2002), Courbard JR (2002), Courbard JR (2002), Courbard JR (2002)	4
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
UBE2D2	0	TRIM31	0	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
RNF114	0	RNF38	4	two hybrid	Woodsmith J (2012)	1
TRIM27	2	TRIM11	1	two hybrid	Reymond A (2001)	1
RNF2	1	SIAH1	2	affinity chromatography technology	Woodsmith J (2012)	1
SYVN1	2	UBE2D2	0	pull down, pull down	Lee KA (2011), Fang S (2001)	2
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
TRIM25	5	RNF38	4	affinity chromatography technology	Choudhury NR (2017)	1
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
STUB1	4	SQSTM1	0	biochemical	Villella VR (2013)	1
RNF5	0	UBC	7	enzymatic study	Didier C (2003)	1
RNF165	0	UBC	7	enzymatic study, x-ray crystallography, pull down	Wright JD (2016), Wright JD (2016), Wright JD (2016)	3
UBE2D2	0	RNF181	0	two hybrid, pull down	van Wijk SJ (2009), Pedersen SM (2015)	2
UBC	7	RNF38	4	pull down, enzymatic study	Buetow L (2015), Buetow L (2015)	2
NEDD4	2	UBE2D2	0	two hybrid, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hatakeyama S (1997), Anan T (1998), Sehat B (2008), Arevalo JC (2006), Woelk T (2006), Persaud A (2009), Zeng F (2009), Sarkari F (2013), Liu PY (2012), Sugeno N (2014), Bustos F (2015), Chesarino NM (2015), Sun M (2016)	13
RAG1	1	UBE2D2	0	pull down, pull down, pull down	Grazini U (2010), Yurchenko V (2003), Singh SK (2015)	3
TRIM23	3	RNF126	2	two hybrid	Woodsmith J (2012)	1
RNF11	0	WWP2	7	two hybrid	Colland F (2004)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
TRIM23	3	LNX1	7	two hybrid	Rual JF (2005)	1
MID1	1	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reymond A (2001), Reymond A (2001), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2006), Short KM (2006), Rolland T (2014), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016)	13
LTN1	8	UBC	7	enzymatic study	Chu J (2009)	1
RBX1	2	RNF126	2	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	XIAP	0	two hybrid, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Dynek JN (2010), Nakatani Y (2012), Nakatani Y (2012), Markson G (2009), Fang S (2001), Hu S (2003), Buetow L (2015), Foglizzo M (2016), Edison N (2017)	10
ZNRF1	1	UBC	7	enzymatic study	Hoxhaj G (2012)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
MUL1	1	UBC	7	enzymatic study	Braschi E (2009)	1
PRKN	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique	Sarraf SA (2013), Song P (2016), Song P (2016), Song P (2016), Song P (2016), Hou XO (2015), Geisler S (2014)	7
LNX1	7	NKD2	1	pull down	Wolting CD (2011)	1
TRIM21	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
MDM2	2	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2010), Nie J (2010), Nie J (2010)	3
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
UBE4B	5	STUB1	4	biochemical	Wan C (2015)	1
RCHY1	0	UBC	7	enzymatic study	Wu G (2010)	1
UBC	7	RNF114	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Capon F (2008), Fenner BJ (2009), Fenner BJ (2009)	4
RNF115	1	UBC	7	two hybrid, pull down, protein complementation assay, pull down	Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008)	4
UBE2D2	0	RNF38	4	two hybrid, pull down, pull down	Markson G (2009), Sheren JE (2013), Buetow L (2015)	3
BRCA1	7	TRIM25	5	affinity chromatography technology	Ertych N (2016)	1
NEDD4L	3	RNF7	0	pull down	Persaud A (2009)	1
SPRY2	4	MID2	1	two hybrid	Rolland T (2014)	1
TRIM11	1	UBE2D2	0	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
NEDD4	2	RNF7	0	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Persaud A (2009), Zhou W (2014), Zhou W (2014), Zhou W (2014)	4
TRIM31	0	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Reymond A (2001)	2
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
UBE2D2	0	RNF43	5	two hybrid, pull down	van Wijk SJ (2009), Sugiura T (2008)	2
UBE3A	4	RNF2	1	enzymatic study, affinity chromatography technology, pull down, enzymatic study	Zaaroor-Regev D (2010), Zaaroor-Regev D (2010), Zaaroor-Regev D (2010), Mortensen F (2015)	4
TRIM23	3	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Sparrer KMJ (2017), Sparrer KMJ (2017)	2
RNF31	3	PRKN	1	affinity chromatography technology	Khan M (2016)	1
DTX3L	1	UBE2D2	0	affinity chromatography technology, two hybrid, pull down	Takeyama K (2003), Markson G (2009), Yan Q (2009)	3
TRIM10	3	TRIM11	1	affinity chromatography technology	Huttlin EL (2015)	1
TRIM21	0	DZIP3	6	two hybrid	Woodsmith J (2012)	1
HUWE1	22	UBE2D2	0	pull down, pull down, pull down, pull down	Warr MR (2005), Kristariyanto YA (2015), Li L (2015), Zhang W (2016)	4
BRCA1	7	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Wang X (2014), Wang X (2014)	2
