PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MYC	2	RUVBL1	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Fuchs M (2001), Park J (2002), Park J (2002), Koch HB (2007)	4
RPS6KA1	3	GSK3B	1	enzymatic study	Larrea MD (2009)	1
VHL	0	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid	Lai Y (2011), Lai Y (2011), Duan DR (1995), Minervini G (2015)	4
MYC	2	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Gregory MA (2003), Gregory MA (2003), Arnold HK (2009), Zhou Z (2014)	4
AURKA	1	RASSF1	3	enzymatic study, fluorescent resonance energy transfe	Chow C (2011), Ivanov AA (2017)	2
MAP2K5	1	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNE1	1	CDKN1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Shanahan F (1999), Connor MK (2003), Connor MK (2003), Jeon Y (2007), Bustany S (2011), Xu X (1999), Xu X (1999), Datta NS (1998), Orend G (1998), Liu J (1997), Sheaff RJ (1997), Sheaff RJ (1997), Bresnahan WA (1996), Vlach J (1996), Vlach J (1997), Ciarallo S (2002), Ciarallo S (2002), Ciarallo S (2002), Chu I (2007), Chu I (2007), Chen J (1996), Levkau B (1998), Larrea MD (2009), Grimmler M (2007), Chen TC (2014), Qiu H (2016)	26
AURKA	1	LATS2	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, fluorescent resonance energy transfe	Yabuta N (2011), Toji S (2004), Toji S (2004), Toji S (2004), Toji S (2004), Ivanov AA (2017)	6
AURKA	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kwon YW (2012), Chou CH (2013), Chou CH (2013)	3
TSC1	4	NEFL	1	two hybrid, affinity chromatography technology	Haddad LA (2002), Haddad LA (2002)	2
CDKN1B	1	YWHAE	0	affinity chromatography technology, pull down	Sekimoto T (2004), Sekimoto T (2004)	2
TSC1	4	RPS6KA1	3	affinity chromatography technology	Roux PP (2004)	1
TSC2	17	RPS6KA1	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Roux PP (2004), Rolfe M (2005), Roux PP (2004), Roux PP (2004)	4
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
BECN1	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RASSF1	3	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Kehn K (2004), Kehn K (2004), Sweeney KJ (1997), Huttlin EL (2015), Huttlin EL (2017), Denicourt C (2008), Ivanov AA (2017)	8
HSH2D	1	TSC1	4	two hybrid	Grossmann A (2015)	1
RUVBL1	2	URI1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Izumi N (2010), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017), Mita P (2016)	5
MOV10	6	DOCK7	3	affinity chromatography technology	Castello A (2012)	1
MYC	2	RIN3	2	affinity chromatography technology	Agrawal P (2010)	1
TBC1D7	1	CPVL	0	affinity chromatography technology	Cloutier P (2017)	1
FBXW5	6	TSC1	4	affinity chromatography technology	Hu J (2008)	1
MYC	2	KAT2A	1	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	McMahon SB (2000), Faiola F (2005), Liu X (2008), Conacci-Sorrell M (2010), Liu X (2003), Liu X (2003), Ivanov AA (2017)	7
TBC1D7	1	DYRK1A	36	affinity chromatography technology	Cloutier P (2017)	1
TSC1	4	CPVL	0	affinity chromatography technology	Cloutier P (2017)	1
TBC1D7	1	RRAGA	1	affinity chromatography technology	Cloutier P (2017)	1
NF2	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K5	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LATS2	1	DYRK1A	36	enzymatic study	Tschoep K (2011)	1
EZR	8	NF2	1	far western blotting, affinity chromatography technology, pull down	Groenholm M (1999), Groenholm M (1999), Tang X (2007)	3
LATS2	1	RASSF1	3	fluorescent resonance energy transfe, pull down, fluorescent resonance energy transfe	Mo XL (2015), Mo XL (2015), Ivanov AA (2017)	3
TSC1	4	PIH1D1	0	affinity chromatography technology	Cloutier P (2017)	1
MAPK14	0	TSC1	4	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Pilot-Storck F (2010), Pilot-Storck F (2010), Ivanov AA (2017)	3
BECN1	2	KAT2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAE	0	MAPK14	0	biochemical	Wan C (2015)	1
TSC1	4	EZR	8	affinity chromatography technology	Lamb RF (2000)	1
CDK4	2	MYC	2	enzymatic study, two hybrid, fluorescent resonance energy transfe	Anders L (2011), Wang J (2011), Ivanov AA (2017)	3
CCND2	2	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K5	1	BECN1	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AURKA	1	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
