PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF31	3	UBE2D1	0	pull down, pull down	Nakamura M (2006), Kirisako T (2006)	2
LRSAM1	2	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBE2D1	0	RFWD3	5	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
HUWE1	22	UBA1	1	affinity chromatography technology	Thompson JW (2014)	1
SMURF1	4	UBE2D1	0	pull down, enzymatic study	Kristariyanto YA (2015), Andrews PS (2010)	2
NEDD4	2	RBX1	2	affinity chromatography technology	Liu J (2014)	1
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
DTX3L	1	RNF111	2	two hybrid	Woodsmith J (2012)	1
RNF115	1	NFKBIA	0	enzymatic study	Colomer-Lluch M (2017)	1
RBX1	2	CUL2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Dias DC (2002), Ohta T (1999), Ohta T (1999), Maine GN (2007), Hu J (2004), Furukawa M (2002), Mao X (2011), Sufan RI (2006), Sufan RI (2006), Sufan RI (2006), Brower CS (2002), Tron AE (2012), Kamura T (2004), Kristensen AR (2012), Costessi A (2011), Huang DT (2009), Kamura T (1999), Kamura T (1999), Xu J (2015), Cardote TAF (2017)	20
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
UBE2D1	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Kreft SG (2003)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
NFKBIA	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
UBE2D1	0	UBE3A	4	enzymatic study, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Nuber U (1999), Burch L (2004), Scheffner M (1994), Schwarz SE (1998), Uchiki T (2009), Nuber U (1996), Nuber U (1996), Jacobson AD (2014), Honda R (1997), Wu PY (2003), Kim HT (2007), McClurg UL (2016)	12
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
UBE2D1	0	CHFR	5	two hybrid, pull down, pull down, pull down	Markson G (2009), Kim JM (2010), Kang D (2002), Jung I (2012)	4
TRIM23	3	UBE2D1	0	pull down, pull down	Vichi A (2005), Vichi A (2006)	2
UBE2D1	0	AMFR	2	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Wang Y (2014)	3
AMFR	2	MGRN1	4	affinity chromatography technology, affinity chromatography technology	Mukherjee R (2016), Mukherjee R (2016)	2
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
UBE2D1	0	RNF7	0	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Markson G (2009), Yasukawa T (2008), Zakaria R (2013), Kuang Z (2010), Lamsoul I (2011), Heuze ML (2008), Kershaw NJ (2014), Uematsu K (2016), Lo JY (2017)	9
BIRC2	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Xu M (2009), Phu L (2011), Oberoi TK (2012), Bertrand MJ (2011), Guicciardi ME (2014), Takeda AN (2014), Wauer T (2015), Vu NT (2016)	11
TRIM32	2	UBE2D1	0	affinity chromatography technology, pull down, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Albor A (2006), Mokhonova EI (2015)	5
NEDD4	2	SKP1	0	affinity chromatography technology	Liu J (2014)	1
UBE2D1	0	RNF13	0	two hybrid, pull down	van Wijk SJ (2009), Zhang Q (2012)	2
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
RCHY1	0	UBE2D1	0	pull down, pull down	Abou Zeinab R (2013), McClurg UL (2016)	2
UBE3A	4	MDM2	2	enzymatic study	Sionov RV (2001)	1
UBE2D1	0	RNF181	0	two hybrid, pull down, pull down	van Wijk SJ (2009), Brophy TM (2008), Pedersen SM (2015)	3
SIAH1	2	UBE2D1	0	two hybrid, two hybrid, pull down, pull down, pull down	Matsuzawa SI (2001), Markson G (2009), Dimitrova YN (2010), Rott R (2008), Liu QY (2008)	5
UBE2D1	0	MID1	1	two hybrid, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down	Markson G (2009), Han X (2011), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Han X (2011), Du H (2014), Schweiger S (2014), Rolland T (2014), Wright KM (2017)	10
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
