PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF1	0	FBXO28	2	affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Huttlin EL (2017)	2
TRAF2	1	TNFRSF9	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Jang IK (1998), Jang IK (1998), Jang IK (1998), Arch RH (1998), Arch RH (1998), Ma BY (2005), Martinez-Forero I (2013), Saoulli K (1998), Saoulli K (1998)	9
CFLAR	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
TRAF1	0	OLIG3	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TNFRSF1B	4	CHUK	5	affinity chromatography technology	Wicovsky A (2009)	1
CFLAR	1	TNFRSF1A	3	genetic interference	Ma Y (2017)	1
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
MAP3K14	1	IKBKB	1	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Luftig MA (2001), Woronicz JD (1997), Li Q (2006), Huttlin EL (2017)	4
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
LTBR	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF1A	3	TRAF3	1	pull down	Mosialos G (1995)	1
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
TICAM1	3	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Jiang Z (2004), Nguyen VP (2014)	2
IKBKB	1	TNFRSF1A	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang SQ (2000), Chaudhary PM (2000), Fan YH (2011), Park KJ (2002), Guan YJ (2011), Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008), Chen TC (2014)	9
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
TNFRSF1B	4	TRAF3	1	pull down, affinity chromatography technology	Mosialos G (1995), Mosialos G (1995)	2
CD40	3	RNF31	3	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
TANK	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Goncharov T (2013)	2
IKBKG	0	TBK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Fenner BJ (2010), Li S (2011), Wang L (2012), Wang L (2012), Ran Y (2016), Huttlin EL (2017)	7
MAP3K14	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Choudhary S (2013)	6
CHUK	5	RIPK1	2	biochemical	Poyet JL (2000)	1
CHUK	5	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
CD40	3	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
TNFRSF1B	4	TRAIP	0	affinity chromatography technology	Lee SY (1997)	1
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
TRAF1	0	RBCK1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Abdul-Sater AA (2017)	4
TRAF6	0	SRC	2	affinity chromatography technology, pull down	Wong BR (1999), Liu A (2012)	2
TRAF2	1	FBF1	2	two hybrid	Rual JF (2005)	1
TRAF1	0	ECI2	2	affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Huttlin EL (2017)	2
TANK	1	CD40	3	affinity chromatography technology	Qiao G (2007)	1
TRAF1	0	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Greenfeld H (2015), Huttlin EL (2017)	3
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
SHARPIN	1	CHUK	5	affinity chromatography technology	Tokunaga F (2011)	1
IKBKB	1	TNFAIP3	3	enzymatic study, affinity chromatography technology	Zetoune FS (2001), Xiong Y (2011)	2
TNFRSF9	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Jang IK (1998), Ma BY (2005), Saoulli K (1998), Saoulli K (1998)	4
TANK	1	CHUK	5	affinity chromatography technology	Chariot A (2002)	1
TRAF1	0	TBK1	1	affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Huttlin EL (2017)	2
RIPK1	2	IKBKB	1	biochemical, pull down	Yang Y (2011), Poyet JL (2000)	2
TICAM1	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Piao W (2009), Sato S (2003), Sato S (2003), Hu YH (2015), Cai B (2017)	6
TICAM1	3	TANK	1	affinity chromatography technology	Li S (2011)	1
TRADD	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Park YC (2000), Tsao DH (2000), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Vince JE (2009), Jang HD (2001), Park KJ (2003), Lin B (2016)	12
IKBKG	0	TRAF3	1	affinity chromatography technology	Belgnaoui SM (2012)	1
SHARPIN	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, biochemical	Verhelst K (2012), Keusekotten K (2013), Schaeffer V (2014), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), Draber P (2015), Draber P (2015), Draber P (2015), Stieglitz B (2012), Huttlin EL (2017), Elliott PR (2016), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017)	21
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
TRAF2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Li S (2011), Huttlin EL (2017)	3
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
CHUK	5	SRC	2	affinity chromatography technology, affinity chromatography technology	Huang WC (2003), Funakoshi-Tago M (2005)	2