PLK1	0	TSC2	17	affinity chromatography technology	Astrinidis A (2006)	1
FGFR4	6	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARAF	0	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AKT1	1	PTK2	2	imaging technique	Moon HE (2015)	1
RASSF1	3	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MOV10	6	TSC1	4	affinity chromatography technology	Castello A (2012)	1
GSK3B	1	TSC1	4	affinity chromatography technology	Mak BC (2003)	1
NXF1	0	KDM5C	9	affinity chromatography technology	Castello A (2012)	1
AURKA	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARAF	0	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARAF	0	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GSK3B	1	AXIN1	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Mak BC (2003), Hino S (2005), Oosterveen T (2007), Kim MJ (2008), Kitagawa M (1999), Cha B (2011), Cha B (2011), Arnold HK (2009), Kashikar ND (2011), Kashikar ND (2011), Zhou F (2012), Yan D (2012), Zhang YG (2012), Sue Ng S (2010), Kim JW (2003), Tang Y (2008), Luo W (2007), Li VS (2012), Rosano L (2009), Yamamoto H (2006), Fei C (2013), Wang J (2011), Varjosalo M (2013), Gao C (2014), Varjosalo M (2013), Castellone MD (2005), Hein MY (2015), Chen TC (2014), Chen Y (2016), Novellasdemunt L (2017)	36
ARAF	0	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RRAGC	3	TSC1	4	affinity chromatography technology	Demetriades C (2014)	1
NXF1	0	DOCK7	3	affinity chromatography technology	Castello A (2012)	1
TSC1	4	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	CDKN2A	1	affinity chromatography technology, unspecified method, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Fahraeus R (1996), Li J (2004), Sugimoto M (1999), Serrano M (1993), Serrano M (1993), Serrano M (1993), Coleman KG (1997), Zhang Y (1998), Haddad MM (1999), Li J (2002), Li J (2002), Lal G (2000), Yarbrough WG (1999), Della Torre G (2001), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Fei HJ (2017), Huttlin EL (2017), Ivanov AA (2017)	25
CDKN2A	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Herkert B (2010), Amente S (2007), Zhang Q (2013), Ivanov AA (2017)	4
YWHAZ	1	CDKN1B	1	pull down	Sekimoto T (2004)	1
CDK6	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AURKA	1	EZR	8	biochemical	Wan C (2015)	1
RPAP3	1	WDR92	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Cloutier P (2009), Itsuki Y (2008), Itsuki Y (2008), Taipale M (2014), Taipale M (2014), Wan C (2015), Cloutier P (2017), Cloutier P (2017)	8
NXF1	0	RUVBL1	2	affinity chromatography technology	Castello A (2012)	1
TSC1	4	PCM1	5	affinity chromatography technology	Cloutier P (2017)	1
ARAF	0	MAP2K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RASSF1	3	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAG	5	ARAF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Jin J (2004), So J (2015), Ivanov AA (2017)	4
AKT1	1	GSK3B	1	pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Thimmaiah KN (2005), Drendall CI (2010), Connor MK (2005), Hunter MG (2004), Zhu QS (2011), Li L (2003), Nam SY (2010), Yang WL (2009), Zeng L (2013), Yang H (2005), Boehme KA (2008), Cross DA (1995), Hinton CV (2007), Kapoor GS (2004), Pitre A (2012), Guo J (2016)	16
SOX4	5	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARAF	0	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Choudhary C (2009), So J (2015)	4
YWHAB	1	PPM1H	3	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), St-Denis N (2016)	2
CDK1	0	TSC1	4	pull down	Astrinidis A (2003)	1
CDKN2B	0	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
KAT2A	1	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNE1	1	CDK4	2	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
LATS2	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FGFR4	6	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AXIN1	1	TSC1	4	affinity chromatography technology	Mak BC (2003)	1
CDKN1B	1	CDK6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Radu M (2008), Bockstaele L (2006), Chen TC (2014), Carrasco-Garcia E (2011), Huttlin EL (2017)	6
RPS6KA1	3	CDKN1B	1	enzymatic study, affinity chromatography technology	Larrea MD (2009), Larrea MD (2009)	2