UBE2D1	0	LRSAM1	2	two hybrid, pull down, enzymatic study	Markson G (2009), Chua HH (2016), Hakonen JE (2017)	3
UBE2D1	0	UBE2D1	0	pull down, enzymatic study, pull down	Gutierrez JA (1997), David Y (2010), David Y (2010)	3
AMFR	2	RNF5	0	affinity chromatography technology	Morito D (2008)	1
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
UBE2D1	0	RLIM	1	two hybrid, pull down, pull down, pull down	Markson G (2009), Gontan C (2012), Her YR (2009), Gao K (2016)	4
RCHY1	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Corcoran CA (2009), Wang L (2011), Wang L (2011), Corcoran CA (2009)	4
EP300	36	UBE2D1	0	pull down, pull down	Shi D (2009), Grossman SR (2003)	2
SKP1	0	RING1	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
MKRN3	2	RNF7	0	two hybrid	Woodsmith J (2012)	1
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
RNF13	0	RNF167	2	affinity chromatography technology	Huttlin EL (2017)	1
MKRN3	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
BARD1	4	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down	Mallery DL (2002), Dong Y (2003), Wu-Baer F (2003), Hashizume R (2001), Nhukeaw T (2014), Thakar A (2010)	6
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TOPORS	6	UBE2D1	0	pull down, affinity chromatography technology, two hybrid, pull down, pull down	Park HJ (2008), Park HJ (2008), van Wijk SJ (2009), Guan B (2008), Rajendra R (2004)	5
UFM1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
MDM4	0	EP300	36	pull down	Kadakia M (2002)	1
MDM4	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
TRIM25	5	DTX2	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM17	5	LRSAM1	2	two hybrid	Woodsmith J (2012)	1
UBE2D1	0	TRIM27	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
SMURF1	4	RNF114	0	enzymatic study	Andrews PS (2010)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
TRIP12	20	UBE2D1	0	pull down, pull down, pull down, pull down	Park Y (2008), Schwarz SE (1998), An CI (2013), Park Y (2009)	4
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D1	0	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
MDM4	0	MDM2	2	pull down, two hybrid, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, two hybrid, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Kadakia M (2002), Tanimura S (1999), Badciong JC (2002), Tanimura S (1999), Tanimura S (1999), Linke K (2008), Okamoto K (2005), Pan Y (2003), Kashuba E (2011), Kashuba E (2011), Ohtsubo C (2009), Singh RK (2007), Zhu Y (2009), Zhu Y (2009), Allende-Vega N (2010), Okamoto K (2009), Okamoto K (2009), Li X (2011), Nie J (2010), Nie J (2010), Li M (2011), Li M (2011), Singh RK (2007), de Graaf P (2003), Wade M (2012), Uldrijan S (2007), Wade M (2012), Stad R (2000), Dolezelova P (2012), Kulikov R (2005), Kawai H (2007), Kawai H (2007), Miller KR (2010), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Li C (2002), Wu S (2012), Ranaweera RS (2013), Woodsmith J (2012), Wang J (2011), Egorova O (2014), Chang YS (2013), Malbert-Colas L (2014), Yasuhara T (2014), Yasuhara T (2014), Iyappan S (2010), Stad R (2001), Marcar L (2015), Ling X (2014), Leslie PL (2015), Jacob AG (2014), Jacob AG (2014), Tournillon AS (2015), Tournillon AS (2015), Tournillon AS (2015), Zhang H (2015), Chen L (2015), Pellegrino M (2015), Pellegrino M (2015), Pellegrino M (2015), Medina-Medina I (2016), Medina-Medina I (2016), Moscetti I (2016), Liu T (2017), Liu T (2017), Liu T (2017), Huttlin EL (2017), Wu W (2015), Ivanov AA (2017), Mancini F (2016), Mancini F (2016)	74
BRCA1	7	UBE3A	4	pull down	Wu-Baer F (2003)	1
