PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MST1	1	TNNC1	2	enzymatic study	You B (2009)	1
TNNT2	1	APP	1	pull down	Olah J (2011)	1
TNNC1	2	TNNI1	0	pull down, x-ray crystallography, two hybrid, two hybrid	Lindhout DA (2002), Julien O (2008), Mogensen J (2004), Wang J (2011)	4
TNNC1	2	TNNT2	1	two hybrid	Mogensen J (2004)	1
TNNI1	0	TNNT2	1	two hybrid	Mogensen J (2004)	1
MST1	1	TNNI3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	You B (2009), You B (2009), You B (2009), You B (2009)	4
TNNT2	1	KDM1A	2	two hybrid	Weimann M (2013)	1
NOTCH3	9	TNNT2	1	pull down	Jung JG (2014)	1
TNNI3	0	TNNT2	1	pull down, pull down	Schmidtmann A (2002), You B (2009)	2
TNNT2	1	MORF4L2	0	two hybrid	Rolland T (2014)	1
TPM1	0	TNNT2	1	pull down	Tanokura M (1984)	1
TNNI1	0	TPM1	0	biochemical	Wan C (2015)	1
TNNI3	0	TNNC1	2	pull down, pull down, pull down, x-ray crystallography, unspecified method, pull down, pull down	Ward DG (2004), Ward DG (2004), Ward DG (2003), Wang X (2002), Li MX (2002), al-Hillawi E (1994), You B (2009)	7
MST1	1	TNNT2	1	enzymatic study	You B (2009)	1