Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
TP53 7157 ENALAPRIL CHEMBL578 NCI 16900775
TP53 7157 RIZATRIPTAN CHEMBL905 NCI 14614330
TP53 7157 SIROLIMUS CHEMBL413 CKB, NCI 16651424, 26144316
TP53 7157 THIOTEPA CHEMBL671 NCI 12058967
TP53 7157 FLUOROURACIL CHEMBL185 PharmGKB
TP53 7157 DOXORUBICIN CHEMBL53463 CKB, CGI, CIViC 22698404, 9569050, 21399868, 25658463, 16243804, 23165797, 26826118
TP53 7157 GEMCITABINE CHEMBL888 CKB, CGI 23520471, 21389100, 26228206, 27167172, 27815358
TP53 7157 TAMOXIFEN CHEMBL83 CIViC 10786679
TP53 7157 GANETESPIB CHEMBL2103879 CKB 26009011
TP53 7157 TOPOTECAN CHEMBL84 CKB 26438783
TP53 7157 DASATINIB CHEMBL1421 CKB 26855149
TP53 7157 PF-04217903 CHEMBL2001019 CKB 27659046
TP53 7157 VORINOSTAT CHEMBL98 CKB 26009011, 25669829
TP53 7157 AZD-5363 CHEMBL2178577 CKB 26910118
TP53 7157 ETOPOSIDE CHEMBL44657 CKB 25964101
TP53 7157 DUVELISIB CHEMBL3039502 CKB
TP53 7157 Lesogaberan CHEMBL448343 DrugBank
TP53 7157 INTERFERON ALFA-2B CHEMBL1201558 NCI 16001656
TP53 7157 PROPYLTHIOURACIL CHEMBL1518 NCI 7790147
TP53 7157 TRIFLUOPERAZINE CHEMBL422 NCI 12415616
TP53 7157 BEVACIZUMAB CHEMBL1201583 CKB, NCI 21399868, 11720743, 15579019, 17145525, 27466356, 23670029
TP53 7157 GRANISETRON CHEMBL289469 ClearityFoundationClinicalTrial
TP53 7157 ZINC CHLORIDE CHEMBL1200679 NCI 16585387
TP53 7157 BORTEZOMIB CHEMBL325041 inhibitor TALC
TP53 7157 AZD-1775 CHEMBL1976040 CKB, CGI 27998224, 22713237, 23520471, 28652249, 19887545, 21389100, 21799033, 27196784, 27601554, 21992793
TP53 7157 PRAMLINTIDE CHEMBL2103758 CGI
TP53 7157 DOCETAXEL CHEMBL92 CKB, CIViC 22425996, 21399868
TP53 7157 CRIZOTINIB CHEMBL601719 CKB 26438783, 25971938, 27149990
TP53 7157 DEMCIZUMAB CHEMBL2109384 CKB 26855149
TP53 7157 PD-0325901 CHEMBL507361 CKB 26272063
TP53 7157 NAVITOCLAX CHEMBL443684 CKB 26474387, 27659046
TP53 7157 DABRAFENIB CHEMBL2028663 CKB 27659046
TP53 7157 DACTOLISIB CHEMBL1879463 CKB 26272063
TP53 7157 ALPELISIB CHEMBL2396661 CKB 27659046
TP53 7157 NUTLIN-3 CHEMBL191334 CKB 26883273, 25964101, 26494859
TP53 7157 HEMICHOLINIUM-3 CHEMBL268697 CKB 21980130
TP53 7157 LY-3009120 CHEMBL3545195 CKB 26343583
TP53 7157 PHA-680632 CHEMBL363160 CKB 18026198
TP53 7157 PANITUMUMAB CHEMBL1201827 CKB 28514312
TP53 7157 ERLOTINIB CHEMBL553 CKB 27659046
TP53 7157 CHEMBL1235116 CHEMBL1235116 DrugBank 10592235
TP53 7157 DIETHYLSTILBESTROL CHEMBL411 NCI 15545218
TP53 7157 GOSSYPOL CHEMBL51483 NCI 16020667
TP53 7157 OXALIPLATIN CHEMBL414804 CKB, CIViC 21468686, 24957073
TP53 7157 CARBOPLATIN CHEMBL1351 CKB, CIViC 11595686, 27998224, 25658463, 25567130, 26494859
TP53 7157 CYCLOPHOSPHAMIDE CHEMBL88 CKB 26438783, 17388661, 16243804
TP53 7157 INK-128 CHEMBL3545056 CKB 26272063, 25261369
TP53 7157 VX-970 CHEMBL3545202 CKB
TP53 7157 GEDATOLISIB CHEMBL592445 CKB 21325073, 23980093
TP53 7157 CYTARABINE CHEMBL803 CKB
TP53 7157 DS-7423 CHEMBL3545248 CKB 24504419
TP53 7157 TANESPIMYCIN CHEMBL109480 CKB 26009011
TP53 7157 ALVESPIMYCIN CHEMBL383824 CKB 26009011
TP53 7157 CHEMBL392068 CHEMBL392068 CKB 26855149
TP53 7157 PROXYPHYLLINE CHEMBL37390 NCI 16751417
TP53 7157 METHIMAZOLE CHEMBL1515 NCI 7790147
TP53 7157 PUROMYCIN CHEMBL469912 NCI 11866936
TP53 7157 VESNARINONE CHEMBL17423 NCI 7750082
TP53 7157 AZD-6738 CHEMBL3545178 CKB, CGI 28062704, 26563132
TP53 7157 DECITABINE CHEMBL1201129 CGI
TP53 7157 MITOMYCIN CHEMBL105 CGI
TP53 7157 SELUMETINIB CHEMBL1614701 CKB, CIViC 22425996, 26272063, 26343583
