PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBA6	4	UCHL3	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PSMD7	1	ADRM1	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	4
PINK1	2	PSMD1	2	affinity chromatography technology	Imai Y (2010)	1
UBC	7	EEF1B2	1	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
RAD23A	1	PSMD11	0	affinity chromatography technology	Scanlon TC (2009)	1
PRKN	1	UBE2N	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Joch M (2007), Olzmann JA (2007), Chaugule VK (2011), Sha D (2010), Lim GG (2013), Durcan TM (2011), McKeon JE (2014), Sha D (2010)	8
OTUD4	2	USP9X	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao Y (2015), Zhao Y (2015), Zhao Y (2015)	3
BTRC	1	ARIH1	3	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
CYLD	2	C1QBP	0	affinity chromatography technology	Elliott PR (2016)	1
UBE2D2	0	STAM2	0	enzymatic study	Hoeller D (2007)	1
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
ZC3H12A	1	USP10	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Niu J (2013), Niu J (2013), Wang W (2015)	3
MAP1LC3A	0	TOLLIP	3	affinity chromatography technology	Lu K (2014)	1
TSG101	1	PABPC4	2	affinity chromatography technology	Schlundt A (2009)	1
BRCA1	7	ARIH1	3	affinity chromatography technology	Ertych N (2016)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
PSMD14	3	PSMD11	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015)	6
ANAPC7	2	EP300	36	affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005)	2
CALCOCO2	0	MAP1LC3A	0	affinity chromatography technology, affinity chromatography technology	Thurston TL (2009), Verlhac P (2015)	2
USP2	0	EGFR	5	affinity chromatography technology	Kim J (2012)	1
RNF11	0	PSMD8	1	affinity chromatography technology	Poulsen SL (2013)	1
GGA3	6	RABEP1	4	two hybrid, unspecified method, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, two hybrid	Mattera R (2003), Miller GJ (2003), Miller GJ (2003), Miller GJ (2003), Zhu G (2006), Zhu G (2006), Mattera R (2004)	7
PRKN	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Sarraf SA (2013), Huttlin EL (2017)	3
TRAF6	0	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Ling L (2000), Ling L (2000), Ling L (2000), Wang J (2011)	4
USP10	2	HIST2H2AC	1	enzymatic study	Draker R (2011)	1
CUL3	17	PABPC4	2	affinity chromatography technology	Bennett EJ (2010)	1
MYO6	3	TOM1L2	0	affinity chromatography technology, two hybrid	Tumbarello DA (2012), Tumbarello DA (2012)	2
HUWE1	22	UBA1	1	affinity chromatography technology	Thompson JW (2014)	1
UIMC1	4	TP53	0	affinity chromatography technology, pull down	Yan J (2009), Yan J (2009)	2
ANAPC11	0	UBE2S	2	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Huang NJ (2012), Wang W (2013), Frye JJ (2013), Chang L (2014), Brown NG (2014), Wu T (2010), Sedgwick GG (2013), Fukushima H (2013), Yamaguchi M (2015), Brown NG (2015), Brown NG (2014), Kelly A (2014), Kelly A (2014), Craney A (2016), Zhang S (2016), Williamson A (2011), Qiao R (2016), Brown NG (2016), Li Q (2016)	19
USP37	1	BRCA1	7	bioid	Yeh C (2015)	1
UBE2D2	0	RNF4	1	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013), Erker Y (2013), Banka PA (2015), DiBello A (2016)	6
PINK1	2	TRAF6	0	affinity chromatography technology, enzymatic study	Lee HJ (2012), Murata H (2013)	2
STAM	3	ITCH	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Malik R (2012), Malik R (2012), Malik R (2012), OConnor HF (2015)	4
SMURF1	4	UBE2D2	0	pull down, pull down	Kristariyanto YA (2015), Andrews PS (2010)	2
SPRTN	0	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Davis EJ (2012), Davis EJ (2012)	2
YOD1	0	RIPK1	2	enzymatic study	Mevissen TE (2013)	1
UCHL5	1	USP14	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009)	2
VCP	6	FAF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Song EJ (2005), Song EJ (2005), Shin HY (2010), Haenzelmann P (2011), Haenzelmann P (2011), Kang W (2011), Alexandru G (2012), Lee JJ (2013), Lee JJ (2013), Lee JJ (2013), Yu CC (2013), Baron Y (2014), Franz A (2016), Raman M (2015)	17
CDC20	1	CCT6A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Kelly A (2014), Craney A (2016)	3
FAF2	4	RNF126	2	affinity chromatography technology	Alexandru G (2008)	1
VCP	6	TOM1	3	affinity chromatography technology	Yu CC (2013)	1
PSMC5	4	UBE3C	5	affinity chromatography technology, pull down	You J (2003), You J (2001)	2
BRCA1	7	CCT3	1	affinity chromatography technology	Ertych N (2016)	1
CUL2	3	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
PRKN	1	TAX1BP1	3	affinity chromatography technology	Sarraf SA (2013)	1
USP28	3	USP33	1	enzymatic study	Loch CM (2012)	1
CUL1	7	USP11	3	affinity chromatography technology	Bennett EJ (2010)	1
USP13	2	UBC	7	enzymatic study, pull down, pull down, pull down, pull down	Zhang YH (2012), Nathan JA (2013), Zhang YH (2012), Zhang X (2017), Kwasna D (2018)	5
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
HUWE1	22	CDC20	1	affinity chromatography technology	Hein MY (2015)	1
NPM1	0	KEAP1	0	affinity chromatography technology	Chen R (2013)	1
TP53	0	STAM2	0	genetic interference	Xie L (2013)	1
FAF1	1	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Lee JJ (2013), Lee JJ (2013), Raman M (2015), Raman M (2015)	7
WWP2	7	POLR2C	0	affinity chromatography technology	Chaudhary N (2014)	1
USP7	14	WWP2	7	two hybrid, affinity chromatography technology	Lim J (2006), Chaudhary N (2014)	2
PSMC4	6	PSMC1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Um JW (2010), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	9
ARRB2	5	CUL5	1	affinity chromatography technology	Xiao K (2007)	1
DCUN1D1	0	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
PSMC4	6	PSMD1	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Lu X (2017)	7
USP28	3	OTUB2	0	enzymatic study	Loch CM (2012)	1
DDX58	3	USP3	1	affinity chromatography technology, enzymatic study	Cui J (2014), Cui J (2014)	2
MYO6	3	EPS15	1	affinity chromatography technology	Wollscheid HP (2016)	1
UBC	7	RIOK3	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Matsumoto M (2005), Fenner BJ (2009), Fenner BJ (2009), Zhang X (2017)	4
HDAC6	0	USP9X	15	affinity chromatography technology	Joshi P (2013)	1
ZUFSP	0	USP11	3	affinity chromatography technology	Hermanns T (2018)	1
HUWE1	22	PSMC5	4	affinity chromatography technology	Thompson JW (2014)	1
HERC2	9	PSMD11	0	affinity chromatography technology	Galligan JT (2015)	1
ABL1	9	HUWE1	22	enzymatic study	Gu J (1994)	1
PELI1	1	UBC	7	enzymatic study, enzymatic study	Smith H (2009), Smith H (2011)	2
RAD23B	1	USP5	2	affinity chromatography technology, affinity chromatography technology	Chen L (2006), Chen L (2006)	2
USP2	0	UBE2S	2	enzymatic study	Bremm A (2010)	1
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
UBQLN1	1	UBXN1	0	biochemical, two hybrid	Havugimana PC (2012), Rolland T (2014)	2
UBC	7	PCBP2	3	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
CDKN2A	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, imaging technique	He L (2008), He L (2008), He L (2008)	3
SMURF1	4	TOM1	3	enzymatic study	Andrews PS (2010)	1
UCHL5	1	PSMC6	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	5
ZRANB1	3	UBC	7	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, x-ray crystallography, pull down	Tran H (2008), Tran H (2008), Tran H (2008), Bremm A (2010), Komander D (2009), Licchesi JD (2012), Licchesi JD (2012), Mevissen TE (2013), Komander D (2009), Wauer T (2015), Kristariyanto YA (2015), Kristariyanto YA (2015), Kristariyanto YA (2015), Michel MA (2015), Michel MA (2015), Michel MA (2015), Michel MA (2015), Zhang X (2017)	18
SPRTN	0	BRAP	0	affinity chromatography technology	Hein MY (2015)	1
CDC34	3	CUL3	17	pull down	Plafker KS (2009)	1
UBA1	1	UBE2B	3	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Wauer T (2015), Kumar B (2010), Huguenin-Dezot N (2016)	5
PSMD10	1	WWP2	7	affinity chromatography technology	Qian YW (2012)	1
PRKN	1	MYO6	3	affinity chromatography technology	Sarraf SA (2013)	1
USP19	1	FAF2	4	affinity chromatography technology	Lee JG (2014)	1
HIF1A	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chew EH (2007), Sufan RI (2006), Luo W (2010), Heir P (2013), Russell RC (2008)	5
OTUB2	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down	Edelmann MJ (2009), Mevissen TE (2013), Altun M (2015), Altun M (2015), Kwasna D (2018)	5
TNFAIP3	3	TNIP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Van Huffel S (2001), Dong G (2011), Dong G (2011), Bohgaki M (2008), Klinkenberg M (2001)	5
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
CYLD	2	USP10	2	affinity chromatography technology	Elliott PR (2016)	1
WWP2	7	UBE2K	0	pull down	Sheng Y (2012)	1
HUWE1	22	PSMC2	2	affinity chromatography technology	Thompson JW (2014)	1
USP28	3	JOSD1	1	enzymatic study	Loch CM (2012)	1
UBC	7	UBASH3A	3	pull down, pull down, pull down	Kowanetz K (2004), Ikeda F (2007), Hoeller D (2006)	3
OTUB1	0	UBE2V2	0	pull down	Sato Y (2012)	1
SQSTM1	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji K (2012), Chen K (2016), Chen K (2016)	3
UBE2V2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
ERCC6	6	CUL4A	2	affinity chromatography technology	Latini P (2011)	1
RNF11	0	PSMD5	0	affinity chromatography technology	Poulsen SL (2013)	1
FANCD2	3	FAN1	2	imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology	Smogorzewska A (2010), Kratz K (2010), Kratz K (2010), MacKay C (2010), MacKay C (2010), MacKay C (2010), MacKay C (2010), Chaudhury I (2014), Unno J (2014)	9
RAD23A	1	PSMD5	0	affinity chromatography technology	Scanlon TC (2009)	1
PSMC5	4	RAD23B	1	biochemical	Wan C (2015)	1
PLAA	1	UBC	7	x-ray crystallography, pull down	Fu QS (2009), Fu QS (2009)	2
USP13	2	PTEN	24	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Zhang J (2013), Zhang J (2013), Zhang J (2013), Zhang J (2013), Geng J (2015), Geng J (2015), Geng J (2015), Yuan L (2015)	8
FAF1	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
CDKN2A	1	ZUFSP	0	two hybrid	Daakour S (2016)	1
CYLD	2	TAB3	1	affinity chromatography technology	Elliott PR (2016)	1
KEAP1	0	LAMA1	15	affinity chromatography technology	Lu K (2017)	1
CUL3	17	PEF1	0	affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), McGourty CA (2016), McGourty CA (2016)	3
PELI1	1	BIRC3	1	affinity chromatography technology, pull down, pull down	Jeon YK (2016), Jeon YK (2016), Jeon YK (2016)	3
USP11	3	KEAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Sowa ME (2009)	3
RNF126	2	USP7	14	affinity chromatography technology	OConnor HF (2015)	1
PSMD7	1	PSMC1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
UBXN1	0	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
TAB3	1	UBC	7	x-ray crystallography, pull down, pull down, pull down	Sato Y (2009), Kanayama A (2004), Wang J (2015), Zhang X (2017)	4
UBE2B	3	UBR4	15	affinity chromatography technology	Hong JH (2015)	1
ATXN3	2	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Liu H (2016), Liu H (2016), Liu H (2016), Liu H (2016), Liu H (2016)	5
USP11	3	UBC	7	enzymatic study, pull down, pull down	Faesen AC (2011), Zhang X (2017), Kwasna D (2018)	3
USP7	14	HIST2H2AC	1	affinity chromatography technology, enzymatic study	Lecona E (2015), Yu M (2016)	2
UBR5	13	UBE2D3	1	pull down	Honda Y (2002)	1
SMURF1	4	ADRM1	4	enzymatic study	Andrews PS (2010)	1
RNF11	0	AP2M1	5	affinity chromatography technology	Poulsen SL (2013)	1
UBE2D3	1	NEDD8	0	biochemical	Wan C (2015)	1
ITCH	1	RIPK1	2	affinity chromatography technology	Shembade N (2009)	1
PSMD4	1	UBXN1	0	affinity chromatography technology	McNeill H (2004)	1
TRAF2	1	SMURF1	4	genetic interference	Li S (2010)	1
RNF11	0	EPS15	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2004), Kostaras E (2012), Kostaras E (2014)	3
HGS	5	ITCH	1	affinity chromatography technology, affinity chromatography technology	Marchese A (2003), OConnor HF (2015)	2
PSMC6	0	SDCBP	0	two hybrid	Rolland T (2014)	1
HIF1A	1	BCR	3	affinity chromatography technology	Bento CF (2010)	1
TSG101	1	RNF126	2	two hybrid	Markson G (2009)	1
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
EGFR	5	AP2M1	5	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	5
CUL4A	2	MDM2	2	affinity chromatography technology, affinity chromatography technology	Banks D (2006), Latini P (2011)	2
UBE2S	2	CDC20	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Williamson A (2009), Williamson A (2009), Brown NG (2014), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016)	7
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
UBXN7	3	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015)	3
CUL4B	8	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
SMURF1	4	ANKRD13A	1	enzymatic study	Andrews PS (2010)	1
TOLLIP	3	TRAF6	0	affinity chromatography technology	Lee JY (2009)	1
ANKRD13B	1	VCP	6	affinity chromatography technology, affinity chromatography technology	Burana D (2016), Burana D (2016)	2
PSMD7	1	PSMD5	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
UIMC1	4	ABRAXAS2	1	affinity chromatography technology	Sowa ME (2009)	1
USP10	2	USP15	4	biochemical	Havugimana PC (2012)	1
USP25	0	UBC	7	enzymatic study, pull down, enzymatic study, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, enzymatic study, pull down	Faesen AC (2011), Nathan JA (2013), Meulmeester E (2008), Meulmeester E (2008), Zhang X (2017), Yang Y (2017), Wrigley JD (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kwasna D (2018)	12
TNF	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	4
UBE2D2	0	STUB1	4	pull down, pull down, biochemical, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down	Demand J (2001), Soss SE (2011), Shimura H (2004), Esser C (2005), Kalia LV (2011), Xie P (2009), Grelle G (2006), Westhoff B (2005), Hatakeyama S (2004), Dolan PJ (2010), Tsukahara F (2010), Chen Z (2013), Dreiseidler M (2012), Zhang H (2015), Liu X (2017), Liu X (2017), Blessing NA (2017)	17
BAP1	4	PSMD11	0	affinity chromatography technology	Hauri S (2016)	1
USP11	3	OTUD1	3	affinity chromatography technology	Sowa ME (2009)	1
UBQLN2	0	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chang L (2015), Hjerpe R (2016), Hjerpe R (2016)	3
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
UBXN7	3	USP9X	15	biochemical	Havugimana PC (2012)	1
RBCK1	0	TAB3	1	affinity chromatography technology	Tian Y (2007)	1
USP2	0	IKBKG	0	enzymatic study	Zhou H (2004)	1
UCHL5	1	PSMC3	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	5
RABGEF1	1	TAX1BP1	3	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	HDAC6	0	enzymatic study	Hoeller D (2007)	1
BIRC2	1	UBE2S	2	two hybrid, pull down	Dynek JN (2010), Phu L (2011)	2
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
RAD23B	1	STUB1	4	biochemical	Havugimana PC (2012)	1
CD2AP	0	CBLB	3	x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Moncalian G (2006), Moncalian G (2006), Moncalian G (2006), Ceregido MA (2013), Ceregido MA (2013)	5
CUL4A	2	HSPD1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	EEF1B2	1	affinity chromatography technology	Bennett EJ (2010)	1
BRCA1	7	PABPC4	2	affinity chromatography technology	Ertych N (2016)	1
YOD1	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Ernst R (2009), Locke M (2014), Locke M (2014), Ernst R (2009), Ernst R (2009), Schimmack G (2017), Schimmack G (2017)	7
UBC	7	TOM1L2	0	pull down, pull down	Nathan JA (2013), Zhang X (2017)	2
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
HUWE1	22	PCBP2	3	affinity chromatography technology	Thompson JW (2014)	1
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
BRCA1	7	PSMD1	2	affinity chromatography technology	Ertych N (2016)	1
KEAP1	0	PSMD10	1	affinity chromatography technology, affinity chromatography technology	Yang C (2016), Yang C (2016)	2
RAD23A	1	FAF1	1	affinity chromatography technology	Scanlon TC (2009)	1
ATXN3	2	PSMC5	4	affinity chromatography technology	Wang H (2007)	1
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
UBE2G2	0	USP15	4	affinity chromatography technology	Ewing RM (2007)	1
MDM2	2	PSMD4	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, pull down	Kulikov R (2010), Kulikov R (2010), Uchiki T (2009), Dolezelova P (2012), Kim HT (2012), Sparks A (2014)	6
SMURF1	4	EPN1	4	enzymatic study	Andrews PS (2010)	1
TRAF6	0	DDB1	6	affinity chromatography technology	Antonioli M (2014)	1
USP2	0	RIPK1	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2012)	4
XIAP	0	TAB2	5	affinity chromatography technology	Sanna MG (2002)	1
TRAF6	0	PSMD12	1	affinity chromatography technology	Bouwmeester T (2004)	1
USP15	4	RNF126	2	two hybrid	Hayes SD (2012)	1
FAF2	4	UBXN7	3	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
UBL7	0	VCP	6	affinity chromatography technology	Huttlin EL (2017)	1
RIPK1	2	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wright A (2007), Nagabhushana A (2011), ODonnell MA (2012), Wu GR (2017)	4
TRIM32	2	UBE2V2	0	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
DDB1	6	UCHL1	1	affinity chromatography technology, affinity chromatography technology	Hussain S (2013), Hussain S (2013)	2
CUL5	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Zhu Z (2017)	3
USP5	2	UCHL3	1	biochemical	Havugimana PC (2012)	1
AMFR	2	UBC	7	pull down, pull down, imaging technique, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Zhong X (2004), Yang H (2010), Ying Z (2009), Jo Y (2011), Ye Y (2003), Xu Y (2012), Liu S (2012), Liu S (2012), Xu Y (2012), Morito D (2008), Flierman D (2006), Liu W (2014), Fang S (2001)	13
RNF11	0	IKBKG	0	two hybrid	Colland F (2004)	1
BAP1	4	ANAPC7	2	affinity chromatography technology	Sowa ME (2009)	1
RNF11	0	CALCOCO2	0	two hybrid	Colland F (2004)	1
UBC	7	NAP1L1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007), Bish RA (2007)	3
TRAF6	0	ZC3H12A	1	affinity chromatography technology	Wang W (2015)	1
IKBKG	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Henn IH (2007), Henn IH (2007), Sha D (2010)	3
EGFR	5	PLAA	1	affinity chromatography technology	Foerster S (2013)	1
ANAPC11	0	UBE2D2	0	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Chang TS (2004), Townsend K (2009), Van Voorhis VA (2014), ODonovan KJ (2010), Tang Z (2001), Tang Z (2001), Vodermaier HC (2003), Shoji S (2014), Brown NG (2014), Brown NG (2015)	10
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
CUL4A	2	TP53	0	affinity chromatography technology	Banks D (2006)	1
PSMC6	0	PSMC3	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Kaneko T (2009), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	8
USP4	3	USP19	1	affinity chromatography technology	Zhang L (2012)	1
NPM1	0	TAB2	5	affinity chromatography technology	Chen R (2013)	1
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
USP37	1	ANAPC7	2	affinity chromatography technology, bioid	Huang X (2011), Yeh C (2015)	2
CYLD	2	CCT3	1	affinity chromatography technology	Elliott PR (2016)	1
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
USP1	4	USP4	3	affinity chromatography technology	Sowa ME (2009)	1
CDC34	3	CUL2	3	pull down	Sandoval D (2014)	1
USP27X	0	UBC	7	enzymatic study, pull down	Weber A (2016), Kwasna D (2018)	2
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
RAD23B	1	UBQLN1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
OTUB1	0	UBE2G2	0	affinity chromatography technology	Scholz CC (2016)	1
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
NPM1	0	SQSTM1	0	affinity chromatography technology	Chen R (2013)	1
RNF11	0	EPN1	4	two hybrid	Colland F (2004)	1
UBXN1	0	HUWE1	22	affinity chromatography technology	Alexandru G (2008)	1
UBC	7	PEF1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), McGourty CA (2016)	2
IKBKE	2	BIRC2	1	affinity chromatography technology, enzymatic study	Zhou AY (2013), Zhou AY (2013)	2
USP11	3	MYO6	3	affinity chromatography technology	Sowa ME (2009)	1
SQSTM1	0	PSMD12	1	biochemical	Kristensen AR (2012)	1
CDC34	3	HIF1A	1	enzymatic study	Miller F (2005)	1
OTUB1	0	STAMBP	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009)	2
BTRC	1	UBE2D3	1	pull down	Chong RA (2014)	1
PSMC3	0	HIF1A	1	affinity chromatography technology	Corn PG (2003)	1
PTPN5	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Kurup P (2010), Kurup P (2010)	2
VCP	6	HSPD1	0	affinity chromatography technology	Fogeron ML (2013)	1
CUL3	17	USP15	4	affinity chromatography technology	Bennett EJ (2010)	1
PELI1	1	UBE2D2	0	pull down	Smith H (2009)	1
ARRB2	5	VCP	6	affinity chromatography technology	Xiao K (2007)	1
UBR5	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ling S (2011), Ling S (2011), Ling S (2011), Fogeron ML (2013), Flack JE (2017)	5
ARIH1	3	KLHL7	5	affinity chromatography technology	Huttlin EL (2017)	1
SH3KBP1	1	ABL1	9	affinity chromatography technology	Havrylov S (2009)	1
RAD23B	1	PDE12	2	biochemical	Kristensen AR (2012)	1
RNF11	0	CBLB	3	two hybrid	Colland F (2004)	1
USP10	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Niu J (2013), Niu J (2013), Niu J (2013), Wang W (2015)	4
ATXN3	2	USP13	2	affinity chromatography technology	Sowa ME (2009)	1
CAV1	0	UFD1	1	affinity chromatography technology	Chen SF (2013)	1
PSMD4	1	HUWE1	22	affinity chromatography technology	Poulsen EG (2012)	1
CYLD	2	HDAC6	0	affinity chromatography technology, pull down, affinity chromatography technology	Wickstroem SA (2010), Wickstroem SA (2010), Sun L (2010)	3
AMFR	2	ERLIN2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jo Y (2011), Jo Y (2011), Jo Y (2011), Pearce MM (2007), Huber MD (2013), Christianson JC (2012)	6
GGA3	6	UBC	7	pull down, pull down, pull down, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down	Shiba Y (2004), Shiba Y (2004), Kang EL (2010), Kametaka S (2005), Kawasaki M (2005), Kawasaki M (2005), Kawasaki M (2005), Prag G (2005), Prag G (2005), Bilodeau PS (2004), Zhang X (2017)	11
VCP	6	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li JM (2013), Riemer A (2014), Zhang Z (2015)	3
USP14	1	PSMC4	6	affinity chromatography technology, biochemical	Sowa ME (2009), Havugimana PC (2012)	2
CDC20	1	HSPD1	0	affinity chromatography technology	Fogeron ML (2013)	1
UBC	7	ABRAXAS1	0	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2009), Zhang X (2017)	3
BABAM2	2	BRCC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Dong Y (2003), Dong Y (2003), Dong Y (2003), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009)	17
HDAC6	0	RAD23B	1	affinity chromatography technology, affinity chromatography technology	New M (2013), New M (2013)	2
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
EGFR	5	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Tanno H (2012), Foerster S (2013)	2
OTUD1	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Piao S (2017), Piao S (2017)	2
CALCOCO2	0	PEF1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PSMC1	2	PSMD8	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	6
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
WWP2	7	BRCC3	0	affinity chromatography technology	Chaudhary N (2014)	1
UBE2D2	0	EPS15	1	enzymatic study	Hoeller D (2007)	1
UBC	7	NCK2	2	unspecified method, x-ray crystallography	Kang J (2008), Kang J (2008)	2
NEDD4	2	SKP1	0	affinity chromatography technology	Liu J (2014)	1
STUB1	4	SNCA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Kalia LV (2011), Kalia LV (2011), Tetzlaff JE (2008)	3
KLHL7	5	UBC	7	enzymatic study, pull down	Kigoshi Y (2011), Zhang X (2017)	2
BTRC	1	NPLOC4	4	affinity chromatography technology	Riemer A (2014)	1
EGFR	5	NPM1	0	affinity chromatography technology	Liccardi G (2014)	1
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
BRCA1	7	PSMC3	0	affinity chromatography technology	Ertych N (2016)	1
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
OTUD5	2	USP11	3	affinity chromatography technology	Sowa ME (2009)	1
JUN	0	HNRNPM	1	affinity chromatography technology	Westermarck J (2002)	1
HUWE1	22	TRIM28	1	affinity chromatography technology	Thompson JW (2014)	1
USP15	4	USP14	1	enzymatic study	Loch CM (2012)	1
NEDD8	0	UCHL3	1	pull down, two hybrid, affinity chromatography technology, enzymatic study, pull down	Wada H (1998), Wada H (1998), Norman JA (2006), Wada H (1998), Hemelaar J (2004)	5
PSMC4	6	PSMC2	2	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Hartmann-Petersen R (2001), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
WRNIP1	3	USP11	3	affinity chromatography technology	Sowa ME (2009)	1
ARRB2	5	HGS	5	affinity chromatography technology, affinity chromatography technology	Han SO (2012), Malik R (2010)	2
USP5	2	XIAP	0	biochemical	Havugimana PC (2012)	1
UBE2V2	0	XIAP	0	two hybrid	Markson G (2009)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
UBE3A	4	MDM2	2	enzymatic study	Sionov RV (2001)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
CYLD	2	USP15	4	affinity chromatography technology	Elliott PR (2016)	1
HSPD1	0	EEF1B2	1	biochemical	Havugimana PC (2012)	1
CBL	7	ABL1	9	affinity chromatography technology, enzymatic study, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, far western blotting, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Soubeyran P (2003), Miyoshi-Akiyama T (2001), Miyoshi-Akiyama T (2001), Miyoshi-Akiyama T (2001), Patel H (2006), Johnson KJ (2009), Shishido T (2000), Shishido T (2000), Shishido T (2000), Gaston I (2004), Jain SK (1997), Reedquist KA (1996), Bhat A (1997), Bhat A (1997), Bhat A (1997), Grossmann AH (2004), Brehme M (2009), Brehme M (2009), Brehme M (2009), Nishihara T (2003), Tsukahara F (2010)	21
BCR	3	ABL1	9	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Ling X (2003), Pendergast AM (1991), Puil L (1994), Puil L (1994), Slupianek A (2011)	5
BRAP	0	USP15	4	two hybrid, affinity chromatography technology, two hybrid	Hayes SD (2012), Hayes SD (2012), Hayes SD (2012)	3
AMFR	2	UBE2K	0	pull down	Flierman D (2006)	1
HGS	5	STAM2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Rual JF (2005), Bache KG (2003), Bache KG (2003), Mizuno E (2004), Kanazawa C (2003), Kanazawa C (2003), Stuible M (2010), Havugimana PC (2012), Hoeller D (2006), Wan C (2015)	10
FAF2	4	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
TP53	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dhar SK (2006), Kurki S (2004), Kurki S (2004), Lambert B (2006), Colombo E (2002), Colombo E (2002), Colombo E (2002), Fogeron ML (2013), Li J (2005)	9
EGFR	5	USP9X	15	affinity chromatography technology	Foerster S (2013)	1
OPTN	1	MYO6	3	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down	Ying H (2010), Sahlender DA (2005), Sahlender DA (2005), Sahlender DA (2005), Tumbarello DA (2015), He F (2016), He F (2016), Phichith D (2009), Phichith D (2009)	9
ATXN3	2	DDB1	6	affinity chromatography technology, affinity chromatography technology	Tu Y (2017), Tu Y (2017)	2
PEF1	0	ARIH1	3	affinity chromatography technology	McGourty CA (2016)	1
UBA1	1	UBE2R2	2	pull down, enzymatic study	Jin J (2007), Huguenin-Dezot N (2016)	2
USP21	2	USP28	3	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
PRKN	1	EPS15	1	pull down, enzymatic study	Fallon L (2006), Fallon L (2006)	2
BABAM2	2	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sowa ME (2009), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Zheng H (2013)	14
NCK2	2	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Chen M (1998), Braverman LE (1999), Tu Y (1998), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
RAD23A	1	UBC	7	pull down, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, unspecified method, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, pull down	Kang Y (2006), Sims JJ (2009), Kang Y (2007), Kang Y (2007), Wang Q (2003), Scanlon TC (2009), Raasi S (2003), Sokratous K (2012), Varadan R (2005), Fenner BJ (2009), Raasi S (2005), Massey LK (2004), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Jung J (2014), Goh AM (2008), Castaneda CA (2013), Nakasone MA (2013), Lai MY (2012), Kristariyanto YA (2015), Zhang X (2017)	22
STUB1	4	TRAF2	1	affinity chromatography technology	Jang KW (2011)	1
CUL3	17	TNRC6A	6	affinity chromatography technology	Bennett EJ (2010)	1
HDAC6	0	PSMC5	4	affinity chromatography technology	New M (2013)	1
CUL4A	2	BTRC	1	affinity chromatography technology	He YJ (2006)	1
CYLD	2	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Kim JY (2009), Kim JY (2009)	2
UBC	7	VPS28	2	affinity chromatography technology, pull down	Bishop N (2002), Zhang X (2017)	2
DAZAP2	1	UBASH3B	4	two hybrid	Rolland T (2014)	1
OTUD7B	3	EGFR	5	affinity chromatography technology	Pareja F (2011)	1
TAB2	5	IKBKG	0	affinity chromatography technology, two hybrid, pull down, pull down	Suzuki S (2007), Wang J (2011), Emmerich CH (2013), Emmerich CH (2013)	4
TSG101	1	RAD18	3	two hybrid	Markson G (2009)	1
CUL3	17	HNRNPM	1	affinity chromatography technology	Bennett EJ (2010)	1
DAZAP2	1	DCUN1D1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UFD1	1	SH3KBP1	1	biochemical	Wan C (2015)	1
CUL3	17	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
CUL4A	2	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
HNRNPM	1	SFPQ	2	biochemical	Havugimana PC (2012)	1
ITCH	1	CDC34	3	pull down	Sheng Y (2012)	1
TP53	0	UBR4	15	affinity chromatography technology	Fogeron ML (2013)	1
TRAF2	1	USP4	3	affinity chromatography technology, enzymatic study	Xiao N (2011), Xiao N (2011)	2
HUWE1	22	PSMD11	0	affinity chromatography technology	Thompson JW (2014)	1
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
EPS15	1	CCT3	1	affinity chromatography technology	Brehme M (2009)	1
DDX58	3	CYLD	2	affinity chromatography technology	Friedman CS (2008)	1
PRKN	1	UBE2T	0	pull down	Kazlauskaite A (2014)	1
TOM1	3	TSG101	1	affinity chromatography technology	Yanagida-Ishizaki Y (2008)	1
BRCC3	0	HUWE1	22	biochemical	Kristensen AR (2012)	1
RNF4	1	UBE2B	3	pull down	DiBello A (2016)	1
PSMC5	4	USP4	3	pull down, affinity chromatography technology, affinity chromatography technology	Zhao B (2012), Zhao B (2012), Huttlin EL (2017)	3
UBR5	13	UBE2B	3	pull down	Honda Y (2002)	1