MAP3K14	1	CHUK	5	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Regnier CH (1997), Regnier CH (1997), Xiao G (2000), Luftig MA (2001), Ninomiya-Tsuji J (1999), Ninomiya-Tsuji J (1999), Qing G (2007), Sanjo H (2010), Hu WH (2004), Liao G (2004), Li Q (2006), Chen TC (2014), Huttlin EL (2017)	13
TRAIP	0	TBK1	1	affinity chromatography technology	Zhang M (2012)	1
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
HIVEP3	12	TRAF2	1	two hybrid, affinity chromatography technology	Oukka M (2002), Oukka M (2002)	2
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
TRAF3	1	CFLAR	1	affinity chromatography technology	Kataoka T (2000)	1
TNFRSF11A	2	TRAF6	0	affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mizukami J (2002), Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998), Lin J (2015), Yu J (2016)	9
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
TBK1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bouwmeester T (2004), Bonnard M (2000), Behrends C (2010), Li S (2011), Li S (2011), Shen RR (2012), Zhang W (2010), Huttlin EL (2017), Fang R (2017), Fang R (2017)	10
LTBR	0	TRAF3	1	affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	VanArsdale TL (1997), Wu MY (1999), Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Mosialos G (1995), Li C (2003), Li C (2003), Force WR (1997), Force WR (1997), Huttlin EL (2015), Huttlin EL (2017)	12
TICAM1	3	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Sasai M (2010), Sasai M (2010), Jiang Z (2004), Wang YY (2004), Sato S (2003), Sato S (2003), Sato S (2003), Takaki H (2009), Verstak B (2014), Hu YH (2015)	10
TANK	1	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method	Bouwmeester T (2004), Rothe M (1996), Rothe M (1996), Nomura F (2000), Nomura F (2000), Pomerantz JL (1999), Behrends C (2010), Li S (2011), Li S (2011), Li C (2002), Shen RR (2012), Shen RR (2012), Wang J (2011), Huttlin EL (2017), Kim CM (2017)	15
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
TRAF6	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Bidere N (2006), Bidere N (2006), He L (2006), He L (2006), Zinngrebe J (2016)	5
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
CHUK	5	TRADD	0	biochemical	Poyet JL (2000)	1
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
TNFRSF11A	2	TRAF1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	4
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
CFLAR	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
TRADD	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chang YL (2014), Chang YL (2014)	2
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
LTBR	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SHARPIN	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Verhelst K (2012), Verhelst K (2012)	2
FBXO28	2	GIT2	2	affinity chromatography technology	Huttlin EL (2017)	1
TICAM1	3	TRAF1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Jiang Z (2004), Su X (2006), Su X (2006), Su X (2006), Takaki H (2009)	5
EDA2R	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
TRAF1	0	TRAF1	0	affinity chromatography technology, two hybrid, two hybrid	Pullen SS (1998), Rothe M (1994), Rolland T (2014)	3
TICAM1	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meylan E (2004), Meylan E (2004), Chang M (2009), Hu YH (2015)	4
TRAF3	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013)	2
TRAF1	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017), Abdul-Sater AA (2017)	4
CASP8	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
MAP3K14	1	TRAF2	1	pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Luftig MA (2001), Luftig MA (2001), Malinin NL (1997), Malinin NL (1997), Malinin NL (1997), Sanjo H (2010), Kanno Y (2010), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Lee S (2014), Rolland T (2014)	13
RNF31	3	RIPK1	2	affinity chromatography technology	Draber P (2015)	1
CD40	3	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Hostager BS (2010), Hostager BS (2010)	3
TNFRSF13C	5	TRAF2	1	affinity chromatography technology	Hildebrand JM (2010)	1
EDA2R	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sinha SK (2002), Sinha SK (2004), Huttlin EL (2015), Huttlin EL (2017)	4
BIRC3	1	TANK	1	affinity chromatography technology	Goncharov T (2013)	1
TRAF1	0	TRADD	0	affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Wicovsky A (2009)	2
