PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TNNT1	0	TNNT1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TNNT1	0	TMEM98	0	two hybrid	Vinayagam A (2011)	1
SNW1	0	TFIP11	5	two hybrid	Rolland T (2014)	1
TNNT1	0	NACAD	4	two hybrid	Vinayagam A (2011)	1
TNNT1	0	FYN	1	two hybrid	Vinayagam A (2011)	1
TNNT1	0	IMMT	0	two hybrid	Vinayagam A (2011)	1
TNNT1	0	CCDC85B	0	two hybrid	Rual JF (2005)	1
TNNT1	0	NINL	1	two hybrid	Rual JF (2005)	1
TNNT1	0	SEC31A	7	two hybrid	Vinayagam A (2011)	1
TNNT1	0	MARS	1	two hybrid	Vinayagam A (2011)	1
TNNT1	0	TPM3	0	two hybrid	Rolland T (2014)	1
SNW1	0	KRT40	0	two hybrid	Rolland T (2014)	1
CCDC85B	0	LDOC1	0	two hybrid	Rual JF (2005)	1
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
FXR2	2	CCDC85B	0	two hybrid	Rual JF (2005)	1
TNNT1	0	ARMC8	1	two hybrid	Vinayagam A (2011)	1
TNNT1	0	TFIP11	5	two hybrid	Rolland T (2014)	1
NINL	1	ZNF250	2	two hybrid	Rual JF (2005)	1
PSMC5	4	PRKG1	3	affinity chromatography technology	Huttlin EL (2017)	1
TNNT1	0	ZC3H15	2	two hybrid	Vinayagam A (2011)	1
PSMC5	4	KRT40	0	two hybrid	Rolland T (2014)	1
CCDC136	1	CCDC85B	0	affinity chromatography technology	Huttlin EL (2017)	1
TNNT1	0	FAF1	1	two hybrid	Vinayagam A (2011)	1
TNNT1	0	HAP1	1	two hybrid	Vinayagam A (2011)	1
FXR2	2	MORF4L1	1	two hybrid	Rolland T (2014)	1
TNNT1	0	PPFIA1	5	two hybrid	Rual JF (2005)	1
TNNT1	0	PLEKHF1	0	two hybrid	Rual JF (2005)	1
NFE2L2	1	TNNT1	0	two hybrid	Rolland T (2014)	1
SNW1	0	VIM	0	affinity chromatography technology	Lleres D (2010)	1
TNNT1	0	ZKSCAN5	3	two hybrid	Vinayagam A (2011)	1
TNNT1	0	PI4KA	7	two hybrid	Vinayagam A (2011)	1
TRIM63	0	EEF1G	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
CHD3	19	DDX5	2	affinity chromatography technology	Carter CL (2010)	1
FYN	1	HSP90AB1	2	affinity chromatography technology	Huttlin EL (2017)	1
SNW1	0	EEF1G	0	affinity chromatography technology	Zhang C (2003)	1
TNNT1	0	HSP90AB1	2	two hybrid	Vinayagam A (2011)	1
TNNT1	0	VIM	0	two hybrid	Vinayagam A (2011)	1
ZC3H15	2	FAF1	1	biochemical	Wan C (2015)	1
TNNC1	2	TNNT1	0	two hybrid	Stefancsik R (1998)	1
TRIM63	0	UBE2D1	0	pull down, pull down, pull down	Bosanac I (2011), Uchiki T (2009), Kim HT (2007)	3
KAT5	1	CCDC136	1	two hybrid	Rolland T (2014)	1
TNNT1	0	ZNF768	2	two hybrid	Vinayagam A (2011)	1
TNNT1	0	SNW1	0	two hybrid	Vinayagam A (2011)	1
PSMC5	4	VIM	0	two hybrid	Albers M (2005)	1
VIM	0	OSBP2	1	biochemical	Wang C (2002)	1
CCDC85B	0	ZNF250	2	two hybrid	Rual JF (2005)	1
CHD3	19	IMMT	0	two hybrid, two hybrid	Stelzl U (2005), Goehler H (2004)	2
TNNT1	0	NSG2	0	two hybrid	Vinayagam A (2011)	1
FXR2	2	LDOC1	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
SNW1	0	CHD3	19	affinity chromatography technology	Lleres D (2010)	1
TNNT1	0	HMGXB4	0	two hybrid	Vinayagam A (2011)	1
TNNT1	0	BLOC1S2	0	two hybrid	Vinayagam A (2011)	1
TNNT1	0	MORF4L1	1	two hybrid	Rolland T (2014)	1