TP53 7157 EPIRUBICIN CHEMBL417 CKB 17388661, 22903472
TP53 7157 ENCORAFENIB CHEMBL3301612 CKB
TP53 7157 CHEMBL376408 CHEMBL376408 CKB 21468686
TP53 7157 TRAMETINIB CHEMBL2103875 CKB 27659046
TP53 7157 PF-00477736 CHEMBL3545137 CKB 22713237
TP53 7157 RG-547 CHEMBL384304 CKB 17121911
TP53 7157 VEMURAFENIB CHEMBL1229517 CKB 26343583, 28514312
TP53 7157 CAPMATINIB CHEMBL3188267 CKB 25971938
TP53 7157 AMG-337 CHEMBL3545212 CKB 26432108
TP53 7157 HALOPERIDOL CHEMBL54 NCI 16476148
TP53 7157 STREPTONIGRIN CHEMBL11417 NCI 12027749
TP53 7157 CAPECITABINE CHEMBL1773 CIViC 24957073
TP53 7157 SELICICLIB CHEMBL14762 CKB 22862161, 26826118
TP53 7157 PRODIGIOSIN CHEMBL275787 CKB 26759239
TP53 7157 DAUNORUBICIN CHEMBL178 CKB 16243804
TP53 7157 SP-600125 CHEMBL1725279 CKB 22438244
TP53 7157 PIMASERTIB CHEMBL2107832 CKB 26228206
TP53 7157 INOSITOL CHEMBL1222251 NCI 16733561
TP53 7157 METHYLPREDNISOLONE CHEMBL650 NCI 16684279
TP53 7157 PACLITAXEL CHEMBL428647 PharmGKB, CKB, NCI 16459017
TP53 7157 YONDELIS CHEMBL297812 NCI 16888811
TP53 7157 GARLIC CHEMBL2108463 NCI 16351512
TP53 7157 ABEMACICLIB CHEMBL3301610 CKB, CGI 27217383
TP53 7157 IFOSFAMIDE CHEMBL1024 CKB 23165797
TP53 7157 OLAPARIB CHEMBL521686 CKB 22172724
TP53 7157 AZD-6482 CHEMBL2165191 CKB 26563132
TP53 7157 IBRUTINIB CHEMBL1873475 CKB 26563132
TP53 7157 TEMOZOLOMIDE CHEMBL810 CKB 21730979
TP53 7157 RG-7602 CHEMBL3545007 CKB 27815358
TP53 7157 TARENFLURBIL CHEMBL190083 NCI 15710360
TP53 7157 ASPIRIN CHEMBL25 acetylation DrugBank 21475861
TP53 7157 CHEMBL1221512 CHEMBL1221512 NCI 16224182
TP53 7157 RITUXIMAB CHEMBL1201576 NCI 11895917
TP53 7157 PAZOPANIB CHEMBL477772 CKB 25669829, 26646755
TP53 7157 LORLATINIB CHEMBL3286830 CKB 28285684
TP53 7157 PEMBROLIZUMAB CHEMBL3137343 CKB 28039262
TP53 7157 AZD-7762 CHEMBL2041933 CKB 23839309
TP53 7157 MYCOPHENOLIC ACID CHEMBL866 NCI 16684279
TP53 7157 TIRAPAZAMINE CHEMBL50882 NCI 9647614
TP53 7157 URSODIOL CHEMBL1551 NCI 15885361
TP53 7157 CETUXIMAB CHEMBL1201577 CIViC 24957073
TP53 7157 Tepotinib CHEMBL3402762 CKB 26358474
TP53 7157 IRINOTECAN CHEMBL481 CKB 25567130
TP53 7157 TRIFLURIDINE CHEMBL1129 CKB 25700705
TP53 7157 AMG-900 CHEMBL2140408 CKB 24091768
TP53 7157 CHEMBL303958 CHEMBL303958 CKB 21730979

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
TP53 rs1042522 CG + GG cisplatin efficacy yes Association reported for 72 ProPro and Arg/Pro (Pro is interpreted as C on coding strand, gene is on minus strand, and therefore risk allele is given as G on plus strand as shown above) Genotypes CG + GG are associated with decreased response to cisplatin and paclitaxel in people with Stomach Neoplasms as compared to genotype CC. 19052714 827810841
TP53 rs1042522 CG + GG oxaliplatin efficacy yes Patients receiving FOLFOX (oxaliplatin+fluorouracil+leucovorin) with or without bevacizumab. No significant association with progression-free survival or overall survival was seen. Genotypes CG + GG is associated with decreased response to oxaliplatin in people with Colorectal Neoplasms as compared to genotype CC. 29925895 1449752734
TP53 rs1042522 GG capecitabine efficacy yes Outcomes were response rate, progression free survival, and overall survival. Alleles given as Pro/Arg, which Pro (G on + strand) associated with worse response. Genotype GG is associated with decreased response to capecitabine and paclitaxel in people with Stomach Neoplasms as compared to genotype CC. 26696550 1448266865