AKT1	1	ACTA1	1	affinity chromatography technology, affinity chromatography technology	Foster KS (2006), Kim JH (2013)	2
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
TBC1D7	1	WDR92	2	affinity chromatography technology, affinity chromatography technology	Cloutier P (2017), Cloutier P (2017)	2
ESR1	0	TOP1	1	affinity chromatography technology	Tarallo R (2011)	1
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
RASSF1	3	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K5	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PAM	2	TSC1	4	imaging technique	Murthy V (2004)	1
AKT1	1	MAPK14	0	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Rane MJ (2001), Rane MJ (2001), Hartman AD (2006), Rane MJ (2001), Rane MJ (2001), Ivanov AA (2017)	6
NF2	1	KAT2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GSK3B	1	CCNE1	1	enzymatic study, imaging technique	Welcker M (2003), Chen TC (2014)	2
TSC1	4	ACTA1	1	imaging technique	Lamb RF (2000)	1
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
BECN1	2	TBC1D7	1	affinity chromatography technology	Behrends C (2010)	1
TSC1	4	DYRK1A	36	affinity chromatography technology	Cloutier P (2017)	1
TBC1D7	1	URI1	2	affinity chromatography technology	Cloutier P (2017)	1
TSC1	4	KDM1A	2	two hybrid	Weimann M (2013)	1
YWHAB	1	TSC1	4	affinity chromatography technology, affinity chromatography technology	Nellist M (2002), Jin J (2004)	2
CDKN2A	1	BECN1	2	pull down, fluorescent resonance energy transfe	Pimkina J (2009), Ivanov AA (2017)	2
NF2	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC1	4	AKT1	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Roux PP (2004), Dan HC (2002), Ivanov AA (2017)	3
CIAO1	3	TSC2	17	affinity chromatography technology	Stehling O (2013)	1
ARAF	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC2	17	RUVBL2	4	affinity chromatography technology	Cloutier P (2017)	1
CDKN2A	1	CCND2	2	pull down, pull down, fluorescent resonance energy transfe	Li J (2004), Li J (2002), Ivanov AA (2017)	3
TSC2	17	AKT1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dan HC (2002), Roux PP (2004), Dan HC (2002), Dan HC (2002)	4
TSC1	4	PRMT6	2	two hybrid	Weimann M (2013)	1
YWHAZ	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC2	17	YWHAZ	1	two hybrid, pull down, affinity chromatography technology	Nellist M (2002), Nellist M (2002), Hernandez G (2011)	3
CDK6	0	MYC	2	enzymatic study, fluorescent resonance energy transfe	Anders L (2011), Ivanov AA (2017)	2
RPAP3	1	RUVBL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cloutier P (2009), Izumi N (2010), Taipale M (2014), Taipale M (2014), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	7
AXIN1	1	TSC2	17	affinity chromatography technology, affinity chromatography technology	Mak BC (2003), Mak BC (2003)	2
NXF1	0	MAP2K5	1	affinity chromatography technology	Castello A (2012)	1
CDKN2A	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RASSF1	3	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NXF1	0	RUVBL2	4	affinity chromatography technology	Castello A (2012)	1
KDM5C	9	TSC1	4	genetic interference	Shen JP (2017)	1
TSC1	4	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PIH1D1	0	URI1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Cloutier P (2017), Mita P (2016)	4
APPL2	4	TSC1	4	two hybrid	Grossmann A (2015)	1
URI1	2	YWHAB	1	affinity chromatography technology	Mita P (2016)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
TBC1D7	1	RUVBL2	4	affinity chromatography technology	Cloutier P (2017)	1
MAPK14	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MSN	0	TSC1	4	two hybrid	Haddad LA (2002)	1
CDKN2A	1	IKBKB	1	affinity chromatography technology	Guo Y (2010)	1
BECN1	2	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ESR1	0	RUVBL1	2	affinity chromatography technology	Tarallo R (2011)	1
BECN1	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	RUVBL2	4	pull down	Souza-Rodrigues E (2007)	1
RASSF1	3	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LATS2	1	CPVL	0	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
MAP2K5	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	RUVBL2	4	biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Park J (2002), Li W (2010), Koch HB (2007), Liu X (2003)	4
