PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FYN	1	SYK	3	affinity chromatography technology, pull down	Deckert M (1998), Deckert M (1998)	2
RHOA	0	CAV1	0	pull down	Nethe M (2010)	1
SIKE1	1	STRN	1	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	6
ARHGDIA	3	MSN	0	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
USP2	0	EGFR	5	affinity chromatography technology	Kim J (2012)	1
BABAM2	2	FAS	2	affinity chromatography technology, affinity chromatography technology	Li Q (2004), Li Q (2004)	2
JAK2	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study	Olayioye MA (1999), Olayioye MA (1999), Jones RB (2006), He K (2013)	4
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
TRAF6	0	BCL10	0	affinity chromatography technology	Bidere N (2006)	1
TNFRSF10B	1	CBL	7	affinity chromatography technology, affinity chromatography technology	Song JJ (2010), Xu L (2017)	2
CASP2	1	NOL3	0	affinity chromatography technology	Koseki T (1998)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
TRPC4AP	4	TRPC1	0	affinity chromatography technology	Mace KE (2010)	1
FASLG	0	PIK3R1	6	imaging technique	Chen TC (2014)	1
TRADD	0	STAT1	1	affinity chromatography technology, pull down	Wang Y (2000), Wang Y (2000)	2
TNFRSF1A	3	STRN	1	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1B	4	CHUK	5	affinity chromatography technology	Wicovsky A (2009)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
EZR	8	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CASP10	1	CASP2	1	enzymatic study	Srinivasula SM (1996)	1
IKBKB	1	MAP3K7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofer-Warbinek R (2000), Wu ZH (2010), Wu ZH (2010), Prickett TD (2008), Fan YH (2011), Neil JR (2008), Wu X (2007), Shambharkar PB (2007), Shambharkar PB (2007), Niu J (2013), Yao F (2015), Yao F (2015), Mei ZZ (2016), Zheng C (2015)	14
BID	1	FASLG	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
PSMD2	2	UBQLN1	1	biochemical	Havugimana PC (2012)	1
CFLAR	1	TNFRSF1A	3	genetic interference	Ma Y (2017)	1
PIK3R1	6	PIK3CA	8	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Woscholski R (1994), Chamberlain MD (2004), Ren SY (2005), Kamal M (2010), Sun M (2010), Hein MY (2015), Fang D (2001), Xiong Y (2009), Ivanov AA (2017)	9
IKBKB	1	PRKCD	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	4
ELAVL1	0	TNFAIP3	3	affinity chromatography technology	Balkhi MY (2013)	1
CASP10	1	RIPK1	2	affinity chromatography technology	Chaudhary PM (2000)	1
TRIM25	5	RABGEF1	1	affinity chromatography technology	Choudhury NR (2017)	1
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
STRN3	3	SLMAP	3	affinity chromatography technology, bioid, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Hauri S (2013), Hein MY (2015)	6
KHDRBS1	1	SYNCRIP	6	biochemical	Wan C (2015)	1
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
TNFRSF1A	3	TRAF3	1	pull down	Mosialos G (1995)	1
RIPK2	0	CFLAR	1	affinity chromatography technology	Inohara N (1998)	1
SRC	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Burnham MR (1999), Song JJ (2010), Liu W (2010), Chen TC (2014)	4
BID	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
FAS	2	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
GRB2	2	KHDRBS1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, two hybrid	Liu SK (1998), Oneyama C (2002), Shen Z (1999), Shen Z (1999), Bandyopadhyay S (2010), Asbach B (2012), Bisson N (2011), Wang J (2011)	8
TNFRSF1A	3	SYK	3	affinity chromatography technology	Lee CK (2015)	1
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
MOB4	0	STRN3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, biochemical, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Glatter T (2009), Couzens AL (2013), Hauri S (2013), Wan C (2015), Hein MY (2015)	7
CYLD	2	ELAVL1	0	affinity chromatography technology	Elliott PR (2016)	1
EGFR	5	MOB4	0	protein complementation assay	Deribe YL (2009)	1
TNF	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	4