TNFRSF1A	3	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Y (1999), Schuetze S (1999), Pan G (1997), Hsu H (1996), Hsu H (1996), Hsu H (1996), Shu HB (1996), Blankenship JW (2009), Kolliputi N (2009), Fujikura D (2012), Park KJ (2002), Guan YJ (2011), Hsu H (1995), Kumar A (2001), Zheng L (2006), Kim TW (2013), Zhang H (2004), Chang YL (2014), Nakazawa S (2016), Huttlin EL (2017)	20
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
TNFRSF1B	4	TRAF2	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Song HY (1995), Song HY (1995), Takeuchi M (1996), Hostager BS (2002), Rothe M (1996), Marsters SA (1997), Carpentier I (2008), Rothe M (1995), Park YC (1999), Boucher LM (1997), Rothe M (1994), Rothe M (1994)	13
CD40	3	DIABLO	2	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
ECH1	2	ECI2	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Floyd BJ (2016), Huttlin EL (2017)	4
CASP8	1	TRADD	0	affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kolliputi N (2009)	2
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
CFLAR	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kataoka T (2000), Chaudhary PM (2000), Rebe C (2007), Feoktistova M (2011), Ranjan K (2016), Ranjan K (2016)	6
SHARPIN	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Verhelst K (2012), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Draber P (2015), Liu J (2017)	6
TNFRSF18	4	TRAF3	1	affinity chromatography technology, two hybrid	Kwon B (1999), Esparza EM (2005)	2
TNFRSF9	1	TRAF3	1	pull down, affinity chromatography technology	Jang IK (1998), Ma BY (2005)	2
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
HIVEP3	12	TRAF1	0	two hybrid, affinity chromatography technology	Oukka M (2002), Oukka M (2002)	2
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
MAP3K14	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Mochida Y (2000), Song HY (1997), Li Q (2006), Chen TC (2014)	4
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
TRAF1	0	TANK	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Rothe M (1996), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017), Kim CM (2017), Kim CM (2017)	6
DIABLO	2	BIRC3	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Verhagen AM (2000), Yang QH (2004), Hu S (2003), Burke SP (2010), Budhidarmo R (2014), Hu S (2003), Wo L (2016)	7
TRAF1	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Wong BR (1999), Narita T (2005)	2
TRAF1	0	CCDC146	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRAF2	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Kataoka T (2000), Kataoka T (2000)	3
TRAF1	0	FBF1	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
TRAIP	0	TRAF1	0	two hybrid, pull down, affinity chromatography technology	Lee SY (1997), Lee SY (1997), Besse A (2007)	3
TNFRSF1B	4	TRADD	0	affinity chromatography technology	Wicovsky A (2009)	1
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TNFRSF8	2	TRAF2	1	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Aizawa S (1997), Aizawa S (1997), Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Horie R (2002), Huttlin EL (2017)	7
IKBKG	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Verhelst K (2012), Zak DE (2011), Tokunaga F (2011), Tokunaga F (2011), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017), Bal E (2017)	10
TNFRSF11A	2	TRAF2	1	pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Darnay BG (1998), Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	7
MAP3K14	1	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
LTBR	0	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Huttlin EL (2015), Huttlin EL (2017)	3
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
LTBR	0	DIABLO	2	affinity chromatography technology, affinity chromatography technology	Kuai J (2003), Kuai J (2003)	2
IKBKB	1	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
TRAF1	0	ZNF440	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TNFAIP3	3	CHUK	5	affinity chromatography technology	Zetoune FS (2001)	1
CASP8	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
TNFRSF18	4	TRAF1	0	affinity chromatography technology, two hybrid	Kwon B (1999), Esparza EM (2005)	2
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
TRAF6	0	TNFRSF1B	4	affinity chromatography technology	Khursigara G (1999)	1