YWHAB	1	RPS6KA1	3	pull down, affinity chromatography technology	Cavet ME (2003), Cavet ME (2003)	2
RRAGA	1	RRAGC	3	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Sekiguchi T (2001), Sekiguchi T (2001), Gong R (2011), Gong R (2011), Duran A (2011), Li L (2013), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010), Huttlin EL (2015), Deng L (2015), Huttlin EL (2017)	14
RPAP3	1	PIH1D1	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cloutier P (2009), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Inoue M (2010), Wan C (2015), Mir RA (2016), Huttlin EL (2017), Bizarro J (2014), Cloutier P (2017)	12
MAP2K5	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MOV10	6	PPM1H	3	affinity chromatography technology	Castello A (2012)	1
NXF1	0	PIH1D1	0	affinity chromatography technology	Castello A (2012)	1
NXF1	0	TSC1	4	affinity chromatography technology	Castello A (2012)	1
MYC	2	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NEFL	1	PRMT6	2	two hybrid	Weimann M (2013)	1
CDKN1B	1	TSC2	17	affinity chromatography technology, affinity chromatography technology	Rosner M (2004), Rosner M (2007)	2
PCM1	5	PLK1	0	bioid	Gupta GD (2015)	1
WDR92	2	RUVBL1	2	affinity chromatography technology	Cloutier P (2017)	1
PLK1	0	IKBKB	1	enzymatic study	Higashimoto T (2008)	1
TBC1D7	1	TSC1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima A (2007), Nakashima A (2007), Nakashima A (2007), Huttlin EL (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	7
MOV10	6	DYRK1A	36	affinity chromatography technology	Castello A (2012)	1
NF2	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAPK14	0	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	CDKN2B	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Rual JF (2005), Stelzl U (2005), Vinayagam A (2011), Xin X (2009), Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Ivanov AA (2017)	12
VHL	0	AURKA	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Martin B (2013), Martin B (2013), Hasanov E (2017), Hasanov E (2017), Hasanov E (2017)	5
TSC1	4	RUVBL1	2	affinity chromatography technology	Cloutier P (2017)	1
TBC1D7	1	RRAGC	3	affinity chromatography technology	Cloutier P (2017)	1
TSC1	4	URI1	2	affinity chromatography technology, affinity chromatography technology	Cloutier P (2017), Cloutier P (2017)	2
SH2D2A	2	TSC1	4	two hybrid	Grossmann A (2015)	1
MAPK14	0	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RASSF1	3	KAT2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RASSF1	3	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TBC1D7	1	TSC2	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima A (2007), Nakashima A (2007), Nakashima A (2007), Huttlin EL (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	7
MAP2K5	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAPK14	0	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARAF	0	RASSF1	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AKT1	1	CDKN1B	1	enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology	Fujita N (2002), Fujita N (2002), Nacusi LP (2006), Chen TC (2014), Zhang H (2017), Zhang H (2017)	6
YWHAG	5	NEFL	1	affinity chromatography technology	Jin J (2004)	1
NXF1	0	YWHAZ	1	affinity chromatography technology	Castello A (2012)	1
ESR1	0	TSC1	4	affinity chromatography technology	York B (2005)	1
TSC1	4	WDR92	2	affinity chromatography technology, affinity chromatography technology	Cloutier P (2017), Cloutier P (2017)	2
TNS2	3	YWHAG	5	affinity chromatography technology	St-Denis N (2016)	1
BECN1	2	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAB	1	CDKN1B	1	pull down	Sekimoto T (2004)	1
TSC2	17	RRAGA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Demetriades C (2014), Demetriades C (2014), Deng L (2015)	3
KAT2A	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPM1H	3	YWHAE	0	affinity chromatography technology	St-Denis N (2016)	1
AKT1	1	YWHAG	5	affinity chromatography technology	Klein JB (2005)	1
