PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAQ	0	TSC2	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Ewing RM (2007), Pozuelo-Rubio M (2010), Meek SE (2004), Pozuelo-Rubio M (2010), Pozuelo-Rubio M (2010)	5
RPS6KA1	3	GSK3B	1	enzymatic study	Larrea MD (2009)	1
P4HA3	3	TSC2	17	affinity chromatography technology	Huttlin EL (2017)	1
UBE3A	4	CALM1	0	affinity chromatography technology, pull down	Jung SY (2005), Kapoor I (2015)	2
TSC2	17	CCNT1	3	genetic interference	Housden BE (2015)	1
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
HECW2	13	GSK3B	1	affinity chromatography technology	Lu L (2013)	1
AKT1	1	FOXO1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Matsuzaki H (2005), Brent MM (2008), Rena G (1999), Tang ED (1999), Chen TC (2014)	5
ESR1	0	FOXO1	2	two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Schuur ER (2001), Schuur ER (2001), Zhao HH (2001), Zhao HH (2001), Castoria G (2012)	5
PIN1	0	SPERT	0	two hybrid	Rolland T (2014)	1
TK1	0	TSC2	17	two hybrid	Vinayagam A (2011)	1
PIN1	0	SMAD3	1	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid	Nakano A (2009), Nakano A (2009), Nakano A (2009), Aragon E (2011), Matsuura I (2010), Matsuura I (2010), Wang J (2011)	7
CDKN1B	1	YWHAE	0	affinity chromatography technology, pull down	Sekimoto T (2004), Sekimoto T (2004)	2
TSC1	4	RPS6KA1	3	affinity chromatography technology	Roux PP (2004)	1
CALM1	0	AKT1	1	pull down, affinity chromatography technology	Shen X (2005), Shen X (2005)	2
TSC2	17	RPS6KA1	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Roux PP (2004), Rolfe M (2005), Roux PP (2004), Roux PP (2004)	4
TSC2	17	PRKAA1	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Inoki K (2003), Inoki K (2003), Shaw RJ (2004), Inoki K (2003)	4
RAP1A	1	TSC2	17	affinity chromatography technology, biochemical	Castro AF (2003), Yamamoto Y (2002)	2
FBXW5	6	TSC1	4	affinity chromatography technology	Hu J (2008)	1
UBE3A	4	YWHAE	0	two hybrid	Vinayagam A (2011)	1
CAV1	0	MAPK1	1	affinity chromatography technology	Hua H (2003)	1
SMAD2	5	TSC2	17	affinity chromatography technology, affinity chromatography technology	Birchenall-Roberts MC (2004), Birchenall-Roberts MC (2004)	2
TBC1D7	1	RRAGA	1	affinity chromatography technology	Cloutier P (2017)	1
PIN1	0	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakano A (2009), Nakano A (2009), Matsuura I (2010), Matsuura I (2010)	4
MDFI	1	PIN1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NTRK1	1	RPS6KA1	3	affinity chromatography technology	Emdal KB (2015)	1
SIRT1	3	RAP1A	1	affinity chromatography technology	Kim JE (2008)	1
RHEB	2	RAP1A	1	affinity chromatography technology	Long X (2005)	1
NTRK1	1	YWHAE	0	affinity chromatography technology	Emdal KB (2015)	1
TSC2	17	TSC2	17	affinity chromatography technology	Cloutier P (2017)	1
YWHAE	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
PLK1	0	TSC2	17	affinity chromatography technology	Astrinidis A (2006)	1
AKT1	1	PTK2	2	imaging technique	Moon HE (2015)	1
SPINT2	0	TSC2	17	affinity chromatography technology	Huttlin EL (2015)	1
GSK3B	1	TSC1	4	affinity chromatography technology	Mak BC (2003)	1
GSK3B	1	AXIN1	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Mak BC (2003), Hino S (2005), Oosterveen T (2007), Kim MJ (2008), Kitagawa M (1999), Cha B (2011), Cha B (2011), Arnold HK (2009), Kashikar ND (2011), Kashikar ND (2011), Zhou F (2012), Yan D (2012), Zhang YG (2012), Sue Ng S (2010), Kim JW (2003), Tang Y (2008), Luo W (2007), Li VS (2012), Rosano L (2009), Yamamoto H (2006), Fei C (2013), Wang J (2011), Varjosalo M (2013), Gao C (2014), Varjosalo M (2013), Castellone MD (2005), Hein MY (2015), Chen TC (2014), Chen Y (2016), Novellasdemunt L (2017)	36
MDFI	1	FBXW5	6	two hybrid	Rual JF (2005)	1
