PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PDLIM7	0	TRADD	0	affinity chromatography technology	Ikeda O (2009)	1
PRKN	1	UBE2N	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Joch M (2007), Olzmann JA (2007), Chaugule VK (2011), Sha D (2010), Lim GG (2013), Durcan TM (2011), McKeon JE (2014), Sha D (2010)	8
TRAF1	0	FBXO28	2	affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Huttlin EL (2017)	2
USP2	0	EGFR	5	affinity chromatography technology	Kim J (2012)	1
TRAF2	1	TNFRSF9	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Jang IK (1998), Jang IK (1998), Jang IK (1998), Arch RH (1998), Arch RH (1998), Ma BY (2005), Martinez-Forero I (2013), Saoulli K (1998), Saoulli K (1998)	9
CFLAR	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
EGFR	5	APPL1	1	unspecified method	Jones RB (2006)	1
TRAF6	0	BCL10	0	affinity chromatography technology	Bidere N (2006)	1
TNFRSF1B	4	CHUK	5	affinity chromatography technology	Wicovsky A (2009)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
IKBKB	1	MAP3K7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofer-Warbinek R (2000), Wu ZH (2010), Wu ZH (2010), Prickett TD (2008), Fan YH (2011), Neil JR (2008), Wu X (2007), Shambharkar PB (2007), Shambharkar PB (2007), Niu J (2013), Yao F (2015), Yao F (2015), Mei ZZ (2016), Zheng C (2015)	14
FBXO7	1	GSK3B	1	enzymatic study, affinity chromatography technology, pull down	Teixeira FR (2016), Teixeira FR (2016), Teixeira FR (2016)	3
CFLAR	1	TNFRSF1A	3	genetic interference	Ma Y (2017)	1
TNFSF14	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
TRAF2	1	TRAF3IP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Qian Y (2004), Sun D (2011)	3
PTPN2	0	EGFR	5	affinity chromatography technology	Klingler-Hoffmann M (2001)	1
MAP3K14	1	IKBKB	1	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Luftig MA (2001), Woronicz JD (1997), Li Q (2006), Huttlin EL (2017)	4
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
TNFRSF1A	3	TRAF3	1	pull down	Mosialos G (1995)	1
RIPK2	0	CFLAR	1	affinity chromatography technology	Inohara N (1998)	1
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
LTBR	0	TRAF4	1	pull down	Krajewska M (1998)	1
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
TRAF2	1	TRAF2	1	two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, pull down, x-ray crystallography, enzymatic study, fluorescent resonance energy transfe, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, x-ray crystallography, two hybrid, enzymatic study, pull down	Rual JF (2005), Takeuchi M (1996), McWhirter SM (1999), Malinin NL (1997), Shi CS (2003), Yin Q (2009), Alvarez SE (2010), He L (2004), Zheng C (2010), Jang HD (2001), Pullen SS (1998), Park YC (1999), Rothe M (1994), Mace PD (2010), Rolland T (2014), Shen RR (2012), Ceccarelli A (2015)	17
TRAF3IP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Liu C (2009), Kanamori M (2002), Kanamori M (2002), Kanamori M (2002), Qian Y (2007), Qu F (2012), Wu NL (2014), Wu NL (2014), Rolland T (2014), Garg AV (2013), Sun D (2011), Yu H (2011)	12
PDLIM7	0	ENKD1	3	two hybrid	Rual JF (2005)	1
USP2	0	TRAIP	0	two hybrid	Hayes SD (2012)	1
TICAM1	3	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Jiang Z (2004), Nguyen VP (2014)	2
FBXO7	1	APEX1	1	enzymatic study	Teixeira FR (2016)	1
USP2	0	IKBKG	0	enzymatic study	Zhou H (2004)	1
MAP3K1	4	RAD23A	1	enzymatic study	Charlaftis N (2014)	1
IKBKB	1	TNFRSF1A	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang SQ (2000), Chaudhary PM (2000), Fan YH (2011), Park KJ (2002), Guan YJ (2011), Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008), Chen TC (2014)	9
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
PDLIM7	0	TRAF3	1	protein complementation assay, protein complementation assay	Talaty P (2011), Talaty P (2011)	2
MAP4K2	1	MAP3K1	4	pull down, affinity chromatography technology, affinity chromatography technology	Yuasa T (1998), Chadee DN (2002), Chadee DN (2002)	3
GSK3B	1	BIRC2	1	affinity chromatography technology	Sun M (2009)	1
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
MAVS	1	BIRC3	1	affinity chromatography technology	Mao AP (2010)	1
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
TRAF5	1	MAP3K14	1	affinity chromatography technology	Song HY (1997)	1
USP2	0	RIPK1	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2012)	4
IKBKE	2	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ng MH (2011), Charoenthongtrakul S (2013), Peng Y (2014), Gu L (2017), Fang R (2017)	5
TNFRSF1A	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moquin DM (2013), Nakazawa S (2016), Elliott PR (2016)	3
RIPK1	2	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wright A (2007), Nagabhushana A (2011), ODonnell MA (2012), Wu GR (2017)	4
TNFRSF1B	4	TRAF3	1	pull down, affinity chromatography technology	Mosialos G (1995), Mosialos G (1995)	2
TRAF2	1	PTPN2	0	affinity chromatography technology, affinity chromatography technology	van Vliet C (2005), van Vliet C (2005)	2
TANK	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Goncharov T (2013)	2
TBK1	1	CYLD	2	affinity chromatography technology, imaging technique, affinity chromatography technology	Friedman CS (2008), Genin P (2015), Genin P (2015)	3
IKBKG	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Henn IH (2007), Henn IH (2007), Sha D (2010)	3
IKBKG	0	TBK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Fenner BJ (2010), Li S (2011), Wang L (2012), Wang L (2012), Ran Y (2016), Huttlin EL (2017)	7
GSTP1	0	GABPB1	0	affinity chromatography technology	Hein MY (2015)	1
IKBKB	1	COPS5	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Orel L (2010), Orel L (2010), Orel L (2010), Orel L (2010), Asare Y (2013), Asare Y (2013)	6
MAP3K14	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Choudhary S (2013)	6
CYLD	2	TRAIP	0	two hybrid, far western blotting	Regamey A (2003), Regamey A (2003)	2
TNFRSF13B	0	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Xia XZ (2000), Xia XZ (2000), He B (2010)	3
IKBKE	2	BIRC2	1	affinity chromatography technology, enzymatic study	Zhou AY (2013), Zhou AY (2013)	2
TNFSF14	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
TRPC4AP	4	IKBKB	1	affinity chromatography technology	Soond SM (2003)	1
IKBKE	2	TANK	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nomura F (2000), Nomura F (2000), Nomura F (2000), Gatot JS (2007), Renner F (2011), Shen RR (2012), Ryzhakov G (2007), So J (2015)	8
TRAF2	1	UBXN11	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
TICAM1	3	TRAF5	1	affinity chromatography technology	Jiang Z (2004)	1
NGFR	3	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ye X (1999), Gentry JJ (2004), Gentry JJ (2004), Gentry JJ (2004), Gentry JJ (2004), Geetha T (2012), Geetha T (2012)	7
CHUK	5	RIPK1	2	biochemical	Poyet JL (2000)	1
CHUK	5	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
CD40	3	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
TNFRSF1B	4	TRAIP	0	affinity chromatography technology	Lee SY (1997)	1
TRAF2	1	SPG21	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
ERN1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Qiu Q (2013), Qiu Q (2013)	2
RIPK2	0	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
RIPK2	0	TRAF5	1	affinity chromatography technology	McCarthy JV (1998)	1
PRKN	1	FBXO7	1	affinity chromatography technology, pull down, pull down	Burchell VS (2013), Burchell VS (2013), Burchell VS (2013)	3
CD27	1	TRAF1	0	affinity chromatography technology	Yamamoto H (1998)	1