UBE2I	0	TRAF6	0	enzymatic study, enzymatic study	Li Y (2013), Pham LV (2008)	2
RHOA	0	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
TNFRSF1A	3	PIP4K2B	2	two hybrid, pull down, affinity chromatography technology	Castellino AM (1997), Castellino AM (1997), Castellino AM (1997)	3
USP2	0	IKBKG	0	enzymatic study	Zhou H (2004)	1
IKBKB	1	TNFRSF1A	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang SQ (2000), Chaudhary PM (2000), Fan YH (2011), Park KJ (2002), Guan YJ (2011), Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008), Chen TC (2014)	9
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
TNFRSF1A	3	GPRC5C	2	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	SLMAP	3	affinity chromatography technology	Huttlin EL (2017)	1
ADAM17	2	MAPK1	1	pull down, enzymatic study, affinity chromatography technology	Diaz-Rodriguez E (2002), Diaz-Rodriguez E (2002), Diaz-Rodriguez E (2002)	3
IKBKG	0	ARHGDIA	3	pull down	Kim HJ (2014)	1
PIK3R1	6	DAB2IP	3	pull down, affinity chromatography technology, affinity chromatography technology	Xie D (2009), Xie D (2009), Xie D (2009)	3
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
BIRC3	1	CASP7	1	pull down, affinity chromatography technology	Roy N (1997), Eckelman BP (2006)	2
USP2	0	RIPK1	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2012)	4
TNFRSF1A	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moquin DM (2013), Nakazawa S (2016), Elliott PR (2016)	3
RIPK1	2	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wright A (2007), Nagabhushana A (2011), ODonnell MA (2012), Wu GR (2017)	4
TNFRSF1B	4	TRAF3	1	pull down, affinity chromatography technology	Mosialos G (1995), Mosialos G (1995)	2
MOB4	0	KIDINS220	4	two hybrid	Stelzl U (2005)	1
CDK6	0	ZNF101	0	enzymatic study	Anders L (2011)	1
CASP10	1	TNFRSF10B	1	biochemical, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997)	2
TNFRSF1A	3	TRPC1	0	affinity chromatography technology	Mace KE (2010)	1
PPP1CA	3	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li L (2003), Xiao L (2010), Xiao L (2010), Xiao L (2010), Chen CS (2005), Chen CS (2005)	6
TRPC4AP	4	IKBKB	1	affinity chromatography technology	Soond SM (2003)	1
ARHGDIA	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
DAXX	5	SUMO1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, two hybrid, x-ray crystallography, two hybrid	Lin DY (2002), Ryu SW (2000), Ryu SW (2000), Ryu SW (2000), Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Naik MT (2011), Chang CC (2011), Chang CC (2011), Chen A (2006), Chen A (2006), Saul VV (2014), Ullmann R (2012), Lin DY (2006), Lin DY (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Naik MT (2011), Li C (2017)	20
RABGEF1	1	SHARPIN	1	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	GPR50	1	affinity chromatography technology	Huttlin EL (2017)	1
MSN	0	BID	1	biochemical	Gajate C (2005)	1
CHUK	5	RIPK1	2	biochemical	Poyet JL (2000)	1
CHUK	5	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
CAV1	0	MAPK1	1	affinity chromatography technology	Hua H (2003)	1
CASP10	1	FASLG	0	biochemical	Gajate C (2005)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
TRIM25	5	STRN4	2	affinity chromatography technology	Choudhury NR (2017)	1
BAG4	2	HSPA8	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Miki K (2002), Miki K (2002), Taipale M (2014), Taipale M (2014)	4
IKBKG	0	ATR	6	affinity chromatography technology	Wu ZH (2008)	1
HNRNPD	3	UBE2I	0	two hybrid, pull down	Moraes KC (2003), Moraes KC (2003)	2
TRAF2	1	RIPK3	2	affinity chromatography technology	Yu PW (1999)	1
TRAF6	0	PRKCD	2	affinity chromatography technology	Liu Y (2012)	1
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
TRAF3	1	UCHL1	1	affinity chromatography technology	Karim R (2013)	1
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
TRAF1	0	RBCK1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Abdul-Sater AA (2017)	4