UBE2D1	0	TRIM39	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Huang NJ (2012), Woodsmith J (2012), Rolland T (2014), Yu H (2011)	6
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
MDM2	2	RNF2	1	affinity chromatography technology, affinity chromatography technology	Wen W (2013), Wen W (2013)	2
SIAH1	2	RLIM	1	affinity chromatography technology	Kraemer OH (2008)	1
TRIM27	2	SIAH1	2	two hybrid	Rolland T (2014)	1
TRIM11	1	UBE2D1	0	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
RFWD2	0	UBE2D1	0	pull down, pull down	Choi HH (2011), Lu G (2014)	2
RNF8	2	BARD1	4	affinity chromatography technology	Yang Q (2016)	1
BIRC3	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
RFWD2	0	CUL2	3	affinity chromatography technology	Olma MH (2009)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
UHRF2	1	SKP1	0	far western blotting	Mori T (2011)	1
MDM4	0	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
TRIM25	5	AMFR	2	enzymatic study, pull down	Wang Y (2014), Wang Y (2014)	2
CUL2	3	UBE2D1	0	pull down, affinity chromatography technology, pull down	Sufan RI (2006), Sufan RI (2006), Maine GN (2007)	3
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
RING1	2	RNF2	1	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Gearhart MD (2006), Wang H (2004), Trojer P (2011), Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015)	8
TRIM31	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
TRIM21	0	UBE2D1	0	pull down, pull down	Mallery DL (2010), Kong HJ (2007)	2
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
NEDD4L	3	UBE2D1	0	pull down, pull down, pull down, pull down	Schwarz SE (1998), Herhaus L (2013), Bosanac I (2011), Todaro DR (2017)	4
UBE3C	5	UBE2D1	0	pull down, pull down, pull down, biochemical, biochemical, pull down, pull down	You J (2003), Wang M (2006), Schwarz SE (1998), Havugimana PC (2012), You J (2001), You J (2001), Kristariyanto YA (2015)	7
UBE2D1	0	RNF115	1	two hybrid, two hybrid	van Wijk SJ (2009), Rolland T (2014)	2
MDM2	2	NEDD4	2	unspecified method, enzymatic study, affinity chromatography technology	Burch LR (2004), Xu C (2014), Xu C (2014)	3
OTUB1	0	RNF126	2	two hybrid	Hayes SD (2012)	1
BIRC2	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1
NFKBIA	0	UBE2D1	0	two hybrid, enzymatic study	Desterro JM (1997), Kroll M (1997)	2
ANAPC11	0	RNF111	2	two hybrid	Woodsmith J (2012)	1
TRIM27	2	MDM2	2	affinity chromatography technology, enzymatic study	Chu Y (2011), Chu Y (2011)	2
UBE2D1	0	RNF130	0	two hybrid, pull down	van Wijk SJ (2009), Guais A (2006)	2
TRIM21	0	TRIM39	0	two hybrid, two hybrid	Woodsmith J (2012), Rolland T (2014)	2
MDM4	0	UBE2D1	0	pull down, pull down	Badciong JC (2002), Singh RK (2007)	2
TRIM27	2	UHRF2	1	two hybrid	Woodsmith J (2012)	1
RFWD2	0	SKP1	0	affinity chromatography technology	Olma MH (2009)	1
TNFAIP3	3	RNF114	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rodriguez MS (2014), Rodriguez MS (2014), Rodriguez MS (2014), Rodriguez MS (2014), Huttlin EL (2017)	5
TRIM25	5	CHFR	5	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D1	0	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Morizane Y (2005), Janzer A (2012), Liu WH (2007), Takeda AN (2014), Markson G (2009), Hao Y (2004), Hanson AJ (2012)	10
RNF2	1	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
TRIM63	0	UBE2D1	0	pull down, pull down, pull down	Bosanac I (2011), Uchiki T (2009), Kim HT (2007)	3
MID2	1	UBE2D1	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Rolland T (2014)	4
MDM2	2	XIAP	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Gu L (2009), Huang X (2013), Huang X (2013), Huang X (2013), Liu T (2015)	5
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