CD40	3	TRAF3	1	pull down, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsukamoto N (1999), Hu HM (1994), Hu HM (1994), Hu HM (1994), Ni CZ (2000), Roy N (1997), Qiao G (2007), Mosialos G (1995), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Li C (2003), Boucher LM (1997), Graham JP (2009), Sato T (1995), Sato T (1995), Sato T (1995), Deregibus MC (2003), Hostager BS (1999), Basaki Y (2002), Cheng G (1995), Miliara S (2013), Elmetwali T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	27
TRAIP	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Besse A (2007), Zhang M (2012)	2
MAP3K14	1	TANK	1	affinity chromatography technology	Kanno Y (2010)	1
GIT2	2	IKBKG	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TRAF1	0	CCDC116	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CHUK	5	TNFRSF1A	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008)	3
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
CD40	3	CHUK	5	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
SHARPIN	1	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Keusekotten K (2013), Nakazawa S (2016)	2
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
TRAF1	0	OTUD4	2	affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Huttlin EL (2017)	2
TBK1	1	TANK	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Bouwmeester T (2004), Pomerantz JL (1999), Gatot JS (2007), Li S (2011), Li S (2011), Shen RR (2012), Ryzhakov G (2007), Wang J (2011), Seo S (2013), Saul VV (2014), Richter B (2016), Shostak K (2014)	12
TRAIP	0	TRAF6	0	affinity chromatography technology	Besse A (2007)	1
TNFRSF1A	3	RBCK1	0	affinity chromatography technology	Nakazawa S (2016)	1
TNFRSF11A	2	TRAF3	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	4
EDA2R	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF1	0	TNFRSF13C	5	affinity chromatography technology, affinity chromatography technology	Lavorgna A (2009), Lavorgna A (2009)	2
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
TBK1	1	SRC	2	affinity chromatography technology	Johnsen IB (2009)	1
LTBR	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRC	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Funakoshi-Tago M (2005), Funakoshi-Tago M (2005), Lee SH (2012)	3
TRAF1	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Wicovsky A (2009), Henkler F (2003)	2
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
TICAM1	3	TRAF2	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Sasai M (2010), Sasai M (2010), Sasai M (2010), Jiang Z (2004), Takaki H (2009)	5
TRAF3	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kayagaki N (2007), Mankouri J (2010), Mankouri J (2010), Tzieply N (2012), Wang Y (2012), Ng MH (2011), Charoenthongtrakul S (2013), van Zuylen WJ (2012), van Zuylen WJ (2012), Karim R (2013), Chen X (2014), Peng Y (2014), Wang S (2013), Zhou Y (2016), Cai B (2017), Fang R (2017), Fang R (2017)	17
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
TRAF3	1	SRC	2	affinity chromatography technology, affinity chromatography technology	Wong BR (1999), Johnsen IB (2009)	2
IKBKG	0	TANK	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Chariot A (2002), Chariot A (2002), Chariot A (2002), Zhang W (2010), Zhang W (2010), Zhao T (2007), Wang J (2011), Wang W (2015), Huttlin EL (2017)	9
TNFRSF8	2	TRAF3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Huttlin EL (2017)	4
EDA2R	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sinha SK (2002), Sinha SK (2004), Huttlin EL (2015), Huttlin EL (2017)	4
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
TNFAIP3	3	SRC	2	affinity chromatography technology	Huttlin EL (2017)	1
CD40	3	TRAF6	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Tsukamoto N (1999), Roy N (1997), Davies CC (2005), Pullen SS (1998), Peters AL (2010), Ye H (2002), Deregibus MC (2003), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Hostager BS (2010), Hostager BS (2010), Verstak B (2014)	14
CD40	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Werneburg BG (2001), Peters AL (2010), Hostager BS (2010), Hostager BS (2010)	4
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
TNFRSF1B	4	RIPK1	2	affinity chromatography technology	Wicovsky A (2009)	1
TNFRSF1A	3	SRC	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Narita T (2005), Pincheira R (2008), Darnay BG (1997)	3
TRAF3	1	BIRC3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mao AP (2010), de Jong SJ (2013), Goncharov T (2013)	3
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