MAPK14	0	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2B	0	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K5	1	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SOX4	5	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RUVBL1	2	RUVBL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, two hybrid, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ewing RM (2007), Jeronimo C (2007), Jeronimo C (2007), Puri T (2007), Rashid S (2009), Kim JH (2007), Kim JH (2007), McKeegan KS (2007), Lee JS (2010), Lee JS (2010), Cai Y (2007), Cai Y (2007), Ikura T (2000), Havugimana PC (2012), Venteicher AS (2008), Venteicher AS (2008), Bauer A (2000), Bauer A (2000), Bauer A (2000), Salzer U (1999), Izumi N (2010), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Jeganathan A (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	29
MOV10	6	NF2	1	affinity chromatography technology	Castello A (2012)	1
MAPK14	0	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC1	4	DOCK7	3	affinity chromatography technology	Nellist M (2005)	1
EZR	8	PTK2	2	pull down	Poullet P (2001)	1
RUVBL1	2	PIH1D1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), McKeegan KS (2007), Izumi N (2010), Huttlin EL (2015), Mir RA (2016), Huttlin EL (2017), Bizarro J (2014)	7
TSC1	4	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SOX4	5	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2B	0	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAE	0	TSC2	17	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009)	2
LATS2	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SOX4	5	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAPK14	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AURKA	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K5	1	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNE1	1	CDK1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Koff A (1992), Koff A (1992), Horton LE (1997)	4
CDKN2A	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RIN3	2	TSC1	4	two hybrid	Grossmann A (2015)	1
RASSF1	3	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
KAT2A	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
MYC	2	YWHAB	1	affinity chromatography technology	Koch HB (2007)	1
RPAP3	1	URI1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cloutier P (2009), Taipale M (2014), Taipale M (2014), Wan C (2015), Cloutier P (2017), Cloutier P (2017), Mita P (2016)	8
ESR1	0	RUVBL2	4	affinity chromatography technology	Tarallo R (2011)	1
PPM1H	3	YWHAZ	1	affinity chromatography technology	St-Denis N (2016)	1
SOX4	5	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GSK3B	1	PTK2	2	affinity chromatography technology	Huang D (2002)	1
RUVBL2	4	PIH1D1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), McKeegan KS (2007), Huttlin EL (2015), Mir RA (2016), Huttlin EL (2017), Bizarro J (2014), Cloutier P (2017)	7
CDK4	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK6	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC1	4	TSC1	4	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Nellist M (1999), Cloutier P (2017), Ivanov AA (2017)	3
TSC2	17	YWHAB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Y (2003), Shumway SD (2003), Li Y (2002), Nellist M (2002), Shumway SD (2003), Li Y (2002), Cai SL (2006), Nellist M (2002), Jin J (2004), Couzens AL (2013), Li Y (2003)	11
CDKN1B	1	VHL	0	genetic interference	Shen JP (2017)	1
TSC1	4	BEX3	0	two hybrid, affinity chromatography technology	Yasui S (2007), Yasui S (2007)	2
CIAO1	3	TSC1	4	affinity chromatography technology	Stehling O (2013)	1
CDK6	0	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Sweeney KJ (1997), Varjosalo M (2013), Ivanov AA (2017)	4
TSC1	4	PLK1	0	affinity chromatography technology, affinity chromatography technology	Astrinidis A (2006), Astrinidis A (2006)	2
PIH1D1	0	DOCK7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SH2D2A	2	PTK2	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
KAT2A	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LATS2	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC1	4	RHEB	2	enzymatic study	Garami A (2003)	1
TOP1	1	TSC1	4	genetic interference	Shen JP (2017)	1
ATXN1	2	YWHAE	0	two hybrid	Suter B (2013)	1
RASSF1	3	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
AKT1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Vandermoere F (2005), Vandermoere F (2005), Chen TC (2014), Busch F (2012)	4
MAPK14	0	ACTA1	1	affinity chromatography technology	Lin Z (2003)	1