TIFA	4	TRAF6	0	affinity chromatography technology	Takatsuna H (2003)	1
RAD23A	1	UBC	7	pull down, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, unspecified method, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, pull down	Kang Y (2006), Sims JJ (2009), Kang Y (2007), Kang Y (2007), Wang Q (2003), Scanlon TC (2009), Raasi S (2003), Sokratous K (2012), Varadan R (2005), Fenner BJ (2009), Raasi S (2005), Massey LK (2004), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Jung J (2014), Goh AM (2008), Castaneda CA (2013), Nakasone MA (2013), Lai MY (2012), Kristariyanto YA (2015), Zhang X (2017)	22
TAB2	5	IKBKG	0	affinity chromatography technology, two hybrid, pull down, pull down	Suzuki S (2007), Wang J (2011), Emmerich CH (2013), Emmerich CH (2013)	4
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
TNFRSF13B	0	TRAF3	1	affinity chromatography technology	Xu LG (2002)	1
TRAF2	1	USP4	3	affinity chromatography technology, enzymatic study	Xiao N (2011), Xiao N (2011)	2
APEX1	1	PRKN	1	affinity chromatography technology, imaging technique	Scott TL (2016), Scott TL (2016)	2
CD40	3	TRAF5	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsukamoto N (1999), Ishida TK (1996), Werneburg BG (2001), Peters AL (2010), Mizushima S (1998), Basaki Y (2002), He B (2010), Hostager BS (2010), Hostager BS (2010)	9
TNFRSF1B	4	CAV1	0	affinity chromatography technology	Feng X (2001)	1
TICAM1	3	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
TRAF3IP2	0	UBC	7	enzymatic study	Liu C (2009)	1
IKBKE	2	TRAF2	1	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Shen RR (2012), Shen RR (2012), Shen RR (2012), Zhang W (2010), Zhou AY (2013), Zhou AY (2013), So J (2015), Fang R (2017)	8
EDARADD	0	MAP3K7	2	affinity chromatography technology	Morlon A (2005)	1
TNFRSF4	1	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Arch RH (1998), Arch RH (1998), Ma BY (2005)	3
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
TANK	1	CD40	3	affinity chromatography technology	Qiao G (2007)	1
TRAF1	0	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Greenfeld H (2015), Huttlin EL (2017)	3
CD27	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
RIPK2	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Hasegawa M (2008)	2
IKBKB	1	TNFAIP3	3	enzymatic study, affinity chromatography technology	Zetoune FS (2001), Xiong Y (2011)	2
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
PIN1	0	THAP7	0	two hybrid	Rolland T (2014)	1
USP2	0	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011)	2
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
TNFRSF9	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Jang IK (1998), Ma BY (2005), Saoulli K (1998), Saoulli K (1998)	4
EDARADD	0	TAB2	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Morlon A (2005), Morlon A (2005), Morlon A (2005)	3
TANK	1	CHUK	5	affinity chromatography technology	Chariot A (2002)	1
SPHK1	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, pull down	Harikumar KB (2014), Harikumar KB (2014), Harikumar KB (2014)	3
TRAF1	0	TBK1	1	affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Huttlin EL (2017)	2
RIPK1	2	IKBKB	1	biochemical, pull down	Yang Y (2011), Poyet JL (2000)	2
RIPK1	2	MAP3K8	2	affinity chromatography technology	Eliopoulos AG (2006)	1
DNAJB2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TICAM1	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Piao W (2009), Sato S (2003), Sato S (2003), Hu YH (2015), Cai B (2017)	6
CASP8	1	USP2	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
RIPK2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hasegawa M (2008), Kim JY (2008), Yang Y (2007), Yang Y (2007), Windheim M (2007)	5
EGFR	5	GSTP1	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Okamura T (2015), Okamura T (2009), Okamura T (2009), Okamura T (2009)	4
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
BECN1	2	TRAF6	0	affinity chromatography technology, enzymatic study	Shi CS (2010), Shi CS (2010)	2
MALT1	1	IKBKB	1	affinity chromatography technology	Bidere N (2009)	1
TRAF3	1	TNFRSF4	1	affinity chromatography technology	Ma BY (2005)	1
EGFR	5	APEX1	1	affinity chromatography technology, affinity chromatography technology	Liccardi G (2014), Yao Z (2017)	2
IKBKG	0	TRAF3IP2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Leonardi A (2000), Li X (2000), Mauro C (2003), Mauro C (2003), Mauro C (2003)	5
IKBKE	2	TRAF3IP2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Qu F (2012), Qu F (2012), Qu F (2012), Ryzhakov G (2012)	4
TAB2	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Li S (2009), Ishitani T (2003), Hong S (2007)	4
TICAM1	3	TANK	1	affinity chromatography technology	Li S (2011)	1
EIF4G1	9	AIMP2	0	biochemical	Kristensen AR (2012)	1
MAP3K14	1	MAP3K8	2	affinity chromatography technology	Lin X (1999)	1
TRADD	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Park YC (2000), Tsao DH (2000), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Vince JE (2009), Jang HD (2001), Park KJ (2003), Lin B (2016)	12
TRAIP	0	MAP3K7	2	affinity chromatography technology	Kong QZ (2016)	1
FBXO7	1	EIF4G1	9	affinity chromatography technology	Teixeira FR (2016)	1
TNF	0	CYLD	2	affinity chromatography technology, affinity chromatography technology	Draber P (2015), Schlicher L (2016)	2
EDARADD	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Morlon A (2005), Fujikawa H (2013), Fujikawa H (2013), Fujikawa H (2013), Rolland T (2014)	5
TRAF5	1	GORASP2	1	two hybrid	Rolland T (2014)	1
TICAM1	3	TRAF4	1	affinity chromatography technology	Takeshita F (2005)	1
IKBKG	0	TRAF3	1	affinity chromatography technology	Belgnaoui SM (2012)	1
TRAF2	1	PPP4R1	3	two hybrid, affinity chromatography technology	Hadweh P (2014), Hadweh P (2014)	2
PIN1	0	CDKN1B	1	pull down, affinity chromatography technology, unspecified method	Zhou W (2009), Zhou W (2009), Zhou W (2009)	3
EGFR	5	MAP3K14	1	affinity chromatography technology	Habib AA (2001)	1
IKBKB	1	MAVS	1	enzymatic study	Liu S (2015)	1
TRAF2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Li S (2011), Huttlin EL (2017)	3
TRAF6	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999), Mochida Y (2000), Fujino G (2007), Fujino G (2007)	5
PCSK9	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Xu W (2012), Xu W (2012), Xu W (2012), Xu W (2012), Xu W (2012)	5
TRAF2	1	CAV1	0	affinity chromatography technology, affinity chromatography technology	Feng X (2001), Cao H (2002)	2
TRAF3	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakhaei P (2009), Arnaud N (2011), Paz S (2011), Wang Y (2012), Saha SK (2006), Saha SK (2006), Ng MH (2011), Johnsen IB (2009), van Zuylen WJ (2012), Belgnaoui SM (2012), Chen X (2014), Wang P (2013), Wang P (2013), Minassian A (2015), Gu L (2017), Khan M (2016), Fang R (2017), Fang R (2017)	18
MALT1	1	TNFAIP3	3	affinity chromatography technology	Yang Y (2014)	1
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
TRAF5	1	TRAF3IP2	0	affinity chromatography technology, affinity chromatography technology	Sun D (2011), Sun D (2011)	2
PKN1	4	TNFRSF1B	4	affinity chromatography technology, pull down, pull down	Kato T (2008), Kato T (2008), Kato T (2008)	3
UBC	7	CDKN1B	1	affinity chromatography technology	Huang G (2014)	1
TRPC4AP	4	CHUK	5	affinity chromatography technology	Soond SM (2003)	1
PRKN	1	AIMP2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Corti O (2003), Corti O (2003), Hampe C (2006), Ko HS (2005), Ko HS (2005), Ko HS (2005), Sriram SR (2005), Kim DG (2016)	8