CAV1	0	SMAD2	5	biochemical	Razani B (2001)	1
TSC2	17	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
RRAGC	3	TSC1	4	affinity chromatography technology	Demetriades C (2014)	1
GSK3B	1	UBE3A	4	affinity chromatography technology	Kuslansky Y (2016)	1
PIN1	0	CDKN1B	1	pull down, affinity chromatography technology, unspecified method	Zhou W (2009), Zhou W (2009), Zhou W (2009)	3
YWHAZ	1	CDKN1B	1	pull down	Sekimoto T (2004)	1
CALM1	0	CCND2	2	pull down	Chen BB (2012)	1
CDKN1B	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Fujita N (2002), Rosner M (2007)	2
RIPK4	0	YWHAZ	1	affinity chromatography technology	Rodriguez J (2016)	1
CD79B	0	RIPK4	0	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	GSK3B	1	pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Thimmaiah KN (2005), Drendall CI (2010), Connor MK (2005), Hunter MG (2004), Zhu QS (2011), Li L (2003), Nam SY (2010), Yang WL (2009), Zeng L (2013), Yang H (2005), Boehme KA (2008), Cross DA (1995), Hinton CV (2007), Kapoor GS (2004), Pitre A (2012), Guo J (2016)	16
FOXO1	2	YWHAG	5	affinity chromatography technology, fluorescent resonance energy transfe	Rena G (2001), Ivanov AA (2017)	2
MAPK1	1	TSC2	17	pull down, affinity chromatography technology	Ma L (2005), Ma L (2005)	2
TSC2	17	SPERT	0	two hybrid	Corominas R (2014)	1
RIPK4	0	TSC2	17	affinity chromatography technology	Rodriguez J (2016)	1
CD83	0	TSC2	17	affinity chromatography technology	Huttlin EL (2017)	1
RIPK4	0	YWHAE	0	affinity chromatography technology	Rodriguez J (2016)	1
HECW2	13	TSC2	17	affinity chromatography technology	Lu L (2013)	1
PIN1	0	PLK1	0	affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Shen M (1998), Shen M (1998), Shen M (1998), Lu PJ (1999), Eckerdt F (2005), Eckerdt F (2005)	6
SIRT1	3	TSC2	17	affinity chromatography technology, affinity chromatography technology	Ghosh HS (2010), Ghosh HS (2010)	2
AXIN1	1	TSC1	4	affinity chromatography technology	Mak BC (2003)	1
RPS6KA1	3	CDKN1B	1	enzymatic study, affinity chromatography technology	Larrea MD (2009), Larrea MD (2009)	2
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
TBC1D7	1	WDR92	2	affinity chromatography technology, affinity chromatography technology	Cloutier P (2017), Cloutier P (2017)	2
CCNT1	3	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Wittmann BM (2005), Wittmann BM (2005), Wittmann BM (2005), Wittmann BM (2005)	4
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
PAM	2	TSC1	4	imaging technique	Murthy V (2004)	1
GRB2	2	YWHAZ	1	affinity chromatography technology	Bisson N (2011)	1
TSC2	17	RRAGB	1	affinity chromatography technology	Demetriades C (2014)	1
TSC2	17	HERC1	12	affinity chromatography technology	Chong-Kopera H (2006)	1
YWHAB	1	TSC1	4	affinity chromatography technology, affinity chromatography technology	Nellist M (2002), Jin J (2004)	2
NTRK1	1	YWHAB	1	affinity chromatography technology	Emdal KB (2015)	1
TSC1	4	AKT1	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Roux PP (2004), Dan HC (2002), Ivanov AA (2017)	3
TSC2	17	CALM1	0	far western blotting, pull down, unspecified method, pull down	Noonan DJ (2002), Noonan DJ (2002), Noonan DJ (2002), York B (2005)	4
CIAO1	3	TSC2	17	affinity chromatography technology	Stehling O (2013)	1
NTRK1	1	PTK2	2	affinity chromatography technology	Emdal KB (2015)	1
TSC2	17	RUVBL2	4	affinity chromatography technology	Cloutier P (2017)	1
TSC2	17	AKT1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dan HC (2002), Roux PP (2004), Dan HC (2002), Dan HC (2002)	4
NTRK1	1	TSC2	17	affinity chromatography technology	Emdal KB (2015)	1
TSC2	17	YWHAZ	1	two hybrid, pull down, affinity chromatography technology	Nellist M (2002), Nellist M (2002), Hernandez G (2011)	3