MAP2K5	1	YWHAZ	1	two hybrid	Bandyopadhyay S (2010)	1
LATS2	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Yao F (2015), Yao F (2015)	2
ARAF	0	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AKT1	1	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method	Guo J (2016), Guo J (2016), Guo J (2016), Guo J (2016), Guo J (2016)	5
TSC1	4	RUVBL2	4	affinity chromatography technology	Cloutier P (2017)	1
NF2	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
DAPK1	6	TSC2	17	affinity chromatography technology	Lin Y (2011)	1
NF2	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	TOP1	1	affinity chromatography technology	Koch HB (2007)	1
NXF1	0	NF2	1	affinity chromatography technology	Castello A (2012)	1
LATS2	1	YWHAG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe	Okada N (2011), Okada N (2011), Okada N (2011), Ivanov AA (2017)	4
CCND2	2	CDKN1B	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
AKT1	1	NF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Tang X (2007), Tang X (2007), Tang X (2007), Tang X (2007), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Ivanov AA (2017)	9
NF2	1	KDM1A	2	two hybrid	Weimann M (2013)	1
PPM1H	3	YWHAG	5	affinity chromatography technology	St-Denis N (2016)	1
CCNE1	1	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
RHEB	2	TSC2	17	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Castro AF (2003), Inoki K (2003), Garami A (2003), Zhang Y (2003), Cao Y (2006), Castro AF (2003), Long X (2005), Long X (2005)	8
RUVBL2	4	WDR92	2	affinity chromatography technology, affinity chromatography technology	Cloutier P (2017), Cloutier P (2017)	2
RUVBL2	4	RPAP3	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Ni L (2009), Cloutier P (2009), Taipale M (2014), Taipale M (2014), Cloutier P (2017), Cloutier P (2017)	7
CDKN2A	1	CDK6	0	unspecified method, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Fahraeus R (1996), Russo AA (1998), Kaldis P (2001), Yarbrough WG (1999), Della Torre G (2001), Ezhevsky SA (1997), Ezhevsky SA (1997), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Souza-Rodrigues E (2007), Huttlin EL (2015), Huttlin EL (2017), Ivanov AA (2017)	15
BECN1	2	TSC1	4	affinity chromatography technology, fluorescent resonance energy transfe	Behrends C (2010), Ivanov AA (2017)	2
BECN1	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K5	1	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARAF	0	YWHAZ	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Bandyopadhyay S (2010), So J (2015), Ivanov AA (2017)	3
CDKN1B	1	MYC	2	affinity chromatography technology, protein complementation assay	Bahram F (2016), Bahram F (2016)	2
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
YWHAZ	1	DOCK7	3	affinity chromatography technology	Brajenovic M (2004)	1
TSC2	17	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mak BC (2003), Inoki K (2006), Mak BC (2003)	3
TSC2	17	PAM	2	two hybrid, affinity chromatography technology, imaging technique	Murthy V (2004), Murthy V (2004), Murthy V (2004)	3
ATXN1	2	CDK6	0	two hybrid	Lim J (2006)	1
CDK6	0	CDKN2B	0	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Mo XL (2015), Huttlin EL (2017), Ivanov AA (2017)	8
AKT1	1	YWHAE	0	affinity chromatography technology	Klein JB (2005)	1
SOX4	5	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PTK2	2	TSC1	4	affinity chromatography technology	Gan B (2006)	1
ARAF	0	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC1	4	VHL	0	genetic interference	Shen JP (2017)	1
TSC1	4	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAPK14	0	KAT2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RASSF1	3	GSK3B	1	affinity chromatography technology	Zhou X (2012)	1
MYC	2	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC1	4	DAPK1	6	affinity chromatography technology	Lin Y (2011)	1
YWHAG	5	TSC1	4	affinity chromatography technology	Jin J (2004)	1
AKT1	1	AKTIP	3	affinity chromatography technology, pull down, pull down	Remy I (2004), Remy I (2004), Remy I (2004)	3
NF2	1	CDK1	0	affinity chromatography technology	Zhou L (2015)	1
DAPK1	6	BECN1	2	enzymatic study, pull down, affinity chromatography technology	Zalckvar E (2009), Zalckvar E (2009), Zalckvar E (2009)	3