ADRM1	4	UBC	7	x-ray crystallography, pull down, two hybrid, pull down, pull down, x-ray crystallography, pull down	Schreiner P (2008), Hennig J (2012), Husnjak K (2008), Sahtoe DD (2015), Chen X (2016), Chen X (2016), Zhang X (2017)	7
STUB1	4	BCR	3	enzymatic study	Tsukahara F (2010)	1
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
UBC	7	UBAP1	2	pull down, pull down, pull down, pull down	Fenner BJ (2009), Stefani F (2011), Kharitidi D (2015), Zhang X (2017)	4
PMS2	4	PSMC1	2	affinity chromatography technology	Cannavo E (2007)	1
ASB2	1	UBC	7	enzymatic study, enzymatic study, enzymatic study	Bello NF (2009), Lamsoul I (2011), Heuze ML (2008)	3
UBC	7	LCK	0	unspecified method, x-ray crystallography	Kang J (2008), Kang J (2008)	2
ARIH1	3	CUL3	17	affinity chromatography technology	Kelsall IR (2013)	1
IKBKE	2	TRAF2	1	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Shen RR (2012), Shen RR (2012), Shen RR (2012), Zhang W (2010), Zhou AY (2013), Zhou AY (2013), So J (2015), Fang R (2017)	8
CDKN2A	1	NPM1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Enomoto T (2006), Enomoto T (2006), Chen D (2005), Chen D (2005), Haindl M (2008), Itahana K (2003), Itahana K (2003), Chio II (2012), Herkert B (2010), Lo D (2014), Wang L (2015), Enomoto T (2006)	12
NPM1	0	C1QBP	0	affinity chromatography technology	Chen R (2013)	1
ITCH	1	USP5	2	affinity chromatography technology	OConnor HF (2015)	1
RNF11	0	STAMBP	2	two hybrid, pull down, affinity chromatography technology	Li H (2004), Li H (2004), Li H (2004)	3
OTUD1	3	RIPK1	2	enzymatic study	Mevissen TE (2013)	1
HUWE1	22	PSMC6	0	affinity chromatography technology	Thompson JW (2014)	1
AMFR	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JN (2008), Lee JN (2008), Alexandru G (2008), Wang Q (2011), Xu Y (2013), Wang Q (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015)	9
NEDD4L	3	CDC34	3	pull down	Sheng Y (2012)	1
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
AP2M1	5	UBC	7	affinity chromatography technology, pull down	Brehme M (2009), Zhang X (2017)	2
RNF169	1	DDB1	6	affinity chromatography technology	An L (2017)	1
PSMD14	3	UBR4	15	affinity chromatography technology, affinity chromatography technology	Jacobson AD (2014), Jacobson AD (2014)	2
BAP1	4	PSMC2	2	affinity chromatography technology	Hauri S (2016)	1
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
TRAF6	0	UCHL1	1	affinity chromatography technology	Karim R (2013)	1
UBC	7	USP3	1	affinity chromatography technology, enzymatic study, pull down, pull down	Nicassio F (2007), Sloper-Mould KE (1999), Zhang X (2017), Kwasna D (2018)	4
RAD23A	1	PSMC5	4	affinity chromatography technology, pull down	Scanlon TC (2009), Zhu Q (2004)	2
USP37	1	CUL1	7	affinity chromatography technology	Burrows AC (2012)	1
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
CUL3	17	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
STAMBP	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
MID1	1	PSMC6	0	affinity chromatography technology	Gholkar AA (2016)	1
UBC	7	BAP1	4	pull down, pull down, pull down, pull down	Duerksen-Hughes PJ (1989), Daou S (2015), Kwasna D (2018), Hanpude P (2017)	4
STAM	3	UBQLN2	0	biochemical	Havugimana PC (2012)	1
UBE3A	4	UBQLN1	1	two hybrid, affinity chromatography technology	Kleijnen MF (2000), Kleijnen MF (2000)	2
SMURF1	4	PSMD4	1	enzymatic study	Andrews PS (2010)	1
UBXN7	3	BIRC2	1	affinity chromatography technology	Alexandru G (2008)	1
STAM2	0	USP8	7	unspecified method, pull down, affinity chromatography technology, pull down, protein complementation assay	Kaneko T (2003), Kato M (2000), Kato M (2000), Kato M (2000), Berlin I (2010)	5
OTUD4	2	UBC	7	enzymatic study, enzymatic study, pull down, pull down	Mevissen TE (2013), Zhao Y (2015), Zhang X (2017), Kwasna D (2018)	4
RNF11	0	USP2	0	affinity chromatography technology	Poulsen SL (2013)	1
OTULIN	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rivkin E (2013), Schaeffer V (2014), Elliott PR (2014), Draber P (2015)	4
ARRB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2006), Wang Y (2006), Xiao N (2015)	3
EGFR	5	XIAP	0	affinity chromatography technology	Yao Z (2017)	1
HIF1A	1	OTUD7B	3	affinity chromatography technology	Bremm A (2014)	1
UBASH3B	4	CCT6A	1	affinity chromatography technology	Brehme M (2009)	1
PRKN	1	CUL1	7	affinity chromatography technology, pull down, affinity chromatography technology	Staropoli JF (2003), Staropoli JF (2003), Gong Y (2014)	3
UBQLN1	1	DNAJB2	0	pull down	Heir R (2006)	1
PSMC5	4	PSMD14	3	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Braunstein I (2015), Huttlin EL (2017)	7
PSMD11	0	PSMD4	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Sparks A (2014)	3
CAV1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology	Dubiel D (2017), Dubiel D (2017)	2
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
RNF11	0	MYO6	3	two hybrid	Colland F (2004)	1
FAF1	1	CUL2	3	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
UBC	7	MINDY2	6	pull down, pull down	Kwasna D (2018), Kristariyanto YA (2017)	2
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
EP300	36	UBC	7	enzymatic study, affinity chromatography technology	Delvecchio M (2013), Kirilyuk A (2012)	2
PRKN	1	PSMD10	1	affinity chromatography technology	Sarraf SA (2013)	1
UBA1	1	UBE2D3	1	enzymatic study, pull down, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Song AX (2014), Huguenin-Dezot N (2016)	4
HUWE1	22	PSMC1	2	affinity chromatography technology	Thompson JW (2014)	1
RNF11	0	PSMD14	3	affinity chromatography technology	Poulsen SL (2013)	1
TOLLIP	3	ITCH	1	affinity chromatography technology	Li S (2011)	1
CUL1	7	PABPC4	2	affinity chromatography technology	Bennett EJ (2010)	1
SQSTM1	0	PSMC2	2	affinity chromatography technology, affinity chromatography technology	Seibenhener ML (2004), Seibenhener ML (2004)	2
PSMD14	3	PSMD1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Jacobson AD (2014), Jacobson AD (2014), Wan C (2015), Hein MY (2015), Leznicki P (2015)	9
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
USP11	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Maertens GN (2010), Maertens GN (2010), Ma H (2012), Hein MY (2015)	7
RNF126	2	MYO6	3	affinity chromatography technology	OConnor HF (2015)	1
DNAJB2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
IKBKG	0	ATG16L1	1	affinity chromatography technology	Bouwmeester T (2004)	1
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
CDKN2A	1	UCHL1	1	affinity chromatography technology	Li L (2010)	1
PSMC4	6	ADRM1	4	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Lu X (2015), Huttlin EL (2017), Lu X (2017)	6
USP7	14	RBCK1	0	two hybrid	Hayes SD (2012)	1
TP53	0	CYLD	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016)	4
CUL1	7	HNRNPM	1	affinity chromatography technology	Bennett EJ (2010)	1
STUB1	4	ABL1	9	enzymatic study, affinity chromatography technology	Tsukahara F (2010), Huang H (2017)	2
SMURF2	3	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Kim S (2010), Nie J (2010), Lu K (2011), Maspero E (2013), Kristariyanto YA (2015), Mari S (2014), Emanuelli A (2017)	7
PSMC1	2	PSMD11	0	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	4
TP53	0	ERCC6	6	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Wang XW (1995), Yu A (2000), Yu A (2000), Latini P (2011), Latini P (2011)	5
PSMD10	1	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Qiu W (2008), Qiu W (2008), Higashitsuji H (2005), Higashitsuji H (2005), Higashitsuji H (2005), Higashitsuji H (2007)	6
PSMD14	3	PSMC2	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Sun S (2017)	7
ERCC6	6	USP7	14	affinity chromatography technology	Latini P (2011)	1
AMFR	2	HSPD1	0	affinity chromatography technology	Cao J (2007)	1
FANCD2	3	BRCA1	7	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reuter TY (2003), Vandenberg CJ (2003), Garcia-Higuera I (2001), Garcia-Higuera I (2001), Loke J (2015)	5
FAF1	1	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
PRKN	1	PSMD11	0	affinity chromatography technology	Sarraf SA (2013)	1
TRAF2	1	UBE2V2	0	pull down	Sasai M (2010)	1
RNF115	1	TAX1BP1	3	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	PSMD5	0	pull down, pull down	Baboshina OV (1996), Zhang X (2017)	2
UBE2D3	1	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
SQSTM1	0	RIPK1	2	pull down, affinity chromatography technology, affinity chromatography technology	Sanz L (1999), Sanz L (1999), Sanz L (1999)	3
BRCA1	7	PSMC1	2	affinity chromatography technology	Ertych N (2016)	1
POLH	1	USP7	14	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Qian J (2014), Qian J (2014), Qian J (2014), Qian J (2014), Qian J (2014)	5
LCK	0	BRCA1	7	two hybrid	Hill SJ (2014)	1
TOLLIP	3	TOM1L2	0	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Katoh Y (2006)	2
TNF	0	TNIP1	1	affinity chromatography technology	Haas TL (2009)	1
PSMD14	3	RAD23B	1	affinity chromatography technology	Wang X (2007)	1
UBC	7	EPN1	4	pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Hawryluk MJ (2006), Zhang X (2017)	4
RNF31	3	VCP	6	affinity chromatography technology, pull down, x-ray crystallography, unspecified method	Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Elliott PR (2014)	4
TAB2	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Li S (2009), Ishitani T (2003), Hong S (2007)	4
HGS	5	UBQLN1	1	two hybrid, affinity chromatography technology	Rual JF (2005), Regan-Klapisz E (2005)	2
PRKN	1	UBE2S	2	pull down	Kazlauskaite A (2014)	1
PRKN	1	UBASH3A	3	pull down	Ikeda F (2007)	1
BABAM2	2	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Hu X (2011), Hu X (2011), Kristensen AR (2012), Zhang J (2014), Yan K (2015), Zheng H (2013)	8
UBE2D3	1	WWP2	7	pull down, pull down, pull down	Maspero E (2013), Lv Y (2014), Kristariyanto YA (2015)	3
UBQLN1	1	ATXN3	2	pull down	Heir R (2006)	1
CUL2	3	BRAP	0	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	PSMC3	0	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Jacobson AD (2014), Zhang X (2017)	3
CYLD	2	PSMC5	4	affinity chromatography technology	Elliott PR (2016)	1
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
NSFL1C	1	CUL3	17	affinity chromatography technology	Alexandru G (2008)	1
NSFL1C	1	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
TNF	0	CYLD	2	affinity chromatography technology, affinity chromatography technology	Draber P (2015), Schlicher L (2016)	2
UBC	7	ABRAXAS2	1	pull down, pull down	Wang B (2009), Nathan JA (2013)	2
UBASH3A	3	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004), Feshchenko EA (2004)	3
BRCA1	7	UBE2K	0	two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011), Shabbeer S (2013)	6
CUL3	17	USP7	14	affinity chromatography technology	Bennett EJ (2010)	1
PSMD5	0	ADRM1	4	affinity chromatography technology	Huttlin EL (2017)	1
PSMC1	2	HERC2	9	affinity chromatography technology	Hein MY (2015)	1
RABGEF1	1	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	TAX1BP1	3	affinity chromatography technology	Yu CC (2013)	1
TOLLIP	3	ANKRD13A	1	affinity chromatography technology	Li S (2011)	1
OTUB1	0	NPM1	0	affinity chromatography technology	Edelmann MJ (2009)	1
SQSTM1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji K (2012), Yan J (2013), Yan J (2013), Chen Q (2015)	4
USP15	4	UBE2S	2	enzymatic study	Bremm A (2010)	1
PSMC3	0	PSMC5	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ishizuka T (2001), Ishizuka T (2001), Um JW (2010), Lee SH (2012), Lee SH (2012), Divald A (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	10
TRAF6	0	OTUD7A	6	affinity chromatography technology	Xu Z (2014)	1
POLH	1	BRCA1	7	affinity chromatography technology	Tian F (2013)	1
PTEN	24	EGFR	5	affinity chromatography technology	Zheng J (2016)	1
SQSTM1	0	TAX1BP1	3	affinity chromatography technology	Mildenberger J (2017)	1
HIST2H2AC	1	UBC	7	pull down, pull down	Long L (2014), Zhang X (2017)	2
CALCOCO2	0	POLI	5	two hybrid	Rual JF (2005)	1
USP1	4	VPS36	3	biochemical	Havugimana PC (2012)	1
UCHL3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
CUL4A	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
UBC	7	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Matsumoto M (2005), Bennett EJ (2010), Singh RK (2012), Singh RK (2012)	4
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
TNFAIP3	3	CCDC50	0	two hybrid, affinity chromatography technology	Bohgaki M (2008), Bohgaki M (2008)	2
CDC34	3	BTRC	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, bioid, affinity chromatography technology	Semplici F (2002), Cenciarelli C (1999), Sowa ME (2009), Fernandez-Sanchez ME (2010), Chong RA (2014), Burrows AC (2012), Coyaud E (2015), Huttlin EL (2017)	8
SMURF1	4	ANKRD13D	4	enzymatic study	Andrews PS (2010)	1
UBR4	15	PSMC6	0	biochemical	Kristensen AR (2012)	1
BRCA1	7	HERC2	9	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wu W (2010), Wu W (2010), Wu W (2010), Peng Y (2015)	4
RABEP2	0	BRCC3	0	biochemical	Kristensen AR (2012)	1
DAZAP2	1	RNF115	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SQSTM1	0	NBR1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	DAgostino C (2011), Lange S (2005), Lamark T (2003), Lamark T (2003), Yang JQ (2010), Erdogan E (2006), Yamashita SI (2014), Nicot AS (2014)	8
UBC	7	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haque M (2013), Haque M (2013), Kuo YC (2015), Fan CM (1990), Mabjeesh NJ (2003)	5
HUWE1	22	ABRAXAS2	1	biochemical	Kristensen AR (2012)	1
MDM2	2	UBE2N	1	pull down	David Y (2011)	1
STAM2	0	EPS15	1	affinity chromatography technology	Bache KG (2003)	1
ATG16L1	1	AP2M1	5	affinity chromatography technology	Ravikumar B (2010)	1
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
UIMC1	4	UBC	7	pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, unspecified method, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Sobhian B (2007), Sobhian B (2007), Wang B (2009), Hu X (2012), Sekiyama N (2012), Cho HJ (2009), Markin CJ (2010), Sekiyama N (2012), Sekiyama N (2012), Sato Y (2009), Sato Y (2009), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Guzzo CM (2012), Nathan JA (2013), Anamika A (2014), Kensche T (2012), Yan J (2007), Castaneda CA (2013), Nakasone MA (2013), Thach TT (2015), Zhang X (2017), Li Y (2017), Kristariyanto YA (2017)	25
OPTN	1	IKBKG	0	affinity chromatography technology	Nakazawa S (2016)	1
NPM1	0	HIST2H2AC	1	pull down	Swaminathan V (2005)	1
UBXN7	3	VCPIP1	4	affinity chromatography technology	Raman M (2015)	1
TRAF2	1	CAV1	0	affinity chromatography technology, affinity chromatography technology	Feng X (2001), Cao H (2002)	2
IKBKG	0	LCK	0	pull down	Fenner BJ (2010)	1
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
HDAC6	0	UBC	7	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Pai MT (2007), Pozo FM (2011), Sekimoto T (2010), Kovacs JJ (2004), Hao R (2013), Lee JH (2013), Nakashima H (2014), Banerjee I (2014), Hao R (2013), Zhang X (2017), Yu Q (2018)	11
CALCOCO2	0	SQSTM1	0	affinity chromatography technology	Cemma M (2011)	1
CYLD	2	PCBP2	3	affinity chromatography technology	Elliott PR (2016)	1
PSMD14	3	PSMD10	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Roelofs J (2009), Sowa ME (2009), Havugimana PC (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Sun S (2017)	7
ZFAND2B	1	PSMC6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBXN7	3	UBR5	13	affinity chromatography technology	Alexandru G (2008)	1
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
BRCA1	7	UBE2D2	0	two hybrid, two hybrid, x-ray crystallography, pull down	Dynek JN (2010), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
UBXN1	0	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
SDCBP	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chen F (2008), Chen F (2008)	2
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
ADRM1	4	PSMD4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hamazaki J (2006), Jorgensen JP (2006), Jorgensen JP (2006), Berko D (2014), Huttlin EL (2015), Huttlin EL (2017), Sparks A (2014)	7
UBC	7	WRNIP1	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Nathan JA (2013), Bish RA (2007), Bish RA (2007), Bish RA (2007), Bish RA (2007), Herhaus L (2015), Zhang X (2017)	7
EGFR	5	USP8	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Mizuno E (2005), Meijer IM (2013), Meijer IM (2013), Ali N (2013), Reincke M (2015), Reincke M (2015), Jeong CH (2015)	7
EGFR	5	EPN1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sigismund S (2005), Bertelsen V (2011), Kazazic M (2009)	3
OTUD4	2	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Zhao Y (2015), Zhao Y (2015), Zhao Y (2015), Zhao Y (2015)	4
NPM1	0	HNRNPM	1	affinity chromatography technology	Park G (2010)	1
ANKRD13D	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burana D (2016), Burana D (2016), Burana D (2016)	3
XIAP	0	NOD1	3	pull down	Krieg A (2009)	1
PRKN	1	PSMD14	3	affinity chromatography technology	Sarraf SA (2013)	1
RBBP8	1	FANCD2	3	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, genetic interference, imaging technique, affinity chromatography technology	Yeo JE (2014), Murina O (2014), Murina O (2014), Murina O (2014), Murina O (2014), Murina O (2014), Unno J (2014), Unno J (2014), Unno J (2014), Unno J (2014), Unno J (2014), Unno J (2014)	12
RNF168	0	NUB1	2	affinity chromatography technology	Hein MY (2015)	1
HDAC6	0	STUB1	4	affinity chromatography technology	Cook C (2012)	1
USP3	1	ZFAND6	0	biochemical	Havugimana PC (2012)	1
CYLD	2	ERLIN2	2	affinity chromatography technology	Elliott PR (2016)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
WWP2	7	ABRAXAS2	1	affinity chromatography technology	Chaudhary N (2014)	1
UBXN1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
DCUN1D1	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Wu K (2011), Bennett EJ (2010), Huang G (2011), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	16
PSMD1	2	PSMC1	2	biochemical, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Thompson D (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
TOLLIP	3	BIRC2	1	affinity chromatography technology	Li S (2011)	1
MDM2	2	MAP1LC3A	0	enzymatic study	Guo Z (2013)	1
UBE2T	0	FANCD2	3	enzymatic study	Hira A (2015)	1
TOM1	3	TOLLIP	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down	Yamakami M (2003), Yamakami M (2003), Yamakami M (2003), Katoh Y (2006), Katoh Y (2004), Rolland T (2014), Katoh Y (2004), Xiao S (2015), Xiao S (2015)	9
DCUN1D1	0	PABPC4	2	affinity chromatography technology	Bennett EJ (2010)	1
PSMD14	3	PSMC6	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Roelofs J (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015)	6
UBC	7	FAF2	4	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Alexandru G (2008)	2
AP2M1	5	SFPQ	2	affinity chromatography technology	Brehme M (2009)	1
CD2AP	0	EGFR	5	affinity chromatography technology	Lynch DK (2003)	1
CUL4B	8	USP15	4	affinity chromatography technology	Bennett EJ (2010)	1
DDX58	3	IKBKG	0	affinity chromatography technology	Oshiumi H (2013)	1
CDC34	3	ZFAND6	0	two hybrid	Duan W (2000)	1
UBE3A	4	UBQLN2	0	two hybrid, biochemical, affinity chromatography technology	Kleijnen MF (2000), Kleijnen MF (2000), Kleijnen MF (2000)	3
HDAC6	0	PSMD1	2	affinity chromatography technology	New M (2013)	1
VCP	6	PSMC4	6	affinity chromatography technology	Fogeron ML (2013)	1
SDCBP	0	TRIM32	2	two hybrid	Rolland T (2014)	1
AMFR	2	ATXN3	2	affinity chromatography technology, imaging technique	Ying Z (2009), Ying Z (2009)	2
CDKN2A	1	HIF1A	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Fatyol K (2001), Fatyol K (2001), Ivanov AA (2017)	3
PSMC2	2	PSMD8	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Grune T (2011), Kim YC (2011), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	7
NEDD4L	3	SNCA	0	enzymatic study	Sugeno N (2014)	1
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
CAV1	0	HDAC6	0	affinity chromatography technology	Li Y (2008)	1
TAB3	1	RNF4	1	affinity chromatography technology	Tan B (2015)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
EP300	36	HIST2H2AC	1	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Brackertz M (2006), Kutney SN (2004), Cereseto A (2005), Loven MA (2004), Thomas MC (2005)	5
NBR1	0	UBE2D3	1	pull down	Peng H (2017)	1
USP37	1	CDC20	1	affinity chromatography technology	Huang X (2011)	1
PSMC4	6	PSMD8	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
SMURF1	4	NEDD8	0	affinity chromatography technology, pull down	He S (2017), He S (2017)	2
USP24	6	TP53	0	enzymatic study	Zhang L (2015)	1
CYLD	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
UBE2D2	0	RNF126	2	two hybrid, pull down, pull down, pull down	Markson G (2009), Hou X (2012), Smith CJ (2013), Delker RK (2013)	4
RAD23A	1	UBQLN1	1	x-ray crystallography, affinity chromatography technology, biochemical	Kang Y (2007), Kang Y (2007), Wan C (2015)	3
EGFR	5	FAF2	4	affinity chromatography technology	Tong J (2014)	1
PSMD14	3	PSMD12	1	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
CBLB	3	LCK	0	affinity chromatography technology	Kumar S (2011)	1
UBA6	4	UBE2S	2	pull down	Jin J (2007)	1
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
TNRC6A	6	AGO2	10	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	El-Shami M (2007), Baillat D (2009), Lazzaretti D (2009), Lazzaretti D (2009), Fabian MR (2009), Li S (2014), Li S (2014)	7
PSMC3	0	PSMD4	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CUL4A	2	C1QBP	0	affinity chromatography technology	Bennett EJ (2010)	1
PSMD5	0	PSMD14	3	biochemical, affinity chromatography technology	Wan C (2015), Sun S (2017)	2
UBXN7	3	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012)	2
NEDD4L	3	ABL1	9	enzymatic study	Persaud A (2009)	1
NPM1	0	COPB1	0	affinity chromatography technology	Chen R (2013)	1
USP7	14	UBE2S	2	enzymatic study	Bremm A (2010)	1
UBE2V2	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
UBE2D3	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
GGA1	0	UBC	7	pull down, affinity chromatography technology, two hybrid, pull down, pull down	Shiba Y (2004), Mattera R (2004), Mattera R (2004), Fenner BJ (2009), Wang J (2007)	5
SQSTM1	0	UBE2D3	1	two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
PSMC1	2	CBL	7	affinity chromatography technology	Hein MY (2015)	1
RNF126	2	COPB1	0	affinity chromatography technology	OConnor HF (2015)	1
UBC	7	UBE2T	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
HUWE1	22	CD2AP	0	biochemical	Kristensen AR (2012)	1
SMURF2	3	TRAF2	1	affinity chromatography technology	Carpentier I (2008)	1
PINK1	2	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Koyano F (2014), Kane LA (2014), Kane LA (2014), Shiba-Fukushima K (2014), Okatsu K (2015), Fiesel FC (2015), Ando M (2017), Klosowiak JL (2016)	8
VCP	6	UBE2S	2	affinity chromatography technology	Yu CC (2013)	1
NUB1	2	PSMD4	1	pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kamitani T (2001), Rani N (2012), Rani N (2012), Rani N (2012), Tanji K (2005), Tanji K (2005), Jeong YY (2016), Jeong YY (2016)	8
CUL1	7	PDE12	2	biochemical	Wan C (2015)	1
ZFAND2B	1	PSMC5	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	PSMC2	2	affinity chromatography technology	Bennett EJ (2010)	1
PRKN	1	SFPQ	2	affinity chromatography technology	Zanon A (2013)	1
BRCA1	7	TNRC6A	6	affinity chromatography technology	Ertych N (2016)	1
USP8	7	UBC	7	enzymatic study, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, pull down	Faesen AC (2011), Ernst A (2013), Row PE (2007), Ernst A (2013), Wauer T (2015), Reincke M (2015), Kwasna D (2018)	7
PMS2	4	DDB1	6	affinity chromatography technology	Cannavo E (2007)	1
VCPIP1	4	HUWE1	22	affinity chromatography technology	Sowa ME (2009)	1
BRCA1	7	BAP1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Jensen DE (1998), Jensen DE (1998), Jensen DE (1998), Jensen DE (1998)	4
UBC	7	NPM1	0	affinity chromatography technology, pull down	Matsumoto M (2005), Koike A (2010)	2
CYLD	2	HNRNPM	1	affinity chromatography technology	Elliott PR (2016)	1
UBXN7	3	UCHL3	1	biochemical	Havugimana PC (2012)	1
UBXN7	3	SKP1	0	affinity chromatography technology	Alexandru G (2008)	1
PSMD14	3	STUB1	4	biochemical	Havugimana PC (2012)	1
SMURF1	4	RNF114	0	enzymatic study	Andrews PS (2010)	1
UBE2N	1	RBCK1	0	two hybrid	Markson G (2009)	1
USP21	2	UCHL3	1	enzymatic study	Loch CM (2012)	1
BTRC	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Strack P (2000), Margottin F (1998), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Watanabe N (2004), Wu G (2003), Kawakami T (2001), Hattori K (1999), Hattori K (1999), Hattori K (1999), Kitagawa M (1999), Hart M (1999), Su Y (2008), Banerjee S (2010), Winston JT (1999), Winston JT (1999), Estrabaud E (2007), Latres E (1999), Latres E (1999), Liu J (2004), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Busino L (2012), Li T (2005), da Silva Almeida AC (2013), Sahasrabuddhe AA (2014), Choi BH (2014), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Deng W (2015), Coyaud E (2015), Liu YQ (2015), He N (2005), Kuchay S (2017), Hauri S (2016)	40
ZFAND2B	1	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Glinka T (2014), Glinka T (2014), Glinka T (2014), Braunstein I (2015)	4
RNF115	1	RAD23A	1	affinity chromatography technology, two hybrid	Bacopulos S (2012), Bacopulos S (2012)	2
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
UBC	7	NPLOC4	4	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2003), Bish RA (2007), Kristariyanto YA (2015), Zhang X (2017)	5
UIMC1	4	C1QBP	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Cho HJ (2013), Chung HJ (2017), Chung HJ (2017), Chung HJ (2017), Chung HJ (2017)	5
PSMC4	6	PSMD10	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, two hybrid, two hybrid, biochemical, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Ewing RM (2007), Dawson S (2002), Dawson S (2002), Dawson S (2002), Dawson S (2002), Roelofs J (2009), Kaneko T (2009), Kaneko T (2009), Nagao T (2003), Nagao T (2003), Havugimana PC (2012), Wang J (2011), Rolland T (2014), Wan C (2015), Huttlin EL (2017)	17
TSG101	1	EP300	36	affinity chromatography technology, pull down	Sun Z (1999), Sun Z (1999)	2
RNF11	0	USP7	14	affinity chromatography technology	Poulsen SL (2013)	1
EGFR	5	SNCA	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
USP7	14	TRAF6	0	pull down, affinity chromatography technology, enzymatic study	Zapata JM (2001), Daubeuf S (2009), Bremm A (2010)	3
UBE2D3	1	EPS15	1	enzymatic study	Hoeller D (2007)	1
TRIM28	1	UBE2N	1	pull down	Doyle JM (2010)	1
UBXN7	3	NSFL1C	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
UBE2S	2	ANAPC7	2	pull down	Brown NG (2014)	1
USP21	2	BAP1	4	enzymatic study	Loch CM (2012)	1
ANAPC11	0	UBE2K	0	pull down, pull down, pull down	Bassermann F (2008), Rodrigo-Brenni MC (2007), Van Voorhis VA (2014)	3
PARP10	4	SQSTM1	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Kleine H (2012), Kleine H (2012), Kleine H (2012)	3
UBQLN2	0	RAD23A	1	biochemical	Wan C (2015)	1
PSMD5	0	PSMD4	1	biochemical, affinity chromatography technology	Shim SM (2012), Huttlin EL (2017)	2
ITCH	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Shembade N (2008), Shembade N (2008)	2
PSMC6	0	PSMD1	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
UBE3A	4	TTC3	1	two hybrid	Vinayagam A (2011)	1
IKBKG	0	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Zhao T (2007), Zhou AY (2013)	2
UBL7	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP2	0	RNF126	2	two hybrid	Hayes SD (2012)	1
CDC20	1	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005), Huttlin EL (2017)	3
HERC2	9	MINDY1	0	affinity chromatography technology	Huttlin EL (2015)	1
PTEN	24	SDCBP	0	pull down	Verrastro I (2015)	1
PSMD11	0	PSMD8	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
BRCA1	7	PSMD11	0	affinity chromatography technology	Ertych N (2016)	1
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
SPRTN	0	NSFL1C	1	affinity chromatography technology, affinity chromatography technology	Davis EJ (2012), Davis EJ (2012)	2
BABAM2	2	BRCA1	7	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Woods NT (2012), Hill SJ (2014)	5
UBC	7	UBR4	15	affinity chromatography technology, pull down, affinity chromatography technology	Matsumoto M (2005), Nathan JA (2013), Bish RA (2007)	3
UFD1	1	UBAC2	1	affinity chromatography technology	Raman M (2015)	1
USP25	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
VCP	6	PSMD4	1	affinity chromatography technology, affinity chromatography technology	Arrojo E Drigo R (2013), McNeill H (2004)	2
TRAF6	0	SNCA	0	affinity chromatography technology	Zucchelli S (2010)	1
CYLD	2	PSMD4	1	affinity chromatography technology	Elliott PR (2016)	1
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
UBC	7	HERC2	9	affinity chromatography technology, pull down	Rendtlew Danielsen J (2012), Zhang X (2017)	2
NEDD8	0	UBE2D2	0	x-ray crystallography	Sakata E (2007)	1
FAN1	2	PSMD11	0	affinity chromatography technology	Hein MY (2015)	1
RAD23A	1	PSMD12	1	affinity chromatography technology	Scanlon TC (2009)	1
MDM2	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2005), Wang C (2005), Wang C (2005), Gilmore-Hebert M (2010), Okamoto K (2006), Okamoto K (2006), Okamoto K (2006)	7
USP7	14	USP14	1	affinity chromatography technology	Sowa ME (2009)	1
NEDD4	2	POLR2C	0	pull down	Ingham RJ (2005)	1
RNF31	3	HDAC6	0	enzymatic study	Kliza K (2017)	1
USP14	1	UBC	7	unspecified method, pull down, enzymatic study, pull down, pull down	Ernst A (2013), Phillips AH (2013), Flierman D (2016), Zhang X (2017), Kwasna D (2018)	5
RNF11	0	TNIP1	1	two hybrid	Colland F (2004)	1
USP21	2	RBCK1	0	two hybrid	Hayes SD (2012)	1
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
RAD18	3	SPRTN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Centore RC (2012), Centore RC (2012), Ghosal G (2012), Ghosal G (2012)	4
TRIM28	1	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Neo SH (2015), Neo SH (2015), Neo SH (2015), Neo SH (2015)	4