TRAF2	1	ERN1	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kaneko M (2003), Zhu X (2014), Chen TC (2014), Zeng T (2015)	4
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
TNFRSF11A	2	TRAF5	1	pull down, pull down, pull down, affinity chromatography technology	Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Wong BR (1998)	4
PRKN	1	BECN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Choubey V (2014), Lonskaya I (2014), Lonskaya I (2014), Lonskaya I (2014)	4
TRAF2	1	TIFA	4	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
TNFRSF4	1	TRAF5	1	affinity chromatography technology, pull down, affinity chromatography technology	Kawamata S (1998), Kawamata S (1998), Ma BY (2005)	3
LTBR	0	TNFRSF10B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K14	1	CHUK	5	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Regnier CH (1997), Regnier CH (1997), Xiao G (2000), Luftig MA (2001), Ninomiya-Tsuji J (1999), Ninomiya-Tsuji J (1999), Qing G (2007), Sanjo H (2010), Hu WH (2004), Liao G (2004), Li Q (2006), Chen TC (2014), Huttlin EL (2017)	13
TRAF5	1	TNFRSF9	1	affinity chromatography technology	Ma BY (2005)	1
TRAF1	0	SPG21	0	two hybrid	Rolland T (2014)	1
TRAIP	0	TBK1	1	affinity chromatography technology	Zhang M (2012)	1
CHUK	5	EIF2AK2	1	affinity chromatography technology, affinity chromatography technology	Bonnet MC (2000), Gil J (2000)	2
IKBKG	0	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Zhao T (2007), Zhou AY (2013)	2
MAP3K7	2	TRAF5	1	affinity chromatography technology	Hong S (2007)	1
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
HIVEP3	12	TRAF2	1	two hybrid, affinity chromatography technology	Oukka M (2002), Oukka M (2002)	2
EGFR	5	RPS6KA3	2	affinity chromatography technology	Tong J (2014)	1
CDKN1B	1	TRAF2	1	two hybrid, imaging technique	Rual JF (2005), Chen TC (2014)	2
TRAF1	0	CDCA3	0	two hybrid	Rolland T (2014)	1
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
TNFRSF13B	0	TNFRSF10B	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF3	1	CFLAR	1	affinity chromatography technology	Kataoka T (2000)	1
UBC	7	CAV1	0	affinity chromatography technology, imaging technique	Luo X (2017), Luo X (2017)	2
TNF	0	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Legler DF (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Skaug B (2011), Fu J (2013), Fritsch J (2014), Schlicher L (2016)	10
TRAF6	0	IKBKE	2	affinity chromatography technology	Fang R (2017)	1
TNFRSF13B	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xia XZ (2000), Xia XZ (2000), Kanno Y (2010), He B (2010)	4
TNFRSF11A	2	TRAF6	0	affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mizukami J (2002), Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998), Lin J (2015), Yu J (2016)	9
MAVS	1	TRAF5	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Tang ED (2010), Minassian A (2015), Khan M (2016)	4
TNFRSF1A	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
TNFRSF1A	3	USP4	3	affinity chromatography technology	Fan YH (2011)	1
APPL1	1	TRAF6	0	affinity chromatography technology	Cheng KK (2013)	1
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
BIRC3	1	RIPK2	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	6
TNF	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Yamaguchi N (2015)	2
TRAF2	1	DAB2IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Zhang H (2004), Dai X (2014)	3
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
PRKAB2	0	BANP	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
MAP3K1	4	IKBKB	1	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Deng L (2000), Nemoto S (1998), Nemoto S (1998), Li Q (2006)	4
TBK1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bouwmeester T (2004), Bonnard M (2000), Behrends C (2010), Li S (2011), Li S (2011), Shen RR (2012), Zhang W (2010), Huttlin EL (2017), Fang R (2017), Fang R (2017)	10
TRAF5	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999)	2
LTBR	0	TRAF3	1	affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	VanArsdale TL (1997), Wu MY (1999), Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Mosialos G (1995), Li C (2003), Li C (2003), Force WR (1997), Force WR (1997), Huttlin EL (2015), Huttlin EL (2017)	12
TICAM1	3	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Sasai M (2010), Sasai M (2010), Jiang Z (2004), Wang YY (2004), Sato S (2003), Sato S (2003), Sato S (2003), Takaki H (2009), Verstak B (2014), Hu YH (2015)	10
EGFR	5	RPS3	0	affinity chromatography technology	Yao Z (2017)	1
TANK	1	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method	Bouwmeester T (2004), Rothe M (1996), Rothe M (1996), Nomura F (2000), Nomura F (2000), Pomerantz JL (1999), Behrends C (2010), Li S (2011), Li S (2011), Li C (2002), Shen RR (2012), Shen RR (2012), Wang J (2011), Huttlin EL (2017), Kim CM (2017)	15
WNT3A	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC3	1	IKBKE	2	enzymatic study	Zhou AY (2013)	1
TNF	0	CASP8	1	affinity chromatography technology	Fritsch J (2014)	1
BCL10	0	TRADD	0	affinity chromatography technology	Costanzo A (1999)	1
BECN1	2	UBC	7	pull down	Shi CS (2010)	1
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
TRAF6	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Bidere N (2006), Bidere N (2006), He L (2006), He L (2006), Zinngrebe J (2016)	5
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
USP2	0	TRADD	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
TBK1	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Qin Y (2016), Qin Y (2016)	2
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
IKBKB	1	EIF2AK2	1	affinity chromatography technology	Bonnet MC (2000)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
AIMP2	0	TRAF2	1	affinity chromatography technology, two hybrid, two hybrid	Choi JW (2009), Choi JW (2009), Choi JW (2009)	3
TRAF1	0	TNFRSF4	1	affinity chromatography technology	Ma BY (2005)	1
TNF	0	CDC42	3	affinity chromatography technology	Kuai J (2004)	1
CHUK	5	TAB2	5	affinity chromatography technology	Kishida S (2005)	1
COPS5	0	CDKN1B	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Caballero OL (2002), Kouvaraki MA (2006), Kouvaraki MA (2006), Kouvaraki MA (2006), Hsieh YH (2007), Hwang CY (2004), Hwang CY (2004), Pan Y (2012), Wang Y (2008), Wang Y (2008), Yamaguchi F (2008), Wang Y (2014), Zhang H (2017), Zhang H (2017)	14
IKBKG	0	BCL10	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu CJ (2008), Wu CJ (2008), Bhattacharyya S (2010), Stilo R (2004), Poyet JL (2001), Poyet JL (2001), Park Y (2013), Zhou H (2004), Yang YK (2016)	9
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
TRAF6	0	SPHK1	0	affinity chromatography technology	Ryu J (2006)	1
CHUK	5	TRADD	0	biochemical	Poyet JL (2000)	1
MAVS	1	TRAF1	0	affinity chromatography technology	Minassian A (2015)	1
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
TNFRSF11A	2	TRAF1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	4
TAB2	5	ZBTB16	4	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
CFLAR	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
TNF	0	UBE2N	1	genetic interference, affinity chromatography technology	Deng L (2000), Fritsch J (2014)	2
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
TRAF5	1	TBK1	1	affinity chromatography technology, pull down	Fang R (2017), Fang R (2017)	2
TRAF3	1	RIPK2	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Cai X (2013), Cai X (2013), Cai X (2013), Cai X (2013)	4