RNF11	0	SMURF1	4	two hybrid	Colland F (2004)	1
TRIM25	5	HUWE1	22	affinity chromatography technology	Choudhury NR (2017)	1
RNF2	1	RCHY1	0	affinity chromatography technology	Cao Q (2014)	1
SMURF2	3	RNF111	2	two hybrid	Colland F (2004)	1
TNFAIP3	3	RNF5	0	two hybrid	Hayes SD (2012)	1
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
UBE2D1	0	MGRN1	4	two hybrid, pull down	Markson G (2009), Kim BY (2007)	2
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
WWP2	7	USP9X	15	affinity chromatography technology	Chaudhary N (2014)	1
BIRC2	1	RNF181	0	two hybrid	Woodsmith J (2012)	1
UBE2D1	0	RNF14	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM23	3	SIAH1	2	two hybrid	Rolland T (2014)	1
TNFAIP3	3	RLIM	1	two hybrid	Hayes SD (2012)	1
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
RNF146	4	UBE2D1	0	enzymatic study, x-ray crystallography	DaRosa PA (2014), DaRosa PA (2014)	2
MDM2	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
BIRC3	1	RCHY1	0	two hybrid	Wang J (2011)	1
BRCA1	7	CUL2	3	affinity chromatography technology	Ertych N (2016)	1
RNF11	0	NEDD4L	3	two hybrid	Colland F (2004)	1
RNF11	0	SMURF2	3	pull down, affinity chromatography technology, two hybrid, two hybrid	Subramaniam V (2003), Santonico E (2010), Colland F (2004), Colland F (2004)	4
UBE2D1	0	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
MID2	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
UBE2D1	0	RNF111	2	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Rolland T (2014)	3
TRIM32	2	MID2	1	two hybrid	Reymond A (2001)	1
UBE2D1	0	RNF114	0	two hybrid, pull down, enzymatic study	Markson G (2009), Bijlmakers MJ (2011), Lin B (2017)	3
MDM2	2	RNF8	2	two hybrid	Woodsmith J (2012)	1
RBX1	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Li Y (2010), Shaik S (2012), Costessi A (2011), Bashir T (2010), Lan L (2012), Welcker M (2011), Wilkins A (2004), Yada M (2004), Li C (2011), Lee DF (2009), Santra MK (2009), Chen BB (2012), Liu J (2002), Duan S (2011), Barbash O (2011), Kamura T (2003), Abbas T (2008), Peschiaroli A (2009), Popov N (2010), Uchida S (2011), Dimitrova YN (2010), Maerki S (2009), Malatesta M (2012), Davis MA (2013), Chen H (2013), Mallampalli RK (2013), Rossi M (2013), Mori Y (2013), Lu A (2013), Fischer ES (2014), Andresen CA (2014), Herrero-Ruiz J (2014), Johansson P (2014), Uchiki T (2009), Min SH (2012), Gao D (2010), Canettieri G (2010), Lin MY (2011), Read MA (2000), Zhang DD (2004), Zhang DD (2005), Fukushima H (2013), Matsumoto S (2015), Ibeawuchi SR (2015), Malonia SK (2015), Liu Y (2015), Liu Y (2015), Gao J (2015), Zhang C (2015), Chu WK (2015), Barbash O (2009), Kershaw NJ (2014), Nam S (2009), Wu HC (2014), Kim JH (2015), Kung YA (2017), Nguyen TV (2016), Shimizu K (2017), Gschweitl M (2016), Terai K (2013), Chandra S (2013), Dai X (2017), Qie S (2017), Chen BB (2013), Kroenke J (2014)	65
RNF11	0	NEDD4	2	affinity chromatography technology, enzymatic study, two hybrid	Santonico E (2010), Persaud A (2009), Colland F (2004)	3
UBE2D1	0	RNF167	2	two hybrid, pull down	van Wijk SJ (2009), Yamada HY (2006)	2
UBE2D1	0	RNF4	1	two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Plechanovova A (2011), Plechanovova A (2011), Tatham MH (2008), Tatham MH (2013), Yang YC (2013), Groocock LM (2014), Rojas-Fernandez A (2014), Guo L (2014), Xu Y (2014), Lecona E (2016), DiBello A (2016)	13
TRIM32	2	TRIM27	2	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
SKP1	0	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down	Hattori K (1999), Tan P (1999), Suzuki H (1999), Winston JT (1999), Surjit M (2012), Chong RA (2014)	6