ECH1	2	TRAF1	0	two hybrid, affinity chromatography technology	Rolland T (2014), Greenfeld H (2015)	2
TNFRSF13C	5	TRAF3	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Xu LG (2002), Ni CZ (2004), Ni CZ (2004), Hildebrand JM (2010)	4
LTBR	0	TRAF2	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Li C (2003), Liu HP (2011), Huttlin EL (2015), Huttlin EL (2017)	7
TNFRSF18	4	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Kwon B (1999), Esparza EM (2005), Esparza EM (2005)	3
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
LTBR	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TANK	1	TRAF3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology	Bouwmeester T (2004), Rothe M (1996), Gatot JS (2007), Li S (2011), Li C (2003), Li C (2002), Li C (2002), Ng MH (2011)	8
TNFRSF8	2	TRAIP	0	affinity chromatography technology	Lee SY (1997)	1
TRAF1	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shu HB (1997), Kataoka T (2000), Kataoka T (2000), Rolland T (2014)	4
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
BIRC2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Verhagen AM (2000), Samuel T (2006), Samuel T (2006), Yang QH (2004), Hu S (2003), Hu S (2003), Csomos RA (2009), Burke SP (2010), Kulathila R (2009), Kulathila R (2009), Arnt CR (2002), Budhidarmo R (2014), Lee S (2014), Wo L (2016), Huttlin EL (2017)	16
MAP3K14	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varfolomeev E (2007), Kanno Y (2010), Lee S (2014), Lee S (2014)	4
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
RBCK1	0	RIPK1	2	affinity chromatography technology	Tian Y (2007)	1
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
TNFRSF1B	4	TRAF1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Marsters SA (1997), Mosialos G (1995), Mosialos G (1995), Boucher LM (1997), Rothe M (1994), Kato T (2008)	6
IKBKB	1	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Huang WC (2003), Huang WC (2003), Funakoshi-Tago M (2005), Chang YJ (2004)	4
ECH1	2	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAIP	0	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Lee SY (1997), Lee SY (1997), Besse A (2007), Park ES (2015)	4
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
GIT2	2	TRAF1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
IKBKG	0	MAP3K14	1	affinity chromatography technology, affinity chromatography technology	Li Y (1999), Huttlin EL (2017)	2
LTBR	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
TNFRSF1B	4	TNFRSF1A	3	affinity chromatography technology	Wicovsky A (2009)	1
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
TRAF2	1	CD40	3	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McWhirter SM (1999), Tsukamoto N (1999), Malinin NL (1997), Knox PG (2011), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Boucher LM (1997), Graham JP (2009), Deregibus MC (2003), Yacoub D (2010), Hostager BS (1999), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Rolland T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	21
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
MAP3K14	1	TRAF3	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Sanjo H (2010), Sanjo H (2010), Song HY (1997), Hu WH (2004), Liao G (2004), Liao G (2004), Choudhary S (2013), Lee S (2014), Huttlin EL (2017)	10
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
TNFAIP3	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gao L (2011), Saitoh T (2005)	3
SHARPIN	1	IKBKB	1	affinity chromatography technology	Tokunaga F (2011)	1
TRADD	0	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Hsu H (1996), Ea CK (2006), Guan YJ (2011), Jeon J (2014), Lin B (2016)	7
GIT2	2	TNFAIP3	3	two hybrid	Wang J (2011)	1
TRAF3	1	RIPK1	2	affinity chromatography technology	Hsu H (1996)	1
TICAM1	3	TNFAIP3	3	affinity chromatography technology	Wang YY (2004)	1
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
TNFAIP3	3	RBCK1	0	affinity chromatography technology, two hybrid	Verhelst K (2012), Hayes SD (2012)	2
IKBKB	1	TRAF1	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid	Sughra K (2010), Sughra K (2010), Sughra K (2010), Henkler F (2003)	4
TRAF2	1	FBXO28	2	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
CASP8	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Oshima S (2009), Saitoh Y (2016)	2
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
TNFRSF8	2	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Huttlin EL (2017)	4