TRADD	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chang YL (2014), Chang YL (2014)	2
MAP3K7	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Sakurai H (1999), Ninomiya-Tsuji J (1999), Lin X (1998), Lin X (1998), Ear T (2010), Huangfu WC (2006), Chen TC (2014)	7
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
RIPK1	2	TRAF5	1	affinity chromatography technology	Tada K (2001)	1
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
MAP3K14	1	UBC	7	affinity chromatography technology	Sanjo H (2010)	1
CDC42	3	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
TRADD	0	DAB2IP	3	affinity chromatography technology	Zhang H (2004)	1
TRAF5	1	TRAF2	1	affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Pullen SS (1998)	3
TRAF4	1	BANP	1	two hybrid	Rolland T (2014)	1
RIPK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertrand MJ (2008), Li H (2006), Yang Y (2011), Yang Y (2011), Yang Y (2011), Hu MM (2014)	6
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
MAP3K5	1	MAP3K7	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochida Y (2000), Mochida Y (2000), Mochida Y (2000), Kim SY (2012), Kim SY (2012)	5
TRAF2	1	APPL1	1	two hybrid, imaging technique	Rual JF (2005), Chen TC (2014)	2
TNFRSF14	2	TRAF1	0	pull down	Marsters SA (1997)	1
TRAF2	1	116349	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRAF3IP2	0	CHUK	5	affinity chromatography technology, biochemical	Leonardi A (2000), Mauro C (2003)	2
BIRC2	1	AIMP2	0	affinity chromatography technology	Choi JW (2009)	1
RPS3	0	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Yang HJ (2013), Yang HJ (2013), Yang HJ (2013), Yang HJ (2013)	4
TICAM1	3	TRAF1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Jiang Z (2004), Su X (2006), Su X (2006), Su X (2006), Takaki H (2009)	5
EDA2R	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
MAVS	1	BIRC2	1	affinity chromatography technology	Mao AP (2010)	1
TBK1	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Wang L (2012), Liu XY (2011), Liu S (2015), Fang R (2017), Zhang Q (2017)	7
CD27	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Yamamoto H (1998), Akiba H (1998), Gravestein LA (1998), Huttlin EL (2015), Huttlin EL (2017)	5
USP4	3	MAP3K7	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Fan YH (2011), Fan YH (2011), Fan YH (2011)	3
TRAF2	1	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuiken HJ (2012), Chen CM (2014), Huttlin EL (2017)	3
TAB2	5	UBC	7	pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Kulathu Y (2009), Kulathu Y (2009), Sato Y (2009), van Wijk SJ (2012), Kanayama A (2004), Niu J (2011), van Wijk SJ (2013), Hooper C (2014), Komander D (2009), Emmerich CH (2013), Wauer T (2015), Kristariyanto YA (2015), Zhang X (2017)	13
PDLIM7	0	TRAF2	1	protein complementation assay, protein complementation assay	Talaty P (2011), Talaty P (2011)	2
IKBKE	2	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Saitoh T (2005)	2
UBE2N	1	RIPK1	2	enzymatic study	Bohgaki M (2008)	1
BECN1	2	TRAF2	1	affinity chromatography technology, affinity chromatography technology, pull down	Liu H (2017), Liu H (2017), Liu H (2017)	3
TICAM1	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meylan E (2004), Meylan E (2004), Chang M (2009), Hu YH (2015)	4
AIMP2	0	TRAF6	0	affinity chromatography technology	Kim DG (2016)	1
TRAF5	1	ZFAND6	0	two hybrid	Rolland T (2014)	1
MALT1	1	USP2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Li Y (2013), Li Y (2013), Ginster S (2017)	3
TRAF3IP2	0	MAP3K7	2	affinity chromatography technology	Qian Y (2007)	1
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TRAF3	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013)	2
TRPC4AP	4	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Soond SM (2003), Soond SM (2006)	2
CYLD	2	EIF4G1	9	affinity chromatography technology	Elliott PR (2016)	1
MALT1	1	UBE2N	1	pull down	Zhou H (2004)	1
TRAF2	1	ENKD1	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CASP8	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
MAP3K14	1	TRAF2	1	pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Luftig MA (2001), Luftig MA (2001), Malinin NL (1997), Malinin NL (1997), Malinin NL (1997), Sanjo H (2010), Kanno Y (2010), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Lee S (2014), Rolland T (2014)	13
PDLIM7	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Uemura N (2006), Uemura N (2006)	2
CD40	3	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Hostager BS (2010), Hostager BS (2010)	3
TRAF2	1	ZFAND6	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Chang EJ (2011), Chang EJ (2011), Chang EJ (2011), Huttlin EL (2017)	5
EDA2R	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sinha SK (2002), Sinha SK (2004), Huttlin EL (2015), Huttlin EL (2017)	4
BIRC3	1	TANK	1	affinity chromatography technology	Goncharov T (2013)	1
TRAF1	0	TRADD	0	affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Wicovsky A (2009)	2
LTBR	0	TRAF5	1	pull down, pull down, pull down	Marsters SA (1997), Li C (2003), Mizushima S (1998)	3
MAP3K14	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Ninomiya-Tsuji J (1999), Hofer-Warbinek R (2000)	2
TNFRSF1A	3	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Y (1999), Schuetze S (1999), Pan G (1997), Hsu H (1996), Hsu H (1996), Hsu H (1996), Shu HB (1996), Blankenship JW (2009), Kolliputi N (2009), Fujikura D (2012), Park KJ (2002), Guan YJ (2011), Hsu H (1995), Kumar A (2001), Zheng L (2006), Kim TW (2013), Zhang H (2004), Chang YL (2014), Nakazawa S (2016), Huttlin EL (2017)	20
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
TRAF2	1	MAP3K1	4	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Baud V (1999), Baud V (1999), Wu Y (2006), Charlaftis N (2014), Chen TC (2014)	5
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
TNFRSF13B	0	TRAF5	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Xia XZ (2000), Xia XZ (2000), He B (2010)	3
TNFRSF1B	4	TRAF2	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Song HY (1995), Song HY (1995), Takeuchi M (1996), Hostager BS (2002), Rothe M (1996), Marsters SA (1997), Carpentier I (2008), Rothe M (1995), Park YC (1999), Boucher LM (1997), Rothe M (1994), Rothe M (1994)	13
TNF	0	MAP3K7	2	affinity chromatography technology	Ea CK (2006)	1
TRAF2	1	SPHK1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xia P (2002), Xia P (2002), Park ES (2015), Liu H (2017), Liu H (2017)	5
CD40	3	DIABLO	2	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
COPS5	0	GSK3B	1	affinity chromatography technology	Huang X (2009)	1
CASP8	1	TRADD	0	affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kolliputi N (2009)	2
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
TNFSF14	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
TRAF5	1	UBC	7	enzymatic study	Middleton AJ (2017)	1
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
GSK3B	1	MAP3K1	4	affinity chromatography technology, pull down	Kim JW (2003), Kim JW (2003)	2
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
CFLAR	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kataoka T (2000), Chaudhary PM (2000), Rebe C (2007), Feoktistova M (2011), Ranjan K (2016), Ranjan K (2016)	6
TRAF2	1	USP2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Rolland T (2014), Mahul-Mellier AL (2012), Mahul-Mellier AL (2012)	7
TNFSF14	0	DIABLO	2	affinity chromatography technology	Kuai J (2003)	1
TNFRSF18	4	TRAF3	1	affinity chromatography technology, two hybrid	Kwon B (1999), Esparza EM (2005)	2