CYLD	2	SFPQ	2	affinity chromatography technology	Elliott PR (2016)	1
BRCA1	7	UBE3A	4	pull down	Wu-Baer F (2003)	1
UBC	7	HNRNPM	1	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
JUN	0	TSG101	1	two hybrid, affinity chromatography technology	Camus G (2007), Camus G (2007)	2
BRCA1	7	HSPD1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
TOLLIP	3	CAV1	0	affinity chromatography technology	Ohnuma K (2005)	1
BIRC3	1	USP7	14	affinity chromatography technology	Goncharov T (2013)	1
NBR1	0	UBC	7	pull down, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down	Waters S (2009), Kirkin V (2009), Walinda E (2014), Walinda E (2014), Nicot AS (2014), Nakayasu ES (2013), Nakayasu ES (2013), Zhang X (2017)	8
UBC	7	CAV1	0	affinity chromatography technology, imaging technique	Luo X (2017), Luo X (2017)	2
UBE2N	1	UFD1	1	biochemical	Havugimana PC (2012)	1
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
TAX1BP1	3	RAD18	3	two hybrid	Rolland T (2014)	1
PSMD7	1	PSMC6	0	affinity chromatography technology, biochemical, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
RNF168	0	USP10	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guturi KK (2016), Guturi KK (2016), Guturi KK (2016)	3
POLH	1	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Yuasa MS (2006), Yuasa MS (2006)	2
TRAF6	0	IKBKE	2	affinity chromatography technology	Fang R (2017)	1
PSMD11	0	ADRM1	4	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
KEAP1	0	CUL2	3	affinity chromatography technology	Zhang DD (2004)	1
FAF1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Zhang L (2012), Zhang L (2012)	4
TRAF6	0	YOD1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Schimmack G (2017), Schimmack G (2017), Schimmack G (2017), Schimmack G (2017), Schimmack G (2017)	5
RNF11	0	UBQLN2	0	two hybrid	Colland F (2004)	1
ARIH1	3	CUL4A	2	affinity chromatography technology	Kelsall IR (2013)	1
TRIM32	2	DDX58	3	affinity chromatography technology	Zhang J (2012)	1
PSMD4	1	PSMC5	4	biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Hamazaki J (2007), Thompson D (2009), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	6
FAAP20	1	UBC	7	pull down, x-ray crystallography, pull down, pull down, x-ray crystallography, pull down, pull down	Yan Z (2012), Toma A (2015), Toma A (2015), Ali AM (2012), Wojtaszek JL (2014), Wojtaszek JL (2014), Lim K (2015)	7
USP28	3	UCHL3	1	enzymatic study	Loch CM (2012)	1
MDM2	2	CUL4B	8	affinity chromatography technology	Latini P (2011)	1
TRIM32	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
BRCA1	7	HNRNPM	1	affinity chromatography technology	Ertych N (2016)	1
TSG101	1	MDM2	2	affinity chromatography technology, affinity chromatography technology	Li L (2001), Cheng TH (2007)	2
USP21	2	ATXN3	2	enzymatic study	Loch CM (2012)	1
SMURF1	4	UBE2K	0	enzymatic study	Andrews PS (2010)	1
RAD23A	1	UBA6	4	biochemical	Kristensen AR (2012)	1
UBXN7	3	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	3
BABAM1	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang B (2009), Shao G (2009), Shao G (2009), Shao G (2009), Bian C (2012), Hill SJ (2014)	6
CUL3	17	VCP	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Besten Wd (2012)	2
RNF8	2	UBE2D3	1	pull down, pull down, pull down, two hybrid	Mallette FA (2012), Zhang S (2008), Zhang S (2013), Schimmack G (2017)	4
TNF	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Yamaguchi N (2015)	2
USP5	2	CDC34	3	biochemical	Kristensen AR (2012)	1
MDM2	2	DDB1	6	affinity chromatography technology, affinity chromatography technology	Latini P (2011), Jacob AG (2014)	2
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
BTRC	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Inuzuka H (2010), Inuzuka H (2010), Inuzuka H (2010)	3
BABAM2	2	TP53	0	affinity chromatography technology, affinity chromatography technology, biochemical	Dong Y (2003), Dong Y (2003), Dong Y (2003)	3
MDM2	2	HNRNPM	1	affinity chromatography technology	Okoro DR (2013)	1
HIF1A	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Nowicka AM (2016), Nowicka AM (2016), Nowicka AM (2016), Nowicka AM (2016)	4
PSMC6	0	ADRM1	4	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
UBXN1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Hu Y (2017), Hu Y (2017)	4
USP21	2	OTUB2	0	enzymatic study	Loch CM (2012)	1
TRAF6	0	PSMC3	0	affinity chromatography technology	Bouwmeester T (2004)	1
UBC	7	PSMC5	4	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhu Q (2004), Zhang X (2017)	3
PCBP2	3	BRCA1	7	affinity chromatography technology	Shimizu Y (2012)	1
ITCH	1	UBA6	4	affinity chromatography technology	OConnor HF (2015)	1
OPTN	1	PRKN	1	imaging technique	Wong YC (2014)	1
UCHL5	1	PSMD12	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Huttlin EL (2015), Huttlin EL (2017)	4
EGFR	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soubeyran P (2002), Szymkiewicz I (2002), Schmidt MH (2004), Schmidt MH (2003), Ronning SB (2011), Ronning SB (2011), Yang S (2006), Schmidt MH (2003)	8
USP15	4	SMURF2	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Eichhorn PJ (2012), Iyengar PV (2015), Iyengar PV (2015)	3
ARRB2	5	NPM1	0	affinity chromatography technology	Xiao K (2007)	1
SMURF1	4	UBXN7	3	enzymatic study	Andrews PS (2010)	1
HSPD1	0	UBR4	15	biochemical	Havugimana PC (2012)	1
USP10	2	UBC	7	enzymatic study, unspecified method, pull down	Bomberger JM (2009), Ernst A (2013), Kwasna D (2018)	3
USP7	14	RNF168	0	pull down, affinity chromatography technology	Zhu Q (2015), Zhu Q (2015)	2
BIRC3	1	IKBKE	2	enzymatic study	Zhou AY (2013)	1
UBC	7	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Hong JH (2015)	2
PSMD14	3	UBQLN1	1	affinity chromatography technology	Wang X (2007)	1
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
RAD23B	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBC	7	ATG16L1	1	affinity chromatography technology, pull down, pull down	Fujita N (2013), Fujita N (2013), Ver Heul AM (2013)	3
PSMC5	4	PSMD8	1	affinity chromatography technology, biochemical, biochemical, biochemical	Kim YC (2011), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
USP37	1	UBC	7	unspecified method, affinity chromatography technology, pull down, enzymatic study, pull down, pull down	Ernst A (2013), Tanno H (2014), Tanno H (2014), Tanno H (2014), Kawaguchi K (2017), Kwasna D (2018)	6
MAP1LC3A	0	HNRNPM	1	affinity chromatography technology	Wang BS (2013)	1
NPM1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Sato K (2004), Ertych N (2016)	2
USP4	3	USP32	0	affinity chromatography technology	Sowa ME (2009)	1
GGA3	6	ITCH	1	affinity chromatography technology	Santonico E (2014)	1
ATXN3L	0	UBC	7	x-ray crystallography, enzymatic study	Weeks SD (2011), Weeks SD (2011)	2
UCHL1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu J (2008), Li L (2010), Ilic A (2017), Ilic A (2017)	4
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
SDCBP	0	CALCOCO2	0	two hybrid	Rolland T (2014)	1
UBC	7	SDCBP	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
USP25	0	WRNIP1	3	affinity chromatography technology	Sowa ME (2009)	1
UBTD2	2	UBA1	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Song AX (2014), Song AX (2014), Song AX (2014), Song AX (2014)	4
UCHL5	1	HERC2	9	affinity chromatography technology	Huttlin EL (2015)	1
ITCH	1	POLR2C	0	pull down	Ingham RJ (2005)	1
USP14	1	PSMC2	2	affinity chromatography technology	Sowa ME (2009)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
USP21	2	DDX58	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Fan Y (2014), Fan Y (2014), Fan Y (2014)	3
UBE3A	4	PSMC3	0	enzymatic study	Jacobson AD (2014)	1
UBE2S	2	RBCK1	0	two hybrid	Markson G (2009)	1
ATXN3	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Chhangani D (2014), Chhangani D (2014)	2
UBC	7	USP32	0	pull down, pull down	Zhang X (2017), Kwasna D (2018)	2
CUL1	7	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
ARRB2	5	USP33	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Berthouze M (2009), Shenoy SK (2009), Shenoy SK (2009), Shenoy SK (2014), Shenoy SK (2014), Shenoy SK (2009), Shenoy SK (2009), Shenoy SK (2009), Liu H (2016)	9
UBC	7	CALCOCO2	0	pull down, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique	Fenner BJ (2009), Fenner BJ (2009), Rolland T (2014), Tumbarello DA (2015), Xie X (2015), Xie X (2015), Xie X (2015), Xie X (2015), Ordureau A (2015), Minowa-Nozawa A (2017)	10
EP300	36	HDAC6	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Han Y (2009), Han Y (2009), Liu Y (2012), Kirilyuk A (2012), Girdwood D (2003)	5
USP37	1	SKP1	0	affinity chromatography technology, bioid	Burrows AC (2012), Yeh C (2015)	2
UBE2N	1	USP14	1	biochemical	Havugimana PC (2012)	1
ARRB2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down	Shenoy SK (2008), Bhandari D (2007), Bhandari D (2007)	3
PSMD11	0	PSMD12	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
USP15	4	YOD1	0	enzymatic study	Loch CM (2012)	1
HUWE1	22	ADRM1	4	affinity chromatography technology	Thompson JW (2014)	1
ZFAND2B	1	PSMC4	6	affinity chromatography technology	Huttlin EL (2017)	1
CUL5	1	AGO2	10	affinity chromatography technology	Bennett EJ (2010)	1
LCK	0	SQSTM1	0	pull down	Joung I (1996)	1
BRCA1	7	EXOSC8	2	affinity chromatography technology	Ertych N (2016)	1
RNF168	0	HNRNPM	1	affinity chromatography technology	Guturi KK (2016)	1
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
CUL3	17	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Bish RA (2007), Wu K (2016)	3
UBC	7	ANKRD13A	1	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Tanno H (2012), Zhang X (2017)	3
CUL2	3	ACLY	3	affinity chromatography technology	Bennett EJ (2010)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
STAM	3	STAMBP	2	pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, pull down	Kato M (2000), Tanaka N (1999), Tanaka N (1999), Tanaka N (1999), Kim MS (2006), Agromayor M (2006), McCullough J (2004), Sierra MI (2010), Sierra MI (2010), Sierra MI (2010), Row PE (2006), Kikuchi K (2003), McCullough J (2006), McCullough J (2006), Tsang HT (2006), Davies CW (2013), Davies CW (2013), McCullough J (2006)	18
RNF126	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Smith CJ (2013), Smith CJ (2013), Smith CJ (2013)	3
UBXN7	3	KLHL12	4	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
UBXN7	3	FAF1	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
ARRB2	5	PABPC4	2	affinity chromatography technology	Xiao K (2007)	1
ZRANB1	3	UBE2S	2	enzymatic study	Bremm A (2010)	1
RAD23A	1	UIMC1	4	affinity chromatography technology	Scanlon TC (2009)	1
RNF168	0	HERC2	9	affinity chromatography technology	Bekker-Jensen S (2010)	1
CUL4B	8	UBE2D3	1	pull down	Li X (2011)	1
OTUD1	3	UBC	7	enzymatic study, pull down	Mevissen TE (2013), Kwasna D (2018)	2
PRKN	1	PSMC3	0	affinity chromatography technology, affinity chromatography technology	Um JW (2010), Sarraf SA (2013)	2
MDM2	2	USP2	0	two hybrid, pull down, affinity chromatography technology, pull down	Stevenson LF (2007), Stevenson LF (2007), Stevenson LF (2007), Stevenson LF (2007)	4
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
RABGEF1	1	RABEP2	0	affinity chromatography technology	Huttlin EL (2017)	1
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
UBXN7	3	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
CAV1	0	MAP1LC3A	0	imaging technique	Luo X (2017)	1
BRCA1	7	RAD18	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian F (2013), Tian F (2013), Hill SJ (2014)	3
CYLD	2	DDB1	6	affinity chromatography technology	Elliott PR (2016)	1
BTRC	1	UFD1	1	affinity chromatography technology	Riemer A (2014)	1
RNF11	0	USP5	2	two hybrid, affinity chromatography technology	Colland F (2004), Poulsen SL (2013)	2
ADRM1	4	PSMD10	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAF2	4	UBE3C	5	affinity chromatography technology	Raman M (2015)	1
USP15	4	USP33	1	enzymatic study	Loch CM (2012)	1
BRCA1	7	PSMC5	4	affinity chromatography technology	Ertych N (2016)	1
UBR5	13	UBC	7	pull down, x-ray crystallography, pull down	Kozlov G (2007), Kozlov G (2007), Zhang X (2017)	3
USP48	3	MDM2	2	affinity chromatography technology, affinity chromatography technology	Cetkovska K (2017), Cetkovska K (2017)	2
CUL4A	2	USP7	14	affinity chromatography technology	Bennett EJ (2010)	1
USP28	3	BAP1	4	enzymatic study	Loch CM (2012)	1
PMS2	4	UBR5	13	affinity chromatography technology	Cannavo E (2007)	1
JUN	0	NEDD4	2	two hybrid, affinity chromatography technology	Camus G (2007), Camus G (2007)	2
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
NEDD4	2	ABL1	9	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
BRCA1	7	UBE2D3	1	two hybrid, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down	Dynek JN (2010), Polanowska J (2006), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Calvo V (2011), Wu-Baer F (2010), Yu X (2006), Starita LM (2005), Sato K (2012), Starita LM (2004), Wei L (2011), Wu W (2007), David Y (2011), Kentsis A (2002), Kleiman FE (2005), Zhao GY (2007), Wenzel DM (2011), Wenzel DM (2011), McGinty RK (2014), Chen A (2002), Shabbeer S (2013), Ando K (2017)	23
UBC	7	CISH	1	affinity chromatography technology, affinity chromatography technology	Jensik PJ (2015), Jensik PJ (2015)	2
NPM1	0	PABPC4	2	affinity chromatography technology	Hein MY (2015)	1
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
UBC	7	PABPC4	2	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
HERC2	9	RABEP1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP1	4	FANCD2	3	affinity chromatography technology, enzymatic study, biochemical	Nijman SM (2005), Cohn MA (2007), Nijman SM (2005)	3
NEDD8	0	ARIH1	3	affinity chromatography technology, pull down, pull down	Bennett EJ (2010), Kelsall IR (2013), Dove KK (2017)	3
SH3KBP1	1	CBLB	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Szymkiewicz I (2002), Szymkiewicz I (2002), Szymkiewicz I (2002), Havrylov S (2009), Moncalian G (2006), Jozic D (2005), Jozic D (2005), Kowanetz K (2003), Ceregido MA (2013), Ceregido MA (2013), Ceregido MA (2013)	11
CUL3	17	USP25	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Xu D (2017)	2
JUN	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alfranca A (2002), Yu B (2009), Yu B (2009)	3
YOD1	0	FAF2	4	affinity chromatography technology	Ernst R (2009)	1
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
BTRC	1	CCT6A	1	bioid	Coyaud E (2015)	1
TP53	0	POLI	5	affinity chromatography technology, imaging technique	Hampp S (2016), Hampp S (2016)	2
BRCC3	0	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang B (2007), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2010), Solyom S (2012), Zheng H (2013)	19
PSMC1	2	UBE3A	4	affinity chromatography technology	Hein MY (2015)	1
PSMC2	2	PSMD11	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
TNF	0	UBE2N	1	genetic interference, affinity chromatography technology	Deng L (2000), Fritsch J (2014)	2
BIRC2	1	USP15	4	affinity chromatography technology	Goncharov T (2013)	1
PEF1	0	DAZAP2	1	two hybrid	Venkatesan K (2009)	1
DAZAP2	1	ZFAND2B	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
BRCA1	7	AGO2	10	affinity chromatography technology	Ertych N (2016)	1
UBA1	1	UBE2G2	0	pull down, enzymatic study, enzymatic study	Jin J (2007), Wauer T (2015), Huguenin-Dezot N (2016)	3
UBC	7	CCT3	1	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
UBQLN1	1	EPS15	1	pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Heir R (2006), Heir R (2006), Regan-Klapisz E (2005), Regan-Klapisz E (2005), NDiaye EN (2008)	5
SH3KBP1	1	USP27X	0	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	EEF1B2	1	affinity chromatography technology	Ertych N (2016)	1
UBC	7	TNIP1	1	affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down	Wagner S (2008), Wagner S (2008), Fenner BJ (2009), Verhelst K (2012), Zhang X (2017), Kliza K (2017)	6
PRKN	1	RAD23B	1	affinity chromatography technology	Sarraf SA (2013)	1
KEAP1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang XJ (2008), Rachakonda G (2008), Rachakonda G (2008), Nioi P (2007), Chew EH (2007), Chew EH (2007), Zhang DD (2005), Furukawa M (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2004), Cullinan SB (2004), Kobayashi A (2004), Kobayashi A (2004), McMahon M (2006), Ichikawa T (2009), Lee DF (2009), Wong DP (2010), Wong DP (2010), Lau A (2010), Lau A (2010), Hur W (2010), Bennett EJ (2010), Yao JW (2012), Li Y (2012), Choo YY (2012), Kansanen E (2011), Kansanen E (2011), Niture SK (2013), Hast BE (2014), Cleasby A (2014), Kaspar JW (2012), Kaspar JW (2012), Su C (2015), Su C (2015), Huo L (2015), Dubiel D (2015), Lo SC (2006), Wu G (2017), Villeneuve NF (2013), Villeneuve NF (2013), Villeneuve NF (2013), Dong T (2016)	43
ARRB2	5	HNRNPM	1	affinity chromatography technology	Xiao K (2007)	1
RNF8	2	UBC	7	enzymatic study, enzymatic study, enzymatic study	Feng L (2012), Hodge CD (2015), Ho YK (2015)	3
DDX58	3	IKBKE	2	affinity chromatography technology	Oshiumi H (2013)	1
USP5	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
SPRTN	0	UBXN1	0	affinity chromatography technology	Ghosal G (2012)	1
TRIM28	1	UBE2D3	1	pull down	Doyle JM (2010)	1
UBL7	0	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2D3	1	DDX58	3	enzymatic study	Arimoto K (2008)	1
PSMD12	1	PSMC6	0	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Suo J (2010), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
USP28	3	STAM	3	enzymatic study	Loch CM (2012)	1
USP13	2	FAF2	4	affinity chromatography technology	Sowa ME (2009)	1
PSMD5	0	PSMC3	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
HUWE1	22	PSMD7	1	affinity chromatography technology	Thompson JW (2014)	1
FAF1	1	AMFR	2	affinity chromatography technology	Alexandru G (2008)	1
TSG101	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Li L (2001), Li L (2001)	2
SMURF1	4	RABEP1	4	enzymatic study	Andrews PS (2010)	1
DCUN1D1	0	HIF1A	1	affinity chromatography technology	Heir P (2013)	1
EGFR	5	HUWE1	22	affinity chromatography technology	Tong J (2014)	1
NCK2	2	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Buvall L (2013), Buvall L (2013), Huttlin EL (2015), Huttlin EL (2017)	4
USP28	3	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, pull down	Loch CM (2012), Zhen Y (2014), Wen Y (2015), Wen Y (2015), Wen Y (2015), Wrigley JD (2017), Kwasna D (2018)	7
ERCC6	6	UBC	7	pull down, pull down	Anindya R (2010), Anindya R (2010)	2
ARRB2	5	UBR5	13	affinity chromatography technology	Xiao K (2007)	1
SPRTN	0	PSMD4	1	affinity chromatography technology	Kim MS (2013)	1
USP21	2	USP7	14	enzymatic study	Loch CM (2012)	1
BIRC2	1	TSG101	1	two hybrid	Dynek JN (2010)	1
IKBKE	2	RNF11	0	affinity chromatography technology, affinity chromatography technology	Charoenthongtrakul S (2013), Charoenthongtrakul S (2013)	2
PSMD7	1	STAMBP	2	biochemical	Wan C (2015)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
UFD1	1	NPLOC4	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Botta A (2001), Lass A (2008), Vong QP (2005), Bruderer RM (2004), Havugimana PC (2012), Li JM (2013), Pye VE (2007), Wan C (2015), Raman M (2015), Raman M (2015)	10
UBC	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
UBQLN2	0	UBQLN1	1	two hybrid, affinity chromatography technology	Ford DL (2006), Ford DL (2006)	2
TP53	0	DDB1	6	affinity chromatography technology	Fogeron ML (2013)	1
POLI	5	UBC	7	two hybrid, two hybrid, far western blotting, x-ray crystallography, pull down, far western blotting	Plosky BS (2006), Plosky BS (2006), McIntyre J (2012), Bomar MG (2010), Plosky BS (2006), McIntyre J (2012)	6
USP16	0	HERC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Zhang Z (2014), Zhang Z (2014), Huttlin EL (2017)	4
IKBKE	2	CCT6A	1	affinity chromatography technology	So J (2015)	1
PRKN	1	UBE2R2	2	pull down	Kazlauskaite A (2014)	1
RNF11	0	PSMD1	2	affinity chromatography technology	Poulsen SL (2013)	1
PSMC4	6	PSMD11	0	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
CYLD	2	MYO6	3	affinity chromatography technology	Sowa ME (2009)	1
ARRB2	5	TRIM28	1	affinity chromatography technology	Xiao K (2007)	1
PRKN	1	TOM1	3	affinity chromatography technology	Sarraf SA (2013)	1
UBQLN1	1	ZFAND2B	1	two hybrid	Rolland T (2014)	1
PTEN	24	DDB1	6	pull down	Verrastro I (2015)	1
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
SPRTN	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Ghosal G (2012), Ghosal G (2012), Davis EJ (2012), Davis EJ (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012)	8
CUL3	17	PSMC5	4	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	HERC2	9	affinity chromatography technology	Yao Z (2017)	1
USP7	14	HUWE1	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Thompson JW (2014), Thompson JW (2014), Hein MY (2015)	4
PSMD4	1	NEDD8	0	pull down	Kamitani T (2001)	1
RAD23B	1	BRCA1	7	affinity chromatography technology	Chen L (2006)	1
MDM2	2	PSMD1	2	biochemical	Kulikov R (2010)	1
GGA3	6	TSG101	1	two hybrid	Puertollano R (2004)	1
CUL4A	2	PSMC6	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC20	1	UBC	7	enzymatic study, enzymatic study	Kelly A (2014), Craney A (2016)	2
ARRB2	5	STUB1	4	affinity chromatography technology	Zhang Z (2009)	1
UBAC2	1	UBC	7	pull down, pull down, pull down	Christianson JC (2012), Lloyd SJ (2013), Zhang X (2017)	3
EGFR	5	TRIM28	1	affinity chromatography technology	Liccardi G (2014)	1
PMS2	4	PSMC3	0	affinity chromatography technology	Cannavo E (2007)	1
CUL5	1	POLR2C	0	affinity chromatography technology	Bennett EJ (2010)	1
ERLIN2	2	TRIM28	1	affinity chromatography technology	Jo Y (2011)	1
BIRC2	1	USP7	14	affinity chromatography technology	Goncharov T (2013)	1
BTRC	1	KEAP1	0	affinity chromatography technology, bioid	Sowa ME (2009), Coyaud E (2015)	2
UBC	7	PSMD14	3	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
TRIM28	1	UBE2D2	0	pull down	Doyle JM (2010)	1
UBC	7	EXOSC8	2	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
KEAP1	0	BRCA1	7	affinity chromatography technology	Ma J (2012)	1
FAF2	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP4	3	PSMD11	0	two hybrid, affinity chromatography technology, pull down	Zhao B (2012), Zhao B (2012), Zhao B (2012)	3
MDM2	2	NEDD4	2	unspecified method, enzymatic study, affinity chromatography technology	Burch LR (2004), Xu C (2014), Xu C (2014)	3
BTRC	1	PSMD4	1	enzymatic study, enzymatic study	Uchiki T (2009), Kim HT (2012)	2
PSMD10	1	SQSTM1	0	biochemical	Kristensen AR (2012)	1
EGFR	5	PSMD4	1	protein complementation assay	Deribe YL (2009)	1
MDM2	2	NPM1	0	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kurki S (2004), Kurki S (2004), Nicholson J (2012), Nicholson J (2012)	4
CUL4B	8	USP4	3	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	PSMD10	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
HERC2	9	RNF115	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBL7	0	RAD23B	1	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology	Zhang H (2000), Zhang H (2000), Ertych N (2016)	3
ERCC6	6	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Anindya R (2010), Latini P (2011), Latini P (2011)	3
PSMD4	1	CUL1	7	pull down	Bloom J (2006)	1
EGFR	5	EEF1B2	1	affinity chromatography technology	Tong J (2014)	1
OTUB1	0	RNF126	2	two hybrid	Hayes SD (2012)	1
VPS36	3	TSG101	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, imaging technique	Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Kumar B (2016), Kumar B (2016)	5
UBL7	0	UBQLN1	1	biochemical	Havugimana PC (2012)	1
USP7	14	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Zhang J (2014), Zhang J (2014), Zhang J (2014)	4
CUL3	17	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
BRCA1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
ZFAND2B	1	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Glinka T (2014), Glinka T (2014)	2
PSMD7	1	PSMD11	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
PSMC4	6	RAD23B	1	biochemical	Wan C (2015)	1
TP53	0	CCT3	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBC	7	MYO6	3	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Bish RA (2007), He F (2016), He F (2016), Zhang X (2017)	5
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
UBC	7	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Jo Y (2011)	2
ANAPC11	0	UBE2D3	1	pull down	Choudhury R (2016)	1
MAP1LC3A	0	UBC	7	biochemical, imaging technique	Fujita N (2013), Govindaraju VK (2017)	2
OTUB1	0	UBE2N	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Nakada S (2010), Nakada S (2010), Sato Y (2012), Sato Y (2012), Sato Y (2012), Wiener R (2012), Herhaus L (2013), Herhaus L (2015), Scholz CC (2016), Boldt K (2016), Weber E (2017)	12
USP28	3	USP4	3	enzymatic study	Loch CM (2012)	1
ATXN3	2	SQSTM1	0	affinity chromatography technology, pull down	Zhou L (2014), Zhou L (2014)	2
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
BIRC2	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1
EGFR	5	ADRM1	4	protein complementation assay	Deribe YL (2009)	1
CDC20	1	CUL1	7	affinity chromatography technology	Wu F (2017)	1
WWP2	7	BABAM2	2	affinity chromatography technology	Chaudhary N (2014)	1
UFD1	1	TP53	0	two hybrid	Vinayagam A (2011)	1
ARIH1	3	CUL2	3	affinity chromatography technology	Kelsall IR (2013)	1
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
UCHL5	1	RAD23B	1	affinity chromatography technology	Sowa ME (2009)	1
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
UBA1	1	UBE2T	0	pull down, enzymatic study	Jin J (2007), Huguenin-Dezot N (2016)	2
USP2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
EGFR	5	HDAC6	0	affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gao YS (2010), Deribe YL (2009), Deribe YL (2009), Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	7
CUL5	1	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
UBQLN1	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim PJ (2009), Yu CC (2013), Lim PJ (2009), Lim PJ (2009)	4
AUP1	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2
UBC	7	PDE12	2	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Nathan JA (2013), Zhang X (2017)	3
USP1	4	TRAF6	0	two hybrid	Hayes SD (2012)	1
TRAF6	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Sun H (2013), Sun H (2013), Sun H (2013), Rezaeian AH (2017), Rezaeian AH (2017)	5
BAP1	4	PSMC4	6	affinity chromatography technology	Hauri S (2016)	1
TAB3	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology	Ishitani T (2003), Kanayama A (2004), Shinohara H (2016)	3
UBC	7	UBASH3B	4	pull down, pull down, affinity chromatography technology, pull down, pull down	Kowanetz K (2004), Ikeda F (2007), Brehme M (2009), Hoeller D (2006), Zhang X (2017)	5
TRAF2	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
TNF	0	OTULIN	0	affinity chromatography technology	Schaeffer V (2014)	1
VCPIP1	4	UBC	7	enzymatic study, enzymatic study, pull down	Totsukawa G (2013), Mevissen TE (2013), Kwasna D (2018)	3
RAD23A	1	RAD23B	1	biochemical, affinity chromatography technology	van der Spek PJ (1996), Hsieh HC (2005)	2
UBC	7	ABL1	9	affinity chromatography technology, two hybrid	Chen R (2013), Chen R (2013)	2
ASB2	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohroki J (2005), Nie L (2011), Nie L (2011), Bello NF (2009), Zakaria R (2013), Huttlin EL (2017)	6
UBQLN1	1	MAP1LC3A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rothenberg C (2010), Rothenberg C (2010), Lee DY (2013)	3
VCP	6	USP10	2	affinity chromatography technology	Yu CC (2013)	1
UBE2D3	1	ITCH	1	pull down, pull down	Maspero E (2013), Kristariyanto YA (2015)	2
CBL	7	PSMC5	4	affinity chromatography technology	Kulikov R (2010)	1
CUL3	17	N4BP1	3	affinity chromatography technology	Bennett EJ (2010)	1
UBE3A	4	ADRM1	4	enzymatic study	Jacobson AD (2014)	1
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
ZC3H12A	1	UBC	7	enzymatic study, pull down, affinity chromatography technology	Liang J (2010), Niu J (2013), Liang J (2010)	3
RAD23B	1	PSMC2	2	affinity chromatography technology, biochemical, biochemical, pull down	Chen L (2006), Havugimana PC (2012), Wan C (2015), Sun S (2017)	4
IKBKE	2	CCT3	1	affinity chromatography technology	So J (2015)	1
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
RNF31	3	UBE2D3	1	pull down, pull down, pull down	Inn KS (2011), Tokunaga F (2011), Kirisako T (2006)	3
UBC	7	ANAPC7	2	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
MDM2	2	PSMC5	4	affinity chromatography technology, pull down, biochemical, pull down	Kulikov R (2010), Kulikov R (2010), Kulikov R (2010), Kulikov R (2010)	4
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
UBC	7	RABEP2	0	pull down, pull down	Nathan JA (2013), Zhang X (2017)	2
CUL2	3	USP25	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Xu D (2017)	2
IKBKG	0	TAX1BP1	3	two hybrid	Wang J (2011)	1
BTRC	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, bioid	Schweitzer K (2007), Schweitzer K (2007), Coyaud E (2015)	3
CUL4B	8	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
WWP2	7	USP24	6	affinity chromatography technology	Chaudhary N (2014)	1
ABL1	9	EPS15	1	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
NEDD4L	3	UBE2K	0	pull down, pull down	Sullivan JA (2007), Sheng Y (2012)	2
CDC20	1	CUL3	17	affinity chromatography technology	Wu F (2017)	1
EEF1B2	1	UBQLN2	0	biochemical	Havugimana PC (2012)	1
PRKN	1	PSMD12	1	affinity chromatography technology	Sarraf SA (2013)	1
TP53	0	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Rolfo A (2012), Rolfo A (2012)	6
OTULIN	0	VCP	6	unspecified method, biochemical	Elliott PR (2014), Elliott PR (2014)	2
GGA1	0	GGA3	6	imaging technique, pull down, pull down	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003)	3
TNFAIP3	3	RNF114	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rodriguez MS (2014), Rodriguez MS (2014), Rodriguez MS (2014), Rodriguez MS (2014), Huttlin EL (2017)	5
FAF1	1	USP11	3	affinity chromatography technology	Raman M (2015)	1