CDKN1B	1	UBE3A	4	affinity chromatography technology, enzymatic study	Mishra A (2009), Mishra A (2009)	2
AXIN1	1	TSC2	17	affinity chromatography technology, affinity chromatography technology	Mak BC (2003), Mak BC (2003)	2
ALDH3A2	1	TSC2	17	affinity chromatography technology	Huttlin EL (2015)	1
RIPK4	0	PNKD	2	affinity chromatography technology	Rodriguez J (2016)	1
PNKD	2	TSC2	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRB2	2	YWHAG	5	affinity chromatography technology	Bisson N (2011)	1
GRB2	2	YWHAB	1	affinity chromatography technology	Bisson N (2011)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
TBC1D7	1	RUVBL2	4	affinity chromatography technology	Cloutier P (2017)	1
NTRK1	1	RUVBL2	4	affinity chromatography technology	Emdal KB (2015)	1
UBE3A	4	YWHAZ	1	two hybrid	Vinayagam A (2011)	1
NTRK1	1	YWHAZ	1	affinity chromatography technology	Emdal KB (2015)	1
AXIN1	1	CAV1	0	affinity chromatography technology	Yamamoto H (2006)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
TIGAR	0	TSC2	17	biochemical	Havugimana PC (2012)	1
RAP1A	1	RAB5A	0	biochemical	Wan C (2015)	1
YWHAB	1	RPS6KA1	3	pull down, affinity chromatography technology	Cavet ME (2003), Cavet ME (2003)	2
RRAGA	1	RRAGC	3	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Sekiguchi T (2001), Sekiguchi T (2001), Gong R (2011), Gong R (2011), Duran A (2011), Li L (2013), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010), Huttlin EL (2015), Deng L (2015), Huttlin EL (2017)	14
RRAGB	1	RRAGD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sekiguchi T (2001), Sancak Y (2008), Han JM (2012), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010)	6
RP2	3	TSC2	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LNX1	7	DAPK1	6	pull down	Wolting CD (2011)	1
CDKN1B	1	TSC2	17	affinity chromatography technology, affinity chromatography technology	Rosner M (2004), Rosner M (2007)	2
TBC1D7	1	TSC1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima A (2007), Nakashima A (2007), Nakashima A (2007), Huttlin EL (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	7
YWHAQ	0	ESR1	0	pull down	Zilliacus J (2001)	1
CCND1	1	TSC2	17	affinity chromatography technology	Zacharek SJ (2005)	1
TBC1D7	1	RRAGC	3	affinity chromatography technology	Cloutier P (2017)	1
TBC1D7	1	TSC2	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima A (2007), Nakashima A (2007), Nakashima A (2007), Huttlin EL (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	7
AKT1	1	CDKN1B	1	enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology	Fujita N (2002), Fujita N (2002), Nacusi LP (2006), Chen TC (2014), Zhang H (2017), Zhang H (2017)	6
NTRK1	1	PLK1	0	affinity chromatography technology	Emdal KB (2015)	1
CDKN1B	1	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Guidoboni M (2005), Vlach J (1996), Vlach J (1997), Tsai CH (2009), Ciarallo S (2002), Bindra RS (2002), Kossatz U (2006), Grimmler M (2007), Rolland T (2014), Hein MY (2015), Barbash O (2009), Huttlin EL (2017)	13
FOXO1	2	SIRT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kitamura YI (2005), Bastien-Dionne PO (2011), Yang Y (2005), Yang Y (2005)	4
CALM1	0	ESR1	0	pull down	Garcia Pedrero JM (2002)	1
ESR1	0	TSC1	4	affinity chromatography technology	York B (2005)	1
TSC1	4	WDR92	2	affinity chromatography technology, affinity chromatography technology	Cloutier P (2017), Cloutier P (2017)	2
YWHAB	1	CDKN1B	1	pull down	Sekimoto T (2004)	1
TSC2	17	RRAGA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Demetriades C (2014), Demetriades C (2014), Deng L (2015)	3
SMAD3	1	FOXO1	2	affinity chromatography technology	Seoane J (2004)	1
SIGLECL1	0	TSC2	17	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	YWHAG	5	affinity chromatography technology	Klein JB (2005)	1