TNFRSF9	1	TRAF3	1	pull down, affinity chromatography technology	Jang IK (1998), Ma BY (2005)	2
MAVS	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paz S (2009), Li S (2011), Paz S (2011), Paz S (2011), Fang R (2017)	5
CDC42	3	BIRC2	1	pull down, pull down, affinity chromatography technology, enzymatic study	Marivin A (2013), Marivin A (2013), Marivin A (2013), Murali A (2017)	4
HIVEP3	12	TRAF1	0	two hybrid, affinity chromatography technology	Oukka M (2002), Oukka M (2002)	2
TNFRSF14	2	TRAF3	1	pull down	Marsters SA (1997)	1
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
MALT1	1	TAB2	5	affinity chromatography technology, affinity chromatography technology	Oeckinghaus A (2007), Karim ZA (2015)	2
TRAF1	0	GORASP2	1	two hybrid	Rolland T (2014)	1
SPHK1	0	CYLD	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K14	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Mochida Y (2000), Song HY (1997), Li Q (2006), Chen TC (2014)	4
TRAF2	1	PEG3	2	affinity chromatography technology, two hybrid	Relaix F (1998), Relaix F (1998)	2
TRAF2	1	AASDHPPT	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TNFRSF1A	3	BCL10	0	two hybrid	Costanzo A (1999)	1
PIN1	0	TRAF2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NGFR	3	TRAF1	0	affinity chromatography technology	Ye X (1999)	1
MAP3K7	2	COPS5	0	two hybrid	Bandyopadhyay S (2010)	1
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
TRAF1	0	TANK	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Rothe M (1996), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017), Kim CM (2017), Kim CM (2017)	6
USP4	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fan YH (2011), Hou X (2013), Hou X (2013)	3
MAP4K5	3	COPS5	0	two hybrid	Bandyopadhyay S (2010)	1
DIABLO	2	BIRC3	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Verhagen AM (2000), Yang QH (2004), Hu S (2003), Burke SP (2010), Budhidarmo R (2014), Hu S (2003), Wo L (2016)	7
RAD23A	1	UBE2N	1	affinity chromatography technology	Scanlon TC (2009)	1
NGFR	3	TRAF5	1	affinity chromatography technology	Ye X (1999)	1
RAD23A	1	PRKN	1	enzymatic study, affinity chromatography technology	Scanlon TC (2009), Sarraf SA (2013)	2
TNFSF14	0	LTBR	0	affinity chromatography technology	Kuai J (2003)	1
PKN1	4	TRAF2	1	two hybrid, affinity chromatography technology, pull down	Gotoh Y (2004), Gotoh Y (2004), Gotoh Y (2004)	3
TRAF2	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Kataoka T (2000), Kataoka T (2000)	3
EIF2AK2	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Gil J (2004), Gao L (2015)	2
BCL10	0	IKBKB	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Lobry C (2007), Lobry C (2007), Poyet JL (2001), Zhou H (2004), Bidere N (2009)	5
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
MAP3K1	4	CHUK	5	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Lee FS (1998), Nemoto S (1998), Nemoto S (1998), Li Q (2006)	4
RIPK1	2	DAB2IP	3	affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Zhang H (2004)	2
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
BIRC2	1	BCL10	0	affinity chromatography technology, affinity chromatography technology	Yoneda T (2000), Hu S (2006)	2
TRAIP	0	TRAF1	0	two hybrid, pull down, affinity chromatography technology	Lee SY (1997), Lee SY (1997), Besse A (2007)	3
TNF	0	CAV1	0	affinity chromatography technology	Legler DF (2003)	1
MAP3K7	2	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
MLKL	1	RIPK1	2	affinity chromatography technology	Pescatore A (2016)	1
TNFRSF1B	4	TRADD	0	affinity chromatography technology	Wicovsky A (2009)	1
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TNFRSF8	2	TRAF2	1	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Aizawa S (1997), Aizawa S (1997), Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Horie R (2002), Huttlin EL (2017)	7
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
TNFRSF1A	3	CAV1	0	biochemical	Legler DF (2003)	1
TRAF3IP2	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian Y (2002), Qian Y (2004), Boisson B (2013)	3
TRAF2	1	BANP	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRAF2	1	FLNA	10	affinity chromatography technology, imaging technique	Leonardi A (2000), Chen TC (2014)	2
TNFRSF11A	2	TRAF2	1	pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Darnay BG (1998), Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	7
MAP3K14	1	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
ZFAND6	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
CYLD	2	TAB2	5	affinity chromatography technology	Elliott PR (2016)	1
PRKN	1	MAVS	1	affinity chromatography technology, affinity chromatography technology	Khan M (2016), Khan M (2016)	2
MAP3K8	2	TRAF6	0	affinity chromatography technology	Chan H (2005)	1
TNFRSF11A	2	MAP3K7	2	affinity chromatography technology	Mizukami J (2002)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
LTBR	0	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Huttlin EL (2015), Huttlin EL (2017)	3
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
TRAF2	1	DUSP14	2	enzymatic study, affinity chromatography technology	Yang CY (2016), Yang CY (2016)	2
MAP3K5	1	DAB2IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Xie D (2009), Xie D (2009), Zhang H (2004), Zhang H (2004), Wang H (2015)	6
EGFR	5	DUSP14	2	affinity chromatography technology	Yao Z (2017)	1
LTBR	0	DIABLO	2	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
IKBKB	1	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
CYLD	2	RPS3	0	affinity chromatography technology	Elliott PR (2016)	1
MAP3K8	2	CHUK	5	enzymatic study, affinity chromatography technology	Lin X (1999), Lin X (1999)	2
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
COPS5	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
NGFR	3	CAV1	0	pull down	Bilderback TR (1999)	1
RXRA	1	ZBTB16	4	imaging technique	Chen TC (2014)	1
TNFAIP3	3	CHUK	5	affinity chromatography technology	Zetoune FS (2001)	1
CASP8	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
TRAF3IP2	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Qu F (2012), Qu F (2012), Qu F (2012)	3
TNFRSF18	4	TRAF1	0	affinity chromatography technology, two hybrid	Kwon B (1999), Esparza EM (2005)	2
TNFRSF8	2	TRAF5	1	pull down, affinity chromatography technology, pull down	Aizawa S (1997), Aizawa S (1997), Mizushima S (1998)	3
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
TNFRSF10B	1	TRADD	0	affinity chromatography technology	Chaudhary PM (1997)	1
TRAF3	1	MAP3K5	1	affinity chromatography technology	Nishitoh H (1998)	1
ERN1	1	COPS5	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Hsieh YH (2007), Oono K (2004), Oono K (2004)	3
CHUK	5	COPS5	0	enzymatic study, affinity chromatography technology	Orel L (2010), Asare Y (2013)	2
TRAF1	0	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
COPS5	0	TRPC4AP	4	affinity chromatography technology	Bennett EJ (2010)	1
TNF	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
CD27	1	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Yamamoto H (1998), Akiba H (1998)	2
EIF4G1	9	TRAF2	1	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Kim WJ (2005), Kim WJ (2005), Kim WJ (2005), Kim WJ (2005)	4
CYLD	2	FLNA	10	affinity chromatography technology	Elliott PR (2016)	1
TRAF5	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Li S (2011), He L (2004), Chen TC (2014)	3
TRAF6	0	TNFRSF1B	4	affinity chromatography technology	Khursigara G (1999)	1
MALT1	1	DIABLO	2	affinity chromatography technology	Garrison JB (2009)	1
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