UBC	7	PSMC6	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
SMURF1	4	ATXN3	2	enzymatic study	Andrews PS (2010)	1
TRAF6	0	CUL5	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhu Z (2016), Zhu Z (2016), Zhu Z (2017)	3
NEDD4	2	PTEN	24	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wang X (2008), Wang X (2008), Yim EK (2009), Chung S (2011), Wu Y (2013), Hong SW (2013), Hong SW (2013), Li N (2015), Li Z (2014), Chen Z (2016), Ahn Y (2008)	11
CUL4B	8	STUB1	4	biochemical	Kristensen AR (2012)	1
ERCC6	6	MDM2	2	affinity chromatography technology, affinity chromatography technology	Latini P (2011), Latini P (2011)	2
HDAC6	0	ATXN3	2	pull down	Bonanomi M (2014)	1
CUL3	17	AP2M1	5	affinity chromatography technology	Bennett EJ (2010)	1
SDCBP	0	KLHL12	4	two hybrid	Rolland T (2014)	1
FAF2	4	CUL3	17	affinity chromatography technology	Alexandru G (2008)	1
ITCH	1	CYLD	2	affinity chromatography technology, affinity chromatography technology, pull down	Ahmed N (2011), Ahmed N (2011), Ahmed N (2011)	3
USP11	3	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Ke JY (2014), Ke JY (2014)	3
HUWE1	22	UBE2D3	1	pull down, pull down	Yang Y (2010), Kristariyanto YA (2015)	2
TAB2	5	UBC	7	pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Kulathu Y (2009), Kulathu Y (2009), Sato Y (2009), van Wijk SJ (2012), Kanayama A (2004), Niu J (2011), van Wijk SJ (2013), Hooper C (2014), Komander D (2009), Emmerich CH (2013), Wauer T (2015), Kristariyanto YA (2015), Zhang X (2017)	13
UBC	7	ACLY	3	pull down, affinity chromatography technology	Nathan JA (2013), Bish RA (2007)	2
UBE3C	5	UBE2D2	0	pull down, pull down	Wu PY (2003), Kristariyanto YA (2015)	2
CUL5	1	UBQLN2	0	biochemical	Kristensen AR (2012)	1
IKBKE	2	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Saitoh T (2005)	2
CDC34	3	UBE2D3	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
HGS	5	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CUL2	3	PSMD4	1	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	RNF38	4	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Lunardi A (2010), Sheren JE (2013), Sheren JE (2013), Sheren JE (2013)	4
USP13	2	NPLOC4	4	affinity chromatography technology	Sowa ME (2009)	1
UBE2N	1	RIPK1	2	enzymatic study	Bohgaki M (2008)	1
AREL1	1	UBC	7	enzymatic study, enzymatic study, enzymatic study	Michel MA (2015), Kristariyanto YA (2015), Michel MA (2017)	3
HUWE1	22	NPM1	0	affinity chromatography technology	Thompson JW (2014)	1
POLH	1	RAD18	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yuasa MS (2006), Yuasa MS (2006), Day TA (2010), Watanabe K (2004), Watanabe K (2004), Watanabe K (2004), Lin JR (2011), Durando M (2013)	8
VCP	6	PSMC1	2	affinity chromatography technology	Dai RM (1998)	1
CUL2	3	HSPD1	0	affinity chromatography technology	Bennett EJ (2010)	1
UBE2D3	1	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
SQSTM1	0	CUL1	7	affinity chromatography technology	Tanji K (2012)	1
RNF11	0	SDCBP	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMC2	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
UBC	7	TRIM28	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Doyle JM (2010)	2
VCPIP1	4	NSFL1C	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Alexandru G (2008), Uchiyama K (2002), Raman M (2015)	4
UBE3A	4	UFD1	1	biochemical	Havugimana PC (2012)	1
CALCOCO2	0	IKBKG	0	two hybrid	Wang J (2011)	1
BCR	3	USP15	4	affinity chromatography technology	Boldt K (2016)	1
HIF1A	1	TRIM28	1	affinity chromatography technology	Cai Q (2013)	1
CAV1	0	VCP	6	affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Kirchner P (2013), Kirchner P (2013), Chen SF (2013), Chen SF (2013)	4
RNF11	0	PSMD12	1	affinity chromatography technology	Poulsen SL (2013)	1
PRKN	1	UBE2G2	0	pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Kazlauskaite A (2014)	5
UBE3A	4	USP14	1	biochemical	Havugimana PC (2012)	1
NEDD4	2	DCUN1D1	0	enzymatic study	Wu K (2011)	1
CDC20	1	CCT3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Kelly A (2014), Craney A (2016), Huttlin EL (2017)	4
PSMC2	2	PSMD5	0	two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Gorbea C (2000), Roelofs J (2009), Kaneko T (2009), Kaneko T (2009), Shim SM (2012), Shim SM (2012), Shim SM (2012), Havugimana PC (2012), Rolland T (2014), Wan C (2015), Yu H (2011), Huttlin EL (2017), Sun S (2017)	14
USP4	3	DDX58	3	affinity chromatography technology, affinity chromatography technology	Wang L (2013), Wang L (2013)	2
DNAJB2	0	RNF115	1	affinity chromatography technology	Huttlin EL (2015)	1
USP4	3	USP15	4	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang L (2012), Loch CM (2012), Das T (2017)	3
TP53	0	HNRNPM	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
RNF31	3	RIPK1	2	affinity chromatography technology	Draber P (2015)	1
USP7	14	RNF169	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Hein MY (2015), An L (2017), An L (2017), An L (2017), An L (2017), An L (2017)	6
ATXN3	2	ACLY	3	affinity chromatography technology	Kristensen LV (2018)	1
ERCC6	6	HIST2H2AC	1	affinity chromatography technology	Anindya R (2010)	1
RNF31	3	DDX58	3	affinity chromatography technology, affinity chromatography technology	Inn KS (2011), Inn KS (2011)	2
USP19	1	HIF1A	1	two hybrid, affinity chromatography technology	Altun M (2012), Altun M (2012)	2
ADRM1	4	PSMC5	4	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hamazaki J (2006), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
DDX58	3	UBC	7	pull down, pull down	Feng M (2012), Zeng W (2010)	2
ATXN3	2	STUB1	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Scaglione KM (2011), Scaglione KM (2011), Scaglione KM (2011), Todi SV (2010), Todi SV (2010), Gao XC (2011), Todi SV (2009), Kristensen LV (2018), Kristensen LV (2018)	9
TSG101	1	NEDD4	2	affinity chromatography technology	Medina G (2005)	1
UBE2S	2	UBE2D3	1	affinity chromatography technology	Kuang P (2016)	1
BRCA1	7	PMS2	4	affinity chromatography technology	Hill SJ (2014)	1
UBC	7	RABGEF1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down	Mattera R (2004), La Rosa P (2011), Kalesnikoff J (2007), Penengo L (2006), Sokratous K (2012), Rolland T (2014), Mattera R (2006), Zhang X (2017), Kristariyanto YA (2017)	9
UBC	7	ZFAND3	0	pull down, affinity chromatography technology	Fenner BJ (2009), Fenner BJ (2009)	2
TRIM28	1	CDC34	3	pull down	Doyle JM (2010)	1
USP32	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
PRKN	1	TBC1D15	1	affinity chromatography technology	Sarraf SA (2013)	1
WWP2	7	NPM1	0	affinity chromatography technology	Chaudhary N (2014)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
UBE2N	1	HERC2	9	affinity chromatography technology, pull down	Bekker-Jensen S (2010), Bai B (2016)	2
CDKN2A	1	ACLY	3	pull down	Souza-Rodrigues E (2007)	1
JOSD1	1	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down	Nicastro G (2009), Nicastro G (2009), Seki T (2013), Weeks SD (2011), Kwasna D (2018)	5
BRCA1	7	ADRM1	4	affinity chromatography technology	Ertych N (2016)	1
EGFR	5	UBASH3B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Raguz J (2007), Raguz J (2007), Tong J (2008), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	8
PSMD4	1	SQSTM1	0	affinity chromatography technology	Seibenhener ML (2004)	1
UBC	7	PSMD7	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
CYLD	2	PABPC4	2	affinity chromatography technology	Elliott PR (2016)	1
UBC	7	RNF126	2	affinity chromatography technology, enzymatic study, pull down	Matsumoto M (2005), Hou X (2012), Lee NS (2017)	3
MDM2	2	XIAP	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Gu L (2009), Huang X (2013), Huang X (2013), Huang X (2013), Liu T (2015)	5
TSG101	1	CD2AP	0	affinity chromatography technology	Morita E (2007)	1
TRAF2	1	ZFAND6	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Chang EJ (2011), Chang EJ (2011), Chang EJ (2011), Huttlin EL (2017)	5
UCHL5	1	PSMD7	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	5
SQSTM1	0	HIF1A	1	affinity chromatography technology	Liu XW (2013)	1
STAM	3	UBC	7	pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, unspecified method, pull down, pull down, x-ray crystallography, pull down	Kim MS (2006), Mizuno E (2006), Hong YH (2009), Nathan JA (2013), Nathan JA (2013), Stuible M (2010), Lim J (2011), Baiady N (2016), Kharitidi D (2015), Sundd M (2012), Zhang X (2017)	11
BTRC	1	ZC3H12A	1	two hybrid, two hybrid	Vinayagam A (2011), Wang J (2011)	2
KEAP1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, pull down	Gjyshi O (2015), Su C (2015), Zhang X (2017)	3
BIRC3	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down, pull down	Hu S (2003), Dynek JN (2010), Darding M (2011), Hu S (2003)	4
DAZAP2	1	SMURF2	3	affinity chromatography technology, two hybrid	Popova A (2012), Colland F (2004)	2
VPS28	2	UBAP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stefani F (2011), Agromayor M (2012), Wunderley L (2014), Huttlin EL (2015), Huttlin EL (2017)	5
PSMC2	2	PSMC5	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	7
RAD23A	1	USP14	1	affinity chromatography technology	Scanlon TC (2009)	1
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
UBR5	13	C1QBP	0	affinity chromatography technology	Scialpi F (2015)	1
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
CALCOCO2	0	TAB3	1	affinity chromatography technology	Thurston TL (2009)	1
RNF11	0	SMURF1	4	two hybrid	Colland F (2004)	1
PMS2	4	PSMD5	0	affinity chromatography technology	Cannavo E (2007)	1
PSMD10	1	PSMC3	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
HUWE1	22	PSMD14	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Jacobson AD (2014), Jacobson AD (2014)	3
USP7	14	TRAF2	1	pull down	Zapata JM (2001)	1
RNF169	1	C1QBP	0	affinity chromatography technology	An L (2017)	1
RAD23A	1	ADRM1	4	affinity chromatography technology	Scanlon TC (2009)	1
NUB1	2	UBE2K	0	two hybrid	Tanji K (2006)	1
RNF168	0	PABPC4	2	affinity chromatography technology	Guturi KK (2016)	1
NEDD4	2	CBLB	3	pull down, affinity chromatography technology, affinity chromatography technology	Magnifico A (2003), Magnifico A (2003), Magnifico A (2003)	3
RNF169	1	UBC	7	pull down, pull down	Panier S (2012), Chen J (2012)	2
UBXN1	0	TCAF1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL1	7	PCBP2	3	affinity chromatography technology	Bennett EJ (2010)	1
ARRB2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Han SO (2012)	2
CBLB	3	UBE2D2	0	x-ray crystallography	Kobashigawa Y (2011)	1
VCP	6	UBXN7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Raman M (2015), Li ZH (2017), Li ZH (2017)	9
TP53	0	EXOSC8	2	affinity chromatography technology	Fogeron ML (2013)	1
CUL4A	2	VCP	6	affinity chromatography technology	Besten Wd (2012)	1
PRKN	1	PSMC5	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tsai YC (2003), Tsai YC (2003), Um JW (2010), Sarraf SA (2013)	4
POLR2C	0	HIST2H2AC	1	affinity chromatography technology	Ayguen O (2008)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
UBE2N	1	STUB1	4	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Zhang M (2005), Graf C (2010), Soss SE (2011), Huen MS (2008), Lim GG (2013), Taipale M (2014), Taipale M (2014), Zhu X (2014), Zhang M (2005), Zhang M (2005), Kim HT (2007), Blessing NA (2017)	12
PTEN	24	BAP1	4	affinity chromatography technology	Crockett DK (2005)	1
UBE2N	1	UBA1	1	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Huen MS (2008), Wu PY (2003), Wauer T (2015), Boldt K (2016)	4
WWP2	7	CDC34	3	pull down	Sheng Y (2012)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
CUL1	7	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inuzuka H (2010), Inuzuka H (2010), He Y (2014)	3
HDAC6	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Choi SJ (2016), Choi SJ (2016)	2
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
FAF2	4	UBQLN2	0	affinity chromatography technology, affinity chromatography technology, pull down	Xia Y (2013), Xia Y (2013), Xia Y (2013)	3
SNCA	0	PSMC3	0	affinity chromatography technology, affinity chromatography technology	Snyder H (2003), Snyder H (2005)	2
RAD23A	1	PSMD1	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Scanlon TC (2009), Chen L (2006), Wan C (2015), Tan X (2015)	4
DDB1	6	ABL1	9	affinity chromatography technology	Cong F (2002)	1
NSFL1C	1	PSMC1	2	biochemical	Wan C (2015)	1
UCHL3	1	UBE2S	2	enzymatic study	Bremm A (2010)	1
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
PMS2	4	COPB1	0	affinity chromatography technology	Cannavo E (2007)	1
UBE3A	4	UCHL5	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Jacobson AD (2014), Huttlin EL (2015), Huttlin EL (2017)	3
RNF4	1	USP11	3	affinity chromatography technology	Hendriks IA (2015)	1
BRCA1	7	PSMC4	6	affinity chromatography technology	Ertych N (2016)	1
EGFR	5	STAM2	0	affinity chromatography technology, pull down	Kong C (2007), Morino C (2004)	2
SPRTN	0	TRIM28	1	affinity chromatography technology	Kim MS (2013)	1
WWP2	7	USP9X	15	affinity chromatography technology	Chaudhary N (2014)	1
TP53	0	ABRAXAS2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2014), Zhang J (2014), Zhang J (2014), Huttlin EL (2015), Huttlin EL (2017)	5
UBC	7	PARP10	4	pull down, pull down	Nicolae CM (2014), Verheugd P (2013)	2
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
ERCC6	6	CUL4B	8	affinity chromatography technology	Latini P (2011)	1
UBAC2	1	TBC1D15	1	affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Huttlin EL (2017)	2
MYO6	3	TAX1BP1	3	two hybrid, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down	Morriswood B (2007), Morriswood B (2007), Morriswood B (2007), Tumbarello DA (2015), Tumbarello DA (2015), Tumbarello DA (2015), He F (2016)	7
RNF11	0	POLI	5	two hybrid	Colland F (2004)	1
RNF11	0	ANKRD13A	1	two hybrid	Colland F (2004)	1
YOD1	0	NEDD4	2	enzymatic study	Mevissen TE (2013)	1
UBC	7	ANAPC11	0	x-ray crystallography, pull down	Brown NG (2014), Brown NG (2016)	2
USP15	4	UCHL3	1	enzymatic study	Loch CM (2012)	1
MDM2	2	RBBP8	1	affinity chromatography technology	Okoro DR (2013)	1
TP53	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Liu WT (2016), Liu WT (2016)	2
USP2	0	RAD18	3	enzymatic study	Zeman MK (2014)	1
UBE2B	3	UBXN7	3	biochemical	Havugimana PC (2012)	1
USP16	0	UBC	7	unspecified method, enzymatic study, pull down, unspecified method, pull down, pull down	Pai MT (2007), Faesen AC (2011), Kovacs JJ (2004), Ernst A (2013), Zhang X (2017), Kwasna D (2018)	6
TP53	0	USP10	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Yuan J (2010), Yuan J (2010), Yuan J (2010), Yuan J (2010), Oi N (2014), Oi N (2014), Oi N (2014)	7
TRAF2	1	USP2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Rolland T (2014), Mahul-Mellier AL (2012), Mahul-Mellier AL (2012)	7
RABGEF1	1	RABEP1	4	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kalesnikoff J (2007), Christoforidis S (2000), Lippe R (2001), Horiuchi H (1997), Zhang Z (2014), Zhang Z (2014), Kaelin S (2015), Kaelin S (2015), Huttlin EL (2017)	9
PSMD8	1	ADRM1	4	biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	3
PELI1	1	UBE2N	1	pull down	Smith H (2011)	1
RNF11	0	AUP1	0	two hybrid	Colland F (2004)	1
C1QBP	0	HSPD1	0	affinity chromatography technology	Yagi M (2012)	1
BABAM2	2	OPTN	1	biochemical	Kristensen AR (2012)	1
UBL7	0	UBC	7	x-ray crystallography, pull down, pull down	Chang YG (2006), Fenner BJ (2009), Zhang X (2017)	3
MDM2	2	JUN	0	pull down	Miyamoto-Sato E (2010)	1
UBXN1	0	AMFR	2	affinity chromatography technology	Alexandru G (2008)	1
HDAC6	0	HIF1A	1	affinity chromatography technology	Qian DZ (2006)	1
PTEN	24	PINK1	2	affinity chromatography technology	Crockett DK (2005)	1
SMURF1	4	TNIP2	1	enzymatic study	Andrews PS (2010)	1
PSMD12	1	PSMD4	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
ARIH1	3	UBC	7	pull down, x-ray crystallography	Dove KK (2017), Dove KK (2017)	2
UBASH3B	4	UBASH3A	3	affinity chromatography technology	Brehme M (2009)	1
FANCD2	3	RAD18	3	affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, biochemical	Williams SA (2011), Williams SA (2011), Park HK (2010), Chen X (2016), Chen X (2016)	5
BRCA1	7	CCT6A	1	affinity chromatography technology	Ertych N (2016)	1
CYLD	2	UBQLN1	1	affinity chromatography technology	Elliott PR (2016)	1
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
RAD23A	1	USP13	2	affinity chromatography technology	Scanlon TC (2009)	1
PSMD14	3	UBE3C	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang X (2007), Jacobson AD (2014), Jacobson AD (2014)	3
CUL3	17	PSMD1	2	affinity chromatography technology	Bennett EJ (2010)	1
UBA1	1	UBE2D2	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Choi JS (2014), Huang DT (2009), Kang D (2002), Kumar B (2010), Liu X (2017), Huguenin-Dezot N (2016)	8
UBE2N	1	XIAP	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
PSMC5	4	VCP	6	affinity chromatography technology	Braunstein I (2015)	1
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
POLH	1	MDM2	2	affinity chromatography technology	Jung YS (2012)	1
EP300	36	BTRC	1	affinity chromatography technology, affinity chromatography technology	Kimbrel EA (2009), Kimbrel EA (2009)	2
OPTN	1	CYLD	2	two hybrid, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Nagabhushana A (2011), Nagabhushana A (2011), Nagabhushana A (2011), Genin P (2015), Genin P (2015)	5
MAP1LC3A	0	OPTN	1	two hybrid, affinity chromatography technology, pull down, pull down	Wild P (2011), Wild P (2011), Liu Z (2014), Wild P (2011)	4
EGFR	5	CISH	1	unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
PSMD12	1	PSMD1	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
NEDD4	2	RBCK1	0	pull down	Persaud A (2009)	1
PSMD14	3	UBE3A	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang X (2007), Jacobson AD (2014), Jacobson AD (2014), Hein MY (2015)	4
UBQLN1	1	USP9X	15	biochemical	Havugimana PC (2012)	1
BRCA1	7	CUL2	3	affinity chromatography technology	Ertych N (2016)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
UBE2R2	2	RAD23A	1	biochemical	Kristensen AR (2012)	1
CUL3	17	AGO2	10	affinity chromatography technology	Bennett EJ (2010)	1
RNF11	0	NEDD4L	3	two hybrid	Colland F (2004)	1
RNF11	0	SMURF2	3	pull down, affinity chromatography technology, two hybrid, two hybrid	Subramaniam V (2003), Santonico E (2010), Colland F (2004), Colland F (2004)	4
PSMD5	0	PSMD11	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ITCH	1	N4BP1	3	affinity chromatography technology, pull down	Oberst A (2007), Oberst A (2007)	2
PRKN	1	HSPD1	0	affinity chromatography technology	Zanon A (2013)	1
NSFL1C	1	CUL1	7	affinity chromatography technology	Alexandru G (2008)	1
PSMD1	2	ADRM1	4	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, x-ray crystallography, unspecified method	Hamazaki J (2006), Hendil KB (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Lu X (2015), Lu X (2015), Huttlin EL (2017), Lu X (2017), Lu X (2017), Lu X (2017), VanderLinden RT (2017)	12
USP21	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
UBQLN2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
CUL3	17	UBA1	1	affinity chromatography technology	Bennett EJ (2010)	1
TAX1BP1	3	DAZAP2	1	two hybrid	Rolland T (2014)	1
UBE2G2	0	RNF168	0	two hybrid	van Wijk SJ (2009)	1
WRNIP1	3	TRIM28	1	biochemical	Kristensen AR (2012)	1
USP21	2	JOSD1	1	enzymatic study	Loch CM (2012)	1
BAP1	4	PSMD8	1	affinity chromatography technology	Hauri S (2016)	1
EGFR	5	UCHL1	1	protein complementation assay	Deribe YL (2009)	1
RAD23B	1	PSMD4	1	two hybrid, pull down, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, biochemical	Hiyama H (1999), Hiyama H (1999), Ryu KS (2003), Fatimababy AS (2010), Fatimababy AS (2010), Fujiwara K (2004), Wan C (2015)	7
USP8	7	HIST2H2AC	1	enzymatic study	Yu M (2016)	1
TNF	0	OPTN	1	affinity chromatography technology	Klingseisen L (2012)	1
USP4	3	HUWE1	22	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang X (2011), Zhang X (2011), Zhang X (2011)	3
PRKN	1	RBCK1	0	two hybrid	Corominas R (2014)	1
ARRB2	5	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, two hybrid, affinity chromatography technology	Wang P (2003), Wang P (2003), Wang P (2003), Shenoy SK (2008), Shenoy SK (2001), Ahmed MR (2011), Yin C (2011), Yin C (2011), Yin C (2011), Girnita L (2005), Girnita L (2005), Nogues L (2011), Boularan C (2007), Boularan C (2007), Wang J (2011), Shenoy SK (2001), Zheng M (2015)	17
ITCH	1	UBE2D2	0	pull down, pull down, pull down, pull down	Sheng Y (2012), Fang S (2001), Kristariyanto YA (2015), Riling C (2015)	4
BRCA1	7	UBE2N	1	two hybrid, x-ray crystallography, pull down, two hybrid, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011)	5
ABL1	9	EGFR	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
RAD18	3	USP5	2	affinity chromatography technology, affinity chromatography technology	Nakajima S (2014), Nakajima S (2014)	2
UBE2T	0	BRCA1	7	pull down	Ueki T (2009)	1
PRKN	1	HNRNPM	1	affinity chromatography technology	Zanon A (2013)	1
UBC	7	USP24	6	pull down, pull down	Zhang X (2017), Kwasna D (2018)	2
CALCOCO2	0	UBAC2	1	two hybrid	Rolland T (2014)	1
TP53	0	SKP1	0	affinity chromatography technology	Fogeron ML (2013)	1
UCHL5	1	PSMD1	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
BCR	3	TP53	0	two hybrid, imaging technique	Stelzl U (2005), Chen TC (2014)	2
USP4	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fan YH (2011), Hou X (2013), Hou X (2013)	3
UBQLN1	1	ADRM1	4	affinity chromatography technology, pull down, two hybrid	Fatimababy AS (2010), Fatimababy AS (2010), Lim J (2006)	3
PRKN	1	PSMC2	2	affinity chromatography technology, pull down	Sarraf SA (2013), Aguileta MA (2015)	2
PSMD14	3	ADRM1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wang X (2007), Jacobson AD (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
RAD23A	1	UBE2N	1	affinity chromatography technology	Scanlon TC (2009)	1
TAB3	1	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011)	4
USP2	0	HIST2H2AC	1	enzymatic study	Yu M (2016)	1
UBC	7	PSMD11	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
ZFAND2B	1	FAF2	4	affinity chromatography technology, affinity chromatography technology, biochemical	Glinka T (2014), Glinka T (2014), Glinka T (2014)	3
BRCA1	7	JUN	0	affinity chromatography technology, pull down	Hu YF (2002), Hu YF (2002)	2
UBE2B	3	UBQLN1	1	biochemical	Havugimana PC (2012)	1
RNF115	1	EGFR	5	affinity chromatography technology, enzymatic study	Smith CJ (2013), Smith CJ (2013)	2
CBL	7	CBLB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Rorsman C (2016)	2
SQSTM1	0	SNCA	0	imaging technique	Schwarz L (2012)	1
EGFR	5	UBE2S	2	affinity chromatography technology	Tong J (2014)	1
EP300	36	DDB1	6	affinity chromatography technology, affinity chromatography technology	Datta A (2001), Rapic-Otrin V (2002)	2
MDM2	2	RNF8	2	two hybrid	Woodsmith J (2012)	1
KLHL7	5	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kigoshi Y (2011), Bennett EJ (2010), Huttlin EL (2017)	3
RAD23A	1	PRKN	1	enzymatic study, affinity chromatography technology	Scanlon TC (2009), Sarraf SA (2013)	2
CUL5	1	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
STAM	3	STAM2	0	imaging technique	Kanazawa C (2003)	1
UBXN1	0	SQSTM1	0	affinity chromatography technology	Raman M (2015)	1
CUL4B	8	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016)	8
RNF4	1	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay	Bruderer R (2011), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014)	5
USP28	3	USP14	1	enzymatic study	Loch CM (2012)	1
USP21	2	USP33	1	enzymatic study	Loch CM (2012)	1
PRKN	1	CDC34	3	pull down	Kazlauskaite A (2014)	1
UBXN1	0	UBE3A	4	affinity chromatography technology	Alexandru G (2008)	1
UBE2D3	1	OTUB1	0	two hybrid, enzymatic study, pull down, affinity chromatography technology	Rolland T (2014), Li Y (2014), Li Y (2014), Scholz CC (2016)	4
RNF11	0	NEDD4	2	affinity chromatography technology, enzymatic study, two hybrid	Santonico E (2010), Persaud A (2009), Colland F (2004)	3
TRIM32	2	UBE2D3	1	affinity chromatography technology, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Mokhonova EI (2015)	4
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
ANAPC11	0	CUL5	1	two hybrid	Ohta T (1999)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
USP21	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Xu G (2010), Xu G (2010)	2
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
USP15	4	PSMD7	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015)	2
UBTD2	2	UBC	7	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Song AX (2010), Song AX (2010), Song AX (2014), Song AX (2014)	4
PSMC2	2	PSMC6	0	biochemical, biochemical, biochemical, biochemical	Tipler CP (1997), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
HIST2H2AC	1	USP15	4	affinity chromatography technology	Long L (2014)	1
USP21	2	USP15	4	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
TNF	0	BTRC	1	affinity chromatography technology	Kuai J (2004)	1
VCP	6	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bennett EJ (2010), Besten Wd (2012)	3
SH3KBP1	1	NPLOC4	4	biochemical	Wan C (2015)	1
CUL1	7	ARIH1	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Kelsall IR (2013), Kelsall IR (2013), Huttlin EL (2017)	4
RNF168	0	UBR5	13	affinity chromatography technology	Gudjonsson T (2012)	1
TNF	0	CAV1	0	affinity chromatography technology	Legler DF (2003)	1
PSMD7	1	PSMD1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
RNF31	3	UBE2D2	0	pull down, x-ray crystallography, pull down	Kirisako T (2006), Lechtenberg BC (2016), Lechtenberg BC (2016)	3
BRCA1	7	SFPQ	2	affinity chromatography technology	Ertych N (2016)	1
NPM1	0	TRIM28	1	affinity chromatography technology, enzymatic study	Chen R (2013), Neo SH (2015)	2
RIPK1	2	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2008)	2
UBE3A	4	HERC2	9	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Martinez-Noel G (2012), Martinez-Noel G (2012), Kuehnle S (2011), Kuehnle S (2011), Galligan JT (2015)	5
UBE3A	4	UBC	7	enzymatic study, enzymatic study, pull down	Schwarz SE (1998), Ronchi VP (2013), Zhang X (2017)	3
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
CYLD	2	PSMC3	0	affinity chromatography technology	Elliott PR (2016)	1
CDC34	3	SDCBP	0	two hybrid	Rolland T (2014)	1
CUL1	7	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	C1QBP	0	affinity chromatography technology	Bennett EJ (2010)	1
HUWE1	22	PSMC3	0	affinity chromatography technology	Thompson JW (2014)	1
UBC	7	TNRC6A	6	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
STUB1	4	JOSD2	0	enzymatic study	Seki T (2013)	1
TP53	0	UBQLN2	0	genetic interference	Xie L (2013)	1
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
PRKN	1	ADRM1	4	affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, pull down	Sarraf SA (2013), Sarraf SA (2013), Aguileta MA (2015), Aguileta MA (2015), Aguileta MA (2015)	5
ANKS1B	2	UBC	7	two hybrid, pull down	Kim J (2010), Kim J (2010)	2
UBE2D2	0	AMFR	2	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Fang S (2001)	3
WWP2	7	UBE2D2	0	pull down, pull down, pull down	Sheng Y (2012), Kristariyanto YA (2015), Chaudhary N (2014)	3
PSMD5	0	PSMC6	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
BTRC	1	CCT3	1	bioid	Coyaud E (2015)	1
UBC	7	FANCD2	3	pull down, affinity chromatography technology	Rego MA (2012), Yamamoto KN (2011)	2
UBXN7	3	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015)	3
TRAF6	0	PSMD7	1	affinity chromatography technology	Bouwmeester T (2004)	1
STUB1	4	UBE2V2	0	biochemical	Havugimana PC (2012)	1
CYLD	2	OTUD4	2	affinity chromatography technology	Elliott PR (2016)	1
PSMD4	1	ANKRD13B	1	biochemical	Wan C (2015)	1
RNF11	0	RNF168	0	two hybrid	Colland F (2004)	1
UBC	7	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
SMURF1	4	HSPD1	0	affinity chromatography technology	Xie Y (2013)	1
BAP1	4	PSMD7	1	affinity chromatography technology	Hauri S (2016)	1
MYO6	3	TOM1	3	affinity chromatography technology, two hybrid	Tumbarello DA (2012), Tumbarello DA (2012)	2
NPM1	0	PSMC5	4	affinity chromatography technology	Chen R (2013)	1
ZRANB1	3	HERC2	9	affinity chromatography technology	Sowa ME (2009)	1
YOD1	0	BIRC3	1	two hybrid	Schimmack G (2017)	1
RNF31	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	8
OTUD1	3	RAD23A	1	affinity chromatography technology	Sowa ME (2009)	1
UBE2N	1	RNF11	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Scheper J (2009), Colland F (2004), Poulsen SL (2013)	5
PSMD10	1	NCK2	2	pull down	Nanaware PP (2014)	1
BRCA1	7	UCHL5	1	affinity chromatography technology	Ertych N (2016)	1
UBA6	4	UBE2G2	0	pull down	Jin J (2007)	1
PTEN	24	OTUD3	2	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Yuan L (2015), Yuan L (2015), Yuan L (2015), Yuan L (2015)	4
UBE2D2	0	BTRC	1	enzymatic study	Cenciarelli C (1999)	1
PSMD14	3	PSMC1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Hein MY (2015)	7
UBXN1	0	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
UBQLN2	0	EPN1	4	affinity chromatography technology	NDiaye EN (2008)	1
HUWE1	22	UCHL5	1	affinity chromatography technology	Thompson JW (2014)	1
ZFAND2B	1	PSMC3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
PSMD7	1	PSMD8	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
KEAP1	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Huo L (2015), Huo L (2015), Huo L (2015)	3
DAZAP2	1	OPTN	1	two hybrid	Rolland T (2014)	1
ATXN3	2	CUL1	7	affinity chromatography technology	Tu Y (2017)	1
UBE2K	0	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay	Bae Y (2013), Bae Y (2013), Bae Y (2013)	3
GGA1	0	TSG101	1	two hybrid	Mattera R (2004)	1
PSMC3	0	PSMD14	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Jacobson AD (2014), Wan C (2015), Hein MY (2015)	6
USP32	0	UBXN1	0	affinity chromatography technology	Sowa ME (2009)	1
FAF2	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
AUP1	0	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UIMC1	4	MDM2	2	affinity chromatography technology	Yan J (2009)	1
UCHL5	1	PSMC1	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