TSC2	17	YWHAG	5	affinity chromatography technology	Cloutier P (2017)	1
CDK4	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ATXN1	2	TSC1	4	two hybrid	Suter B (2013)	1
AKTIP	3	TSC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAG	5	DYRK1A	36	affinity chromatography technology	Jin J (2004)	1
TNS2	3	YWHAB	1	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
YWHAE	0	RUVBL2	4	affinity chromatography technology, affinity chromatography technology	Zuo S (2010), Zuo S (2010)	2
LATS2	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RASSF1	3	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARAF	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RUVBL2	4	APPL2	4	affinity chromatography technology, affinity chromatography technology, pull down	Rashid S (2009), Rashid S (2009), Rashid S (2009)	3
BECN1	2	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	PLK1	0	affinity chromatography technology, enzymatic study	Koch HB (2007), Xiao D (2016)	2
RASSF1	3	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NEFL	1	KDM1A	2	two hybrid	Weimann M (2013)	1
WDR92	2	TSC2	17	affinity chromatography technology	Cloutier P (2017)	1
TSC2	17	TSC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dan HC (2002), Hodges AK (2001), Aicher LD (2001), van Slegtenhorst M (1998), Nellist M (2002), Li Y (2004), Mak BC (2003), van Slegtenhorst M (1998), van Slegtenhorst M (1998), Ma L (2005), Cai SL (2006), Cao Y (2006), Ma L (2005), Inoki K (2003), Nellist M (2005), Goncharova EA (2006), Astrinidis A (2006), Cao Y (2006), Astrinidis A (2003), Hodges AK (2001), Hodges AK (2001), Nellist M (2001), Aicher LD (2001), Murthy V (2000), van Slegtenhorst M (1998), Dan HC (2002), Miloloza A (2000), Nakashima A (2007), Nakashima A (2007), Benvenuto G (2000), Chong-Kopera H (2006), York B (2005), Vega-Rubin-de-Celis S (2010), Vega-Rubin-de-Celis S (2010), Lin Y (2011), Cloutier P (2017), Cloutier P (2017)	37
MYC	2	YWHAE	0	affinity chromatography technology	Koch HB (2007)	1
AXIN1	1	MYC	2	affinity chromatography technology, affinity chromatography technology, pull down	Arnold HK (2009), Arnold HK (2009), Arnold HK (2009)	3
BECN1	2	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC1	4	YWHAZ	1	two hybrid	Nellist M (2002)	1
CDKN2A	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NXF1	0	DYRK1A	36	affinity chromatography technology	Castello A (2012)	1
TSC2	17	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Finlay GA (2004), Finlay GA (2004), Finlay GA (2004), York B (2005)	4
NF2	1	TOP1	1	affinity chromatography technology	Zhou L (2015)	1
MYC	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN1B	1	CDK4	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Cariou S (2000), Guidoboni M (2005), Bustany S (2011), Hsu SP (2008), Radu M (2008), Mori S (1999), Kokontis JM (1998), Orend G (1998), Vlach J (1996), Vlach J (1997), Ciarallo S (2002), Wang Y (2008), Bockstaele L (2006), Mandal M (1998), Larrea MD (2009), Seo DW (2006), Kossatz U (2006), Kossatz U (2006), Mallampalli RK (2013), Varjosalo M (2013), Huttlin EL (2015), Chen TC (2014), Carrasco-Garcia E (2011), Huttlin EL (2017)	25
AURKA	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Irelan JT (2007), Irelan JT (2007), Irelan JT (2007)	3
CCND2	2	TSC2	17	affinity chromatography technology	Zacharek SJ (2005)	1
NF2	1	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC1	4	RPAP3	1	affinity chromatography technology	Cloutier P (2017)	1
LATS2	1	PCM1	5	bioid	Couzens AL (2013)	1
TSC2	17	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Demetriades C (2014), Demetriades C (2014)	2
MSN	0	EZR	8	biochemical, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Gary R (1995), Gary R (1993), Gary R (1993), Hein MY (2015)	5
DOK5	0	TSC1	4	two hybrid	Grossmann A (2015)	1
MAPK14	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
FBXW5	6	TSC2	17	affinity chromatography technology, affinity chromatography technology	Hu J (2008), Ha JY (2013)	2
KAT2A	1	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAZ	1	PCM1	5	pull down, affinity chromatography technology	Tollenaere MA (2015), Tollenaere MA (2015)	2
MAP2K5	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