CD40	3	TRAF3	1	pull down, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsukamoto N (1999), Hu HM (1994), Hu HM (1994), Hu HM (1994), Ni CZ (2000), Roy N (1997), Qiao G (2007), Mosialos G (1995), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Li C (2003), Boucher LM (1997), Graham JP (2009), Sato T (1995), Sato T (1995), Sato T (1995), Deregibus MC (2003), Hostager BS (1999), Basaki Y (2002), Cheng G (1995), Miliara S (2013), Elmetwali T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	27
DTNB	1	TRAF2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PKN1	4	TRAF1	0	enzymatic study	Kato T (2008)	1
TRAF2	1	TRAF4	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Zhang X (2013), Zhang X (2013), Zhang X (2013), Ren HY (2015)	4
TNF	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
CDC42	3	TRAF2	1	affinity chromatography technology, pull down	Marivin A (2013), Marivin A (2013)	2
TRAIP	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Besse A (2007), Zhang M (2012)	2
MAP3K14	1	TANK	1	affinity chromatography technology	Kanno Y (2010)	1
TRAF2	1	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henn IH (2007), Henn IH (2007), Um JW (2012), Im E (2015)	4
MAP3K7	2	EIF2AK2	1	affinity chromatography technology	Jiang Z (2003)	1
MAP3K5	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Won M (2010), Won M (2010)	2
RIPK2	0	TAB2	5	affinity chromatography technology	Hasegawa M (2008)	1
TRAF2	1	RPS6KA3	2	affinity chromatography technology, affinity chromatography technology	Peng C (2012), Peng C (2012)	2
TNFRSF10B	1	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
MAP4K2	1	TRAF2	1	pull down, affinity chromatography technology	Yuasa T (1998), Yuasa T (1998)	2
TRAF2	1	ZBTB25	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAP3K8	2	TAB2	5	affinity chromatography technology	Chan H (2005)	1
PCSK9	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Xu W (2012), Xu W (2012)	2
CHUK	5	TNFRSF1A	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008)	3
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
CD40	3	CHUK	5	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
BECN1	2	SPHK1	0	affinity chromatography technology, affinity chromatography technology	Liu H (2017), Liu H (2017)	2
MLKL	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Petersen SL (2015), Petersen SL (2015)	2
TRAF4	1	GORASP2	1	two hybrid	Rolland T (2014)	1
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
BECN1	2	TNFAIP3	3	affinity chromatography technology	Shi CS (2010)	1
RAD23A	1	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Fang DF (2013), Fang DF (2013), Rolland T (2014), Akhtar N (2016)	5
MAP3K8	2	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Eliopoulos AG (2002), Chan H (2005)	2
TBK1	1	TANK	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Bouwmeester T (2004), Pomerantz JL (1999), Gatot JS (2007), Li S (2011), Li S (2011), Shen RR (2012), Ryzhakov G (2007), Wang J (2011), Seo S (2013), Saul VV (2014), Richter B (2016), Shostak K (2014)	12
TRAIP	0	TRAF6	0	affinity chromatography technology	Besse A (2007)	1
GSK3B	1	RXRA	1	two hybrid	Vinayagam A (2011)	1
APEX1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Merluzzi S (2008), Merluzzi S (2008)	2
TRAF4	1	RIPK2	0	affinity chromatography technology	Marinis JM (2011)	1
TRAF6	0	TRAF5	1	two hybrid, two hybrid, two hybrid, pull down	Woodsmith J (2012), Rolland T (2014), Yu H (2011), Middleton AJ (2017)	4
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
TNFRSF1B	4	TNF	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Bouwmeester T (2004), Kuai J (2004), Montaldo PG (1994), Liu LS (1998), Zhang L (1994), Higuchi M (1992), Chaturvedi MM (1994), Chainy GB (1996), Nielsen FS (2004), Ameloot P (2001)	10
TNFRSF11A	2	TRAF3	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	4
TNF	0	CHUK	5	affinity chromatography technology, genetic interference	Haas TL (2009), Sahu I (2014)	2
TNFRSF1A	3	TRPC4AP	4	affinity chromatography technology, pull down, affinity chromatography technology	Soond SM (2003), Soond SM (2003), Mace KE (2010)	3
PRKAB2	0	MAP3K5	1	affinity chromatography technology	Behrends C (2010)	1
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
EDA2R	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF6	0	USP4	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Xiao N (2011), Xiao N (2011), Xiao N (2011), Xiao N (2011), Zhou F (2012), Zhou F (2012)	6
TRAF6	0	TRAF4	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Takeshita F (2005), Takeshita F (2005), Chen TC (2014)	3
TRAF2	1	THAP7	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
CD40	3	RIPK2	0	affinity chromatography technology	McCarthy JV (1998)	1
MAVS	1	RIPK2	0	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TRAF2	1	GORASP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
GABPB1	0	TRAF2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SPECC1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	DAgostino L (2011), DAgostino L (2011)	2
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
TNF	0	TBK1	1	affinity chromatography technology	Kuai J (2004)	1
PRKAB2	0	PIAS2	2	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
PRKAB2	0	UBXN11	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
LTBR	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF1A	3	DAB2IP	3	affinity chromatography technology	Zhang H (2004)	1
CHUK	5	RIPK2	0	enzymatic study	Marinis JM (2012)	1
RIPK2	0	UBC	7	affinity chromatography technology	Park S (2013)	1
NGFR	3	TRAF2	1	affinity chromatography technology, pull down	Ye X (1999), Ye X (1999)	2
PDLIM7	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Uemura N (2006), Uemura N (2006)	2
TRAF6	0	PPP4R1	3	affinity chromatography technology	Hadweh P (2014)	1
TRAF1	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Wicovsky A (2009), Henkler F (2003)	2
TRAF2	1	CASP8AP2	3	pull down, affinity chromatography technology	Choi YH (2001), Choi YH (2001)	2
TICAM1	3	TRAF2	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Sasai M (2010), Sasai M (2010), Sasai M (2010), Jiang Z (2004), Takaki H (2009)	5
EIF2AK2	1	TRAF5	1	affinity chromatography technology, affinity chromatography technology	Gil J (2004), Gil J (2004)	2
TRAF3	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kayagaki N (2007), Mankouri J (2010), Mankouri J (2010), Tzieply N (2012), Wang Y (2012), Ng MH (2011), Charoenthongtrakul S (2013), van Zuylen WJ (2012), van Zuylen WJ (2012), Karim R (2013), Chen X (2014), Peng Y (2014), Wang S (2013), Zhou Y (2016), Cai B (2017), Fang R (2017), Fang R (2017)	17
MAVS	1	EIF2AK2	1	affinity chromatography technology	Arnaud N (2011)	1
TRPC4AP	4	TRADD	0	affinity chromatography technology	Soond SM (2003)	1
UBC	7	RPS3	0	pull down	Zhang X (2017)	1
IKBKE	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Zhou AY (2013)	2
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
TRAF3IP2	0	IKBKB	1	affinity chromatography technology, biochemical, affinity chromatography technology	Leonardi A (2000), Mauro C (2003), Valente AJ (2014)	3
IKBKG	0	TANK	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Chariot A (2002), Chariot A (2002), Chariot A (2002), Zhang W (2010), Zhang W (2010), Zhao T (2007), Wang J (2011), Wang W (2015), Huttlin EL (2017)	9
TNFRSF9	1	TNFRSF4	1	affinity chromatography technology, affinity chromatography technology	Ma BY (2005), Ma BY (2005)	2
TRPC4AP	4	IKBKG	0	affinity chromatography technology	Soond SM (2003)	1