ZUFSP	0	UBC	7	enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, enzymatic study	Hermanns T (2018), Hermanns T (2018), Hermanns T (2018), Kwasna D (2018), Kwasna D (2018), Kwasna D (2018), Haahr P (2018), Haahr P (2018), Haahr P (2018)	9
UBXN1	0	DDB1	6	affinity chromatography technology	Alexandru G (2008)	1
USP9X	15	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
CBL	7	TRAF2	1	affinity chromatography technology	Xu L (2017)	1
ZFAND6	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	CCT3	1	affinity chromatography technology	Yu CC (2013)	1
PTEN	24	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wu Y (2013), Zhang J (2013), Zhang J (2013), Yuan L (2015)	4
RNF31	3	OTULIN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, unspecified method, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Rivkin E (2013), Rivkin E (2013), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Schimmack G (2017)	20
UCHL5	1	PSMD11	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	5
USP21	2	CBL	7	two hybrid	Hayes SD (2012)	1
TOLLIP	3	NEDD4L	3	affinity chromatography technology	Li S (2011)	1
UBE2D2	0	CBL	7	pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Joazeiro CA (1999), Dou H (2012), Dou H (2012), Sehat B (2008), Kassenbrock CK (2004), Roxburgh P (2012), Tsukahara F (2010), Bulut GB (2013), Buetow L (2016), Conte A (2017)	10
CYLD	2	TAB2	5	affinity chromatography technology	Elliott PR (2016)	1
TNIP1	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Gao L (2011), Gao L (2011), Rolland T (2014)	3
EGFR	5	CUL4B	8	affinity chromatography technology	Tong J (2014)	1
MID1	1	PSMD7	1	affinity chromatography technology	Gholkar AA (2016)	1
UBE2D2	0	NEDD4L	3	x-ray crystallography, pull down, pull down, pull down, pull down, pull down, enzymatic study	Kamadurai HB (2009), Isasa M (2010), Sheng Y (2012), Persaud A (2009), Nazio F (2016), Todaro DR (2017), Todaro DR (2017)	7
UBE2G2	0	AUP1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Spandl J (2011), Klemm EJ (2011), Klemm EJ (2011), Jo Y (2013), Christianson JC (2012), Christianson JC (2012)	7
PSMC5	4	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Zhu Q (2007), Zhu Q (2007), Kulikov R (2010), Kulikov R (2010)	4
USP14	1	PSMD4	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Andersen KM (2009)	2
FAF2	4	DDB1	6	affinity chromatography technology	Alexandru G (2008)	1
CALCOCO2	0	TRAF6	0	two hybrid	Wang J (2011)	1
BIRC3	1	USP15	4	affinity chromatography technology	Goncharov T (2013)	1
SMURF1	4	TP53	0	affinity chromatography technology	Nie J (2010)	1
DDX58	3	RBCK1	0	affinity chromatography technology	Inn KS (2011)	1
NEDD8	0	HSPD1	0	affinity chromatography technology	Bennett EJ (2010)	1
AGO2	10	BTRC	1	unspecified method	Elcheva I (2009)	1
UBC	7	UCHL5	1	affinity chromatography technology, enzymatic study, pull down, enzymatic study, pull down, pull down, enzymatic study, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Boudreaux D (2012), Sahtoe DD (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	10
USP5	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
CUL3	17	PDE12	2	affinity chromatography technology	Bennett EJ (2010)	1
USP14	1	PSMD1	2	affinity chromatography technology, biochemical	Sowa ME (2009), Wan C (2015)	2
BRCA1	7	GTF2IRD1	6	affinity chromatography technology	Hill SJ (2014)	1
UBQLN1	1	STAM2	0	affinity chromatography technology	Regan-Klapisz E (2005)	1
TSG101	1	VPS28	2	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Stuchell MD (2004), Bishop N (2001), von Schwedler UK (2003), Martin-Serrano J (2003), Stefani F (2011), Venkatesan K (2009), Wunderley L (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
BRCA1	7	ACLY	3	affinity chromatography technology	Ertych N (2016)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
IKBKG	0	PARP10	4	affinity chromatography technology, enzymatic study	Verheugd P (2013), Verheugd P (2013)	2
UBC	7	PSMD12	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
USP11	3	UBA1	1	affinity chromatography technology	Hein MY (2015)	1
CBL	7	PTEN	24	affinity chromatography technology, affinity chromatography technology	Rodriguez S (2013), Rodriguez S (2013)	2
CUL5	1	PTPN5	0	two hybrid	Wang J (2011)	1
TP53	0	UBE2N	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009)	5
UBE3C	5	UBE2D3	1	pull down, pull down	Kristariyanto YA (2015), Okada M (2015)	2
USP15	4	STAM	3	enzymatic study	Loch CM (2012)	1
OTUB1	0	UBE2D2	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Nakada S (2010), Juang YC (2012), Ernst A (2013), Juang YC (2012), Huttlin EL (2015), Scholz CC (2016), Huttlin EL (2017)	8
NEDD4L	3	HGS	5	enzymatic study, affinity chromatography technology	Persaud A (2009), Zhou R (2010)	2
ARRB2	5	NAP1L1	2	affinity chromatography technology	Xiao K (2007)	1
TSG101	1	HGS	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, unspecified method, unspecified method, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Rual JF (2005), Lu Q (2003), Lu Q (2003), Lu Q (2003), Kim BY (2007), Im YJ (2010), Schlundt A (2009), Schlundt A (2009), Pornillos O (2003), Pornillos O (2003), Bache KG (2003), Bache KG (2003), Bouamr F (2007), Kim HJ (2007), Kumar B (2016), Kumar B (2016)	16
ANKRD13B	1	UBC	7	pull down, pull down	Tanno H (2012), Zhang X (2017)	2
PMS2	4	PSMC6	0	affinity chromatography technology	Cannavo E (2007)	1
FAF1	1	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
VCP	6	ANAPC7	2	affinity chromatography technology	Yu CC (2013)	1
CUL1	7	C1QBP	0	affinity chromatography technology	Bennett EJ (2010)	1
PSMC5	4	PSMD12	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
USP28	3	USP15	4	enzymatic study	Loch CM (2012)	1
ITCH	1	CBL	7	affinity chromatography technology	Azakir BA (2009)	1
NPLOC4	4	UBAC2	1	affinity chromatography technology	Raman M (2015)	1
UBQLN2	0	PSMC1	2	pull down	Aguileta MA (2015)	1
HUWE1	22	PSMD1	2	affinity chromatography technology	Thompson JW (2014)	1
PSMD1	2	PSMD5	0	biochemical, biochemical, affinity chromatography technology	Thompson D (2009), Havugimana PC (2012), Huttlin EL (2017)	3
UBE2T	0	AMFR	2	two hybrid	van Wijk SJ (2009)	1
USP5	2	DAZAP2	1	two hybrid	Rolland T (2014)	1
ATXN3	2	CUL4A	2	affinity chromatography technology, affinity chromatography technology	Tu Y (2017), Tu Y (2017)	2
RNF4	1	IKBKG	0	two hybrid	Ravasi T (2010)	1
IKBKE	2	CALCOCO2	0	affinity chromatography technology	Thurston TL (2009)	1
BIRC3	1	UBR4	15	affinity chromatography technology	Goncharov T (2013)	1
SPRTN	0	POLH	1	affinity chromatography technology, affinity chromatography technology	Ghosal G (2012), Ghosal G (2012)	2
IKBKG	0	CUL1	7	affinity chromatography technology	Orel L (2010)	1
PMS2	4	PSMC2	2	affinity chromatography technology	Cannavo E (2007)	1
RAD23B	1	UBE2V2	0	biochemical	Havugimana PC (2012)	1
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
PTPN5	0	FAF2	4	affinity chromatography technology	Li X (2016)	1
PSMC4	6	PSMD7	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
USP25	0	USP28	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
EGFR	5	TRAFD1	2	affinity chromatography technology	Yao Z (2017)	1
HDAC6	0	NPM1	0	affinity chromatography technology	Watson GW (2016)	1
SMURF1	4	TRIM28	1	affinity chromatography technology	Xie Y (2013)	1
OPTN	1	TBC1D15	1	two hybrid	Rolland T (2014)	1
BAP1	4	HIST2H2AC	1	enzymatic study, affinity chromatography technology, enzymatic study	Scheuermann JC (2010), Lee HS (2014), Sahtoe DD (2016)	3
UBXN7	3	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
SMURF1	4	RBCK1	0	enzymatic study	Andrews PS (2010)	1
EP300	36	ZC3H12A	1	two hybrid	Wang J (2011)	1
PSMC5	4	PSMC6	0	pull down, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Hartmann-Petersen R (2001), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	6
MAP1LC3A	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, affinity chromatography technology	Shvets E (2008), Shvets E (2008), Behrends C (2010), Gao Z (2010), Pan JA (2011), Pankiv S (2007), Pankiv S (2007), Shvets E (2011), Tung YT (2010), Bjorkoy G (2005), Kirkin V (2009), Lim J (2011), Lim J (2011), Pan JA (2012), Lee DY (2013), Wang BS (2013), Wang BS (2013), Sansanwal P (2012), Shi J (2013), Fujita N (2013), Chen X (2014), Liu XD (2014), Noda NN (2008), Noda NN (2008), Matsuzawa Y (2015), Matsuzawa Y (2015), Rui YN (2015), Rui YN (2015), Ciuffa R (2015), Wang N (2013), Hua F (2015), Rui YN (2015), Cha-Molstad H (2015), Paul S (2012), Puvirajesinghe TM (2016), Wang L (2017), Cha-Molstad H (2017), Peng H (2017), Lee Y (2017)	39
BRCA1	7	TRIM28	1	affinity chromatography technology	Ertych N (2016)	1
KEAP1	0	SQSTM1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Jain A (2010), Jain A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Inami Y (2011), Fan W (2010), Copple IM (2010), Copple IM (2010), Wright T (2013), Tanji K (2013), Ichimura Y (2013), Ichimura Y (2013), Ichimura Y (2013), Hast BE (2014), Hast BE (2014), Lerner C (2013), Rolland T (2014), Gjyshi O (2015), Bakkar N (2015), Milan E (2015), Park S (2016), Ge W (2017), Mildenberger J (2017), Lu K (2017), Lee Y (2017)	30
CUL4B	8	PABPC4	2	affinity chromatography technology	Bennett EJ (2010)	1
HGS	5	SH3KBP1	1	affinity chromatography technology	Ronning SB (2011)	1
SMURF1	4	VCP	6	affinity chromatography technology	Xie Y (2013)	1
MAP1LC3A	0	KEAP1	0	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Fan W (2010)	2
CBLB	3	TRAF2	1	affinity chromatography technology	Xu L (2017)	1
CUL5	1	UBC	7	affinity chromatography technology, pull down	Bennett EJ (2010), Zhang X (2017)	2
SMURF1	4	EEF1B2	1	affinity chromatography technology	Xie Y (2013)	1
EXOSC8	2	OTUD4	2	two hybrid	Rolland T (2014)	1
USP13	2	ITCH	1	affinity chromatography technology	Sowa ME (2009)	1
ATXN3	2	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doss-Pepe EW (2003), Wang Q (2008), Matsumoto M (2004), Matsumoto M (2004), Reina CP (2010), Zhong X (2006), Morreale G (2009), Fernandez-Saiz V (2010), Laco MN (2012), Laco MN (2012), Yu CC (2013), Liu S (2013), Yang H (2014), Yang H (2014), Yang H (2014), Liu H (2016), Pfeiffer A (2017), Tu Y (2017)	18
RAD23A	1	PSMC3	0	affinity chromatography technology	Scanlon TC (2009)	1
HUWE1	22	UFD1	1	affinity chromatography technology	Thompson JW (2014)	1
PMS2	4	FAN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Smogorzewska A (2010), Smogorzewska A (2010), Smogorzewska A (2010), MacKay C (2010), Hein MY (2015), Hein MY (2015), St-Denis N (2016)	8
NBR1	0	UBE2D2	0	pull down	Peng H (2017)	1
UBXN7	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
HDAC6	0	CCT3	1	affinity chromatography technology	New M (2013)	1
RAD23B	1	ADRM1	4	affinity chromatography technology, pull down	Fatimababy AS (2010), Fatimababy AS (2010)	2
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
CUL3	17	PCBP2	3	affinity chromatography technology	Bennett EJ (2010)	1
OTUD3	2	UBC	7	enzymatic study, enzymatic study, pull down	Mevissen TE (2013), Flierman D (2016), Kwasna D (2018)	3
PLAA	1	UBXN1	0	biochemical, two hybrid	Kristensen AR (2012), Rolland T (2014)	2
UBC	7	GTF2IRD1	6	pull down, pull down	Nathan JA (2013), Zhang X (2017)	2
SFPQ	2	UBC	7	two hybrid, two hybrid, affinity chromatography technology, pull down	Stelzl U (2005), Stelzl U (2005), Matsumoto M (2005), Nathan JA (2013)	4
VCP	6	WRNIP1	3	affinity chromatography technology	Yu CC (2013)	1
CUL3	17	UBR5	13	affinity chromatography technology	Bennett EJ (2010)	1
ITCH	1	PCBP2	3	affinity chromatography technology, affinity chromatography technology	You F (2009), You F (2009)	2
SQSTM1	0	CAV1	0	affinity chromatography technology, affinity chromatography technology	Liang X (2013), Luo X (2017)	2
PSMD7	1	PSMC3	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
HGS	5	ACLY	3	pull down	Pridgeon JW (2009)	1
SPRTN	0	ATXN3	2	affinity chromatography technology	Mosbech A (2012)	1
CUL1	7	PSMD12	1	biochemical	Wan C (2015)	1
ZFAND2B	1	UBC	7	affinity chromatography technology, pull down	Braunstein I (2015), Zhang X (2017)	2
USP14	1	PSMD7	1	affinity chromatography technology, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Wan C (2015)	3
PRKN	1	PSMD5	0	affinity chromatography technology	Sarraf SA (2013)	1
SPRTN	0	UFD1	1	affinity chromatography technology, affinity chromatography technology	Davis EJ (2012), Davis EJ (2012)	2
UBE2K	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
RAD23A	1	PSMD7	1	affinity chromatography technology	Scanlon TC (2009)	1
PSMC1	2	PSMD5	0	pull down, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Gorbea C (2000), Kaneko T (2009), Havugimana PC (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
USP7	14	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, biochemical, x-ray crystallography, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu X (2007), Becker K (2007), Pereg Y (2006), Hu M (2006), Hu M (2006), Hu M (2006), Hu M (2006), Sarkari F (2010), Sarkari F (2010), Tang J (2006), Tang J (2006), Ma J (2010), Song MS (2008), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Ye M (2015), Lim KH (2015), Reddy BA (2014), Rouge L (2016), Nihira NT (2017), Nihira NT (2017), Mungamuri SK (2016), Mungamuri SK (2016), Sun Y (2017)	25
PRKN	1	UBASH3B	4	pull down	Ikeda F (2007)	1
NEDD4	2	EPS15	1	enzymatic study	Woelk T (2006)	1
USP28	3	OTUB1	0	enzymatic study	Loch CM (2012)	1
TNFAIP3	3	ANKRD13D	4	affinity chromatography technology	Huttlin EL (2017)	1
HUWE1	22	NAP1L1	2	affinity chromatography technology	Thompson JW (2014)	1
AMFR	2	UBAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Zhang T (2015), Zhang T (2015)	5
UBR4	15	ACLY	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin R (2013), Lin R (2013), Zhang C (2016)	3
SMURF2	3	ABRAXAS2	1	two hybrid	Colland F (2004)	1
PSMD7	1	PSMD12	1	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
STAMBP	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Bremm A (2010), Komander D (2009), McCullough J (2006), Nakasone MA (2013), Davies CW (2013), Trang VH (2014), Wauer T (2015), Michel MA (2015), Bueno AN (2015), Baiady N (2016), Baiady N (2016), Castaneda CA (2016), Kliza K (2017)	13
FAF1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Zhang L (2012), Zhang L (2012)	3
PSMC3	0	TP53	0	affinity chromatography technology	Kulikov R (2010)	1
RNF114	0	RNF38	4	two hybrid	Woodsmith J (2012)	1
DNAJB2	0	ATXN3	2	affinity chromatography technology	Gao XC (2011)	1
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
UBC	7	TAX1BP1	3	pull down, x-ray crystallography, pull down, pull down	Fenner BJ (2009), Tumbarello DA (2015), Tumbarello DA (2015), Zhang X (2017)	4
RIOK3	2	PSMC4	6	affinity chromatography technology	Ewing RM (2007)	1
BRCA1	7	UIMC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Kim H (2007), Kim H (2007), Sobhian B (2007), Sobhian B (2007), Sowa ME (2009), Strauss C (2011), Strauss C (2011), Feng L (2009), Feng L (2009), Yan J (2007), Wang B (2007), Wang B (2007), Wang B (2007), Nikkilae J (2009), Nikkilae J (2009), Mok MT (2010), Johnson N (2013), Hill SJ (2014), Hu Y (2014), Hu Y (2014), Hu Y (2014), Renaud E (2016), Li Y (2017)	23
ATXN3	2	EP300	36	pull down, affinity chromatography technology	Li F (2002), Li F (2002)	2
VCP	6	ARIH1	3	affinity chromatography technology	Yu CC (2013)	1
HDAC6	0	PLAA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), New M (2013), Hein MY (2015)	3
RABGEF1	1	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
PRKN	1	ARIH1	3	affinity chromatography technology	Parelkar SS (2012)	1
CYLD	2	VCP	6	affinity chromatography technology	Elliott PR (2016)	1
TNF	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
TNFAIP3	3	OTUD5	2	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D1	0	CUL2	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Monda JK (2013), Heir P (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Chen K (2016)	13
NBR1	0	USP8	7	two hybrid, pull down	Waters S (2009), Waters S (2009)	2
USP8	7	OTUB1	0	affinity chromatography technology	Soares L (2004)	1
HGS	5	UBA1	1	pull down	Pridgeon JW (2009)	1
SMURF2	3	STAMBP	2	affinity chromatography technology, affinity chromatography technology	Li H (2004), Li H (2004)	2
RNF11	0	TOM1L2	0	two hybrid	Colland F (2004)	1
PARP10	4	HIST2H2AC	1	enzymatic study	Yu M (2005)	1
UBE2R2	2	UBE2D2	0	biochemical	Wan C (2015)	1
PSMC6	0	PSMD11	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
BRCA1	7	RBBP8	1	unspecified method, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Rodriguez M (2003), Li S (1999), Li S (1999), Li S (1999), Wong AK (1998), Wong AK (1998), Li S (2000), Wu-Baer F (2001), Yu X (1998), Yu X (1998), Yu X (2000), Yu X (2000), Yu X (2000), Kim H (2007), Yu X (2006), Yu X (2006), Wu-Baer F (2010), Volcic M (2012), Wang B (2007), Wang B (2007), Furuta S (2006), Furuta S (2006), Drikos I (2009), Tischkowitz M (2008), Li S (2000), Wu-Baer F (2001), Chen L (2008), Sevcik J (2013), Johnson N (2013), Hill SJ (2014), Cruz-Garcia A (2014), Hu Y (2014), Parameswaran B (2015), Liu H (2015), Renaud E (2016)	35
ARRB2	5	KLHL12	4	affinity chromatography technology	Skieterska K (2016)	1
BABAM1	1	UBXN1	0	affinity chromatography technology	Sowa ME (2009)	1
USP37	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, bioid, affinity chromatography technology	Burrows AC (2012), Burrows AC (2012), Burrows AC (2012), Saxena N (2014), Yeh C (2015), Huttlin EL (2017)	6
ABL1	9	UBASH3B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Brehme M (2009)	3
RAD23B	1	HIF1A	1	affinity chromatography technology	Bandau S (2012)	1
TSG101	1	CBL	7	affinity chromatography technology, imaging technique	Kumar B (2016), Kumar B (2016)	2
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
USP14	1	PSMC3	0	affinity chromatography technology, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Wan C (2015)	3
UBE2N	1	RNF8	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, two hybrid	Markson G (2009), Bekker-Jensen S (2010), Lok GT (2011), Lok GT (2011), Campbell SJ (2012), Plans V (2006), Plans V (2006), Huen MS (2008), Zhang X (2013), Guerra-Rebollo M (2012), Zhao H (2014), Hodge CD (2015), Ho YK (2015), Weber E (2017), Weber E (2017), Schimmack G (2017)	16
EP300	36	TRAF2	1	two hybrid	Wang J (2011)	1
VCP	6	UBR5	13	affinity chromatography technology	Yu CC (2013)	1
TAB2	5	RNF4	1	affinity chromatography technology	Tan B (2015)	1
UCHL5	1	PSMC4	6	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	5
MYO6	3	DDB1	6	affinity chromatography technology	Wollscheid HP (2016)	1
OTUB1	0	NEDD8	0	enzymatic study	Edelmann MJ (2009)	1
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
FAF2	4	CUL2	3	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
RNF11	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shembade N (2009), Pranski EL (2012), Kelly C (2012), Colland F (2004)	4
STAMBP	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
RNF126	2	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL4A	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Wu K (2016)	4
STUB1	4	SQSTM1	0	biochemical	Villella VR (2013)	1
CUL1	7	WWP2	7	affinity chromatography technology	Bennett EJ (2010)	1
RNF11	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2009)	2
USP28	3	USP5	2	enzymatic study	Loch CM (2012)	1
XIAP	0	FAF1	1	two hybrid, pull down, affinity chromatography technology, imaging technique	Caballero-Lopez MJ (2017), Caballero-Lopez MJ (2017), Caballero-Lopez MJ (2017), Caballero-Lopez MJ (2017)	4
MAP1LC3A	0	NBR1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	DAgostino C (2011), Waters S (2009), Waters S (2009), Kirkin V (2009)	4
OPTN	1	TNIP1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
USP1	4	UBC	7	enzymatic study, pull down	Faesen AC (2011), Cohn MA (2009)	2
UBE2R2	2	BTRC	1	pull down, affinity chromatography technology, bioid	Semplici F (2002), Coyaud E (2015), Coyaud E (2015)	3
UBE2D3	1	STAM2	0	enzymatic study	Hoeller D (2007)	1
ABRAXAS1	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method	Wang B (2009), Shao G (2009), Hu X (2011), Feng L (2009), Wang B (2007), Wang B (2007), Liu Z (2007), Liu Z (2007), Nikkilae J (2009), Mok MT (2010), Kim H (2007), Kim H (2007), Kim H (2007), Solyom S (2012), Sevcik J (2013), Hill SJ (2014), Wu Q (2016), Wu Q (2016)	18
ABL1	9	TP53	0	pull down	Nie Y (2000)	1
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
MAP1LC3A	0	EGFR	5	affinity chromatography technology	Wang BS (2013)	1
BTRC	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
EGFR	5	SMURF2	3	affinity chromatography technology, affinity chromatography technology, pull down	Ray D (2011), Ray D (2011), Ray D (2011)	3
LCK	0	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
CUL3	17	ITCH	1	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	UBE3A	4	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study	Nuber U (1998), Huibregtse JM (1993), Yang Y (2007), Kim HC (2009), Scheffner M (1994), Mishra A (2012), Burch L (2004), Ro HS (2006), Nakagawa S (2000), Nakagawa S (2000), Nakagawa S (2000), Huibregtse JM (1991), Honda R (1997), Huibregtse JM (1995), Martinez-Zapien D (2016), Martinez-Zapien D (2016), Rolfe M (1995)	17
TRAF2	1	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henn IH (2007), Henn IH (2007), Um JW (2012), Im E (2015)	4
LCK	0	CBL	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Rao N (2002), Tsygankov AY (1996), Reedquist KA (1996), Nervi S (2005)	4
RAD23A	1	HUWE1	22	affinity chromatography technology	Scanlon TC (2009)	1
RNF165	0	UBC	7	enzymatic study, x-ray crystallography, pull down	Wright JD (2016), Wright JD (2016), Wright JD (2016)	3
UBA6	4	UBE2D3	1	pull down	Jin J (2007)	1
CUL2	3	PABPC4	2	affinity chromatography technology	Bennett EJ (2010)	1
RBCK1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Zenke-Kawasaki Y (2007), Yamanaka K (2003), Inn KS (2011), Kirisako T (2006)	4
USP37	1	WRNIP1	3	bioid	Yeh C (2015)	1
STUB1	4	VCP	6	affinity chromatography technology, pull down	Vij N (2006), Liu S (2013)	2
CDKN2A	1	UBL7	0	two hybrid	Daakour S (2016)	1
ARIH1	3	UBE2D3	1	pull down	Wenzel DM (2011)	1
ANKRD13A	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Burana D (2016), Burana D (2016), Burana D (2016), Burana D (2016)	4
UBC	7	SH3KBP1	1	pull down, x-ray crystallography, pull down, x-ray crystallography, pull down, x-ray crystallography	Bezsonova I (2008), Korzhnev DM (2009), Ortega Roldan JL (2013), Ortega Roldan JL (2013), Stamenova SD (2007), Bezsonova I (2008)	6
PSMC5	4	PSMD11	0	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
VCPIP1	4	UFD1	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
SQSTM1	0	CUL3	17	imaging technique, affinity chromatography technology	Lau A (2010), Mori Y (2015)	2
DAZAP2	1	RABGEF1	1	two hybrid	Rolland T (2014)	1
USP13	2	NEDD8	0	affinity chromatography technology	Sowa ME (2009)	1
BTRC	1	CCDC50	0	bioid	Coyaud E (2015)	1
UBQLN2	0	PDE12	2	biochemical	Kristensen AR (2012)	1
BAP1	4	PSMC6	0	affinity chromatography technology	Hauri S (2016)	1
UBC	7	RNF38	4	pull down, enzymatic study	Buetow L (2015), Buetow L (2015)	2
CUL2	3	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	USP40	1	pull down, pull down	Zhang X (2017), Kwasna D (2018)	2
VPS28	2	BCR	3	affinity chromatography technology	Olabisi OO (2006)	1
CCT6A	1	USP5	2	biochemical	Havugimana PC (2012)	1
UBE2K	0	MDM2	2	two hybrid, pull down, pull down	Bae Y (2013), Saville MK (2004), David Y (2011)	3
UBC	7	NOD1	3	pull down, x-ray crystallography	Ver Heul AM (2013), Ver Heul AM (2013)	2
SMURF1	4	TOM1L2	0	enzymatic study	Andrews PS (2010)	1
CYLD	2	PSMC1	2	affinity chromatography technology	Elliott PR (2016)	1
STAM	3	GGA1	0	biochemical	Wan C (2015)	1
ARRB2	5	CCT6A	1	affinity chromatography technology	Xiao K (2007)	1
NEDD8	0	USP11	3	affinity chromatography technology	Bennett EJ (2010)	1
UBASH3B	4	CCT3	1	affinity chromatography technology	Brehme M (2009)	1
STUB1	4	UBE2D3	1	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Murata S (2001), Soss SE (2011), Page RC (2012), Parsons JL (2009), Stankiewicz M (2010), Gao XC (2011), Kundrat L (2010), Kundrat L (2010), Tsukahara F (2010), Todi SV (2010), Smith MC (2013), Ronnebaum SM (2013), Seki T (2013), Heimdal K (2014), Todi SV (2009), Yuan L (2015), Kim JH (2017), Blessing NA (2017), Pakdaman Y (2017)	19
RNF126	2	UBE2N	1	pull down	Smith CJ (2013)	1
RAD23B	1	MYO6	3	biochemical	Wan C (2015)	1
RAD23A	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Brignone C (2004), Hsieh HC (2005)	2
RAD23A	1	PSMC2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Scanlon TC (2009), Chen L (2006), Tsai NP (2012), Wan C (2015)	4
USP14	1	ADRM1	4	affinity chromatography technology	Sowa ME (2009)	1
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
DDX58	3	CBL	7	affinity chromatography technology	Song Y (2017)	1
USP21	2	STAMBP	2	enzymatic study	Loch CM (2012)	1
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
PRKN	1	PSMD7	1	affinity chromatography technology	Sarraf SA (2013)	1
BRCA1	7	PSMD14	3	affinity chromatography technology	Ertych N (2016)	1
YOD1	0	UBC	7	pull down, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study	Ernst R (2009), Mevissen TE (2013), Mevissen TE (2013), Ernst R (2009), Flierman D (2016)	5
RNF8	2	HIST2H2AC	1	enzymatic study, enzymatic study	Mattiroli F (2012), Paul A (2017)	2
PSMD4	1	MAP1LC3A	0	affinity chromatography technology	Lee DY (2013)	1
PRKN	1	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology	Choi P (2001), Choi P (2001), Kawahara K (2008), Hampe C (2006), Nemes Z (2009), Oluwatosin-Chigbu Y (2003), Yang Y (2003), Norris KL (2015)	8
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
TAX1BP1	3	TNIP3	3	two hybrid	Rolland T (2014)	1
PINK1	2	TOLLIP	3	affinity chromatography technology, affinity chromatography technology	Lee HJ (2012), Lee HJ (2012)	2
NEDD4	2	UBE2D2	0	two hybrid, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hatakeyama S (1997), Anan T (1998), Sehat B (2008), Arevalo JC (2006), Woelk T (2006), Persaud A (2009), Zeng F (2009), Sarkari F (2013), Liu PY (2012), Sugeno N (2014), Bustos F (2015), Chesarino NM (2015), Sun M (2016)	13
ABRAXAS1	0	PSMC5	4	affinity chromatography technology	Huttlin EL (2017)	1
PSMD11	0	PSMD1	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
CDC34	3	CUL1	7	pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Block K (2005), Wirbelauer C (2000), Saha A (2008), Sandoval D (2014), Wu K (2016)	5
UBR4	15	PSMC5	4	biochemical	Kristensen AR (2012)	1
CYLD	2	PSMC6	0	affinity chromatography technology	Elliott PR (2016)	1
UBE2V2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
WWP2	7	OTUD7B	3	affinity chromatography technology	Chaudhary N (2014)	1
PSMC3	0	PSMD8	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Wan C (2015)	4
CUL4B	8	UBC	7	affinity chromatography technology, pull down	Bennett EJ (2010), Nathan JA (2013)	2
VCPIP1	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
USP48	3	UCHL3	1	biochemical	Havugimana PC (2012)	1
UBASH3B	4	CBL	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004), Raguz J (2007), Hoeller D (2006), Peruzzi G (2007), Brehme M (2009)	6
TSG101	1	UBAP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Stefani F (2011), Stefani F (2011), Agromayor M (2012), Agromayor M (2012), Wunderley L (2014), Wunderley L (2014), Wunderley L (2014), Wan C (2015), Kharitidi D (2015), Huttlin EL (2017)	10
CUL4A	2	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
STUB1	4	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
EGFR	5	ANKRD13D	4	affinity chromatography technology	Tanno H (2012)	1
UBE2D2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
RAD23A	1	PSMC1	2	affinity chromatography technology, biochemical	Scanlon TC (2009), Wan C (2015)	2
ATXN3	2	UBAC2	1	affinity chromatography technology	Kristensen LV (2018)	1
RAD23A	1	EPS15	1	affinity chromatography technology	Scanlon TC (2009)	1
RNF11	0	GGA1	0	pull down, two hybrid, affinity chromatography technology, pull down, unspecified method	Santonico E (2010), Colland F (2004), Santonico E (2014), Santonico E (2014), Santonico E (2014)	5
UBC	7	CCT6A	1	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
TP53	0	SQSTM1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Lello P (2006), Horikawa I (2014), Kang JH (2016), Kang JH (2016)	4
CDKN2A	1	C1QBP	0	affinity chromatography technology	Pimkina J (2009)	1
ARRB2	5	PRKN	1	affinity chromatography technology, pull down	Ahmed MR (2011), Ahmed MR (2011)	2
UFD1	1	CD2AP	0	biochemical	Wan C (2015)	1
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
PRKN	1	PSMC6	0	affinity chromatography technology	Sarraf SA (2013)	1
UBC	7	OTUD7B	3	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, pull down	Pareja F (2011), Bremm A (2010), Mevissen TE (2013), Michel MA (2015), Kristariyanto YA (2015), Castaneda CA (2016), Mevissen TE (2016), Mevissen TE (2016), Kwasna D (2018)	9
UBC	7	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
PSMD12	1	PSMD8	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
RNF11	0	WWP2	7	two hybrid	Colland F (2004)	1
USP7	14	BRCC3	0	affinity chromatography technology	Sowa ME (2009)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
ATG16L1	1	NOD1	3	affinity chromatography technology, affinity chromatography technology, pull down	Travassos LH (2010), Travassos LH (2010), Ver Heul AM (2013)	3
MDM2	2	PSMC3	0	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Kulikov R (2010), Kulikov R (2010), Kulikov R (2010), Kulikov R (2010), Dolezelova P (2012)	5
RAD23A	1	PSMD4	1	two hybrid, pull down, x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Hiyama H (1999), Mueller TD (2003), Kang Y (2007), Kang Y (2007), Wang Q (2003), Walters KJ (2003), Walters KJ (2002), Scanlon TC (2009), Hsieh HC (2005)	9
VCP	6	CUL5	1	affinity chromatography technology	Yu CC (2013)	1
UBE2D2	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