TSC2	17	RRAGD	1	affinity chromatography technology	Demetriades C (2014)	1
NTRK1	1	UBE3A	4	affinity chromatography technology	Emdal KB (2015)	1
YWHAE	0	TSC2	17	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009)	2
GRB2	2	PTK2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid	Sieg DJ (2000), Angers-Loustau A (1999), Hildebrand JD (1996), Messina S (2003), Arold ST (2002), Vinayagam A (2011)	6
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
ESR1	0	RUVBL2	4	affinity chromatography technology	Tarallo R (2011)	1
SMAD2	5	AKT1	1	affinity chromatography technology	Song K (2006)	1
RUVBL2	4	LNX1	7	two hybrid	Rolland T (2014)	1
GSK3B	1	PTK2	2	affinity chromatography technology	Huang D (2002)	1
RIPK4	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
GRB2	2	YWHAE	0	affinity chromatography technology	Bisson N (2011)	1
AXIN1	1	PIN1	0	affinity chromatography technology	Arnold HK (2009)	1
RALA	1	TSC2	17	affinity chromatography technology	Castro AF (2003)	1
LNX1	7	TSC2	17	two hybrid	Guo Z (2012)	1
TSC2	17	CAV1	0	biochemical	Yamamoto Y (2002)	1
RAP1A	1	NTRK1	1	affinity chromatography technology	Wu C (2001)	1
TSC2	17	YWHAB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Y (2003), Shumway SD (2003), Li Y (2002), Nellist M (2002), Shumway SD (2003), Li Y (2002), Cai SL (2006), Nellist M (2002), Jin J (2004), Couzens AL (2013), Li Y (2003)	11
CIAO1	3	TSC1	4	affinity chromatography technology	Stehling O (2013)	1
TSC1	4	PLK1	0	affinity chromatography technology, affinity chromatography technology	Astrinidis A (2006), Astrinidis A (2006)	2
SMAD3	1	TSC2	17	affinity chromatography technology, affinity chromatography technology, pull down	Birchenall-Roberts MC (2004), Birchenall-Roberts MC (2004), Birchenall-Roberts MC (2004)	3
TSC1	4	RHEB	2	enzymatic study	Garami A (2003)	1
SMAD3	1	CDK11A	1	affinity chromatography technology	Brown KA (2008)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
CCND1	1	ESR1	0	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Zwijsen RM (1997), Zwijsen RM (1997), Zwijsen RM (1997), Wang C (2005), Wang C (2005)	5
NTRK1	1	CCNT1	3	affinity chromatography technology	Emdal KB (2015)	1
UBE3A	4	YWHAG	5	pull down	Thatte J (2017)	1
NTRK1	1	YWHAG	5	affinity chromatography technology	Emdal KB (2015)	1
NEK1	6	TSC2	17	two hybrid	Surpili MJ (2003)	1
CALM1	0	RALA	1	pull down, two hybrid, pull down	Clough RR (2002), Clough RR (2002), Sidhu RS (2005)	3
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
CAV1	0	NTRK1	1	affinity chromatography technology	Bilderback TR (1999)	1
TSC1	4	RUVBL2	4	affinity chromatography technology	Cloutier P (2017)	1
CCND3	1	TSC2	17	affinity chromatography technology	Zacharek SJ (2005)	1
GSK3B	1	FOXO1	2	imaging technique	Chen TC (2014)	1
DAPK1	6	TSC2	17	affinity chromatography technology	Lin Y (2011)	1
PRKAA1	2	YWHAE	0	affinity chromatography technology	Al-Hakim AK (2005)	1
FAM221B	0	TSC2	17	affinity chromatography technology	Huttlin EL (2017)	1
CCND2	2	CDKN1B	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
YWHAQ	0	RUVBL2	4	pull down	Meek SE (2004)	1
RHEB	2	TSC2	17	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Castro AF (2003), Inoki K (2003), Garami A (2003), Zhang Y (2003), Cao Y (2006), Castro AF (2003), Long X (2005), Long X (2005)	8
RUVBL2	4	WDR92	2	affinity chromatography technology, affinity chromatography technology	Cloutier P (2017), Cloutier P (2017)	2
FOXO1	2	YWHAQ	0	affinity chromatography technology	Pramanik KC (2014)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
DAPK1	6	MAPK1	1	two hybrid, pull down, affinity chromatography technology, enzymatic study	Chen CH (2005), Chen CH (2005), Chen CH (2005), Chen CH (2005)	4