RIPK2	0	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
MAPK8	3	TRAF2	1	affinity chromatography technology	Gravestein LA (1998)	1
TRAF6	0	SRC	2	affinity chromatography technology, pull down	Wong BR (1999), Liu A (2012)	2
MUC1	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid, protein complementation assay, affinity chromatography technology, enzymatic study	Schroeder JA (2001), Li Y (2001), Li Y (2001), Pochampalli MR (2007), Merlin J (2011), Merlin J (2011), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Schroeder JA (2001)	10
CYLD	2	HNRNPD	3	affinity chromatography technology	Elliott PR (2016)	1
ADAM17	2	TNFRSF1B	4	enzymatic study	Tellier E (2006)	1
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
STRN3	3	STRN4	2	affinity chromatography technology, bioid, biochemical, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Kristensen AR (2012), Hauri S (2013), Hein MY (2015)	5
TNFRSF1A	3	FANCD2	3	affinity chromatography technology	Bouwmeester T (2004)	1
TNFRSF1A	3	TNFRSF1A	3	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, fluorescent resonance energy transfe	Song HY (1994), Chan FK (2000), Chan FK (2000), Wang J (2011), Ivanov AA (2017)	5
TRIM25	5	SGTA	1	affinity chromatography technology	Choudhury NR (2017)	1
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
RIPK1	2	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
FAS	2	TRAF3	1	pull down	Mosialos G (1995)	1
TRIM25	5	MAPK1	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	BID	1	affinity chromatography technology	Choudhury NR (2017)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
TRAF2	1	USP4	3	affinity chromatography technology, enzymatic study	Xiao N (2011), Xiao N (2011)	2
FYN	1	KHDRBS1	1	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study	Oneyama C (2002), Fusaki N (1997), Loewenberg M (2006), Asbach B (2012), Asbach B (2012), Kaabeche K (2004)	6
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
TNFRSF1B	4	CAV1	0	affinity chromatography technology	Feng X (2001)	1
TNFRSF1A	3	ZNF865	8	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	MUC1	0	affinity chromatography technology	Ahmad R (2007)	1
ADAM17	2	TNFRSF1A	3	enzymatic study	Tellier E (2006)	1
UCHL1	1	HSPA8	4	affinity chromatography technology, pull down	Kabuta T (2008), Kabuta T (2008)	2
TRIM25	5	KHDRBS1	1	affinity chromatography technology	Choudhury NR (2017)	1
SIKE1	1	FGFR1OP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Hein MY (2015), Hein MY (2015)	3
FAS	2	ARHGDIA	3	biochemical	Gajate C (2005)	1
BIRC2	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
EGFR	5	EZR	8	protein complementation assay	Petschnigg J (2014)	1
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
TRAF6	0	UCHL1	1	affinity chromatography technology	Karim R (2013)	1
PRKCB	4	EGFR	5	enzymatic study	Khaled Z (1995)	1
FAS	2	DAXX	5	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down	Ko YG (2001), Kim YY (2003), Cermak L (2002), Yang X (1997), Yang X (1997), Yang X (1997), Charette SJ (2000), Chen TC (2014), Chang HY (1999)	9
STAMBP	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
TNFRSF1A	3	THADA	6	affinity chromatography technology	Huttlin EL (2017)	1
RIPK2	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Hasegawa M (2008)	2
SUMO1	0	CASP2	1	two hybrid	Shirakura H (2005)	1
SHARPIN	1	CHUK	5	affinity chromatography technology	Tokunaga F (2011)	1
STAT1	1	PRKCD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical	Kristof AS (2003), Kristof AS (2003), DeVries TA (2004), DeVries TA (2004), Uddin S (2002), Uddin S (2002), Uddin S (2002), Deb DK (2003), Deb DK (2003), Fielhaber JA (2009), Fielhaber JA (2009)	11
IKBKB	1	TNFAIP3	3	enzymatic study, affinity chromatography technology	Zetoune FS (2001), Xiong Y (2011)	2
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
FASLG	0	FYN	1	pull down, pull down, pull down, unspecified method, imaging technique	Wenzel J (2001), Hane M (1995), Zuccato E (2007), Voss M (2009), Chen TC (2014)	5
