PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TNNC1	2	UBE2C	1	two hybrid	Wang J (2011)	1
MST1	1	TNNC1	2	enzymatic study	You B (2009)	1
TNNC1	2	TNNI1	0	pull down, x-ray crystallography, two hybrid, two hybrid	Lindhout DA (2002), Julien O (2008), Mogensen J (2004), Wang J (2011)	4
TNNC1	2	TNNT2	1	two hybrid	Mogensen J (2004)	1
TNNI1	0	TNNT2	1	two hybrid	Mogensen J (2004)	1
MST1	1	TNNI3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	You B (2009), You B (2009), You B (2009), You B (2009)	4
TRIM63	0	TNNI3	0	two hybrid, enzymatic study	Witt CC (2008), Kim HT (2007)	2
POLR2G	0	TNNC1	2	two hybrid	Wang J (2011)	1
CDK1	0	TNNC1	2	two hybrid	Wang J (2011)	1
TNNC1	2	TNNT1	0	two hybrid	Stefancsik R (1998)	1
TNNI3	0	TNNT2	1	pull down, pull down	Schmidtmann A (2002), You B (2009)	2
TCP10L	0	TNNC1	2	two hybrid	Wang J (2011)	1
TRIM63	0	TNNI2	2	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
TRIM63	0	TNNI1	0	enzymatic study, two hybrid	Uchiki T (2009), Witt CC (2008)	2
RBM15B	4	TNNC1	2	two hybrid	Wang J (2011)	1
TRIM63	0	TNNC1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kedar V (2004), Kedar V (2004), Kedar V (2004), Kedar V (2004), Kedar V (2004)	5
TNNI3	0	TNNC1	2	pull down, pull down, pull down, x-ray crystallography, unspecified method, pull down, pull down	Ward DG (2004), Ward DG (2004), Ward DG (2003), Wang X (2002), Li MX (2002), al-Hillawi E (1994), You B (2009)	7
TNNC1	2	CNN1	1	biochemical	Takahashi K (1988)	1
TNNC1	2	TNNI2	2	x-ray crystallography	Grand RJ (1982)	1
TRIM63	0	TNNT1	0	two hybrid	Witt SH (2005)	1
MST1	1	TNNT2	1	enzymatic study	You B (2009)	1