TRIM21	0	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBE4B	5	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Wu H (2011), Wu H (2011), Wu H (2011), Wu H (2011), Zhang Y (2014), Zhang Y (2014)	6
TRIM27	2	RBX1	2	two hybrid	Woodsmith J (2012)	1
TRAF6	0	ITCH	1	affinity chromatography technology	Shembade N (2008)	1
UBE2D2	0	RNF165	0	two hybrid, pull down, x-ray crystallography	van Wijk SJ (2009), Wright JD (2016), Wright JD (2016)	3
TRIM32	2	UBE2D2	0	affinity chromatography technology, pull down, pull down	Napolitano LM (2011), Streich FC (2013), Mokhonova EI (2015)	3
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
UBE2D2	0	RNF114	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017), Lin B (2017)	4
FBXO7	1	SPRY2	4	enzymatic study	Teixeira FR (2016)	1
BIRC2	1	CBLC	1	two hybrid	Woodsmith J (2012)	1
UBA6	4	UBE2D2	0	pull down, pull down, enzymatic study, enzymatic study	Pelzer C (2007), Jin J (2007), Huang DT (2009), Liu X (2017)	4
UBE2D2	0	RNF115	1	two hybrid, pull down, pull down	van Wijk SJ (2009), Smith CJ (2013), Amemiya Y (2008)	3
MDM4	0	UBE2D2	0	pull down, enzymatic study	Iyappan S (2010), Bista M (2013)	2
RNF7	0	CHFR	5	two hybrid	Woodsmith J (2012)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
TRIM50	1	SQSTM1	0	affinity chromatography technology	Fusco C (2012)	1
BIRC3	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
UBE2D2	0	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Watkins GR (2012), Du H (2014), Schweiger S (2014)	7
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
TRIM37	7	TRAF6	0	pull down	Zapata JM (2001)	1
LNX1	7	TRIM27	2	affinity chromatography technology, affinity chromatography technology	Lenihan JA (2017), Lenihan JA (2017)	2
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
AMFR	2	SYVN1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Zhong Y (2011), Ballar P (2010), Zhang T (2015), Zhang T (2015), Zhang T (2015)	5
TRIM25	5	RNF4	1	affinity chromatography technology	Choudhury NR (2017)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
RNF25	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
FBXO7	1	NKD2	1	enzymatic study	Teixeira FR (2016)	1
PJA1	1	OTUB1	0	enzymatic study	Loch CM (2012)	1
MID2	1	UBTD1	0	two hybrid	Rolland T (2014)	1
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
MDM2	2	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
UBE2D2	0	UBE2D2	0	pull down, enzymatic study, enzymatic study, pull down	Codding JA (2012), Plafker KS (2010), David Y (2010), David Y (2010)	4
TRIM25	5	ANAPC11	0	affinity chromatography technology	Choudhury NR (2017)	1
BIRC2	1	FBXO7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Chang YF (2006), Kuiken HJ (2012), Teixeira FR (2016)	3
BFAR	0	UBC	7	enzymatic study	Rong J (2011)	1
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
XIAP	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
RNF126	2	UBB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITCH	1	UBA1	1	affinity chromatography technology	OConnor HF (2015)	1
MDM2	2	RNF126	2	two hybrid	Woodsmith J (2012)	1
TRIM25	5	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Zhou W (2008)	2
TRIM32	2	TRIM23	3	two hybrid	Reymond A (2001)	1
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
MID1	1	UBC	7	affinity chromatography technology, affinity chromatography technology	Trockenbacher A (2001), Trockenbacher A (2001)	2
TRIM5	4	TRIM32	2	two hybrid	Woodsmith J (2012)	1
BIRC7	0	UBE2D2	0	two hybrid, pull down, x-ray crystallography, pull down	Dynek JN (2010), Dou H (2012), Dou H (2012), Ma L (2006)	4
UBE2D2	0	RNF11	0	two hybrid, two hybrid, pull down, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Colland F (2004), Markson G (2009)	5
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
BIRC7	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberoi-Khanuja TK (2012), Oberoi-Khanuja TK (2012), Huttlin EL (2015), Huttlin EL (2017)	4
UBE2D2	0	RNF26	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
MDM2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kubo N (2010), Kubo N (2010), Wu H (2015), Wu H (2015)	4
BIRC2	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
RFWD2	0	UBE2D2	0	pull down, pull down, pull down	Dornan D (2006), Dornan D (2004), Choi HH (2011)	3
BIRC3	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
HUWE1	22	MDM2	2	affinity chromatography technology, enzymatic study	Kurokawa M (2013), Kurokawa M (2013)	2
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
TRIM25	5	UBE4B	5	affinity chromatography technology	Choudhury NR (2017)	1
TRIM17	5	TRAF6	0	two hybrid	Woodsmith J (2012)	1
SIAH1	2	XIAP	0	affinity chromatography technology, affinity chromatography technology	Garrison JB (2011), Garrison JB (2011)	2