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
USP2	0	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011)	2
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
SIKE1	1	STRN3	3	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	6
RIPK1	2	IKBKB	1	biochemical, pull down	Yang Y (2011), Poyet JL (2000)	2
TNFRSF1A	3	HSPA8	4	pull down	Miki K (2002)	1
CLIP3	4	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fujikura D (2012), Ding Z (2015), Ding Z (2015)	3
BIRC2	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
CASP8	1	USP2	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
AKT1	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Xiong Y (2009), Xiong Y (2009), Ivanov AA (2017)	3
RHOA	0	BIRC2	1	pull down	Marivin A (2013)	1
RIPK2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hasegawa M (2008), Kim JY (2008), Yang Y (2007), Yang Y (2007), Windheim M (2007)	5
SGTA	1	HSPA8	4	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Winnefeld M (2006), Xu Y (2012), Liu FH (1999), Wang J (2011)	4
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
AKT1	1	UCHL1	1	affinity chromatography technology, two hybrid	Klein JB (2005), Arroyo R (2015)	2
CCND2	2	SGTA	1	affinity chromatography technology	Russo LC (2017)	1
TNFRSF1A	3	SUMO1	0	two hybrid, two hybrid, pull down	Liou ML (1999), Okura T (1996), Okura T (1996)	3
RABGEF1	1	MAPK1	1	affinity chromatography technology	Xu L (2010)	1
TRADD	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Park YC (2000), Tsao DH (2000), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Vince JE (2009), Jang HD (2001), Park KJ (2003), Lin B (2016)	12
TRIM25	5	DAB2IP	3	affinity chromatography technology	Choudhury NR (2017)	1
CASP7	1	ARHGDIA	3	enzymatic study	Walsh JG (2008)	1
TNF	0	CYLD	2	affinity chromatography technology, affinity chromatography technology	Draber P (2015), Schlicher L (2016)	2
IKBKG	0	PRKCB	4	pull down	Fenner BJ (2010)	1
TNFRSF1A	3	ZNF101	0	affinity chromatography technology	Huttlin EL (2017)	1
FAS	2	DPH1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RABGEF1	1	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	CASP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
IKBKG	0	TRAF3	1	affinity chromatography technology	Belgnaoui SM (2012)	1
SHARPIN	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, biochemical	Verhelst K (2012), Keusekotten K (2013), Schaeffer V (2014), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), Draber P (2015), Draber P (2015), Draber P (2015), Stieglitz B (2012), Huttlin EL (2017), Elliott PR (2016), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017)	21
UBC	7	ATF6	3	affinity chromatography technology	Matsumoto M (2005)	1
TNFRSF1A	3	JAK2	1	pull down, affinity chromatography technology, affinity chromatography technology	Guo D (1998), Guo D (1998), Pincheira R (2008)	3
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
STRN	1	STRN4	2	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	4
CHUK	5	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Mitsuhashi S (2008), Mitsuhashi S (2008)	2
BIRC3	1	UBE2I	0	two hybrid, two hybrid	Dynek JN (2010), Dynek JN (2010)	2
OPTN	1	IKBKG	0	affinity chromatography technology	Nakazawa S (2016)	1
TNFRSF1A	3	MADD	8	pull down	Schievella AR (1997)	1
HSPA8	4	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Polanowska-Grabowska R (1997), Cid C (2007)	2
TRAF2	1	CAV1	0	affinity chromatography technology, affinity chromatography technology	Feng X (2001), Cao H (2002)	2
TNFRSF1A	3	MOB4	0	affinity chromatography technology	Huttlin EL (2017)	1
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
TNFRSF1A	3	DPH1	7	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
CLIP3	4	TNFRSF1A	3	two hybrid, affinity chromatography technology	Fujikura D (2012), Fujikura D (2012)	2
DAXX	5	TRAF3	1	two hybrid	Wang J (2011)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