HERC2	9	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Cubillos-Rojas M (2014), Cubillos-Rojas M (2014), Cubillos-Rojas M (2014), Bai B (2016)	4
USP7	14	TNIP2	1	affinity chromatography technology	Bhattacharya S (2015)	1
RAD23A	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Brignone C (2004), Brignone C (2004), Brignone C (2004)	3
CUL2	3	CISH	1	affinity chromatography technology	Zhang W (2008)	1
PSMC5	4	PSMC1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hartmann-Petersen R (2001), Kim YC (2011), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	9
EPS15	1	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Woelk T (2006), De Schutter J (2009), Brehme M (2009), Hoeller D (2006), Zhang X (2017), Kristariyanto YA (2017)	6
NPM1	0	PSMC4	6	affinity chromatography technology, two hybrid	Chen R (2013), Wang J (2011)	2
STAM2	0	STAMBP	2	two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, x-ray crystallography	Rual JF (2005), Sierra MI (2010), Sierra MI (2010), Tsang HT (2006), Venkatesan K (2009), Hologne M (2016)	6
USP15	4	KEAP1	0	enzymatic study	Villeneuve NF (2013)	1
TP53	0	AGO2	10	affinity chromatography technology	Lunardi A (2010)	1
RAD23A	1	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Fang DF (2013), Fang DF (2013), Rolland T (2014), Akhtar N (2016)	5
UBE2D2	0	XIAP	0	two hybrid, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Dynek JN (2010), Nakatani Y (2012), Nakatani Y (2012), Markson G (2009), Fang S (2001), Hu S (2003), Buetow L (2015), Foglizzo M (2016), Edison N (2017)	10
AMFR	2	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Cao J (2007), Cao J (2007), Cao J (2007), Cao J (2007)	4
MAP1LC3A	0	SNCA	0	imaging technique	Schwarz L (2012)	1
PSMD14	3	UBA1	1	affinity chromatography technology, affinity chromatography technology	Jacobson AD (2014), Jacobson AD (2014)	2
FAF1	1	BTRC	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2012), Zhang L (2012)	2
KLHL12	4	PEF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Rolland T (2014), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	6
FAF2	4	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
NEDD4	2	PSMD4	1	enzymatic study, enzymatic study, enzymatic study	Uchiki T (2009), Kim HT (2012), Puig-Sarries P (2015)	3
USP7	14	SNCA	0	enzymatic study	Alexopoulou Z (2016)	1
PSMD10	1	PSMD7	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Ewing RM (2007), Sowa ME (2009), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015)	5
UCHL5	1	PSMD4	1	affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Qiu XB (2006), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	6
CDC34	3	RAD23A	1	biochemical	Kristensen AR (2012)	1
ADRM1	4	PSMD12	1	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
PLAA	1	NSFL1C	1	biochemical	Kristensen AR (2012)	1
UIMC1	4	HIST2H2AC	1	affinity chromatography technology, affinity chromatography technology, pull down	Wu J (2009), Wu J (2009), Zhu B (2014)	3
UBXN7	3	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bandau S (2012)	2
USP13	2	AMFR	2	affinity chromatography technology, pull down, affinity chromatography technology	Liu Y (2014), Liu Y (2014), Liu Y (2014)	3
NPLOC4	4	UBE3A	4	biochemical	Kristensen AR (2012)	1
NPM1	0	USP15	4	affinity chromatography technology	Chen R (2013)	1
RBBP8	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016)	4
UBAC2	1	HNRNPM	1	affinity chromatography technology	Christianson JC (2012)	1
TOLLIP	3	WRNIP1	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
HUWE1	22	ACLY	3	affinity chromatography technology	Thompson JW (2014)	1
EGFR	5	UBE2V2	0	protein complementation assay	Deribe YL (2009)	1
TOLLIP	3	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Lu K (2014), Jongsma ML (2016)	2
DCUN1D1	0	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Huang G (2014), Huang G (2014)	3
PRKN	1	ABL1	9	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ko HS (2010), Ko HS (2010), Ko HS (2010), Ko HS (2010), Imam SZ (2011), Imam SZ (2011), Imam SZ (2011), Imam SZ (2011), Imam SZ (2011)	9
PSMD10	1	PSMD11	0	affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Wan C (2015)	3
ZBTB1	4	UBC	7	pull down, pull down	Kim H (2014), Kim H (2014)	2
USP14	1	PSMD12	1	affinity chromatography technology, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Wan C (2015)	3
PRKN	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique	Sarraf SA (2013), Song P (2016), Song P (2016), Song P (2016), Song P (2016), Hou XO (2015), Geisler S (2014)	7
UBE2D2	0	UBQLN1	1	biochemical	Havugimana PC (2012)	1
PSMD4	1	ANKRD13A	1	biochemical	Wan C (2015)	1
USP19	1	STUB1	4	affinity chromatography technology	He WT (2016)	1
ARRB2	5	UBC	7	affinity chromatography technology, fluorescent resonance energy transfe	Xiao K (2007), Dalrymple MB (2011)	2
MDM2	2	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2010), Nie J (2010), Nie J (2010)	3
USP21	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
TRAF6	0	PSMD1	2	affinity chromatography technology	Bouwmeester T (2004)	1
SMURF1	4	LCK	0	enzymatic study	Andrews PS (2010)	1
RNF8	2	UBE2S	2	affinity chromatography technology	Paul A (2017)	1
BRCC3	0	ABRAXAS2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2010), Kristensen AR (2012), Zhang J (2014), Huttlin EL (2015), Yan K (2015), Huttlin EL (2017), Zheng H (2013), Zheng H (2013)	12
MYO6	3	AP2M1	5	affinity chromatography technology	Wollscheid HP (2016)	1
RAD23A	1	UBA1	1	affinity chromatography technology, affinity chromatography technology	Chen L (2006), Chen L (2006)	2
SMURF1	4	RIOK3	2	enzymatic study	Andrews PS (2010)	1
UBC	7	POLR2C	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
UBXN1	0	BRCA1	7	affinity chromatography technology, pull down	Wu-Baer F (2010), Wu-Baer F (2010)	2
HDAC6	0	HSPD1	0	affinity chromatography technology	Watson GW (2016)	1
UBC	7	CCDC50	0	pull down, two hybrid, pull down, pull down	Fenner BJ (2009), Bohgaki M (2008), Bohgaki M (2008), Zhang X (2017)	4
BIRC2	1	UBE2B	3	two hybrid	Dynek JN (2010)	1
PSMD12	1	PSMD5	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
UBC	7	TBC1D15	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
TNIP2	1	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, two hybrid	Liu WK (2004), Liu WK (2004), Liu WK (2004), Liu WK (2004), Liu WK (2004), Wang J (2011)	6
RNF11	0	PSMD7	1	affinity chromatography technology	Poulsen SL (2013)	1
PMS2	4	CYLD	2	affinity chromatography technology	Cannavo E (2007)	1
TNFAIP3	3	TNIP1	1	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Heyninck K (1999), Heyninck K (1999), Bohgaki M (2008), Klinkenberg M (2001), Heyninck K (2003), Wang J (2011), Rodriguez MS (2014), Rolland T (2014)	8
PSMC3	0	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Pollice A (2007), Pollice A (2007), Pollice A (2004), Pollice A (2004), Pollice A (2004)	5
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
CUL3	17	USP32	0	affinity chromatography technology	Bennett EJ (2010)	1
UIMC1	4	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang B (2007), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2010), Wang B (2007), Wang B (2007), Liu Z (2007), Liu Z (2007), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Kim H (2007), Kim H (2007), Kim H (2007), Solyom S (2012), Cho HJ (2013), Hu Y (2014), Li Y (2017), Zheng H (2013)	30
UBXN7	3	DDB1	6	affinity chromatography technology	Alexandru G (2008)	1
USP14	1	PSMD10	1	affinity chromatography technology	Sowa ME (2009)	1
STAM	3	STUB1	4	biochemical	Havugimana PC (2012)	1
PSMD1	2	PSMD8	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
USP15	4	PSMD11	0	affinity chromatography technology	Sowa ME (2009)	1
NEDD4	2	ANKRD13D	4	enzymatic study	Persaud A (2009)	1
ZFAND2B	1	PSMD10	1	affinity chromatography technology	Huttlin EL (2015)	1
RAD23B	1	USP25	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Xu D (2017)	2
ITCH	1	JUN	0	pull down, affinity chromatography technology, affinity chromatography technology	Gao B (2006), Ahmed SU (2009), Xie M (2010)	3
UBC	7	RNF114	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Capon F (2008), Fenner BJ (2009), Fenner BJ (2009)	4
DCUN1D1	0	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Keuss MJ (2016)	2
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
RNF115	1	UBC	7	two hybrid, pull down, protein complementation assay, pull down	Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008)	4
ARIH1	3	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down	Anan T (1998), Wang X (2008), Maspero E (2011), Katz M (2002), Wu K (2011), Maspero E (2013), Hong SW (2013), Zhou W (2014), Sugeno N (2014), Maspero E (2013), Miyazaki K (2003), Mari S (2014), Song F (2013), Fan CD (2013)	14
TRAF6	0	USP4	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Xiao N (2011), Xiao N (2011), Xiao N (2011), Xiao N (2011), Zhou F (2012), Zhou F (2012)	6
UBC	7	RAD18	3	affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down	Matsumoto M (2005), Fenner BJ (2009), Bish RA (2007), Rizzo AA (2014), Rizzo AA (2014), Shereda RD (2010), Shereda RD (2010), Panier S (2012), Ali AM (2012), Thach TT (2015)	10
UBC	7	TNIP2	1	unspecified method, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down	Laplantine E (2009), Wagner S (2008), Fenner BJ (2009), Komander D (2009), Lin SM (2017), Lin SM (2017)	6
TRIM32	2	UBQLN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBL7	0	UCHL3	1	biochemical	Havugimana PC (2012)	1
UBC	7	CDKN2A	1	pull down, imaging technique	Zhang X (2017), Zhang X (2017)	2
UBQLN2	0	EPN2	4	affinity chromatography technology	NDiaye EN (2008)	1
BRCA1	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Lu Y (2012), Lu Y (2012)	2
COPB1	0	NUB1	2	two hybrid	Wang J (2011)	1
EGFR	5	TSG101	1	affinity chromatography technology	Yao Z (2017)	1
UBE2D2	0	RNF38	4	two hybrid, pull down, pull down	Markson G (2009), Sheren JE (2013), Buetow L (2015)	3
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
BRCA1	7	PSMD4	1	affinity chromatography technology	Ertych N (2016)	1
MYO6	3	CALCOCO2	0	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down	Morriswood B (2007), Morriswood B (2007), Morriswood B (2007), Tumbarello DA (2015), He F (2016)	5
PSMD11	0	TP53	0	two hybrid	Stelzl U (2005)	1
DCUN1D1	0	NEDD8	0	affinity chromatography technology	Bennett EJ (2010)	1
HUWE1	22	HSPD1	0	affinity chromatography technology	Thompson JW (2014)	1
VCP	6	TSG101	1	affinity chromatography technology	Yu CC (2013)	1
NEDD4L	3	UBE2N	1	pull down	Herhaus L (2013)	1
NPLOC4	4	PDE12	2	biochemical	Kristensen AR (2012)	1
CDKN2A	1	PTEN	24	genetic interference	Shen JP (2017)	1
TAX1BP1	3	IKBKE	2	affinity chromatography technology	Gao L (2011)	1
CUL2	3	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
USP33	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Yasunaga J (2011), Yasunaga J (2011)	2
BRCA1	7	NAP1L1	2	affinity chromatography technology	Ertych N (2016)	1
CDKN2A	1	GGA3	6	fluorescent resonance energy transfe	Bill A (2011)	1
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
CYLD	2	PSMD11	0	affinity chromatography technology	Elliott PR (2016)	1
PLAA	1	CAV1	0	affinity chromatography technology	Doroudi M (2012)	1
VCP	6	GGA1	0	affinity chromatography technology	Yu CC (2013)	1
PTEN	24	CAV1	0	affinity chromatography technology	Caselli A (2002)	1
UBC	7	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PSMD14	3	PSMD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Patterson-Fortin J (2010), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	13
PTEN	24	WWP2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study	Crockett DK (2005), Ahmed SF (2012), Wu Y (2013), Maddika S (2011), Maddika S (2011), Maddika S (2011), Bawa-Khalfe T (2016), Bawa-Khalfe T (2016), Bawa-Khalfe T (2016), Chen Z (2016), Chen Z (2016), Chen Z (2017)	12
CUL3	17	POLR2C	0	affinity chromatography technology	Bennett EJ (2010)	1
FAN1	2	OTUD4	2	affinity chromatography technology	St-Denis N (2016)	1
STAM	3	HGS	5	two hybrid, affinity chromatography technology, biochemical, pull down, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Asao H (1997), Bache KG (2003), Malik R (2010), Kanazawa C (2003), Kanazawa C (2003), Havugimana PC (2012), Sirisaengtaksin N (2014), Sirisaengtaksin N (2014), Holleman J (2014), Holleman J (2014), Wan C (2015), Berlin I (2010), Huttlin EL (2017)	14
USP14	1	PSMD11	0	affinity chromatography technology, biochemical	Sowa ME (2009), Wan C (2015)	2
TAX1BP1	3	OPTN	1	affinity chromatography technology, affinity chromatography technology	Journo C (2009), Journo C (2009)	2
MDM2	2	USP10	2	affinity chromatography technology	Yuan J (2010)	1
PSMC2	2	PSMD12	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
HIF1A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen D (2003), Ravi R (2000), Hansson LO (2002), An WG (1998), An WG (1998), Chowdhury AR (2017), Chowdhury AR (2017), Suzuki H (2001), Sanchez-Puig N (2005)	9
RAD23B	1	UBE2N	1	biochemical	Wan C (2015)	1
UBE2G2	0	AMFR	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, pull down	Ewing RM (2007), Cao J (2007), Chen B (2006), Chen B (2006), Chen B (2006), Li W (2009), Li W (2009), Wang Q (2011), Jo Y (2013), Morito D (2008), Das R (2013), Yan L (2014), Liu W (2014), Li W (2009), Liu W (2014), Christianson JC (2012), Liu Y (2014)	17
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
PSMD7	1	PSMC2	2	affinity chromatography technology, biochemical, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
NEDD4	2	TOM1	3	enzymatic study	Persaud A (2009)	1
UBC	7	LAMA1	15	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
JOSD2	0	UBC	7	enzymatic study, enzymatic study, pull down	Seki T (2013), Weeks SD (2011), Kwasna D (2018)	3
CUL1	7	EEF1B2	1	affinity chromatography technology	Bennett EJ (2010)	1
UBE2R2	2	UBC	7	two hybrid, enzymatic study	Vinayagam A (2011), Hill S (2016)	2
ATXN3	2	NEDD8	0	two hybrid, two hybrid, pull down	Ferro A (2007), Ferro A (2007), Ferro A (2007)	3
RIPK1	2	PELI1	1	affinity chromatography technology, enzymatic study	Chang M (2009), Chang M (2009)	2
SMURF1	4	CCT6A	1	affinity chromatography technology	Xie Y (2013)	1
PTEN	24	ANAPC7	2	affinity chromatography technology, affinity chromatography technology	Song MS (2011), Song MS (2011)	2
UBE2B	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Chen S (2012), Chen S (2012)	2
DDB1	6	UBA1	1	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
EPS15	1	HGS	5	pull down, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Bean AJ (2000), Bean AJ (2000), Bache KG (2003), Roxrud I (2008), Roxrud I (2008), Yan Q (2005), Gschweitl M (2016)	7
SMURF2	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
UBE2D3	1	RNF4	1	two hybrid, two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013), Erker Y (2013), DiBello A (2016)	5
UBC	7	COPB1	0	affinity chromatography technology, pull down	Matsumoto M (2005), Xu P (2017)	2
BRCA1	7	POLR2C	0	affinity chromatography technology	Woods NT (2012)	1
UBE2D3	1	UBE3A	4	enzymatic study, pull down, pull down	Anan T (1998), Sionov RV (2001), Jacobson AD (2014)	3
USP21	2	USP8	7	enzymatic study	Loch CM (2012)	1
USP10	2	PTEN	24	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2013), Zhang J (2013), Sun J (2017), Sun J (2017)	4
USP15	4	BTRC	1	affinity chromatography technology	Greenblatt MB (2016)	1
SMURF1	4	USP9X	15	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Xie Y (2013), Xie Y (2013), Xie Y (2013), Xie Y (2013)	4
TNIP1	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Gao L (2011)	2
FAF1	1	UBC	7	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Song EJ (2005), Lee JJ (2012), Song J (2009), Song J (2009), Song J (2009), Lee JJ (2013), Lee JJ (2013), Nathan JA (2013), Baron Y (2014), Alexandru G (2008), Lee JJ (2012)	11
PSMC3	0	PSMD12	1	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
CUL2	3	HNRNPM	1	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	CCT6A	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
RNF11	0	ERCC6	6	two hybrid	Colland F (2004)	1
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
PSMD4	1	PSMD1	2	affinity chromatography technology, biochemical, biochemical, biochemical	Hendil KB (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
CUL2	3	PCBP2	3	affinity chromatography technology	Bennett EJ (2010)	1
RNF31	3	PRKN	1	affinity chromatography technology	Khan M (2016)	1
TP53	0	UBE2V2	0	two hybrid	Daakour S (2016)	1
UBXN1	0	UBR5	13	affinity chromatography technology	Alexandru G (2008)	1
OTUB2	0	RNF126	2	two hybrid	Hayes SD (2012)	1
HUWE1	22	EEF1B2	1	affinity chromatography technology	Thompson JW (2014)	1
JUN	0	NBR1	0	affinity chromatography technology	Li X (2015)	1
ZBTB1	4	TRIM28	1	affinity chromatography technology, affinity chromatography technology	Kim H (2014), Kim H (2014)	2
RAD23B	1	UBA1	1	affinity chromatography technology	Chen L (2006)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
UBXN1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
OTUD5	2	TP53	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique, pull down	Sowa ME (2009), Luo J (2013), Luo J (2013), Luo J (2013), Luo J (2013), Luo J (2013), Park SY (2015), Park SY (2015), Park SY (2015)	9
UBC	7	UCHL1	1	two hybrid, enzymatic study, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, pull down, pull down	Stelzl U (2005), Bremm A (2010), Boudreaux D (2012), Boudreaux DA (2010), Boudreaux DA (2010), Phillips AH (2013), Larsen CN (1998), Duerksen-Hughes PJ (1989), Flierman D (2016), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	13
UBXN1	0	MYO6	3	affinity chromatography technology	Raman M (2015)	1
MDM2	2	HIF1A	1	pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Chen D (2003), Chen D (2003), Ravi R (2000), Lee YM (2009), Lee YM (2009), Lee YM (2009), Maroni P (2014), Amelio I (2015), Yoo YG (2004), LaRusch GA (2007), LaRusch GA (2007), Nieminen AL (2005)	12
SMURF1	4	FAF2	4	enzymatic study	Andrews PS (2010)	1
STUB1	4	USP5	2	biochemical	Wan C (2015)	1
ARRB2	5	C1QBP	0	affinity chromatography technology	Xiao K (2007)	1
OTUB2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
MID1	1	PSMD14	3	affinity chromatography technology	Gholkar AA (2016)	1
UBC	7	TTC3	1	pull down, affinity chromatography technology	Fenner BJ (2009), Fenner BJ (2009)	2
UBC	7	UBQLN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Ko HS (2004), Ko HS (2004), Sokratous K (2012), Raasi S (2005), Raasi S (2005), Massey LK (2004), Ko HS (2004), Ko HS (2004), Rolland T (2014), Castaneda CA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Kristariyanto YA (2015), Kurlawala Z (2017)	16
UBC	7	BABAM2	2	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2009), Zhang X (2017)	3
IKBKE	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Zhou AY (2013)	2
VCP	6	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Thompson JW (2014)	2
BTRC	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Xia Y (2009), Verma S (2011)	2
TNFAIP3	3	TNIP3	3	affinity chromatography technology, two hybrid	Wullaert A (2007), Rolland T (2014)	2
RAD23B	1	UBE3A	4	pull down, enzymatic study	Kumar S (1999), Kumar S (1999)	2
ABL1	9	WRNIP1	3	enzymatic study	Mano Y (2007)	1
TSG101	1	SH3KBP1	1	biochemical	Wan C (2015)	1
RNF115	1	UBE2N	1	pull down	Smith CJ (2013)	1
HUWE1	22	UBE2D2	0	pull down, pull down, pull down, pull down	Warr MR (2005), Kristariyanto YA (2015), Li L (2015), Zhang W (2016)	4
TRAF6	0	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
BRCA1	7	PSMC2	2	affinity chromatography technology	Ertych N (2016)	1
MID1	1	OTUB2	0	two hybrid	Rolland T (2014)	1
VPS28	2	VPS36	3	affinity chromatography technology, x-ray crystallography	Im YJ (2008), Gill DJ (2007)	2
USP19	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Mei Y (2011), Mei Y (2011), Mei Y (2011)	3
NUB1	2	UBC	7	pull down, affinity chromatography technology	Nakayasu ES (2013), Nakayasu ES (2013)	2
CUL1	7	AGO2	10	affinity chromatography technology	Bennett EJ (2010)	1
ZUFSP	0	UBR5	13	affinity chromatography technology, affinity chromatography technology	Hermanns T (2018), Kwasna D (2018)	2
BTRC	1	NSFL1C	1	bioid	Coyaud E (2015)	1
UBC	7	UFD1	1	pull down, x-ray crystallography, affinity chromatography technology, pull down	Nathan JA (2013), Park S (2005), Bish RA (2007), Zhang X (2017)	4
EGFR	5	ANKS1B	2	unspecified method	Jones RB (2006)	1
SNCA	0	UBC	7	fluorescent resonance energy transfe, affinity chromatography technology	Sharma N (2001), Nemes Z (2009)	2
TRAF6	0	OTUD7B	3	affinity chromatography technology	Evans PC (2001)	1
STUB1	4	PSMD1	2	affinity chromatography technology	Arndt V (2005)	1
PSMC4	6	PSMD12	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
BRCA1	7	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Wang X (2014), Wang X (2014)	2
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
PSMC4	6	PSMC6	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
UBA1	1	UBE2S	2	enzymatic study, pull down, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Wauer T (2015), Huguenin-Dezot N (2016)	4
CUL4B	8	C1QBP	0	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	RAD23B	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Ryu KS (2003), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Zhang X (2017)	9
USP5	2	UBA1	1	affinity chromatography technology	Song AX (2014)	1
DAZAP2	1	STAM2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ATG16L1	1	CCT3	1	affinity chromatography technology	Behrends C (2010)	1
HERC2	9	UBE2D3	1	pull down	Wu W (2010)	1
EPS15	1	TRAF2	1	affinity chromatography technology	Brehme M (2009)	1
USP28	3	USP7	14	enzymatic study	Loch CM (2012)	1
HUWE1	22	SFPQ	2	affinity chromatography technology	Thompson JW (2014)	1
PSMD4	1	ABL1	9	biochemical	Liu X (2006)	1
CYLD	2	EEF1B2	1	affinity chromatography technology	Elliott PR (2016)	1
USP21	2	CUL3	17	affinity chromatography technology, affinity chromatography technology	Heride C (2016), Heride C (2016)	2
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
PRKN	1	PSMC4	6	affinity chromatography technology	Sarraf SA (2013)	1
TRAF6	0	ITCH	1	affinity chromatography technology	Shembade N (2008)	1
UBC	7	POLH	1	pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Bienko M (2005), Plosky BS (2006), Sekimoto T (2010), Bienko M (2005), Plosky BS (2006), Ahmed-Seghir S (2015)	6
TNFAIP3	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang M (2013), Wang M (2013), Liu J (2013), Liu J (2013)	4
UBE2D2	0	RNF165	0	two hybrid, pull down, x-ray crystallography	van Wijk SJ (2009), Wright JD (2016), Wright JD (2016)	3
NEDD8	0	UCHL1	1	two hybrid	Stelzl U (2005)	1
PSMC1	2	PSMC2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Gorbea C (2000), Hartmann-Petersen R (2001), Kaneko T (2009), Kaneko T (2009), Kim YC (2011), Kim YC (2011), Shim SM (2012), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	13
TRIM32	2	UBE2D2	0	affinity chromatography technology, pull down, pull down	Napolitano LM (2011), Streich FC (2013), Mokhonova EI (2015)	3
UBC	7	N4BP1	3	pull down, affinity chromatography technology, pull down	Fenner BJ (2009), Fenner BJ (2009), Zhang X (2017)	3
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
SPRTN	0	PSMC2	2	affinity chromatography technology	Kim MS (2013)	1
USP21	2	USP4	3	enzymatic study	Loch CM (2012)	1
ERLIN2	2	UFD1	1	affinity chromatography technology	Pearce MM (2007)	1
OPTN	1	UBC	7	affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down	Wild P (2011), Fenner BJ (2009), Zhu G (2007), Zhu G (2007), Wagner S (2008), Gleason CE (2011), Nagabhushana A (2011), Korac J (2012), Wild P (2011), Tumbarello DA (2015), Heo JM (2015), Ordureau A (2015), Richter B (2016), Richter B (2016), Nakazawa S (2016), Zhang X (2017), Kliza K (2017), Bansal M (2018)	18
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
CCT3	1	CCT6A	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
CDC20	1	ANAPC11	0	affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Nilsson J (2008), Chen TC (2014), Lee SB (2015), Alfieri C (2016)	4
PSMD10	1	PSMD1	2	affinity chromatography technology, biochemical	Ewing RM (2007), Havugimana PC (2012)	2
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
NPM1	0	EEF1B2	1	affinity chromatography technology	Chen R (2013)	1
CBL	7	BCR	3	pull down, pull down, affinity chromatography technology, enzymatic study	Gaston I (2004), Panchamoorthy G (1996), Brehme M (2009), Tsukahara F (2010)	4
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
BTRC	1	TNRC6A	6	bioid	Coyaud E (2015)	1
BRCA1	7	PSMC6	0	affinity chromatography technology	Ertych N (2016)	1
RNF11	0	GGA3	6	two hybrid, unspecified method, imaging technique	Colland F (2004), Santonico E (2014), Santonico E (2014)	3
NUB1	2	VCP	6	affinity chromatography technology, pull down, pull down	Liu S (2013), Liu S (2013), Liu S (2013)	3
TRAF6	0	TRAFD1	2	pull down	Mashima R (2005)	1
FAF1	1	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
UBXN1	0	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
STAM2	0	UBC	7	x-ray crystallography, x-ray crystallography, pull down, pull down, pull down, pull down, pull down	Lange A (2010), Lange A (2012), Lange A (2012), Stuible M (2010), Baiady N (2016), Zhang X (2017), Hologne M (2016)	7
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
UIMC1	4	RBBP8	1	affinity chromatography technology	Wang B (2007)	1
UBE2D3	1	RNF165	0	two hybrid	van Wijk SJ (2009)	1
UBE2D2	0	RNF114	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017), Lin B (2017)	4
OTUB2	0	TRAF6	0	affinity chromatography technology, two hybrid	Li S (2010), Hayes SD (2012)	2
UBASH3B	4	CUL3	17	pull down	Krupina K (2016)	1
ZRANB1	3	KEAP1	0	affinity chromatography technology	Sowa ME (2009)	1
CDKN2A	1	GGA1	0	two hybrid	Lu L (2001)	1
DAZAP2	1	EPN1	4	two hybrid	Rolland T (2014)	1
NEDD8	0	TBC1D15	1	affinity chromatography technology	Bennett EJ (2010)	1
DDX58	3	USP15	4	affinity chromatography technology, pull down	Zhang H (2015), Zhang H (2015)	2
CUL3	17	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
USP25	0	MYO6	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
ITCH	1	UBE2K	0	pull down	Sheng Y (2012)	1
ITCH	1	HDAC6	0	affinity chromatography technology	OConnor HF (2015)	1
TRIM28	1	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Doyle JM (2010), Gilmore-Hebert M (2010), Okamoto K (2006)	3
MDM2	2	PSMC6	0	affinity chromatography technology	Kulikov R (2010)	1
BABAM1	1	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Bian C (2012), Solyom S (2012), Huttlin EL (2015), Huttlin EL (2017), Zheng H (2013)	20
RNF168	0	UBE2D3	1	pull down, pull down, two hybrid	Mallette FA (2012), Pinato S (2009), Schimmack G (2017)	3
OPTN	1	SQSTM1	0	affinity chromatography technology, pull down	Liu Z (2014), Liu Z (2014)	2
PSMD7	1	PSMD4	1	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
NSFL1C	1	FAF1	1	affinity chromatography technology	Raman M (2015)	1
TRIM28	1	BRCC3	0	biochemical	Kristensen AR (2012)	1
RNF126	2	MINDY1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OTUD7B	3	UBE2S	2	enzymatic study	Bremm A (2010)	1
SMURF1	4	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Cui Y (2011), Zhang Y (2017), Zhang Y (2017), Zhang Y (2017), Zhang Y (2017)	5
DDB1	6	BTRC	1	affinity chromatography technology	He YJ (2006)	1
UBC	7	PSMC1	2	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
VCPIP1	4	FAF2	4	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Alexandru G (2008)	2
SMURF2	3	BTRC	1	enzymatic study, affinity chromatography technology	Shukla S (2014), Shukla S (2014)	2
SMURF1	4	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Nie J (2010), Nie J (2010), Fei C (2013), Wang J (2013), Cao Y (2014), Xie P (2014), Xie P (2014), Lu K (2008), Kristariyanto YA (2015), Andrews PS (2010), He S (2017), Zhang Y (2017)	12
CDC20	1	HDAC6	0	affinity chromatography technology	Kim AH (2009)	1
RAD23A	1	PSMD8	1	affinity chromatography technology	Scanlon TC (2009)	1
EGFR	5	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Umebayashi K (2008), Morino C (2004), Meijer IM (2013), Sun Y (2013), Ali N (2013), Tan X (2015)	6
UBQLN1	1	UCHL3	1	biochemical	Havugimana PC (2012)	1
SH3KBP1	1	CD2AP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tossidou I (2010), Gaidos G (2007), Huttlin EL (2017)	3
UBASH3A	3	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Collingwood TS (2007), Kowanetz K (2004), Kowanetz K (2004), Feshchenko EA (2004), Feshchenko EA (2004), Feshchenko EA (2004), Hoeller D (2006)	7
FAF2	4	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Thompson JW (2014)	2
CUL3	17	C1QBP	0	affinity chromatography technology	Bennett EJ (2010)	1
ABL1	9	CBLB	3	affinity chromatography technology	Brehme M (2009)	1
PRKN	1	ATXN3	2	pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography	Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Bai JJ (2013)	7
UBA6	4	UBE2D2	0	pull down, pull down, enzymatic study, enzymatic study	Pelzer C (2007), Jin J (2007), Huang DT (2009), Liu X (2017)	4
UBQLN1	1	PSMD4	1	pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Fallon L (2006), Heir R (2006), Ko HS (2004), Walters KJ (2002), Fatimababy AS (2010), Fatimababy AS (2010), Ko HS (2004), Ko HS (2004), Kurlawala Z (2017), Kurlawala Z (2017)	10
UBE2D2	0	RNF115	1	two hybrid, pull down, pull down	van Wijk SJ (2009), Smith CJ (2013), Amemiya Y (2008)	3
RAD23A	1	UBL7	0	two hybrid	Rual JF (2005)	1
EGFR	5	CBLB	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Schulze WX (2006), Ettenberg SA (1999), Davies GC (2006), Davies GC (2006), Tong J (2009), Ettenberg SA (2001), Tong J (2008), Levkowitz G (1999), Tong J (2014)	9
UBE2T	0	RNF4	1	two hybrid	van Wijk SJ (2009)	1
TAB3	1	TRAF2	1	affinity chromatography technology	Ishitani T (2003)	1
GGA1	0	RABGEF1	1	pull down, affinity chromatography technology, two hybrid	Mattera R (2003), Mattera R (2004), Mattera R (2004)	3
RAD23B	1	UBA6	4	biochemical	Kristensen AR (2012)	1