TSC2	17	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mak BC (2003), Inoki K (2006), Mak BC (2003)	3
TSC2	17	PAM	2	two hybrid, affinity chromatography technology, imaging technique	Murthy V (2004), Murthy V (2004), Murthy V (2004)	3
AKT1	1	YWHAE	0	affinity chromatography technology	Klein JB (2005)	1
NTRK1	1	RNGTT	0	affinity chromatography technology	Emdal KB (2015)	1
ESR1	0	PRKCSH	2	pull down	Nalvarte I (2010)	1
PTK2	2	TSC1	4	affinity chromatography technology	Gan B (2006)	1
TSC1	4	DAPK1	6	affinity chromatography technology	Lin Y (2011)	1
YWHAG	5	TSC1	4	affinity chromatography technology	Jin J (2004)	1
CALM1	0	PAM	2	pull down	Shen X (2005)	1
UBE3A	4	TSC2	17	pull down, affinity chromatography technology, pull down	Lu Z (2004), Zheng L (2008), Zheng L (2008)	3
TSC2	17	YWHAG	5	affinity chromatography technology	Cloutier P (2017)	1
TSC2	17	RAB5A	0	biochemical	Yamamoto Y (2002)	1
SIRT1	3	ESR1	0	affinity chromatography technology	Elangovan S (2011)	1
YWHAE	0	RUVBL2	4	affinity chromatography technology, affinity chromatography technology	Zuo S (2010), Zuo S (2010)	2
PIN1	0	CDK11A	1	pull down	Ingham RJ (2005)	1
RIPK4	0	YWHAQ	0	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	YWHAQ	0	affinity chromatography technology	Emdal KB (2015)	1
ESR1	0	UBE3A	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li L (2006), Sun J (2012), Dhananjayan SC (2006)	3
WDR92	2	TSC2	17	affinity chromatography technology	Cloutier P (2017)	1
TSC2	17	TSC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dan HC (2002), Hodges AK (2001), Aicher LD (2001), van Slegtenhorst M (1998), Nellist M (2002), Li Y (2004), Mak BC (2003), van Slegtenhorst M (1998), van Slegtenhorst M (1998), Ma L (2005), Cai SL (2006), Cao Y (2006), Ma L (2005), Inoki K (2003), Nellist M (2005), Goncharova EA (2006), Astrinidis A (2006), Cao Y (2006), Astrinidis A (2003), Hodges AK (2001), Hodges AK (2001), Nellist M (2001), Aicher LD (2001), Murthy V (2000), van Slegtenhorst M (1998), Dan HC (2002), Miloloza A (2000), Nakashima A (2007), Nakashima A (2007), Benvenuto G (2000), Chong-Kopera H (2006), York B (2005), Vega-Rubin-de-Celis S (2010), Vega-Rubin-de-Celis S (2010), Lin Y (2011), Cloutier P (2017), Cloutier P (2017)	37
RRAGB	1	RRAGC	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sekiguchi T (2001), Duran A (2011), Han JM (2012), Oshiro N (2014), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010), Wang S (2015)	8
TSC1	4	YWHAZ	1	two hybrid	Nellist M (2002)	1
TSC2	17	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Finlay GA (2004), Finlay GA (2004), Finlay GA (2004), York B (2005)	4
MAPK1	1	CCND1	1	affinity chromatography technology	Okabe H (2007)	1
TSC2	17	RNGTT	0	genetic interference	Housden BE (2015)	1
CCND2	2	TSC2	17	affinity chromatography technology	Zacharek SJ (2005)	1
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
NTRK1	1	RALA	1	affinity chromatography technology	Emdal KB (2015)	1
YWHAQ	0	DAPK1	6	affinity chromatography technology	Henshall DC (2003)	1
TSC2	17	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Demetriades C (2014), Demetriades C (2014)	2
RRAGD	1	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Oshiro N (2014), Oshiro N (2014)	2
NTRK1	1	PRKCSH	2	affinity chromatography technology	Emdal KB (2015)	1
FBXW5	6	TSC2	17	affinity chromatography technology, affinity chromatography technology	Hu J (2008), Ha JY (2013)	2
YWHAE	0	TSC1	4	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009)	2
POU5F1	0	TSC2	17	affinity chromatography technology	Oliviero G (2015)	1
MAPK1	1	GSK3B	1	affinity chromatography technology, pull down, enzymatic study	Ding Q (2005), Ding Q (2005), Ding Q (2005)	3