TRPC4AP	4	CHUK	5	affinity chromatography technology	Soond SM (2003)	1
CBL	7	HSPA8	4	affinity chromatography technology	Brehme M (2009)	1
TNFRSF1A	3	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
EZR	8	CASP8	1	biochemical	Gajate C (2005)	1
STK11	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BID	1	TNFRSF10B	1	biochemical	Gajate C (2005)	1
SRC	2	SYK	3	enzymatic study, affinity chromatography technology, enzymatic study	Kurosaki T (1994), Asazuma N (1997), Hirose M (2004)	3
TNFRSF1A	3	TRAP1	0	pull down	Song HY (1995)	1
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
SHARPIN	1	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Draber P (2015), Elliott PR (2016)	3
RIPK1	2	FADD	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Young JA (2011), Tenev T (2011), Ramakrishnan P (2011), Legarda-Addison D (2009), ODonnell MA (2012), Vanlangenakker N (2011), Biton S (2011), Biton S (2011), Lee EW (2012), Puliyappadamba VT (2013), Wu P (2014), Huttlin EL (2015), Baratchian M (2016), Moquin DM (2013), Ranjan K (2016), Pescatore A (2016), Zheng M (2016)	18
TRPC4	3	TRPC1	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Struebing C (2003), Hofmann T (2002), Hofmann T (2002)	3
CHUK	5	SRC	2	affinity chromatography technology, affinity chromatography technology	Huang WC (2003), Funakoshi-Tago M (2005)	2
PRKCD	2	PRKCB	4	affinity chromatography technology	Varjosalo M (2013)	1
KHDRBS1	1	SH3KBP1	1	unspecified method, affinity chromatography technology	Asbach B (2012), Havrylov S (2009)	2
TNFRSF1A	3	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FAS	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Kleber S (2008), Kleber S (2008)	2
SRC	2	KHDRBS1	1	two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Stelzl U (2005), Oneyama C (2002), Koch CA (1992), Shen Z (1999), Shen Z (1999), Finan PM (1996), Asbach B (2012), Asbach B (2012), Asbach B (2012), Kaabeche K (2004), Pincheira R (2008), Wong G (1992), Williger BT (1997), Wong BR (1999)	14
HNRNPD	3	TNF	0	affinity chromatography technology	Xin H (2011)	1
TRIM25	5	UTP6	2	affinity chromatography technology	Choudhury NR (2017)	1
TNFRSF1A	3	CASP2	1	affinity chromatography technology	Duan H (1997)	1
TNFRSF1A	3	TTYH3	1	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	FADD	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CASP2	1	BID	1	enzymatic study, enzymatic study	Paroni G (2001), Guo Y (2002)	2
ARHGDIA	3	EZR	8	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
AKT1	1	SRC	2	imaging technique, affinity chromatography technology	Chen TC (2014), Lee J (2013)	2
CDKN2B	0	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CYLD	2	PSMD2	2	affinity chromatography technology	Elliott PR (2016)	1
TRIM25	5	UBQLN1	1	affinity chromatography technology	Choudhury NR (2017)	1
PIK3R1	6	JAK2	1	pull down, genetic interference	Ren SY (2005), Shen JP (2017)	2
UBC	7	RHOA	0	affinity chromatography technology	Huang G (2014)	1
VANGL2	2	MAPK8	3	affinity chromatography technology	Puvirajesinghe TM (2016)	1
FASLG	0	GRB2	2	affinity chromatography technology, pull down, pull down	Ghadimi MP (2002), Ghadimi MP (2002), Wenzel J (2001)	3
CYLD	2	AKT1	1	enzymatic study, affinity chromatography technology	Yang WL (2013), Yang WL (2013)	2
UBE2I	0	TNFRSF1A	3	two hybrid, pull down	Saltzman A (1998), Saltzman A (1998)	2
STRN3	3	FGFR1OP2	0	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	5
MAPK8	3	CASP10	1	biochemical	Gajate C (2005)	1
MAPK8	3	FASLG	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
IKBKG	0	AKT1	1	pull down, affinity chromatography technology	Fenner BJ (2010), Hou Y (2010)	2
ELAVL1	0	STRN	1	affinity chromatography technology	Abdelmohsen K (2009)	1
STRIP1	3	STRN4	2	affinity chromatography technology, biochemical	Goudreault M (2009), Havugimana PC (2012)	2
MSN	0	FASLG	0	biochemical	Gajate C (2005)	1
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