BRCA1	7	COPB1	0	affinity chromatography technology	Ertych N (2016)	1
PRKN	1	FAF1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Sul JW (2013), Sul JW (2013), Sul JW (2013), Sul JW (2013), Sul JW (2013)	5
USP11	3	USP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Zhang L (2012)	3
EGFR	5	CAV1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, pull down, biochemical	Couet J (1997), Couet J (1997), Khan EM (2006), Feldman R (2009), Hua H (2003), Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Park WY (2000), Abulrob A (2004), Abulrob A (2004)	12
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
UBXN1	0	FAF1	1	affinity chromatography technology	Raman M (2015)	1
UBE2S	2	UBC	7	enzymatic study, pull down, x-ray crystallography, enzymatic study, enzymatic study	Bremm A (2010), Wickliffe KE (2011), Wickliffe KE (2011), Kelly A (2014), Michel MA (2017)	5
RAD23B	1	PSMD1	2	affinity chromatography technology, biochemical, biochemical	Chen L (2006), Havugimana PC (2012), Wan C (2015)	3
NPLOC4	4	UBQLN2	0	biochemical	Kristensen AR (2012)	1
UBXN7	3	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Bandau S (2012), Besten Wd (2012), Besten Wd (2012), Bennett EJ (2010), Besten Wd (2012), Raman M (2015)	8
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
ABL1	9	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, fluorescent resonance energy transfe	Foray N (2002), Foray N (2002), Foray N (2002), Foray N (2002), Foray N (2002), Morell M (2007)	6
BRCC3	0	TP53	0	affinity chromatography technology, affinity chromatography technology, biochemical	Dong Y (2003), Dong Y (2003), Dong Y (2003)	3
RNF11	0	PSMD10	1	affinity chromatography technology	Poulsen SL (2013)	1
HUWE1	22	C1QBP	0	affinity chromatography technology	Thompson JW (2014)	1
RNF11	0	OPTN	1	two hybrid	Colland F (2004)	1
DAZAP2	1	SQSTM1	0	two hybrid	Vinayagam A (2011)	1
PRKN	1	PSMD8	1	affinity chromatography technology	Sarraf SA (2013)	1
AREL1	1	UBE2D3	1	pull down	Kristariyanto YA (2015)	1
RNF168	0	PSMD11	0	affinity chromatography technology	Hein MY (2015)	1
SPRTN	0	PMS2	4	affinity chromatography technology	Mosbech A (2012)	1
USP7	14	RAD18	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Zlatanou A (2016), Zlatanou A (2016), Zlatanou A (2016), Zlatanou A (2016)	4
PSMC3	0	UBXN1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	PSMD10	1	affinity chromatography technology	Higashitsuji H (2005)	1
BIRC3	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
BRCA1	7	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Kang HJ (2006), Kang HJ (2006)	2
HUWE1	22	PSMD12	1	affinity chromatography technology	Thompson JW (2014)	1
ASB2	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Nie L (2011), Nie L (2011)	2
FAF2	4	UBR5	13	affinity chromatography technology	Alexandru G (2008)	1
RAD23A	1	VCP	6	affinity chromatography technology	Laco MN (2012)	1
UBE2N	1	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
EGFR	5	SFPQ	2	affinity chromatography technology	Li J (2013)	1
UBQLN2	0	EPS15	1	affinity chromatography technology	NDiaye EN (2008)	1
UBC	7	TCAF1	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
RNF169	1	HIST2H2AC	1	affinity chromatography technology	Panier S (2012)	1
TOLLIP	3	NBR1	0	affinity chromatography technology	Lu K (2014)	1
USP14	1	PSMD14	3	affinity chromatography technology, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Wan C (2015)	3
UBE2D2	0	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
UBE2D2	0	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Watkins GR (2012), Du H (2014), Schweiger S (2014)	7
PSMC2	2	PSMC3	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
PTEN	24	STUB1	4	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ahmed SF (2012), Ahmed SF (2012), Ahmed SF (2012), Yuan L (2015)	4
AMFR	2	TRIM28	1	affinity chromatography technology	Jo Y (2011)	1
CUL3	17	EEF1B2	1	affinity chromatography technology	Bennett EJ (2010)	1
RNF11	0	USP14	1	affinity chromatography technology	Poulsen SL (2013)	1
RABGEF1	1	OTUD5	2	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	UBC	7	unspecified method, x-ray crystallography, pull down, affinity chromatography technology, x-ray crystallography, pull down	Ernst A (2013), Cook WJ (1994), Chong RA (2014), Bish RA (2007), Michel MA (2015), Michel MA (2015)	6
PINK1	2	PSMC6	0	affinity chromatography technology	Imai Y (2010)	1
RAD23A	1	PSMD14	3	affinity chromatography technology	Scanlon TC (2009)	1
RNF8	2	USP16	0	affinity chromatography technology, affinity chromatography technology	Zhang Z (2014), Zhang Z (2014)	2
CUL2	3	TBC1D15	1	affinity chromatography technology	Bennett EJ (2010)	1
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
TTC3	1	UBE2D2	0	pull down	Suizu F (2009)	1
USP15	4	RBCK1	0	two hybrid	Hayes SD (2012)	1
RBBP8	1	UBC	7	far western blotting, affinity chromatography technology	Murina O (2014), Unno J (2014)	2
PSMC6	0	PSMD4	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
UBC	7	BRAP	0	affinity chromatography technology, two hybrid, pull down, pull down, enzymatic study	Bish RA (2007), Fatima S (2015), Zhang X (2017), Shoji S (2017), Shoji S (2017)	5
TSG101	1	BCR	3	affinity chromatography technology, two hybrid, pull down	Olabisi OO (2006), Olabisi OO (2006), Olabisi OO (2006)	3
BIRC2	1	UBE2N	1	two hybrid	Schimmack G (2017)	1
ATXN3	2	UBC	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, imaging technique, enzymatic study, pull down	Winborn BJ (2008), Mao Y (2005), Berke SJ (2005), Matsumoto M (2005), Bremm A (2010), Nicastro G (2010), Nicastro G (2010), Donaldson KM (2003), Chai Y (2004), Chai Y (2004), Nathan JA (2013), Seki T (2013), Yang H (2014), Yang H (2014), Blount JR (2014), Evers MM (2013), Weeks SD (2011), Donaldson KM (2003), Winborn BJ (2008), Faggiano S (2015), Wauer T (2015), Satoh T (2014), Satoh T (2014), Zhang X (2017), Toonen LJA (2017), Toonen LJA (2017), Kwasna D (2018)	27
USP21	2	TP53	0	enzymatic study	Fernandez-Majada V (2016)	1
UBE2D3	1	NEDD4L	3	pull down, pull down, pull down	Maspero E (2013), Todaro DR (2017), Wang Z (2016)	3
OTUD1	3	RAD23B	1	affinity chromatography technology	Sowa ME (2009)	1
RNF4	1	UBE2N	1	pull down, x-ray crystallography	Branigan E (2015), Branigan E (2015)	2
UBXN1	0	NSFL1C	1	biochemical	Kristensen AR (2012)	1
USP48	3	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
USP5	2	USP13	2	affinity chromatography technology	Sowa ME (2009)	1
PSMC3	0	ATG16L1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP14	1	PSMC6	0	affinity chromatography technology, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Wan C (2015)	3
DCUN1D1	0	KLHL12	4	affinity chromatography technology	Bennett EJ (2010)	1
CDC20	1	ANAPC7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Townsend K (2009), Townsend K (2009), Townsend K (2009), Sedgwick GG (2012), Fogeron ML (2013), Hein JB (2014), Vodermaier HC (2003), Kelly A (2014), Craney A (2016), Craney A (2016), Qiao R (2016), Hein JB (2016)	13
USP21	2	OTUB1	0	enzymatic study	Loch CM (2012)	1
NPM1	0	PSMD1	2	affinity chromatography technology	Chen R (2013)	1
PRKN	1	CDC20	1	affinity chromatography technology, affinity chromatography technology	Lee SB (2015), Lee SB (2015)	2
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
MDM2	2	UCHL1	1	affinity chromatography technology	Li L (2010)	1
CUL3	17	CCT6A	1	affinity chromatography technology	Bennett EJ (2010)	1
HERC2	9	PSMD1	2	affinity chromatography technology	Galligan JT (2015)	1
HUWE1	22	PSMD8	1	affinity chromatography technology	Thompson JW (2014)	1
SMURF1	4	RAD23A	1	enzymatic study	Andrews PS (2010)	1
NEDD4	2	GGA3	6	affinity chromatography technology	Pak Y (2006)	1
IKBKG	0	BTRC	1	affinity chromatography technology	Orel L (2010)	1
HGS	5	UBC	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Mizuno E (2006), Raiborg C (2002), Raiborg C (2002), Nathan JA (2013), Nathan JA (2013), Bishop N (2002), Stuible M (2010), Oved S (2006), Hoeller D (2006), Kharitidi D (2015), Zhang X (2017)	11
CYLD	2	DNAJB2	0	affinity chromatography technology	Elliott PR (2016)	1
PSMC2	2	PSMD4	1	biochemical, biochemical, biochemical, biochemical, pull down, biochemical, affinity chromatography technology	Kim YC (2011), Shim SM (2012), Havugimana PC (2012), Kristensen AR (2012), Berko D (2014), Wan C (2015), Sun S (2017)	7
VCP	6	RNF126	2	affinity chromatography technology	Yu CC (2013)	1
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
SMURF1	4	UBQLN1	1	enzymatic study	Andrews PS (2010)	1
UCHL5	1	PSMD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
ERLIN2	2	HNRNPM	1	affinity chromatography technology	Christianson JC (2012)	1
USP28	3	USP8	7	enzymatic study	Loch CM (2012)	1
UCHL5	1	PSMD14	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Wang X (2007), Jacobson AD (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
XIAP	0	RIPK1	2	pull down	Bertrand MJ (2011)	1
HGS	5	PEF1	0	two hybrid	Rolland T (2014)	1
TP53	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011)	3
PSMD10	1	PSMD12	1	affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Huttlin EL (2017)	3
USP15	4	JOSD1	1	enzymatic study	Loch CM (2012)	1
PSMC6	0	PSMC1	2	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
OTUD7A	6	UBC	7	enzymatic study, pull down	Mevissen TE (2013), Kwasna D (2018)	2
CBLB	3	UBASH3B	4	two hybrid	Rolland T (2014)	1
PLAA	1	VCP	6	x-ray crystallography, affinity chromatography technology, two hybrid	Qiu L (2010), Qiu L (2010), Rolland T (2014)	3
CBL	7	UBE2D3	1	pull down, pull down	Tsukahara F (2010), Sigismund S (2013)	2
PSMC3	0	PSMD1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
RAD23A	1	UBR4	15	affinity chromatography technology	Scanlon TC (2009)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
BAP1	4	PSMC5	4	affinity chromatography technology	Hauri S (2016)	1
CUL4B	8	USP11	3	affinity chromatography technology	Bennett EJ (2010)	1
AUP1	0	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRAP	0	USP4	3	two hybrid, affinity chromatography technology, two hybrid	Hayes SD (2012), Hayes SD (2012), Hayes SD (2012)	3
UFD1	1	NUB1	2	pull down	Liu S (2013)	1
PSMD14	3	HERC2	9	affinity chromatography technology, affinity chromatography technology	Jacobson AD (2014), Jacobson AD (2014)	2
USP1	4	UBE2K	0	enzymatic study	Das DS (2017)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
MDM2	2	SFPQ	2	affinity chromatography technology	Okoro DR (2013)	1
USP4	3	RBBP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wijnhoven P (2015), Wijnhoven P (2015), Liu H (2015), Liu H (2015), Liu H (2015), Liu H (2015)	6
STAM2	0	VCP	6	biochemical	Kristensen AR (2012)	1
CYLD	2	CCT6A	1	affinity chromatography technology	Elliott PR (2016)	1
ATXN3	2	OTUB2	0	affinity chromatography technology	Sowa ME (2009)	1
RNF8	2	UBE2V2	0	pull down	Campbell SJ (2012)	1
PMS2	4	UBC	7	affinity chromatography technology, pull down	Cannavo E (2007), Zhang X (2017)	2
AMFR	2	AUP1	0	affinity chromatography technology	Jo Y (2013)	1
USP21	2	YOD1	0	enzymatic study	Loch CM (2012)	1
PSMD4	1	RBCK1	0	affinity chromatography technology, pull down	Yoshimoto N (2009), Beasley SA (2012)	2
UIMC1	4	USP13	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Li Y (2017), Li Y (2017), Li Y (2017)	3
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
TRAF6	0	POLI	5	two hybrid	Rolland T (2014)	1
SMURF1	4	PSMC5	4	affinity chromatography technology	Wang Y (2012)	1
USP13	2	TCAF1	1	affinity chromatography technology	Sowa ME (2009)	1
PSMD5	0	PSMD10	1	affinity chromatography technology	Huttlin EL (2017)	1
AREL1	1	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
UBXN7	3	JUN	0	affinity chromatography technology	Raman M (2015)	1
C1QBP	0	PRKN	1	affinity chromatography technology, affinity chromatography technology	Li Y (2011), Zanon A (2013)	2
UCHL5	1	PSMD8	1	two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2001), Li T (2001), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	5
PSMC4	6	PSMD4	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
UBXN1	0	FAF2	4	affinity chromatography technology	Raman M (2015)	1
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
TRAF6	0	PSMC1	2	affinity chromatography technology	Bouwmeester T (2004)	1
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
CYLD	2	PSMD1	2	affinity chromatography technology	Elliott PR (2016)	1
DDX58	3	WRNIP1	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Li S (2011), Li S (2011), Tan P (2017), Tan P (2017), Tan P (2017)	5
VCP	6	UBXN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), McNeill H (2004), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), Rolland T (2014), McNeill H (2004), Raman M (2015), Park ES (2017)	11
CYLD	2	NPM1	0	affinity chromatography technology	Elliott PR (2016)	1
RABGEF1	1	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	RNF126	2	two hybrid, two hybrid, pull down	Rual JF (2005), Markson G (2009), Delker RK (2013)	3
HUWE1	22	PSMC4	6	affinity chromatography technology	Thompson JW (2014)	1
UBA6	4	UBE2T	0	pull down	Jin J (2007)	1
UBQLN2	0	PSMC2	2	pull down	Aguileta MA (2015)	1
IKBKE	2	ACLY	3	affinity chromatography technology	Ewing RM (2007)	1
TP53	0	USP1	4	genetic interference	Xie L (2013)	1
SMURF1	4	PSMC4	6	affinity chromatography technology	Xie Y (2013)	1
ABL1	9	USP7	14	enzymatic study, affinity chromatography technology, affinity chromatography technology	Morotti A (2013), Morotti A (2013), Morotti A (2013)	3
PSMC4	6	PSMC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Lee SH (2012), Lee SH (2012), Ohana B (1993), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
PTPN5	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kurup PK (2015), Kurup PK (2015), Kurup PK (2015)	3
STAMBP	2	TP53	0	enzymatic study	Fernandez-Majada V (2016)	1
VCP	6	ERCC6	6	affinity chromatography technology	He J (2016)	1
DAZAP2	1	POLI	5	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
OPTN	1	EPS15	1	two hybrid	Ducharme NA (2007)	1
UBE2D2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBC	7	ZNF451	3	pull down, pull down	Karvonen U (2008), Zhang X (2017)	2
USP15	4	UCHL1	1	enzymatic study	Loch CM (2012)	1
RABEP1	4	RABEP2	0	biochemical	Christoforidis S (2000)	1
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
PTEN	24	SKP1	0	pull down	Verrastro I (2015)	1
HUWE1	22	USP9X	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gomez-Bougie P (2011), Schwickart M (2010), Schwickart M (2010)	3
STAM2	0	TSG101	1	biochemical	Wan C (2015)	1
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
CBLB	3	NCK2	2	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
CUL5	1	PABPC4	2	affinity chromatography technology	Bennett EJ (2010)	1
PRKN	1	PSMC1	2	affinity chromatography technology, pull down	Sarraf SA (2013), Aguileta MA (2015)	2
PRKN	1	NPM1	0	affinity chromatography technology	Zanon A (2013)	1
USP21	2	UCHL1	1	affinity chromatography technology, enzymatic study	Sowa ME (2009), Loch CM (2012)	2
RAD18	3	UBE2B	3	two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, biochemical, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Xin H (2000), Xin H (2000), Tateishi S (2000), Tateishi S (2000), Markson G (2009), Hibbert RG (2011), Inagaki A (2011), Watanabe K (2004), Huang A (2011), Huang A (2011), Huang A (2011), Notenboom V (2007), Notenboom V (2007), Song IY (2010), Tomida J (2008), Masuda Y (2010), Han J (2014), Hong JH (2015), Huttlin EL (2017), Foglizzo M (2016)	20
NEDD8	0	NUB1	2	pull down, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, two hybrid	Kamitani T (2001), Liu G (2010), Liu G (2010), Norman JA (2006), Tanaka T (2003), Tanaka T (2003), Tanji K (2006), Tanji K (2007)	8
USP28	3	ATXN3L	0	enzymatic study	Loch CM (2012)	1
ITCH	1	UBA1	1	affinity chromatography technology	OConnor HF (2015)	1
USP21	2	USP48	3	affinity chromatography technology	Sowa ME (2009)	1
EP300	36	NAP1L1	2	two hybrid	Shikama N (2000)	1
MDM2	2	RNF126	2	two hybrid	Woodsmith J (2012)	1
TP53	0	NUB1	2	affinity chromatography technology, affinity chromatography technology	Liu G (2010), Liu G (2010)	2
PRKN	1	UBE2K	0	pull down	Kazlauskaite A (2014)	1
BAP1	4	PSMD4	1	affinity chromatography technology	Hauri S (2016)	1
EGFR	5	UBE2G2	0	affinity chromatography technology	Tong J (2014)	1
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
ADRM1	4	UBE2N	1	affinity chromatography technology	Boldt K (2016)	1
TRAF2	1	JUN	0	enzymatic study	Park KJ (2003)	1
UBE2K	0	RBCK1	0	two hybrid	Markson G (2009)	1
UBE2K	0	MID1	1	two hybrid	Markson G (2009)	1
NPM1	0	PSMD12	1	affinity chromatography technology	Chen R (2013)	1
PRKN	1	USP30	1	enzymatic study	Gersch M (2017)	1
UCHL5	1	IDE	3	pull down	Fang Y (2011)	1
MDM2	2	USP15	4	pull down	Liu WT (2016)	1
CDC34	3	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, enzymatic study	Choi YS (2010), Choi YS (2010), Sheng Y (2012), Enchev RI (2012), Huang H (2014), Huang H (2014), Huang H (2014), Bish RA (2007), Chong RA (2014), Phillips AH (2013)	10
UBC	7	MINDY1	0	pull down, pull down	Kwasna D (2018), Kristariyanto YA (2017)	2
USP3	1	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fu S (2017), Fu S (2017), Fu S (2017)	3
VCP	6	UBR4	15	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
PSMC5	4	TRAF6	0	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Hauri S (2016)	3
DAZAP2	1	NEDD4L	3	two hybrid	Rolland T (2014)	1
FAN1	2	UBC	7	affinity chromatography technology, pull down, pull down	MacKay C (2010), Shereda RD (2010), Shereda RD (2010)	3
RBCK1	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Tian Y (2007), Tian Y (2007)	2
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
AMFR	2	PSMC2	2	affinity chromatography technology	Christianson JC (2012)	1
UIMC1	4	BRCC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2007), Wang B (2007), Wang B (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Nikkilae J (2009), Wu J (2009), Shao G (2009), Cho HJ (2013)	17
USP14	1	PSMC1	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hein MY (2015)	2
NEDD8	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
RNF11	0	STAM2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Kostaras E (2012), Colland F (2004), Kostaras E (2014), Kostaras E (2012)	4
EGFR	5	BABAM2	2	affinity chromatography technology	Liccardi G (2014)	1
MID1	1	UBC	7	affinity chromatography technology, affinity chromatography technology	Trockenbacher A (2001), Trockenbacher A (2001)	2
PINK1	2	SNCA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Um JW (2009), Um JW (2009), Szargel R (2016), Szargel R (2016)	4
BRCA1	7	USP2	0	two hybrid, two hybrid	Woods NT (2012), Hayes SD (2012)	2
HIF1A	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Luo W (2010), Luo W (2010), Luo W (2010), Luo W (2010)	4
CUL4B	8	TP53	0	affinity chromatography technology	Thirunavukarasou A (2014)	1
UBE2D3	1	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
UBASH3B	4	BCR	3	affinity chromatography technology	Brehme M (2009)	1
RBCK1	0	UBE2D2	0	pull down	Kirisako T (2006)	1
DCUN1D1	0	C1QBP	0	affinity chromatography technology	Bennett EJ (2010)	1
BTRC	1	VCPIP1	4	bioid	Coyaud E (2015)	1
CUL2	3	AGO2	10	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	EPN2	4	pull down, pull down	Fenner BJ (2009), Zhang X (2017)	2
IDE	3	UBC	7	x-ray crystallography, pull down, enzymatic study	Ralat LA (2011), Ralat LA (2011), Ralat LA (2011)	3
ABL1	9	AP2M1	5	affinity chromatography technology	Brehme M (2009)	1
USP19	1	BIRC2	1	affinity chromatography technology	Mei Y (2011)	1
USP15	4	USP8	7	enzymatic study	Loch CM (2012)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
CYLD	2	PSMC2	2	affinity chromatography technology	Elliott PR (2016)	1
BABAM1	1	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hu X (2011), Hu X (2011), Zhang J (2014), Huttlin EL (2015), Yan K (2015), Huttlin EL (2017), Zheng H (2013), Zheng H (2013)	9
BRCA1	7	RNF169	1	affinity chromatography technology	Hill SJ (2014)	1
ZC3H12A	1	HIF1A	1	enzymatic study	Roy A (2013)	1
BIRC2	1	UBXN1	0	affinity chromatography technology, affinity chromatography technology	Wang YB (2015), Wang YB (2015)	2
DAZAP2	1	UBASH3A	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
USP13	2	UFD1	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Chen M (2011)	2
CUL3	17	PSMC4	6	affinity chromatography technology	Bennett EJ (2010)	1
CDKN2A	1	HUWE1	22	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Chio II (2012), Hein MY (2015), Lee CK (2015), Lee CK (2015), Sander B (2017)	9
NPLOC4	4	CD2AP	0	biochemical	Wan C (2015)	1
MID1	1	NPM1	0	affinity chromatography technology	Aranda-Orgilles B (2008)	1
USP2	0	BAP1	4	enzymatic study	Mashtalir N (2014)	1
UBE2D2	0	RNF11	0	two hybrid, two hybrid, pull down, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Colland F (2004), Markson G (2009)	5
TP53	0	PSMD4	1	affinity chromatography technology, pull down	Kulikov R (2010), Sparks A (2014)	2
DNAJB2	0	UBC	7	affinity chromatography technology, pull down, two hybrid	Westhoff B (2005), Fenner BJ (2009), Westhoff B (2005)	3
YOD1	0	UBE3A	4	enzymatic study	Mevissen TE (2013)	1
CUL3	17	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Oshikawa K (2003), Bennett EJ (2010)	2
EGFR	5	STUB1	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Wang T (2014), Wang T (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Chung C (2016), Chung C (2016)	8
TSG101	1	TAX1BP1	3	two hybrid	Rolland T (2014)	1
HUWE1	22	RABEP2	0	biochemical	Kristensen AR (2012)	1
UBXN1	0	UBXN7	3	affinity chromatography technology	Raman M (2015)	1
BRCC3	0	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017)	14
CUL5	1	EEF1B2	1	affinity chromatography technology	Bennett EJ (2010)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2G2	0	MDM2	2	two hybrid	van Wijk SJ (2009)	1
UBXN1	0	UFD1	1	affinity chromatography technology	Alexandru G (2008)	1
AMFR	2	PSMD14	3	affinity chromatography technology	Christianson JC (2012)	1
RNF168	0	UBE2N	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakada S (2010), Stewart GS (2009), Zhang X (2013), Zhao H (2014), Stewart GS (2009)	5
USP15	4	USP11	3	affinity chromatography technology	Sowa ME (2009)	1
PSMC3	0	PSMD11	0	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015)	3
PSMD1	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
BRCA1	7	PSMD7	1	affinity chromatography technology	Ertych N (2016)	1
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
BABAM2	2	BABAM1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	21
HUWE1	22	DDB1	6	affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Yi J (2015)	2
HUWE1	22	CCT3	1	affinity chromatography technology	Thompson JW (2014)	1
RAD23A	1	PSMC4	6	affinity chromatography technology	Scanlon TC (2009)	1
VCP	6	CCT6A	1	affinity chromatography technology	Yu CC (2013)	1
UBE3A	4	PSMD4	1	enzymatic study, biochemical, enzymatic study, enzymatic study, pull down	Uchiki T (2009), Martinez-Noel G (2012), Kim HT (2012), Jacobson AD (2014), Tomaic V (2015)	5
PSMD10	1	PSMD8	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
KLHL12	4	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Rondou P (2008), Rondou P (2008), Angers S (2006), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Rolland T (2014), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	10
BRCA1	7	PSMD12	1	affinity chromatography technology	Ertych N (2016)	1
UBE2D2	0	CUL3	17	pull down	Plafker KS (2009)	1
MDM2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kubo N (2010), Kubo N (2010), Wu H (2015), Wu H (2015)	4
TP53	0	OTUB1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Sun XX (2011), Sun XX (2011), Sun XX (2011), Li Y (2014), Fernandez-Majada V (2016)	5
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
VCP	6	NSFL1C	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, unspecified method, two hybrid, affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Uchiyama K (2003), Uchiyama K (2003), Alexandru G (2008), Alexandru G (2008), Vinayagam A (2011), Madsen L (2011), Fernandez-Saiz V (2010), Noguchi M (2005), Uchiyama K (2002), Uchiyama K (2002), Uchiyama K (2002), Alexandru G (2012), Fogeron ML (2013), Grelle G (2006), Grelle G (2006), Grelle G (2006), Rolland T (2014), Besten Wd (2012), Madsen L (2014), Zhang X (2015), Wan C (2015), Hein MY (2015), Raman M (2015), Raman M (2015), Wang T (2016), Guo X (2017), Park ES (2017), Huttlin EL (2017)	28
RAD23A	1	MYO6	3	biochemical	Wan C (2015)	1
RBCK1	0	RIPK1	2	affinity chromatography technology	Tian Y (2007)	1
RABGEF1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Penengo L (2006), Yao Z (2017)	2
PSMD7	1	PSMC5	4	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
UBXN1	0	KLHL12	4	affinity chromatography technology	Alexandru G (2008)	1
UBC	7	TOM1	3	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Akutsu M (2005), Akutsu M (2005), Nathan JA (2013), Bish RA (2007), Katoh Y (2004), Xiao S (2015), Zhang X (2017)	8
ATXN3	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
UBE2K	0	RNF4	1	two hybrid	Markson G (2009)	1
USP28	3	UCHL1	1	enzymatic study	Loch CM (2012)	1
EGFR	5	UBR4	15	affinity chromatography technology	Tong J (2014)	1
UBC	7	PSMC4	6	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
BIRC3	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
HUWE1	22	MDM2	2	affinity chromatography technology, enzymatic study	Kurokawa M (2013), Kurokawa M (2013)	2
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
UBC	7	BCR	3	affinity chromatography technology, two hybrid	Chen R (2013), Chen R (2013)	2
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
PSMD10	1	PSMC6	0	affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Wan C (2015)	3
PSMD14	3	PSMD8	1	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Jacobson AD (2014), Wan C (2015), Hein MY (2015)	6
USP19	1	UBC	7	enzymatic study, pull down, pull down	Lee JG (2014), Zhang X (2017), Kwasna D (2018)	3
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
CYLD	2	BIRC2	1	affinity chromatography technology	Elliott PR (2016)	1
PSMD10	1	PSMD4	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Andersen KM (2009), Havugimana PC (2012), Wan C (2015)	4
UBA1	1	UBE2K	0	pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Seufert W (1990), Jin J (2007), Whitby FG (1998), Whitby FG (1998), Pickart CM (1994), Huguenin-Dezot N (2016)	6
HDAC6	0	USP7	14	affinity chromatography technology	Joshi P (2013)	1
BIRC3	1	OTUB1	0	affinity chromatography technology	Goncharov T (2013)	1
HUWE1	22	CUL4B	8	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yi J (2015), Yi J (2015), Yi J (2015)	3
STUB1	4	JOSD1	1	enzymatic study	Seki T (2013)	1
UBC	7	CD2AP	0	pull down, x-ray crystallography	Ortega Roldan JL (2013), Ortega Roldan JL (2013)	2
PSMD10	1	HIF1A	1	affinity chromatography technology	Chen J (2015)	1
PRKN	1	CCT3	1	affinity chromatography technology	Zanon A (2013)	1
UBE2G2	0	UBC	7	x-ray crystallography, pull down, pull down	Bocik WE (2011), Bocik WE (2011), Reyes LF (2006)	3
CAV1	0	SNCA	0	pull down	Madeira A (2011)	1
PSMD14	3	PSMD4	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roelofs J (2009), Hendil KB (2009), Havugimana PC (2012), Wang X (2007), Jacobson AD (2014), Wan C (2015), Hein MY (2015), Sun S (2017), Sparks A (2014)	9
POLI	5	POLH	1	two hybrid, far western blotting, two hybrid, far western blotting, affinity chromatography technology	Kannouche P (2003), Kannouche P (2003), McIntyre J (2012), McIntyre J (2012), McIntyre J (2012)	5
RNF11	0	RABGEF1	1	two hybrid	Colland F (2004)	1
BIRC2	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
UBTD2	2	USP5	2	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology	Song AX (2014), Song AX (2014), Song AX (2014), Song AX (2014), Song AX (2014)	5
TRAF6	0	USP10	2	affinity chromatography technology	Wang W (2015)	1
CUL2	3	C1QBP	0	affinity chromatography technology	Bennett EJ (2010)	1
SNCA	0	USP9X	15	affinity chromatography technology, affinity chromatography technology	Rott R (2011), Rott R (2011)	2
NSFL1C	1	CUL2	3	affinity chromatography technology	Alexandru G (2008)	1
TNIP1	1	MAP1LC3A	0	two hybrid	Rolland T (2014)	1
ATXN3	2	RAD23A	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wang G (2000), Wang G (2000), Wang G (2000), Scanlon TC (2009), Lim J (2006), Laco MN (2012), Laco MN (2012), Ferro A (2007), Chen L (2006)	9
UBXN7	3	AMFR	2	affinity chromatography technology	Alexandru G (2008)	1
TRAF6	0	CBLB	3	affinity chromatography technology	Qiao G (2007)	1
RIPK1	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma Q (2008), Ea CK (2006), Kanayama A (2004), Kanayama A (2004)	4
UBXN1	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Wang YB (2015)	2
IKBKG	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Zotti T (2014)	2
CCT6A	1	PSMC2	2	biochemical	Wan C (2015)	1
CUL2	3	CDKN2A	1	affinity chromatography technology	Bennett EJ (2010)	1
PSMC3	0	PSMC1	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
CUL1	7	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	C1QBP	0	affinity chromatography technology	Bennett EJ (2010)	1
ITCH	1	CAV1	0	affinity chromatography technology	Malik R (2012)	1
ERCC6	6	BRCA1	7	affinity chromatography technology, enzymatic study	Wei L (2011), Wei L (2011)	2
PINK1	2	PRKN	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Shiba K (2009), Shiba K (2009), Geisler S (2010), Um JW (2009), Um JW (2009), Xiong H (2009), Xiong H (2009), Xiong H (2009), Kondapalli C (2012), Kondapalli C (2012), Sha D (2010), Sha D (2010), Sha D (2010), Sha D (2010), Lazarou M (2013), Zheng X (2013), Fedorowicz MA (2014), Vives-Bauza C (2010), Shiba-Fukushima K (2014), Bertolin G (2015), Fiesel FC (2015), Kazlauskaite A (2015), Moore DJ (2006), Moore DJ (2006), Zhang T (2016), Klosowiak JL (2016), Gersch M (2017)	27
RNF8	2	HERC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bekker-Jensen S (2010), Bekker-Jensen S (2010), Bekker-Jensen S (2010), Rendtlew Danielsen J (2012), Guerra-Rebollo M (2012), Zhang Z (2014)	6