AIMP2	0	TANK	1	two hybrid	Wang J (2011)	1
EDARADD	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Yan M (2002), Yan M (2002), Rolland T (2014)	3
PDLIM7	0	COPS5	0	pull down, affinity chromatography technology, affinity chromatography technology	Sangadala S (2013), Sangadala S (2013), Sangadala S (2013)	3
TNFSF14	0	TNFRSF14	2	pull down, affinity chromatography technology	Zhang J (2001), Yu KY (1999)	2
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
CD40	3	MAP3K8	2	affinity chromatography technology	Chan H (2005)	1
TNFRSF8	2	TRAF3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Huttlin EL (2017)	4
EDA2R	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sinha SK (2002), Sinha SK (2004), Huttlin EL (2015), Huttlin EL (2017)	4
TRAF2	1	CDCA3	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRAF2	1	84832	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
COPS5	0	GSTP1	0	affinity chromatography technology	Bennett EJ (2010)	1
CD40	3	TRAF4	1	affinity chromatography technology	Werneburg BG (2001)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
CD40	3	TRAF6	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Tsukamoto N (1999), Roy N (1997), Davies CC (2005), Pullen SS (1998), Peters AL (2010), Ye H (2002), Deregibus MC (2003), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Hostager BS (2010), Hostager BS (2010), Verstak B (2014)	14
IKBKG	0	MALT1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Duewel M (2009), Gyrd-Hansen M (2008), Oeckinghaus A (2007), Karim ZA (2015)	4
FBXO7	1	84832	0	enzymatic study	Teixeira FR (2016)	1
CD40	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Werneburg BG (2001), Peters AL (2010), Hostager BS (2010), Hostager BS (2010)	4
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
EGFR	5	TNFRSF10B	1	affinity chromatography technology	Tong J (2014)	1
MAP3K1	4	APPL1	1	enzymatic study	Charlaftis N (2014)	1
TNFRSF1B	4	RIPK1	2	affinity chromatography technology	Wicovsky A (2009)	1
CASP8AP2	3	CASP8	1	affinity chromatography technology	Imai Y (1999)	1
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
TRAF3	1	BIRC3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mao AP (2010), de Jong SJ (2013), Goncharov T (2013)	3
EGFR	5	CAV1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, pull down, biochemical	Couet J (1997), Couet J (1997), Khan EM (2006), Feldman R (2009), Hua H (2003), Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Park WY (2000), Abulrob A (2004), Abulrob A (2004)	12
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
MAP3K7	2	USP2	0	affinity chromatography technology	Li Y (2013)	1
TRAF4	1	TNFRSF9	1	affinity chromatography technology	Ma BY (2005)	1
FBXO7	1	THAP7	0	enzymatic study	Teixeira FR (2016)	1
TAB2	5	BECN1	2	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Criollo A (2011), Takaesu G (2012), Takaesu G (2012), Takaesu G (2012)	4
COPS5	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Wang J (2006), Wang J (2006)	2
BIRC2	1	UBE2N	1	two hybrid	Schimmack G (2017)	1
TRAF2	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
CYLD	2	DNAJB2	0	affinity chromatography technology	Elliott PR (2016)	1
GSK3B	1	BIRC3	1	affinity chromatography technology	Sun M (2009)	1
MAP3K1	4	GSTP1	0	affinity chromatography technology	Wu Y (2006)	1
ERN1	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Estornes Y (2014), Estornes Y (2014)	2
TRAF2	1	AFF4	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
LTBR	0	TRAF2	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Li C (2003), Liu HP (2011), Huttlin EL (2015), Huttlin EL (2017)	7
TNFRSF18	4	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Kwon B (1999), Esparza EM (2005), Esparza EM (2005)	3
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
UBC	7	HIVEP3	12	affinity chromatography technology	Matsumoto M (2005)	1
EGFR	5	EIF2AK2	1	affinity chromatography technology	Tong J (2014)	1
BIRC2	1	FBXO7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Chang YF (2006), Kuiken HJ (2012), Teixeira FR (2016)	3
TANK	1	TRAF3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology	Bouwmeester T (2004), Rothe M (1996), Gatot JS (2007), Li S (2011), Li C (2003), Li C (2002), Li C (2002), Ng MH (2011)	8
IKBKB	1	IKBKE	2	enzymatic study, affinity chromatography technology	Heilker R (1999), Zhou AY (2013)	2
CHUK	5	BCL10	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Poyet JL (2001), Poyet JL (2001), Marinis JM (2012), Zhou H (2004)	4
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
FBXO28	2	TRAF5	1	affinity chromatography technology	Huttlin EL (2017)	1
ERN1	1	MAP3K5	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Nishitoh H (2002), Chen TC (2014), Zeng T (2015)	3
TNFRSF8	2	TRAIP	0	affinity chromatography technology	Lee SY (1997)	1
TRAF3	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang PX (2016), Wang PX (2016), Wang PX (2016)	3
UBE2N	1	CHUK	5	enzymatic study	Deng L (2000)	1
TRAF1	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shu HB (1997), Kataoka T (2000), Kataoka T (2000), Rolland T (2014)	4
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
CD27	1	TRAF5	1	affinity chromatography technology	Akiba H (1998)	1
MAP4K5	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Shi CS (1999), Shi CS (1999)	2
RIPK2	0	TNFRSF1A	3	affinity chromatography technology	McCarthy JV (1998)	1
NGFR	3	IKBKB	1	affinity chromatography technology	Geetha T (2012)	1
TRAF2	1	RXRA	1	affinity chromatography technology, affinity chromatography technology	Zeng Z (2015), Zeng Z (2015)	2
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
BIRC2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Verhagen AM (2000), Samuel T (2006), Samuel T (2006), Yang QH (2004), Hu S (2003), Hu S (2003), Csomos RA (2009), Burke SP (2010), Kulathila R (2009), Kulathila R (2009), Arnt CR (2002), Budhidarmo R (2014), Lee S (2014), Wo L (2016), Huttlin EL (2017)	16
MLKL	1	CASP8	1	affinity chromatography technology	Hein MY (2015)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
CHUK	5	TRAF4	1	enzymatic study	Marinis JM (2012)	1
ATXN1	2	TRAF2	1	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
MAP3K14	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varfolomeev E (2007), Kanno Y (2010), Lee S (2014), Lee S (2014)	4
TRAF4	1	TNFRSF4	1	affinity chromatography technology	Ma BY (2005)	1
DNAJB2	0	UBC	7	affinity chromatography technology, pull down, two hybrid	Westhoff B (2005), Fenner BJ (2009), Westhoff B (2005)	3
EIF2AK2	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Takizawa T (2002), Takizawa T (2002)	2
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
TCEA2	1	TRAF2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RIPK2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	McCarthy JV (1998), Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	8
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
ENKD1	3	UBXN11	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MALT1	1	TRAF2	1	pull down, affinity chromatography technology	Sun L (2004), Garrison JB (2009)	2
UBC	7	CHUK	5	pull down	Zhang X (2017)	1
MALT1	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2004), Sun L (2004), Garrison JB (2009), Li Y (2013), Oeckinghaus A (2007), Oeckinghaus A (2007), Nie Z (2015), Liu Y (2012), Liu Y (2012)	9
NGFR	3	TRAF3	1	affinity chromatography technology	Ye X (1999)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
NGFR	3	TRAF4	1	affinity chromatography technology, pull down, pull down	Ye X (1999), Ye X (1999), Krajewska M (1998)	3