GRB2	2	CASP2	1	two hybrid	Vinayagam A (2011)	1
SLMAP	3	FGFR1OP2	0	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Hein MY (2015)	3
TRAF3	1	CFLAR	1	affinity chromatography technology	Kataoka T (2000)	1
SOS1	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000)	2
ELAVL1	0	FGFR1OP2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBC	7	CAV1	0	affinity chromatography technology, imaging technique	Luo X (2017), Luo X (2017)	2
TNF	0	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Legler DF (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Skaug B (2011), Fu J (2013), Fritsch J (2014), Schlicher L (2016)	10
PRKCB	4	IKBKB	1	imaging technique	Chen TC (2014)	1
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
TRPC5	5	TRPC4	3	affinity chromatography technology, fluorescent resonance energy transfe	Hofmann T (2002), Hofmann T (2002)	2
TNFRSF1A	3	SLC39A1	0	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
TNFRSF1A	3	USP4	3	affinity chromatography technology	Fan YH (2011)	1
TNF	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	5
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
HNRNPD	3	PRDX3	3	two hybrid	Lehner B (2004)	1
BIRC3	1	RIPK2	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	6
TNF	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Yamaguchi N (2015)	2
TRAF2	1	DAB2IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Zhang H (2004), Dai X (2014)	3
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
EGFR	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soubeyran P (2002), Szymkiewicz I (2002), Schmidt MH (2004), Schmidt MH (2003), Ronning SB (2011), Ronning SB (2011), Yang S (2006), Schmidt MH (2003)	8
TRAF1	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
JAK2	1	HSPA8	4	affinity chromatography technology	Sarkar S (2001)	1
ARHGDIA	3	RHOA	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, biochemical, pull down, x-ray crystallography	Ewing RM (2007), Gajate C (2005), Michaelson D (2001), Gorvel JP (1998), Faure J (2001), Man JH (2010), Rolland T (2014), Wan C (2015), Jaffe AB (2004), Kuhlmann N (2016), Kuhlmann N (2016), Kuhlmann N (2016)	12
CFLAR	1	NOL3	0	genetic interference	Koseki T (1998)	1
TNF	0	CASP8	1	affinity chromatography technology	Fritsch J (2014)	1
BCL10	0	TRADD	0	affinity chromatography technology	Costanzo A (1999)	1
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
TRAF6	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Bidere N (2006), Bidere N (2006), He L (2006), He L (2006), Zinngrebe J (2016)	5
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
USP2	0	TRADD	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
GRB2	2	BABAM2	2	affinity chromatography technology	Brehme M (2009)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
FAS	2	UBQLN1	1	two hybrid	Wang J (2011)	1
SYK	3	PIK3R1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Moon KD (2005), Moon KD (2005), Moon KD (2005), Moon KD (2005), Huang ZY (2006)	5
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
IKBKG	0	BCL10	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu CJ (2008), Wu CJ (2008), Bhattacharyya S (2010), Stilo R (2004), Poyet JL (2001), Poyet JL (2001), Park Y (2013), Zhou H (2004), Yang YK (2016)	9
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
CHUK	5	TRADD	0	biochemical	Poyet JL (2000)	1
FADD	1	RIPK3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vanlangenakker N (2011), Lee EW (2012), Lee EW (2012), Moriwaki K (2016), Pescatore A (2016)	5
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
MUC1	0	GRB2	2	pull down, affinity chromatography technology, two hybrid	Pandey P (1995), Pandey P (1995), Bandyopadhyay S (2010)	3
SYK	3	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamada T (2001), Lin YC (2013), Wu NL (2014)	3
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
