PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDC73	1	PAF1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rozenblatt-Rosen O (2005), Rozenblatt-Rosen O (2005), Nordick K (2008), Nordick K (2008), Kim J (2010), Mak AB (2010), Mak AB (2010), Takahashi A (2011), Takahashi A (2011), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Herr P (2015), Huttlin EL (2017)	16
IFT122	2	WDR19	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
TULP2	1	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
TSSC4	2	ZNHIT2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	4
BARD1	4	BRIP1	2	unspecified method, affinity chromatography technology	Thanassoulas A (2010), Wu W (2016)	2
TULP2	1	ZNHIT2	0	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	KIF1B	1	unspecified method	Rodriguez M (2003)	1
TULP2	1	CDC73	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	EWSR1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
BRCA1	7	EWSR1	2	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	TUBA4A	1	affinity chromatography technology	Ertych N (2016)	1
TULP2	1	TUBA4A	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	SAV1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CDC73	1	LEO1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Rozenblatt-Rosen O (2005), Rozenblatt-Rosen O (2005), Rozenblatt-Rosen O (2005), Nordick K (2008), Rozenblatt-Rosen O (2009), Mak AB (2010), Mak AB (2010), Takahashi A (2011), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Horlbeck MA (2018)	15
ELAVL1	0	MYO5C	8	affinity chromatography technology	Abdelmohsen K (2009)	1
TULP2	1	BRIP1	2	affinity chromatography technology	Huttlin EL (2017)	1
TULP2	1	KIF1B	1	affinity chromatography technology	Huttlin EL (2017)	1
TULP2	1	LEO1	3	affinity chromatography technology	Huttlin EL (2017)	1
IFT140	4	WDR35	3	affinity chromatography technology	Boldt K (2016)	1
MTUS2	4	TULP2	1	two hybrid	Yu H (2011)	1
TULP2	1	SAV1	0	affinity chromatography technology	Huttlin EL (2017)	1
TULP2	1	TSSC4	2	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	TULP2	1	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
TULP2	1	ESPL1	2	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	IQGAP3	6	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	AMER1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TULP2	1	MOCOS	5	affinity chromatography technology	Huttlin EL (2017)	1
MTUS2	4	CDC73	1	two hybrid	Rolland T (2014)	1
TULP2	1	WDR19	7	affinity chromatography technology	Huttlin EL (2017)	1
IFT140	4	WDR19	7	affinity chromatography technology	Boldt K (2016)	1
IFT122	2	IFT140	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
TULP2	1	ZSWIM8	8	affinity chromatography technology	Huttlin EL (2017)	1
LEO1	3	PAF1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology	Rozenblatt-Rosen O (2005), Nordick K (2008), Nordick K (2008), Nordick K (2008), Kim J (2010), Mak AB (2010), Mak AB (2010), Takahashi A (2011), Havugimana PC (2012), Rolland T (2014), Wan C (2015), Hein MY (2015)	12
TULP2	1	NSMCE4A	0	affinity chromatography technology	Huttlin EL (2017)	1
TULP2	1	PAF1	6	affinity chromatography technology	Huttlin EL (2017)	1
LEO1	3	CTR9	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rozenblatt-Rosen O (2005), Nordick K (2008), Nordick K (2008), Kim J (2010), Mak AB (2010), Mak AB (2010), Ouna BA (2012), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016)	12
SAV1	0	HDAC6	0	bioid	Couzens AL (2013)	1
TULP2	1	IQGAP3	6	affinity chromatography technology	Huttlin EL (2017)	1
MEOX2	2	TULP2	1	two hybrid	Rual JF (2005)	1
TULP2	1	TRIM32	2	affinity chromatography technology	Huttlin EL (2017)	1
TULP2	1	SIK2	2	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Scott GK (2008), Scott GK (2008)	2
BRIP1	2	BRCA1	7	affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Botuyan MV (2004), Botuyan MV (2004), Botuyan MV (2004), Joo WS (2002), Yu X (2003), Yu X (2003), Rodriguez M (2003), Rodriguez M (2003), Clapperton JA (2004), Clapperton JA (2004), Yu X (2003), Kim H (2007), Sobhian B (2007), Suhasini AN (2011), Xie J (2010), Peng M (2007), Peng M (2007), Gupta R (2007), Nelson AC (2010), Nelson AC (2010), Nomine Y (2008), Dohrn L (2012), Drikos I (2009), Tischkowitz M (2008), Campbell SJ (2010), Hill SJ (2014), Wu W (2016), Suhasini AN (2013), Sakasai R (2012), Guo M (2014), Ertych N (2016)	31
TULP2	1	CTR9	10	affinity chromatography technology	Huttlin EL (2017)	1
SIK2	2	TUBA4A	1	affinity chromatography technology	So J (2015)	1
ELAVL1	0	TULP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TULP2	1	MAPK8IP2	5	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	KIF1B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
IFT122	2	WDR35	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
BARD1	4	TULP2	1	two hybrid	Woods NT (2012)	1
ELAVL1	0	BARD1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
HDAC6	0	POLA2	2	two hybrid	Vinayagam A (2011)	1
TULP2	1	IFT140	4	affinity chromatography technology	Huttlin EL (2017)	1
TULP2	1	AMER1	0	affinity chromatography technology	Huttlin EL (2017)	1
WDR19	7	WDR35	3	affinity chromatography technology	Boldt K (2016)	1
BARD1	4	EWSR1	2	affinity chromatography technology, pull down, fluorescent resonance energy transfe, two hybrid	Spahn L (2002), Spahn L (2002), Spahn L (2002), Spahn L (2002)	4
TULP2	1	IFT122	2	affinity chromatography technology	Huttlin EL (2017)	1
CDC73	1	CTR9	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rozenblatt-Rosen O (2005), Rozenblatt-Rosen O (2005), Nordick K (2008), Nordick K (2008), Rozenblatt-Rosen O (2009), Kim J (2010), Mak AB (2010), Mak AB (2010), Ouna BA (2012), Takahashi A (2011), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	17
PAF1	6	CTR9	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Nordick K (2008), Nordick K (2008), Nordick K (2008), Kim J (2010), Kim J (2010), Mak AB (2010), Mak AB (2010), Takahashi A (2011), Havugimana PC (2012), Wan C (2015), Hein MY (2015)	11
TULP2	1	MYO5C	8	affinity chromatography technology	Huttlin EL (2017)	1
TULP2	1	WDR35	3	affinity chromatography technology	Huttlin EL (2017)	1
EWSR1	2	TULP2	1	two hybrid	Rual JF (2005)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
TULP2	1	HDAC6	0	affinity chromatography technology	Huttlin EL (2017)	1