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
CYLD	2	BIRC2	1	affinity chromatography technology	Elliott PR (2016)	1
TNFRSF1B	4	TRAF1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Marsters SA (1997), Mosialos G (1995), Mosialos G (1995), Boucher LM (1997), Rothe M (1994), Kato T (2008)	6
MALT1	1	BCL10	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uren AG (2000), Uren AG (2000), Uren AG (2000), Noels H (2009), Carvalho G (2010), Welteke V (2009), Oruganti SR (2011), Lucas PC (2001), Langel FD (2008), Langel FD (2008), Blonska M (2007), Oeckinghaus A (2007), Park Y (2013), Park Y (2013), Borthakur A (2013), Zhou H (2004), Zhou H (2004), Chen J (2015), Karim ZA (2015), Nie Z (2015), Eitelhuber AC (2011), Paul S (2012), Yang YK (2016), Liu Y (2012), Bidere N (2009), Bidere N (2009), Afonina IS (2016), Howes A (2016)	28
RIPK1	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma Q (2008), Ea CK (2006), Kanayama A (2004), Kanayama A (2004)	4
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
RAD23A	1	TRAF5	1	two hybrid	Rolland T (2014)	1
TNFRSF11A	2	TAB2	5	affinity chromatography technology	Mizukami J (2002)	1
TRAIP	0	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Lee SY (1997), Lee SY (1997), Besse A (2007), Park ES (2015)	4
COPS5	0	RPS3	0	affinity chromatography technology	Bennett EJ (2010)	1
DNAJB2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GSTP1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, imaging technique	Wu Y (2006), Wu Y (2006), De Luca A (2014), De Luca A (2014), Chen TC (2014)	5
TRAF1	0	MAP3K5	1	affinity chromatography technology	Nishitoh H (1998)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
FBXO7	1	RPS6KA3	2	enzymatic study	Teixeira FR (2016)	1
PRKAB2	0	TRAF2	1	two hybrid, two hybrid, two hybrid	Corominas R (2014), Rolland T (2014), Yu H (2011)	3
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
PIAS2	2	TRAF2	1	pull down, affinity chromatography technology, affinity chromatography technology	Liu J (2011), Liu J (2011), Liu J (2011)	3
TRAF2	1	EIF2AK2	1	affinity chromatography technology, affinity chromatography technology	Gil J (2004), Gao L (2015)	2
FLNA	10	SPECC1	1	affinity chromatography technology	Hein MY (2015)	1
TNFRSF1A	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahmad R (2007), Fan YH (2011), Cusson-Hermance N (2005), Blonska M (2005), Mitsuhashi S (2008)	5
BIRC3	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Yoneda T (2000), Hu S (2006), Yui D (2001), Hu S (2006), Hu S (2006), Hu S (2006), Hu S (2006)	7
IKBKG	0	MAP3K14	1	affinity chromatography technology, affinity chromatography technology	Li Y (1999), Huttlin EL (2017)	2
LTBR	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TAB2	5	IKBKB	1	enzymatic study	Niu J (2011)	1
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
TRAF2	1	RCOR3	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRAIP	0	TRAF5	1	affinity chromatography technology	Besse A (2007)	1
TNFRSF1B	4	TNFRSF1A	3	affinity chromatography technology	Wicovsky A (2009)	1
MALT1	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Oeckinghaus A (2007), Karim ZA (2015)	2
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
TRAF2	1	CD40	3	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McWhirter SM (1999), Tsukamoto N (1999), Malinin NL (1997), Knox PG (2011), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Boucher LM (1997), Graham JP (2009), Deregibus MC (2003), Yacoub D (2010), Hostager BS (1999), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Rolland T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	21
CHUK	5	IKBKE	2	enzymatic study	Heilker R (1999)	1
TRAF3IP2	0	CD40	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian Y (2002), Qian Y (2004), Boisson B (2013)	3
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
TNFRSF14	2	TRAF2	1	two hybrid, affinity chromatography technology, pull down	Hsu H (1997), Hsu H (1997), Marsters SA (1997)	3
MAP3K14	1	TRAF3	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Sanjo H (2010), Sanjo H (2010), Song HY (1997), Hu WH (2004), Liao G (2004), Liao G (2004), Choudhary S (2013), Lee S (2014), Huttlin EL (2017)	10
TRPC4AP	4	RIPK1	2	affinity chromatography technology	Soond SM (2003)	1
MAP3K7	2	BCL10	0	affinity chromatography technology	Blonska M (2007)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
CAV1	0	TRADD	0	affinity chromatography technology	Feng X (2001)	1
TNFAIP3	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gao L (2011), Saitoh T (2005)	3
TRADD	0	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Hsu H (1996), Ea CK (2006), Guan YJ (2011), Jeon J (2014), Lin B (2016)	7
UBC	7	PTPN2	0	pull down	Zhang X (2017)	1
TRAF3	1	RIPK1	2	affinity chromatography technology	Hsu H (1996)	1
BIRC3	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
MALT1	1	COPS5	0	affinity chromatography technology	Welteke V (2009)	1
EGFR	5	TBK1	1	affinity chromatography technology	Tong J (2014)	1
PDLIM7	0	FLNA	10	affinity chromatography technology	Hein MY (2015)	1
USP4	3	IKBKB	1	affinity chromatography technology	Fan YH (2011)	1
TNFRSF10B	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Bellail AC (2012), Gonzalvez F (2012)	2
UBC	7	ZFAND6	0	pull down, affinity chromatography technology, pull down, pull down	Fenner BJ (2009), Fenner BJ (2009), Nathan JA (2013), Zhang X (2017)	4
TICAM1	3	TNFAIP3	3	affinity chromatography technology	Wang YY (2004)	1
MAP3K7	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Koga T (2008), Elliott PR (2016)	2
IKBKB	1	TRAF1	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid	Sughra K (2010), Sughra K (2010), Sughra K (2010), Henkler F (2003)	4
COPS5	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
TRAF2	1	FBXO28	2	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
TRAF4	1	MAP3K7	2	affinity chromatography technology	Zhang L (2013)	1
PIN1	0	TRAF1	0	two hybrid	Rolland T (2014)	1
TRAF1	0	THAP7	0	two hybrid	Rolland T (2014)	1
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
TNFRSF10B	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Gonzalvez F (2012)	4
TRAF2	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Nishitoh H (1998), Hoeflich KP (1999), Gan B (2006), Kolliputi N (2009), Fujino G (2007), Fujino G (2007), Wu Y (2006), Zhang H (2004), Hwang SG (2014), Yoon KW (2009), Yoon KW (2009)	11
TRAF2	1	ZBTB16	4	two hybrid, imaging technique	Rual JF (2005), Chen TC (2014)	2
TAB2	5	TANK	1	affinity chromatography technology	Kanayama A (2004)	1
TNFRSF14	2	TRAF5	1	two hybrid, affinity chromatography technology, pull down	Hsu H (1997), Hsu H (1997), Marsters SA (1997)	3
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
NGFR	3	TRADD	0	affinity chromatography technology	El Yazidi-Belkoura I (2003)	1
CASP8	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Oshima S (2009), Saitoh Y (2016)	2
MAP3K1	4	DNAJB2	0	enzymatic study	Charlaftis N (2014)	1
CASP8	1	CDKN1B	1	genetic interference	Shen JP (2017)	1
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
TNFRSF8	2	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Huttlin EL (2017)	4
GSK3B	1	IKBKG	0	imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Medunjanin S (2016), Medunjanin S (2016), Medunjanin S (2016)	4
FBXO7	1	RPS3	0	affinity chromatography technology	Teixeira FR (2016)	1
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
USP2	0	TBK1	1	affinity chromatography technology	Zhang L (2014)	1