STRIP1	3	SLMAP	3	affinity chromatography technology, bioid, affinity chromatography technology, biochemical	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Wan C (2015)	4
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
STAT1	1	USP2	0	affinity chromatography technology, affinity chromatography technology	Ren Y (2016), Ren Y (2016)	2
FASLG	0	SRC	2	unspecified method	Voss M (2009)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
BID	1	CASP10	1	biochemical	Gajate C (2005)	1
TNFRSF1A	3	MCRS1	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	BAG4	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBC	7	TRAP1	0	affinity chromatography technology	Matsumoto M (2005)	1
TNFRSF1A	3	STRIP1	3	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8	3	CASP8	1	biochemical	Gajate C (2005)	1
TNF	0	FAS	2	affinity chromatography technology	Legler DF (2003)	1
STRN	1	SLMAP	3	affinity chromatography technology, bioid, bioid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Hauri S (2013), Wan C (2015), Hein MY (2015)	7
PIK3CA	8	STAT1	1	enzymatic study	Nguyen H (2001)	1
TRIM25	5	VANGL1	2	affinity chromatography technology	Choudhury NR (2017)	1
DAXX	5	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
RNF8	2	UBC	7	enzymatic study, enzymatic study, enzymatic study	Feng L (2012), Hodge CD (2015), Ho YK (2015)	3
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
TNFAIP3	3	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
FASLG	0	CFLAR	1	affinity chromatography technology	Tao RH (2011)	1
TNFRSF1A	3	PRELID1	0	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	TBC1D15	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF3	1	RIPK2	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Cai X (2013), Cai X (2013), Cai X (2013), Cai X (2013)	4
TRADD	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chang YL (2014), Chang YL (2014)	2
UBE2I	0	CHUK	5	enzymatic study	Bernier-Villamor V (2002)	1
MAP3K7	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Sakurai H (1999), Ninomiya-Tsuji J (1999), Lin X (1998), Lin X (1998), Ear T (2010), Huangfu WC (2006), Chen TC (2014)	7
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
BID	1	CASP8	1	biochemical, enzymatic study	Gajate C (2005), Guo Y (2002)	2
GYS2	2	TNFRSF1A	3	two hybrid	Wang J (2011)	1
GRB2	2	PPP1CA	3	affinity chromatography technology	Bisson N (2011)	1
EZR	8	CASP10	1	biochemical	Gajate C (2005)	1
TNFRSF1A	3	PPP1CA	3	affinity chromatography technology	Mitsuhashi S (2008)	1
RHOA	0	CASP8	1	biochemical	Gajate C (2005)	1
TRADD	0	DAB2IP	3	affinity chromatography technology	Zhang H (2004)	1
RIPK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertrand MJ (2008), Li H (2006), Yang Y (2011), Yang Y (2011), Yang Y (2011), Hu MM (2014)	6
MUC1	0	SOS1	5	affinity chromatography technology, affinity chromatography technology	Pandey P (1995), Schroeder JA (2001)	2
LTB	1	TNFRSF1A	3	pull down	Browning JL (1995)	1
EZR	8	MAPK8	3	biochemical	Gajate C (2005)	1
ELAVL1	0	SH3KBP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SHARPIN	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Verhelst K (2012), Verhelst K (2012)	2
SRC	2	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olayioye MA (1999), Cirri P (1997), Chang YJ (2004), Chang YJ (2004)	4
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
FAS	2	CASP10	1	biochemical, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Vincenz C (1997), MacFarlane M (1997)	3
EGFR	5	TNPO3	16	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
TNFRSF1A	3	FGFR1OP2	0	affinity chromatography technology	Huttlin EL (2017)	1
MOB4	0	SLMAP	3	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Goudreault M (2009), Glatter T (2009), Couzens AL (2013), Hauri S (2013)	4
SRC	2	JAK2	1	affinity chromatography technology	Liang K (2010)	1
FOXK2	9	MCRS1	1	affinity chromatography technology	Li X (2015)	1
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
TNF	0	FADD	1	affinity chromatography technology	Fritsch J (2014)	1