MGRN1	4	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Gunn TM (2012), Gunn TM (2012)	2
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
NEDD4	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Vina-Vilaseca A (2010), Sehat B (2008), Platta HW (2012), Tofaris GK (2011), Uchiki T (2009), Liu PY (2012), Sugeno N (2014), Kim HT (2007), Chen Z (2016)	9
TRIM25	5	UBE3C	5	affinity chromatography technology	Choudhury NR (2017)	1
RLIM	1	MDM2	2	affinity chromatography technology, pull down, pull down, enzymatic study	Gao K (2016), Gao K (2016), Gao K (2016), Gao K (2016)	4
UBE2D1	0	TRIM10	3	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TRIM17	5	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Woodsmith J (2012), Rolland T (2014)	3
BRCA1	7	RCHY1	0	affinity chromatography technology	Ertych N (2016)	1
UBE2D1	0	RNF126	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
BARD1	4	UBE3A	4	pull down	Wu-Baer F (2003)	1
TRIM23	3	TNFAIP3	3	two hybrid	Rolland T (2014)	1
UBE2D1	0	RNF25	1	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Wu PY (2003)	3
RNF2	1	OTUB1	0	affinity chromatography technology	Cao Q (2014)	1
MDM2	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
RFWD3	5	MDM2	2	pull down, affinity chromatography technology	Fu X (2010), Fu X (2010)	2
MDM4	0	RNF115	1	two hybrid	Rolland T (2014)	1
RNF126	2	TRIM11	1	two hybrid	Woodsmith J (2012)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
TRIM27	2	TRIM11	1	two hybrid	Reymond A (2001)	1
RNF2	1	SIAH1	2	affinity chromatography technology	Woodsmith J (2012)	1
RNF11	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shembade N (2009), Pranski EL (2012), Kelly C (2012), Colland F (2004)	4
UBE2D1	0	TRIM17	5	two hybrid, two hybrid, pull down	Markson G (2009), Napolitano LM (2011), Woodsmith J (2012)	3
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
RNF2	1	UBE2D1	0	enzymatic study, two hybrid	Lee SJ (2001), Markson G (2009)	2
TRIM23	3	RNF126	2	two hybrid	Woodsmith J (2012)	1
RNF11	0	WWP2	7	two hybrid	Colland F (2004)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
MID1	1	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reymond A (2001), Reymond A (2001), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2006), Short KM (2006), Rolland T (2014), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016)	13
EP300	36	NFKBIA	0	affinity chromatography technology	Shin DH (2009)	1
UBE2D1	0	MUL1	1	two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Jung JH (2011), Li J (2015), Ni G (2017)	4
RBX1	2	RNF126	2	two hybrid	Woodsmith J (2012)	1
OTUB1	0	UBE2D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sun XX (2011), Herhaus L (2013), Li Y (2014), Scholz CC (2016)	4
UBE2D1	0	USP9X	15	biochemical, biochemical	Havugimana PC (2012), You J (2001)	2
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
TRIM21	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
MDM2	2	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2010), Nie J (2010), Nie J (2010)	3
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
TRIM63	0	OTUB1	0	enzymatic study	Loch CM (2012)	1
DTX3L	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down	Takeyama K (2003), Markson G (2009), Yan Q (2009)	3
NFKBIA	0	BARD1	4	two hybrid	Dechend R (1999)	1
TRIM25	5	RNF8	2	affinity chromatography technology	Choudhury NR (2017)	1
BRCA1	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Lu Y (2012), Lu Y (2012)	2
BRCA1	7	TRIM25	5	affinity chromatography technology	Ertych N (2016)	1
NEDD4L	3	RNF7	0	pull down	Persaud A (2009)	1
NEDD4	2	RNF7	0	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Persaud A (2009), Zhou W (2014), Zhou W (2014), Zhou W (2014)	4