MORF4L1	1	KAT5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayakawa T (2007), Hayakawa T (2010), Doyon Y (2004), Doyon Y (2004), Huttlin EL (2015), Jacquet K (2016), Huttlin EL (2017)	7
TNNT1	0	OSBP2	1	two hybrid	Vinayagam A (2011)	1
TNNT1	0	TRA2A	1	two hybrid	Vinayagam A (2011)	1
TNNT1	0	ZNF250	2	two hybrid	Vinayagam A (2011)	1
TRA2A	1	LARP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HAP1	1	KAT5	1	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
TNNT1	0	KAT5	1	two hybrid	Vinayagam A (2011)	1
PSMC5	4	TNNT1	0	two hybrid, two hybrid	Rual JF (2005), Yu H (2011)	2
ZMYND19	1	ARMC8	1	affinity chromatography technology, affinity chromatography technology	Boldt K (2016), Lampert F (2018)	2
ZNF250	2	CCDC136	1	two hybrid	Rolland T (2014)	1
TNNT1	0	OSM	0	two hybrid	Vinayagam A (2011)	1
TNNT1	0	CHD3	19	two hybrid	Vinayagam A (2011)	1
ZNF250	2	KRT40	0	two hybrid	Rolland T (2014)	1
TPM1	0	TPM3	0	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015)	3
TNNT1	0	TBPL1	0	two hybrid	Rolland T (2014)	1
SNW1	0	HSP90AB1	2	affinity chromatography technology	Lleres D (2010)	1
TNNT1	0	DDX5	2	two hybrid	Vinayagam A (2011)	1
IMMT	0	HAP1	1	two hybrid	Goehler H (2004)	1
TNNT1	0	NAGK	4	two hybrid	Vinayagam A (2011)	1
PRKG1	3	TNNT1	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yuasa K (1999), Yuasa K (1999), Yuasa K (1999), Yuasa K (1999), Yuasa K (1999)	5
KAT5	1	NINL	1	two hybrid	Rolland T (2014)	1
TNNT1	0	LDOC1	0	two hybrid	Rolland T (2014)	1
TNNT1	0	ZMYND19	1	two hybrid	Rual JF (2005)	1
HSP90AB1	2	TPM3	0	affinity chromatography technology	Falsone SF (2005)	1
TNNT1	0	TPM1	0	pull down, two hybrid, two hybrid	Pearlstone JR (1983), Rolland T (2014), Yu H (2011)	3
KAT5	1	KRT40	0	two hybrid	Rolland T (2014)	1
DDX5	2	ARMC8	1	affinity chromatography technology	Boldt K (2016)	1
NSG2	0	ZNF768	2	two hybrid	Vinayagam A (2011)	1
TRIM63	0	TNNC1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kedar V (2004), Kedar V (2004), Kedar V (2004), Kedar V (2004), Kedar V (2004)	5
TNNT1	0	LARP1	2	two hybrid	Vinayagam A (2011)	1
TNNT1	0	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
SNW1	0	PSMC5	4	affinity chromatography technology	Lleres D (2010)	1
TNNT1	0	SH3GL3	1	two hybrid	Vinayagam A (2011)	1
TNNT1	0	SERPINA4	0	two hybrid	Vinayagam A (2011)	1
DDX5	2	SNW1	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TRA2A	1	ZNF768	2	affinity chromatography technology	Huttlin EL (2015)	1
VIM	0	HAP1	1	two hybrid	Goehler H (2004)	1
TNNT1	0	KRT40	0	two hybrid	Rolland T (2014)	1
TNNT1	0	CCDC136	1	two hybrid	Rolland T (2014)	1
LDOC1	0	ZNF250	2	two hybrid	Rual JF (2005)	1
TRIM63	0	TNNT1	0	two hybrid	Witt SH (2005)	1
TNNT1	0	EEF1G	0	two hybrid	Vinayagam A (2011)	1
TNNT1	0	WDCP	2	two hybrid	Vinayagam A (2011)	1
TNNT1	0	FXR2	2	two hybrid	Rual JF (2005)	1
SH3GL3	1	VIM	0	two hybrid	Goehler H (2004)	1