EP300	36	NPM1	0	enzymatic study	Swaminathan V (2005)	1
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
NPLOC4	4	RAD23B	1	biochemical	Kristensen AR (2012)	1
JUN	0	ABL1	9	affinity chromatography technology, enzymatic study, affinity chromatography technology	Xie M (2010), Chen C (2008), Chen C (2008)	3
RABGEF1	1	UBE2D3	1	pull down	Xu L (2010)	1
USP8	7	SNCA	0	affinity chromatography technology, protein complementation assay, enzymatic study	Alexopoulou Z (2016), Alexopoulou Z (2016), Alexopoulou Z (2016)	3
TRAF6	0	ZRANB1	3	affinity chromatography technology, enzymatic study	Evans PC (2001), Bremm A (2010)	2
TAB3	1	IKBKG	0	pull down, pull down	Kanayama A (2004), Emmerich CH (2013)	2
PSMD4	1	PRKN	1	pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Safadi SS (2010), Uchiki T (2009), Sakata E (2003), Safadi SS (2011), Um JW (2010), Um JW (2010), Kim HT (2012), Beasley SA (2012), Sarraf SA (2013), Sarraf SA (2013)	10
CYLD	2	NAP1L1	2	affinity chromatography technology	Elliott PR (2016)	1
UBE2D3	1	RNF38	4	two hybrid	Markson G (2009)	1
DDB1	6	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Norman JA (2006), Bennett EJ (2010)	3
TOLLIP	3	XIAP	0	affinity chromatography technology	Li S (2011)	1
UBA1	1	CDC34	3	enzymatic study, pull down, enzymatic study, pull down, enzymatic study	Tokgoez Z (2012), Jin J (2007), Chong RA (2014), Chong RA (2014), Wauer T (2015)	5
CISH	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavens D (2007), Piessevaux J (2008), Huttlin EL (2015), Huttlin EL (2017)	4
SH3KBP1	1	ANAPC7	2	affinity chromatography technology	Havrylov S (2009)	1
PSMC1	2	ADRM1	4	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
NSFL1C	1	UFD1	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Wan C (2015), Raman M (2015), Raman M (2015)	4
PTEN	24	HSPD1	0	pull down	Verrastro I (2015)	1
IKBKG	0	RBBP8	1	two hybrid	Wang J (2011)	1
OTUD5	2	UBC	7	pull down, enzymatic study, enzymatic study, pull down, pull down	Kayagaki N (2007), Huang OW (2012), Mevissen TE (2013), Zhang X (2017), Kwasna D (2018)	5
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
PRKN	1	PSMD1	2	affinity chromatography technology	Sarraf SA (2013)	1
CUL5	1	BTRC	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
DNAJB2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRB2	5	TAB2	5	imaging technique	Chen TC (2014)	1
FAF2	4	UBAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Zhang T (2015), Zhang T (2015), Raman M (2015), Olzmann JA (2013), Huttlin EL (2017)	9
UBE3A	4	LCK	0	two hybrid, pull down	Oda H (1999), Oda H (1999)	2
PSMC3	0	ADRM1	4	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
CUL3	17	ACLY	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Zhang C (2016), Zhang C (2016), Zhang C (2016), Zhang C (2016)	5
CUL4B	8	USP7	14	affinity chromatography technology	Bennett EJ (2010)	1
USP28	3	UCHL5	1	enzymatic study	Loch CM (2012)	1
ATXN3	2	RAD23B	1	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Wang G (2000), Wang G (2000), Reina CP (2010), Lim J (2006), Chen L (2006)	5
PELI1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2003), Choi KC (2006), Jensen LE (2003)	4
CUL4A	2	PABPC4	2	affinity chromatography technology	Bennett EJ (2010)	1
MDM2	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Zhang Y (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Clark PA (2002), Clark PA (2002), Clark PA (2002), Pomerantz J (1998), Ivanchuk SM (2008), Wang C (2005), Wang X (2001), Midgley CA (2000), Shen J (2011), Li L (2010), Li L (2010), Li X (2011), Woods YL (2004), Bouska A (2008), Lindstroem MS (2007), Lohrum MA (2000), Wang J (2006), Wang J (2006), Wang J (2006), Drago-Ferrante R (2008), Schuster K (2007), Hogan C (2008), Rizos H (2000), Gargano B (2008), Kamijo T (1998), Wang S (2010), Jones R (2007), Stott FJ (1998), Lo D (2014), Pimkina J (2009), Blattner C (2002), Leslie PL (2015), Bothner B (2003), Ivanov AA (2017)	42
UBE2D3	1	RNF115	1	two hybrid, two hybrid	van Wijk SJ (2009), Rolland T (2014)	2
HUWE1	22	USP15	4	affinity chromatography technology	Thompson JW (2014)	1
EP300	36	HIF1A	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Lando D (2002), Freedman SJ (2002), Lewis MD (2004), Matt T (2004), Sang N (2002), Luo W (2010), Freedman SJ (2003), Bodily JM (2011), Lee YM (2009), Lee YM (2009), Lee YM (2009), Kung AL (2004), Kung AL (2004), Kung AL (2004), Land SC (2007), Zhang Y (2010), Zhang Y (2010), Fath DM (2006), Fath DM (2006), Lee SJ (2013), Wang D (2014), Kaluz S (2006), Kaluz S (2006), Kaluz S (2006), Shin DH (2008), Shin DH (2008), Wang Y (2012), Huang C (2009), Hewitson KS (2002), Cook KM (2009), Cook KM (2009), Hubbi ME (2012), Kim SY (2014), Sang N (2003), Sang N (2003), Sang N (2003), Yasinska IM (2003), Na YR (2013), Na YR (2013), Mendonca DB (2011), Arany Z (1996), Arany Z (1996), Chen R (2012), Li SH (2008), Galbraith MD (2013), Chen Z (2014), Li Q (2012), Geng H (2012), Geng H (2012), Kato H (2004), Lim JH (2010), Kyle HF (2015), Kyle HF (2015), Rath S (2016), Kimura M (2008), Dubey R (2013)	56
VCP	6	MAP1LC3A	0	imaging technique	Wang Y (2011)	1
BCR	3	HSPD1	0	affinity chromatography technology	Wu LX (2006)	1
AMFR	2	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011)	2
UBAC2	1	ERLIN2	2	affinity chromatography technology	Christianson JC (2012)	1
BRCA1	7	HIST2H2AC	1	enzymatic study, enzymatic study	Chen A (2002), Thakar A (2010)	2
IKBKG	0	TNIP1	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Ashida H (2010), Wagner S (2008), Wang J (2011)	3
VCPIP1	4	VCP	6	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Totsukawa G (2011), Totsukawa G (2013), Totsukawa G (2013), Zhang X (2014), Raman M (2015)	6
DAZAP2	1	CALCOCO2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
USP21	2	USP14	1	enzymatic study	Loch CM (2012)	1
BIRC2	1	ADRM1	4	affinity chromatography technology	Blankenship JW (2009)	1
IKBKG	0	USP7	14	affinity chromatography technology, affinity chromatography technology	Daubeuf S (2009), Li T (2014)	2
BRAP	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Takashima O (2013), Takashima O (2013)	2
UBE2B	3	USP9X	15	biochemical	Havugimana PC (2012)	1
UBA1	1	NPLOC4	4	biochemical	Wan C (2015)	1
RAD23A	1	USP25	0	affinity chromatography technology, two hybrid	Scanlon TC (2009), Rolland T (2014)	2
CUL1	7	HSPD1	0	affinity chromatography technology	Oshikawa K (2003)	1
TRIM32	2	UBE2N	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Saccone V (2008), Saccone V (2008), van Wijk SJ (2009), Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Boldt K (2016)	8
USP7	14	USP19	1	affinity chromatography technology	Sowa ME (2009)	1
USP8	7	PTEN	24	affinity chromatography technology, affinity chromatography technology	Zhang J (2013), Zhang J (2013)	2
DCUN1D1	0	UFD1	1	biochemical	Wan C (2015)	1
SPRTN	0	UBC	7	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Machida Y (2012), Machida Y (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Centore RC (2012), Davis EJ (2012)	7
USP7	14	BABAM1	1	affinity chromatography technology	Sowa ME (2009)	1
BIRC2	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down	Hu S (2003), Dynek JN (2010), Hu S (2003)	3
PSMC5	4	PSMD5	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
PSMD10	1	PSMC2	2	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Sun S (2017)	5
PSMC2	2	UBQLN1	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Hochrainer K (2015)	2
UBC	7	TRAFD1	2	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
RNF11	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Shembade N (2009), Colland F (2004)	2
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
UBE2V2	0	UBXN1	0	biochemical	Havugimana PC (2012)	1
UBC	7	NSFL1C	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Fenner BJ (2009), Shibata Y (2012), Alexandru G (2008), Raasi S (2005), Zhang X (2017)	5
RAD23A	1	UBE3A	4	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid	Kumar S (1999), Kumar S (1999), Scanlon TC (2009), Kuehnle S (2013), Kumar S (1997), Mortensen F (2015), Kim HT (2007), Cooper EM (2004), Cooper EM (2004)	9
USP28	3	STAMBP	2	enzymatic study	Loch CM (2012)	1
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
BRCA1	7	BRAP	0	two hybrid, pull down, two hybrid	Li S (1998), Li S (1998), Chen CF (1996)	3
UBR4	15	USP9X	15	biochemical	Havugimana PC (2012)	1
DAZAP2	1	TOLLIP	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
UBC	7	CBLB	3	pull down, pull down, pull down, pull down, enzymatic study	De Schutter J (2009), Fenner BJ (2009), Zhou ZR (2008), Raasi S (2005), Kim M (2004)	5
OTUB1	0	UBE2S	2	enzymatic study	Bremm A (2010)	1
CUL4A	2	OTULIN	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	CCT3	1	affinity chromatography technology	Bennett EJ (2010)	1
TRAF2	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1
TSG101	1	SFPQ	2	affinity chromatography technology	Schlundt A (2009)	1
RNF31	3	WRNIP1	3	affinity chromatography technology	Schaeffer V (2014)	1
UCHL3	1	UBC	7	enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Bremm A (2010), Boudreaux D (2012), Misaghi S (2005), Misaghi S (2005), Wilkinson KD (1999), Wilkinson KD (1999), Phillips AH (2013), Larsen CN (1998), Wada H (1998), Hemelaar J (2004), Altun M (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	17
GGA1	0	RABEP1	4	pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, pull down, two hybrid	Mattera R (2003), Mattera R (2003), Mattera R (2003), Zhu G (2004), Zhai P (2003), Zhu G (2006), Zhu G (2006), Inoue M (2007), Hirst J (2000), Zhu G (2004), Mattera R (2004)	11
UBE3C	5	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Wang M (2006), Wu PY (2003), Michel MA (2015), Kristariyanto YA (2015), Okada M (2015)	5
USP7	14	BABAM2	2	affinity chromatography technology	Sowa ME (2009)	1
OPTN	1	RIPK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nagabhushana A (2011), Zhu G (2007), Zhu G (2007), Klingseisen L (2012), Nakazawa S (2016)	5
GGA1	0	TOLLIP	3	pull down	Katoh Y (2004)	1
RAD23A	1	USP5	2	affinity chromatography technology, biochemical	Scanlon TC (2009), Kristensen AR (2012)	2
CDC20	1	UBR5	13	affinity chromatography technology	Scialpi F (2015)	1
FAF2	4	ERLIN2	2	affinity chromatography technology	Christianson JC (2012)	1
UBC	7	KLHL12	4	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), McGourty CA (2016)	2
UBC	7	BRCC3	0	pull down, enzymatic study, pull down	Wang B (2009), Shao G (2009), Zhang X (2017)	3
AP2M1	5	EPN1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFAIP3	3	NEDD4L	3	affinity chromatography technology	Huttlin EL (2017)	1
UBE2N	1	RNF165	0	two hybrid, pull down	van Wijk SJ (2009), Wright JD (2016)	2
CYLD	2	HSPD1	0	affinity chromatography technology	Elliott PR (2016)	1
PSMC4	6	PSMC5	4	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Hendil KB (2009), Kaneko T (2009), Kaneko T (2009), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Albers M (2005), Albers M (2005), Huttlin EL (2017)	13
RAD23A	1	SQSTM1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Scanlon TC (2009)	3
TNFAIP3	3	ARIH1	3	affinity chromatography technology	Huttlin EL (2017)	1
PTEN	24	USP4	3	affinity chromatography technology	Zhang J (2013)	1
NSFL1C	1	IDE	3	affinity chromatography technology	Raman M (2015)	1
CALCOCO2	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Morriswood B (2007), Morriswood B (2007)	2
PSMC2	2	UBR5	13	biochemical	Wan C (2015)	1
FAF2	4	UBE3A	4	affinity chromatography technology	Alexandru G (2008)	1
SQSTM1	0	UBE2D2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
VCP	6	MDM2	2	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Okoro DR (2013)	2
UIMC1	4	BABAM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Wu J (2009)	14
TBC1D15	1	IDE	3	biochemical	Kristensen AR (2012)	1
VCP	6	RNF8	2	two hybrid	Rolland T (2014)	1
NEDD8	0	HGS	5	pull down	Oved S (2006)	1
USP13	2	ACLY	3	affinity chromatography technology	Han C (2016)	1
AUP1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011), Raman M (2015)	3
PRKN	1	UBE2D3	1	pull down, pull down, pull down	Shin JH (2011), Wenzel DM (2011), Kazlauskaite A (2014)	3
AGO2	10	TNF	0	affinity chromatography technology	El Gazzar M (2011)	1
UCHL3	1	XIAP	0	biochemical	Havugimana PC (2012)	1
CUL2	3	ASB2	1	affinity chromatography technology	Nie L (2011)	1
UBA6	4	USP48	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NEDD8	0	SMURF2	3	pull down, affinity chromatography technology, affinity chromatography technology	He S (2017), He S (2017), He S (2017)	3
PSMC4	6	PSMD5	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
USP15	4	BAP1	4	enzymatic study	Loch CM (2012)	1
PSMD4	1	PSMD8	1	pull down, pull down, affinity chromatography technology, biochemical, biochemical, biochemical	Isasa M (2010), Boehringer J (2012), Boehringer J (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	6
NEDD4	2	SNCA	0	enzymatic study, affinity chromatography technology, enzymatic study	Tofaris GK (2011), Tofaris GK (2011), Sugeno N (2014)	3
TNF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Tokunaga F (2012), Verhelst K (2012), Keusekotten K (2013), Fu J (2013), Schaeffer V (2014), Draber P (2015)	7
IKBKG	0	ZC3H12A	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Niu J (2013), Niu J (2013), Wang W (2015)	3
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
ABRAXAS2	1	PSMC5	4	affinity chromatography technology	Huttlin EL (2017)	1
RNF11	0	HGS	5	affinity chromatography technology	Kostaras E (2012)	1
UBXN7	3	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down	Bandau S (2012), Besten Wd (2012), Kelsall IR (2013)	3
UBC	7	PSMD8	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
UBE2B	3	HIST2H2AC	1	enzymatic study, pull down, enzymatic study	An JY (2010), An JY (2010), Sanders MA (2013)	3
USP13	2	VCP	6	pull down, affinity chromatography technology	Liu Y (2014), Liu Y (2014)	2
TNIP1	1	TNIP3	3	two hybrid	Rolland T (2014)	1
ARRB2	5	CUL3	17	affinity chromatography technology	Skieterska K (2016)	1
NAP1L1	2	NPM1	0	biochemical	Havugimana PC (2012)	1
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
CCDC50	0	RIPK1	2	affinity chromatography technology	Bohgaki M (2008)	1
CUL5	1	PDE12	2	biochemical	Kristensen AR (2012)	1
DAZAP2	1	OTULIN	0	two hybrid	Rolland T (2014)	1
PSMD5	0	PSMD8	1	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
SMURF1	4	UBQLN2	0	enzymatic study	Andrews PS (2010)	1
UCHL5	1	PSMC5	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	5
RAD23A	1	UCHL5	1	affinity chromatography technology	Scanlon TC (2009)	1
PTEN	24	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Freeman DJ (2003), Freeman DJ (2003), Zhou M (2003), Zhou M (2003), Hong SW (2013), Li Y (2008)	6
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
NEDD4	2	CUL1	7	affinity chromatography technology	Liu J (2014)	1
ANKRD13D	4	UBC	7	pull down, pull down	Tanno H (2012), Zhang X (2017)	2
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15
NPM1	0	USP10	2	affinity chromatography technology	Hein MY (2015)	1
BIRC2	1	UBR5	13	affinity chromatography technology	Goncharov T (2013)	1
UBR5	13	UBE2D2	0	pull down, pull down, pull down, enzymatic study, pull down	Maddika S (2009), Honda Y (2002), Cojocaru M (2011), Matta-Camacho E (2012), Zhang W (2016)	5
CUL3	17	HUWE1	22	affinity chromatography technology	Bennett EJ (2010)	1
DDB1	6	UBR5	13	affinity chromatography technology	Maddika S (2009)	1
UIMC1	4	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017), Li Y (2017)	15
UCHL5	1	PSMC2	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	6
PSMC6	0	PSMD8	1	affinity chromatography technology, biochemical, biochemical, biochemical	Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
USP19	1	XIAP	0	affinity chromatography technology, affinity chromatography technology	Mei Y (2011), Mei Y (2011)	2
PSMC1	2	PSMD12	1	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, genetic interference	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Horlbeck MA (2018)	6
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
BRCC3	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Kumaraswamy E (2007), Nikkilae J (2009), Woods NT (2012), Hill SJ (2014), Hu Y (2014)	8
BRCA1	7	PDE12	2	affinity chromatography technology	Ertych N (2016)	1
MID1	1	PSMC1	2	affinity chromatography technology	Gholkar AA (2016)	1
NEDD4L	3	PSMD4	1	enzymatic study	Isasa M (2010)	1
UBE2S	2	USP10	2	biochemical	Havugimana PC (2012)	1
OTULIN	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Keusekotten K (2013), Keusekotten K (2013), Rivkin E (2013), Schaeffer V (2014), Mevissen TE (2013), Wauer T (2015), Kliza K (2017), Kwasna D (2018)	8
CUL3	17	TRIM32	2	affinity chromatography technology	Wimuttisuk W (2014)	1
PSMC1	2	PSMD4	1	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Poulsen EG (2012), Sparks A (2014)	6
HERC2	9	RIPK1	2	affinity chromatography technology	Huttlin EL (2015)	1
IKBKG	0	NSFL1C	1	affinity chromatography technology, affinity chromatography technology	Shibata Y (2012), Medunjanin S (2016)	2
ABL1	9	HSPD1	0	affinity chromatography technology	Wu LX (2006)	1
RNF11	0	UBE2V2	0	affinity chromatography technology	Poulsen SL (2013)	1
BIRC3	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
UBE2B	3	MDM2	2	affinity chromatography technology	Chen S (2012)	1
NPM1	0	PSMD4	1	affinity chromatography technology	Chen R (2013)	1
RNF11	0	DCUN1D1	0	two hybrid	Colland F (2004)	1
YOD1	0	UFD1	1	affinity chromatography technology	Ernst R (2009)	1
PRKN	1	UCHL1	1	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	McKeon JE (2014), McKeon JE (2014), McKeon JE (2014), McKeon JE (2014)	4
USP33	1	UBC	7	enzymatic study, pull down	Shenoy SK (2014), Kwasna D (2018)	2
SKP1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
UBE2D3	1	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Bartke T (2004), Bornstein B (2011), Damgaard RB (2013), Markson G (2009)	7
EGFR	5	ANKRD13B	1	affinity chromatography technology	Tanno H (2012)	1
UBE2D2	0	UBE3A	4	enzymatic study, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down	Anan T (1998), Hatakeyama S (1997), Hatakeyama S (1997), Louria-Hayon I (2009), Jacobson AD (2014), Mortensen F (2015), Rolfe M (1995), Kuslansky Y (2016)	8
USP13	2	CYLD	2	affinity chromatography technology	Sowa ME (2009)	1
NEDD8	0	KLHL12	4	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	TNIP3	3	affinity chromatography technology, two hybrid	Wagner S (2008), Wagner S (2008)	2
UBC	7	ZFAND6	0	pull down, affinity chromatography technology, pull down, pull down	Fenner BJ (2009), Fenner BJ (2009), Nathan JA (2013), Zhang X (2017)	4
NEDD4	2	TOM1L2	0	enzymatic study	Persaud A (2009)	1
FAF2	4	CUL1	7	affinity chromatography technology	Alexandru G (2008)	1
UBXN1	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Bennett EJ (2010)	3
RAD18	3	WRNIP1	3	affinity chromatography technology, affinity chromatography technology	Yoshimura A (2009), Yoshimura A (2009)	2
PSMD10	1	PSMC5	4	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Kaneko T (2009), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	5
UBC	7	AGO2	10	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
UBL7	0	UBQLN2	0	biochemical	Havugimana PC (2012)	1
FAF2	4	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
RNF168	0	HIST2H2AC	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Stewart GS (2009), Stewart GS (2009), Pinato S (2011), Poulsen M (2012), Mattiroli F (2012)	5
CUL1	7	BRAP	0	affinity chromatography technology, affinity chromatography technology	Takashima O (2013), Takashima O (2013)	2
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
TNFAIP3	3	RBCK1	0	affinity chromatography technology, two hybrid	Verhelst K (2012), Hayes SD (2012)	2
CUL4A	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Angers S (2006), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009)	7
EP300	36	UBQLN1	1	two hybrid	Wang J (2011)	1
RNF11	0	PSMD4	1	affinity chromatography technology	Poulsen SL (2013)	1
MDM2	2	PSMC1	2	affinity chromatography technology	Kulikov R (2010)	1
HUWE1	22	CCT6A	1	affinity chromatography technology	Thompson JW (2014)	1
PSMD10	1	PSMC1	2	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
UCHL5	1	ADRM1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, x-ray crystallography, biochemical, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Sowa ME (2009), Hamazaki J (2006), Hamazaki J (2006), Hamazaki J (2006), Hamazaki J (2006), Yao T (2006), Yao T (2006), Yao T (2006), Yao T (2006), Chen X (2010), Qiu XB (2006), Qiu XB (2006), Yao T (2008), Yao T (2008), Kristensen AR (2012), Jiao L (2014), Jiao L (2014), Rolland T (2014), Huttlin EL (2015), Sahtoe DD (2015), Sahtoe DD (2015), Wan C (2015), Yu H (2011), Huttlin EL (2017), Lu X (2017), Lu X (2017), VanderLinden RT (2017)	27
UBR5	13	TNRC6A	6	affinity chromatography technology	Su H (2011)	1
ANKRD13A	1	CAV1	0	affinity chromatography technology, affinity chromatography technology	Burana D (2016), Burana D (2016)	2
USP16	0	HIST2H2AC	1	enzymatic study, enzymatic study	Joo HY (2007), Draker R (2011)	2
CALCOCO2	0	ZNF451	3	two hybrid	Rual JF (2005)	1
EP300	36	TNIP2	1	two hybrid	Wang J (2011)	1
CUL4A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
BIRC2	1	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Goncharov T (2013), Goncharov T (2013), Goncharov T (2013)	3
RABGEF1	1	RBCK1	0	affinity chromatography technology	Huttlin EL (2017)	1
PRKN	1	CALCOCO2	0	affinity chromatography technology	Sarraf SA (2013)	1
MAP1LC3A	0	PINK1	2	affinity chromatography technology, affinity chromatography technology	Kawajiri S (2010), Kawajiri S (2010)	2
CUL5	1	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
PSMD10	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Ren YB (2015), Ren YB (2015)	2
UBE2N	1	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
SPRTN	0	VCPIP1	4	affinity chromatography technology	Ghosal G (2012)	1
SPRTN	0	HUWE1	22	affinity chromatography technology	Kim MS (2013)	1
CUL5	1	VPS36	3	affinity chromatography technology	Bennett EJ (2010)	1
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
PTEN	24	XIAP	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Van Themsche C (2009), Van Themsche C (2009), Van Themsche C (2009), Ahmed SF (2012)	4
PSMC6	0	RAD23B	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
UBE2K	0	RNF114	0	two hybrid	Markson G (2009)	1
EPN1	4	EPS15	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology	Chen H (1998), Chen H (1998), Hoeller D (2006), Ko G (2010), Sugiyama S (2005), Huang JH (2008)	6
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
UBE3C	5	USP13	2	biochemical	Havugimana PC (2012)	1
FAF1	1	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Lee JJ (2013), Raman M (2015), Raman M (2015)	6
VPS36	3	UBC	7	x-ray crystallography, pull down, pull down	Alam SL (2006), Alam SL (2006), Langelier C (2006)	3
USP5	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study	Qian G (2016), Qian G (2016), Andrews PS (2010)	3
OTUB2	0	UBE2N	1	pull down	Nakada S (2010)	1
UBC	7	RABEP1	4	pull down, pull down	Nathan JA (2013), Zhang X (2017)	2
TNF	0	RNF8	2	affinity chromatography technology	Fritsch J (2014)	1
EGFR	5	PSMD1	2	affinity chromatography technology	Tong J (2014)	1
USP11	3	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Zhou Z (2017), Zhou Z (2017), Zhou Z (2017)	4
UBE2N	1	ARIH1	3	affinity chromatography technology	Lim GG (2013)	1
CUL3	17	PSMC1	2	affinity chromatography technology	Bennett EJ (2010)	1
TRAF6	0	PSMC2	2	affinity chromatography technology	Bouwmeester T (2004)	1
YOD1	0	NPLOC4	4	affinity chromatography technology	Ernst R (2009)	1
SH3KBP1	1	PABPC4	2	affinity chromatography technology	Havrylov S (2009)	1
FANCD2	3	POLH	1	affinity chromatography technology, affinity chromatography technology, biochemical	Fu D (2013), Fu D (2013), Fu D (2013)	3
KLHL12	4	CUL1	7	affinity chromatography technology	McGourty CA (2016)	1
ADRM1	4	UBQLN2	0	pull down, x-ray crystallography	Chen X (2016), Chen X (2016)	2
PSMC2	2	ADRM1	4	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
ABL1	9	MDM2	2	affinity chromatography technology, pull down, enzymatic study, unspecified method, enzymatic study	Goldberg Z (2002), Goldberg Z (2002), Goldberg Z (2002), Batuello CN (2015), Batuello CN (2015)	5
VCP	6	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
YOD1	0	AMFR	2	affinity chromatography technology	Bernardi KM (2013)	1
DAZAP2	1	TNIP3	3	two hybrid	Rolland T (2014)	1
PRKN	1	UBE2B	3	pull down	Kazlauskaite A (2014)	1
UBA1	1	UCHL3	1	biochemical	Wan C (2015)	1
IKBKE	2	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
UBA6	4	UBC	7	pull down, enzymatic study, unspecified method, affinity chromatography technology	Gavin JM (2012), Gavin JM (2012), Zhao B (2012), Bish RA (2007)	4
ARRB2	5	AP2M1	5	affinity chromatography technology	Boularan C (2007)	1
IKBKE	2	XIAP	0	enzymatic study	Nakhaei P (2012)	1
TP53	0	MYO6	3	affinity chromatography technology	Horikawa I (2014)	1
UBQLN2	0	RAD23B	1	biochemical	Wan C (2015)	1
CDC20	1	BTRC	1	affinity chromatography technology	Guardavaccaro D (2008)	1
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
ARRB2	5	SFPQ	2	affinity chromatography technology	Xiao K (2007)	1
ARRB2	5	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
NSFL1C	1	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
UBC	7	BABAM1	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
STAM2	0	ITCH	1	pull down, pull down	Malik R (2012), Malik R (2012)	2
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
PSMD4	1	STUB1	4	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, biochemical	Connell P (2001), Scaglione KM (2011), Uchiki T (2009), Kim HT (2012), Connell P (2001), Wan C (2015)	6
NEDD4	2	CUL5	1	affinity chromatography technology	Zhou W (2014)	1
OPTN	1	ATG16L1	1	affinity chromatography technology, pull down	Bansal M (2018), Bansal M (2018)	2
TOLLIP	3	TCAF1	1	affinity chromatography technology	Li S (2011)	1
NPM1	0	VCP	6	affinity chromatography technology	Chen R (2013)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
PSMD7	1	UFD1	1	biochemical	Havugimana PC (2012)	1
USP8	7	STAM	3	pull down, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Kato M (2000), Berlin I (2010), Berlin I (2010), Row PE (2006)	4
USP19	1	HERC2	9	affinity chromatography technology	Sowa ME (2009)	1
USP14	1	PSMC5	4	affinity chromatography technology, affinity chromatography technology, biochemical	Sowa ME (2009), Hamazaki J (2007), Wan C (2015)	3
PRKN	1	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Caulfield TR (2014), Kazlauskaite A (2014)	6
PSMC1	2	RAD23B	1	biochemical	Wan C (2015)	1
WWP2	7	USP15	4	affinity chromatography technology	Chaudhary N (2014)	1
AUP1	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5
EPS15	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	van Delft S (1997), Sigismund S (2005), Bertelsen V (2011), Parachoniak CA (2009), Parachoniak CA (2009), Hoeller D (2006)	6
HIF1A	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down	Ryu JH (2011), Ryu JH (2011), Ryu JH (2011)	3
CD2AP	0	RABEP2	0	biochemical	Kristensen AR (2012)	1
PSMD1	2	PSMC5	4	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Hartmann-Petersen R (2001), Park Y (2005), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	7
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
JUN	0	UBC	7	two hybrid, protein complementation assay	Bandyopadhyay S (2010), Fang D (2004)	2
ITCH	1	USP9X	15	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Mouchantaf R (2006), Mouchantaf R (2006), Azakir BA (2009), OConnor HF (2015)	4
CD2AP	0	CBL	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Haglund K (2004), Kirsch KH (2001), Kirsch KH (2001), Cormont M (2003), Lynch DK (2003), Tibaldi EV (2003), Bao M (2012), Yao B (2007), Selbach M (2006), Taipale M (2014), Taipale M (2014), Igloi Z (2015)	13
PSMC4	6	PSMD14	3	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015)	5
AP2M1	5	BCR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	4
CCT3	1	TRIM28	1	biochemical	Kristensen AR (2012)	1
GGA3	6	TOLLIP	3	pull down	Katoh Y (2004)	1
RNF4	1	UBC	7	enzymatic study, enzymatic study	Groocock LM (2014), Branigan E (2015)	2
UCHL5	1	RBCK1	0	two hybrid	Hayes SD (2012)	1
LCK	0	CISH	1	affinity chromatography technology	Venkitachalam S (2011)	1
PSMC2	2	CCT3	1	biochemical	Wan C (2015)	1
SPRTN	0	UBR5	13	affinity chromatography technology	Kim MS (2013)	1
MID1	1	PSMC2	2	affinity chromatography technology	Gholkar AA (2016)	1
UBE2D3	1	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, two hybrid	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Watkins GR (2012), Du H (2014), Schweiger S (2014), Rolland T (2014)	8
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
USP30	1	UBC	7	enzymatic study, pull down	Wauer T (2015), Kwasna D (2018)	2
CD2AP	0	BRCC3	0	biochemical	Kristensen AR (2012)	1
ABL1	9	HNRNPM	1	affinity chromatography technology	So J (2015)	1
BIRC2	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
RNF11	0	PSMD11	0	affinity chromatography technology	Poulsen SL (2013)	1
TNFAIP3	3	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	De Valck D (1999), De Valck D (1999), Klinkenberg M (2001), Kelly C (2012), Huttlin EL (2017)	5
PSMC2	2	PSMD1	2	affinity chromatography technology, biochemical, biochemical, biochemical, biochemical	Grune T (2011), Thompson D (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
BIRC2	1	UBR4	15	affinity chromatography technology	Goncharov T (2013)	1
CUL3	17	USP9X	15	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	CCDC50	0	affinity chromatography technology, affinity chromatography technology	Tashiro K (2006), Tashiro K (2006)	2
ATXN3	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
EPS15	1	USP8	7	affinity chromatography technology, enzymatic study	Mizuno E (2006), Mizuno E (2006)	2
BIRC3	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1