TRIM31	0	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Reymond A (2001)	2
UBE2D1	0	UFM1	0	two hybrid, biochemical	van Wijk SJ (2009), Havugimana PC (2012)	2
SKP1	0	UBE2D1	0	pull down, pull down	Kamura T (2000), Lin DI (2006)	2
SMURF1	4	USP9X	15	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Xie Y (2013), Xie Y (2013), Xie Y (2013), Xie Y (2013)	4
UBE3A	4	RNF2	1	enzymatic study, affinity chromatography technology, pull down, enzymatic study	Zaaroor-Regev D (2010), Zaaroor-Regev D (2010), Zaaroor-Regev D (2010), Mortensen F (2015)	4
UBE2D1	0	TRIM31	0	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
TRIM10	3	TRIM11	1	affinity chromatography technology	Huttlin EL (2015)	1
MYLIP	1	UBE2D1	0	x-ray crystallography, pull down, pull down	Zhang L (2011), Zhang L (2011), Sorrentino V (2011)	3
TRIM21	0	DZIP3	6	two hybrid	Woodsmith J (2012)	1
BRCA1	7	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Wang X (2014), Wang X (2014)	2
TRIM21	0	RNF111	2	two hybrid	Woodsmith J (2012)	1
WWP2	7	UBE2D1	0	pull down, pull down	Kristariyanto YA (2015), Chen Z (2016)	2
TRIM27	2	RBX1	2	two hybrid	Woodsmith J (2012)	1
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
UBA1	1	UBE2D1	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Kang D (2002), Wauer T (2015), Huguenin-Dezot N (2016)	5
UHRF2	1	UBE2D1	0	pull down, pull down	Mori T (2011), Mori T (2004)	2
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
RNF7	0	CHFR	5	two hybrid	Woodsmith J (2012)	1
BIRC3	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Hu S (2006), Guicciardi ME (2014)	6
BIRC3	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
TRIM25	5	USP9X	15	affinity chromatography technology	Choudhury NR (2017)	1
HUWE1	22	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Zhang J (2011), Adhikary S (2005), Schwarz SE (1998), Chen D (2005), Kristariyanto YA (2015), Lee CK (2015), Zhao X (2008)	7
SIAH2	0	UBE2D1	0	pull down, pull down, pull down	Rott R (2008), Uchiki T (2009), Fan L (2015)	3
UBE2D1	0	ZNRF1	1	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Markson G (2009), Hoxhaj G (2012)	4
TRIM37	7	TRAF6	0	pull down	Zapata JM (2001)	1
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
RLIM	1	SMURF2	3	imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Huang Y (2011), Huang Y (2011), Huang Y (2011), Huang Y (2011)	4
ANAPC11	0	UBE2D1	0	pull down, pull down, pull down, pull down	Wu T (2010), Townsend K (2009), Summers MK (2009), Cao J (2015)	4
TRIM25	5	RNF4	1	affinity chromatography technology	Choudhury NR (2017)	1
RNF25	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
TNFAIP3	3	TRIM2	1	two hybrid	Hayes SD (2012)	1
MDM2	2	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
TRIM37	7	UBE2D1	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TRIM25	5	ANAPC11	0	affinity chromatography technology	Choudhury NR (2017)	1
HUWE1	22	USP9X	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gomez-Bougie P (2011), Schwickart M (2010), Schwickart M (2010)	3
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
MDM2	2	RNF126	2	two hybrid	Woodsmith J (2012)	1
STUB1	4	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Xu Z (2008), Xia T (2007), Jiang J (2001), Graf C (2010), Soss SE (2011), Pabarcus MK (2009), Wang Y (2011), Summers DW (2009), Clapp KM (2010), Wang L (2011), Ren HY (2011), Urushitani M (2004), Plechanovova A (2012), Al-Ramahi I (2006), Germano S (2006), Alberti S (2004), Peng HM (2004), Qian SB (2009), Yang M (2011), Lee H (2006), Windheim M (2008), Tsukahara F (2010), Zhou P (2003), Chymkowitch P (2011), Shimamoto S (2013), Spooner RA (2008), Zhang M (2005), Uchiki T (2009), Wang Y (2011), Wang Y (2015), Narayan V (2015), Clapp KM (2012), Kim HT (2007), McClurg UL (2016), Blessing NA (2017), Landre V (2017), Kopp Y (2017)	37