BIRC3	1	OTUB1	0	affinity chromatography technology	Goncharov T (2013)	1
FSD1	3	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
BIRC2	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
UBE2D2	0	RNF5	0	two hybrid, pull down	Markson G (2009), Sakata E (2010)	2
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
NKD2	1	RNF25	1	affinity chromatography technology	Ding W (2008)	1
TRIM5	4	UBB	4	two hybrid	Lukic Z (2011)	1
TRIM39	0	UBTD1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SIAH1	2	TRIM8	6	two hybrid	Woodsmith J (2012)	1
TRIM8	6	TRIM39	0	two hybrid	Woodsmith J (2012)	1
FBXO2	0	STUB1	4	affinity chromatography technology, pull down, enzymatic study	Nelson RF (2006), Nelson RF (2006), Nelson RF (2006)	3
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
UBE3C	5	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Wang M (2006), Wu PY (2003), Michel MA (2015), Kristariyanto YA (2015), Okada M (2015)	5
FBXO2	0	UBE2D2	0	pull down, pull down	Yoshida Y (2002), Nelson RF (2006)	2
SQSTM1	0	UBE2D2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
TRIM21	0	UBE2D2	0	pull down, pull down, pull down, pull down	Wada K (2006), Wada K (2006), Wada K (2009), Wada K (2006)	4
TRIM50	1	UBE2D2	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
RCHY1	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
UBE2D2	0	RNF25	1	two hybrid, two hybrid, pull down, pull down, enzymatic study, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Wu PY (2003), Nguyen L (2014), Nguyen L (2014), Huttlin EL (2015), Li S (2015), Li S (2015), Huttlin EL (2017)	9
LNX1	7	MID2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lenihan JA (2017), Lenihan JA (2017), Lenihan JA (2017)	3
UBE2D2	0	PJA2	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Yu P (2002), Yu P (2002), van Wijk SJ (2009), Yu P (2002), Faust TB (2017)	5
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
PRKN	1	MARCH5	0	affinity chromatography technology	Sarraf SA (2013)	1
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
CBL	7	TRIM21	0	affinity chromatography technology	Brehme M (2009)	1
BIRC2	1	UBR5	13	affinity chromatography technology	Goncharov T (2013)	1
UBR5	13	UBE2D2	0	pull down, pull down, pull down, enzymatic study, pull down	Maddika S (2009), Honda Y (2002), Cojocaru M (2011), Matta-Camacho E (2012), Zhang W (2016)	5
UBE2D2	0	PJA1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yu P (2002), Yu P (2002), Yu P (2002), Loch CM (2011)	4
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
UBE2D2	0	SIAH1	2	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Szargel R (2009), Winter M (2008)	4
SQSTM1	0	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim JY (2009), Kim JY (2009), Kimura T (2015), Milan E (2015), Pan JA (2016), Pan JA (2016)	6
UBE2D2	0	UBE3A	4	enzymatic study, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down	Anan T (1998), Hatakeyama S (1997), Hatakeyama S (1997), Louria-Hayon I (2009), Jacobson AD (2014), Mortensen F (2015), Rolfe M (1995), Kuslansky Y (2016)	8
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
RNF130	0	UBC	7	enzymatic study	Guais A (2006)	1
BIRC2	1	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Goncharov T (2013), Goncharov T (2013), Goncharov T (2013)	3
FBXO7	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vingill S (2016), Teixeira FR (2016), Teixeira FR (2016)	3
SPRY2	4	NEDD4	2	affinity chromatography technology, affinity chromatography technology, pull down	Edwin F (2010), Edwin F (2010), Edwin F (2010)	3
TRIM17	5	UBC	7	enzymatic study	Woodsmith J (2012)	1
FBXO2	0	RBX1	2	affinity chromatography technology	Glenn KA (2008)	1
UBE2D2	0	TRIM5	4	two hybrid, pull down, pull down	Markson G (2009), Yamauchi K (2008), Xu L (2003)	3
UBA6	4	UBC	7	pull down, enzymatic study, unspecified method, affinity chromatography technology	Gavin JM (2012), Gavin JM (2012), Zhao B (2012), Bish RA (2007)	4
UBTD1	0	RNF10	0	two hybrid	Uhler JP (2013)	1
PRKN	1	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Caulfield TR (2014), Kazlauskaite A (2014)	6
RFWD2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Olma MH (2009)	2
RCHY1	0	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hattori T (2007), Duan S (2007), Sheng Y (2008), Wu G (2010), Corcoran CA (2009), Abe K (2008), Shloush J (2011), Bohgaki M (2013), Abou Zeinab R (2013)	9
RNF4	1	UBC	7	enzymatic study, enzymatic study	Groocock LM (2014), Branigan E (2015)	2
RFWD2	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
TRIM25	5	RFWD2	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D2	0	MIB1	5	two hybrid, pull down	van Wijk SJ (2009), McMillan BJ (2015)	2