SIRT1	3	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sundaresan NR (2011), Sundaresan NR (2011), Sundaresan NR (2011)	3
GSK3B	1	CCND1	1	imaging technique	Chen TC (2014)	1
TSC2	17	FOXO1	2	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Cao Y (2006), Cao Y (2006), Cao Y (2006), Cao Y (2006)	4
GRB2	2	TSC2	17	two hybrid	Wang J (2008)	1
ESR1	0	CAV1	0	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Schlegel A (2001), Schlegel A (2001), Ramirez CM (2009), Watson CS (2012)	4
RRAGB	1	YWHAB	1	biochemical	Kristensen AR (2012)	1
GRB2	2	YWHAQ	0	affinity chromatography technology	Bisson N (2011)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
AKT1	1	YWHAZ	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Powell DW (2002), Powell DW (2002), Powell DW (2002), Klein JB (2005)	4
RPS6KA1	3	MAPK1	1	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Roux PP (2003), Eblen ST (2003), Smith JA (1999), Ding Q (2005), Varjosalo M (2013), Jahrling JB (2014), Smith JA (2000)	7
RRAGA	1	RRAGD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sekiguchi T (2001), Sekiguchi T (2001), Huttlin EL (2015), Huttlin EL (2017)	4
CD79B	0	TSC2	17	affinity chromatography technology	Huttlin EL (2017)	1
TSC2	17	MDFI	1	two hybrid	Corominas R (2014)	1
ESR1	0	MAPK1	1	pull down, enzymatic study	Metivier R (2002), Tremblay A (2001)	2
YWHAE	0	CALM1	0	two hybrid, pull down	Luk SC (1999), Luk SC (1999)	2
GRB2	2	LNX1	7	two hybrid	Rolland T (2014)	1
P4HA2	3	TSC2	17	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KA1	3	ESR1	0	enzymatic study	Joel PB (1998)	1
GSK3B	1	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology	Guo X (2008), Guo X (2008), Choi SI (2011)	3
MAPK1	1	SMAD3	1	enzymatic study, affinity chromatography technology	Alarcon C (2009), Brown KA (2008)	2
CCND3	1	CDKN1B	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Lin J (2001), Lin J (2001), Zhang Q (1999), Barnouin K (1999), Barnouin K (1999), Datta NS (1998), Vlach J (1996), Bockstaele L (2006), Bockstaele L (2006), Waaijers S (2013), Waaijers S (2013), Huttlin EL (2015), Huttlin EL (2017)	14
FOXO1	2	YWHAZ	1	affinity chromatography technology, fluorescent resonance energy transfe	Rena G (2001), Ivanov AA (2017)	2
RRAGA	1	TSC1	4	affinity chromatography technology	Demetriades C (2014)	1
NTRK1	1	MAPK1	1	affinity chromatography technology	Emdal KB (2015)	1
TSC2	17	CDK11A	1	genetic interference	Housden BE (2015)	1
CDKN1B	1	GRB2	2	pull down, biochemical	Sugiyama Y (2001), Sugiyama Y (2001)	2
CALM1	0	DAPK1	6	affinity chromatography technology, x-ray crystallography, pull down	Henshall DC (2004), de Diego I (2010), de Diego I (2010)	3
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
PRKAA1	2	YWHAZ	1	affinity chromatography technology	Al-Hakim AK (2005)	1
PRKCSH	2	TSC2	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCND2	2	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN1B	1	TSC1	4	affinity chromatography technology	Rosner M (2004)	1
PIN1	0	TSC2	17	two hybrid	Vinayagam A (2011)	1
TSC2	17	PTK2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Gan B (2006), Gan B (2006), Gan B (2006), Gan B (2006)	4
SMAD3	1	AKT1	1	affinity chromatography technology, imaging technique	Song K (2006), Chen TC (2014)	2
YWHAQ	0	CALM1	0	affinity chromatography technology, pull down, biochemical	Pozuelo-Rubio M (2010), Meek SE (2004), Pozuelo-Rubio M (2010)	3
COL20A1	7	TSC2	17	affinity chromatography technology	Huttlin EL (2017)	1
ESR1	0	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Matsuda T (2001), Ito I (2010), Ito I (2010), Ito I (2010)	4
NTRK1	1	PRKAA1	2	affinity chromatography technology	Emdal KB (2015)	1
SMAD3	1	ESR1	0	affinity chromatography technology	Ito I (2010)	1
CCND2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1