TRIM32	2	TRIM23	3	two hybrid	Reymond A (2001)	1
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
SMURF2	3	UBE2D1	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down	Kim S (2010), Shukla S (2014), Shukla S (2014), Shukla S (2014), Kristariyanto YA (2015)	5
RNF125	0	CHFR	5	two hybrid	Woodsmith J (2012)	1
TNFAIP3	3	RNF14	2	two hybrid	Hayes SD (2012)	1
BIRC2	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
TRIM50	1	UBE2D1	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
BIRC3	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
HUWE1	22	MDM2	2	affinity chromatography technology, enzymatic study	Kurokawa M (2013), Kurokawa M (2013)	2
AREL1	1	UBE2D1	0	pull down, pull down, pull down, pull down	Kim JB (2013), Kristariyanto YA (2015), Zhang W (2016), Lear T (2016)	4
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
UBE2D1	0	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
TRIM17	5	TRAF6	0	two hybrid	Woodsmith J (2012)	1
SIAH1	2	XIAP	0	affinity chromatography technology, affinity chromatography technology	Garrison JB (2011), Garrison JB (2011)	2
BIRC3	1	OTUB1	0	affinity chromatography technology	Goncharov T (2013)	1
BIRC2	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
UBE2D1	0	MKRN3	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
BRCA1	7	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down	Mallery DL (2002), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Wu-Baer F (2003), Hashizume R (2001), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Morris JR (2006), Vandenberg CJ (2003), Morris JR (2006), Nhukeaw T (2014), Thakar A (2010)	14
TRIM31	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
LRSAM1	2	MDM4	0	two hybrid	Woodsmith J (2012)	1
NFKBIA	0	OTUB1	0	affinity chromatography technology	Huttlin EL (2015)	1
RNF7	0	CUL2	3	two hybrid, enzymatic study	Ohta T (1999), Huang DT (2009)	2
TNFAIP3	3	NEDD4L	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM21	0	SKP1	0	affinity chromatography technology, biochemical	Sabile A (2006), Sabile A (2006)	2
UBE2D1	0	RNF125	0	two hybrid, pull down, pull down	Markson G (2009), Bijlmakers MJ (2011), Bijlmakers MJ (2016)	3
RNF2	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014), Hauri S (2016), Hauri S (2016)	4
RNF8	2	UBE2D1	0	pull down, pull down	Ito K (2001), Feng L (2012)	2
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
CBL	7	UBE2D1	0	pull down, pull down, pull down	Umebayashi K (2008), Sehat B (2008), Tsukahara F (2010)	3
CBL	7	TRIM21	0	affinity chromatography technology	Brehme M (2009)	1
LRSAM1	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
MKRN3	2	MDM4	0	two hybrid	Woodsmith J (2012)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
UBE2D1	0	RING1	2	two hybrid, pull down	Markson G (2009), Alchanati I (2009)	2
UBE2D1	0	TRIM2	1	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
BIRC2	1	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Goncharov T (2013), Goncharov T (2013), Goncharov T (2013)	3
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
LRSAM1	2	UBE3A	4	biochemical	Kristensen AR (2012)	1
RFWD2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Olma MH (2009)	2
RFWD2	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
TRIM25	5	RFWD2	0	affinity chromatography technology	Choudhury NR (2017)	1
BIRC3	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1