KDM5C	9	VHL	0	genetic interference	Shen JP (2017)	1
CDK6	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAE	0	TSC1	4	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009)	2
YWHAE	0	BEX3	0	pull down, affinity chromatography technology	Kimura MT (2001), Kimura MT (2001)	2
MYC	2	VHL	0	affinity chromatography technology, affinity chromatography technology	Hwang IY (2012), Hwang IY (2012)	2
AURKA	1	CDKN2A	1	affinity chromatography technology	Ewing RM (2007)	1
BECN1	2	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNE1	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FGFR4	6	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AKT1	1	YWHAZ	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Powell DW (2002), Powell DW (2002), Powell DW (2002), Klein JB (2005)	4
YWHAE	0	PCM1	5	pull down, affinity chromatography technology	Tollenaere MA (2015), Tollenaere MA (2015)	2
NXF1	0	CDKN2A	1	affinity chromatography technology	Castello A (2012)	1
MYC	2	KDM1A	2	two hybrid	Weimann M (2013)	1
ESR1	0	KDM1A	2	affinity chromatography technology, affinity chromatography technology	Garcia-Bassets I (2007), Garcia-Bassets I (2007)	2
MYC	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCND2	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAPK14	0	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
KAT2A	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RPS6KA1	3	ESR1	0	enzymatic study	Joel PB (1998)	1
URI1	2	WDR92	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cloutier P (2017), Cloutier P (2017), Mita P (2016)	3
CDK4	2	VHL	0	genetic interference	Shen JP (2017)	1
ARAF	0	BECN1	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK6	0	VHL	0	genetic interference	Shen JP (2017)	1
IKBKB	1	TSC1	4	affinity chromatography technology, pull down	Lee DF (2007), Lee DF (2007)	2
CDK1	0	CDKN1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Radu M (2008), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
RRAGA	1	TSC1	4	affinity chromatography technology	Demetriades C (2014)	1
CCND2	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK6	0	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MOV10	6	YWHAZ	1	affinity chromatography technology	Castello A (2012)	1
CDKN2A	1	TOP1	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Ayrault O (2004), Ayrault O (2003), Ayrault O (2003)	3
ACTA1	1	CDKN2A	1	biochemical	Kristensen AR (2012)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
TNS2	3	YWHAE	0	affinity chromatography technology	St-Denis N (2016)	1
CDK4	2	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NXF1	0	PPM1H	3	affinity chromatography technology	Castello A (2012)	1
NF2	1	LATS2	1	x-ray crystallography, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Li Y (2015), Yin F (2013), Ivanov AA (2017), Zhu C (2018)	4
MAP2K5	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPM1H	3	TSC1	4	bioid	St-Denis N (2016)	1
CCND2	2	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN1B	1	TSC1	4	affinity chromatography technology	Rosner M (2004)	1
CCND2	2	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RUVBL2	4	URI1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017), Mita P (2016)	5
CDKN2B	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARAF	0	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TSC2	17	PTK2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Gan B (2006), Gan B (2006), Gan B (2006), Gan B (2006)	4
ARAF	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TNS2	3	TSC1	4	two hybrid	Grossmann A (2015)	1
AURKA	1	PLK1	0	affinity chromatography technology, biochemical	Katayama H (2008), Havugimana PC (2012)	2
PIH1D1	0	WDR92	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Inoue M (2010), Inoue M (2010), Huttlin EL (2017), Cloutier P (2017)	5
KAT2A	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	TOP1	1	genetic interference	Shen JP (2017)	1
MOV10	6	CDKN2A	1	affinity chromatography technology	Castello A (2012)	1
CCND2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAG	5	DOCK7	3	affinity chromatography technology	Jin J (2004)	1
YWHAB	1	ARAF	0	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), So J (2015)	2
RASSF1	3	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1