CLIP3	4	AKT1	1	affinity chromatography technology, affinity chromatography technology, pull down	Ding J (2009), Ding J (2009), Ding J (2009)	3
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
TNFRSF1A	3	CRADD	0	affinity chromatography technology	Duan H (1997)	1
USP2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
TRAF2	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
FAS	2	SRC	2	affinity chromatography technology	Kleber S (2008)	1
FOXK1	5	FOXK2	9	affinity chromatography technology	Li X (2015)	1
UCHL1	1	CDK6	0	affinity chromatography technology	Kabuta T (2013)	1
IKBKG	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011)	4
TNFRSF1A	3	DHRS7	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
MAPK8	3	PSMD2	2	affinity chromatography technology	Hein MY (2015)	1
TRAF3	1	CSNK1E	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhou Y (2016), Zhou Y (2016), Zhou Y (2016)	3
ELAVL1	0	STRN3	3	affinity chromatography technology	Abdelmohsen K (2009)	1
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
RHOA	0	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
USP4	3	MAP3K7	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Fan YH (2011), Fan YH (2011), Fan YH (2011)	3
TNFRSF1A	3	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPD	3	TNFRSF1A	3	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	TNFRSF10B	1	affinity chromatography technology	Choudhury NR (2017)	1
FADD	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Won M (2010), Saitoh Y (2016)	2
HSPA8	4	UBC	7	two hybrid	Stelzl U (2005)	1
TNFRSF1A	3	TNPO3	16	affinity chromatography technology	Huttlin EL (2017)	1
TNFSF13	0	TNFRSF1A	3	pull down	Kelly K (2000)	1
TNFRSF1A	3	VANGL2	2	affinity chromatography technology	Huttlin EL (2017)	1
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TNFRSF1A	3	PSMD2	2	two hybrid, two hybrid, affinity chromatography technology, pull down	Boldin MP (1995), Dunbar JD (1997), Dunbar JD (1997), Boldin MP (1995)	4
TRAF3	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013)	2
TRPC4AP	4	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Soond SM (2003), Soond SM (2006)	2
TRAF1	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017), Abdul-Sater AA (2017)	4
FAS	2	UBE2I	0	affinity chromatography technology, two hybrid, pull down, two hybrid	Becker K (1997), Wright DA (1996), Wright DA (1996), Wright DA (1996)	4
TNFRSF1A	3	KIDINS220	4	affinity chromatography technology	Huttlin EL (2017)	1
ATR	6	PIK3CA	8	unspecified method	Kim ST (1999)	1
RNF31	3	RIPK1	2	affinity chromatography technology	Draber P (2015)	1
UBE2I	0	SH3KBP1	1	enzymatic study	Tossidou I (2012)	1
UBC	7	RABGEF1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down	Mattera R (2004), La Rosa P (2011), Kalesnikoff J (2007), Penengo L (2006), Sokratous K (2012), Rolland T (2014), Mattera R (2006), Zhang X (2017), Kristariyanto YA (2017)	9
RHOA	0	CASP10	1	biochemical	Gajate C (2005)	1
TNFRSF1A	3	GPRC5B	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	PPP1CA	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	STRN3	3	affinity chromatography technology	Choudhury NR (2017)	1
TNFRSF1A	3	TRPC4	3	affinity chromatography technology	Mace KE (2010)	1
GRB2	2	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
TRAF1	0	TRADD	0	affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Wicovsky A (2009)	2
FAS	2	EZR	8	biochemical	Gajate C (2005)	1
ELAVL1	0	CHUK	5	affinity chromatography technology	Chu PC (2012)	1
ARHGDIA	3	MAPK8	3	biochemical	Gajate C (2005)	1
STK11	2	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TNFRSF1A	3	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Y (1999), Schuetze S (1999), Pan G (1997), Hsu H (1996), Hsu H (1996), Hsu H (1996), Shu HB (1996), Blankenship JW (2009), Kolliputi N (2009), Fujikura D (2012), Park KJ (2002), Guan YJ (2011), Hsu H (1995), Kumar A (2001), Zheng L (2006), Kim TW (2013), Zhang H (2004), Chang YL (2014), Nakazawa S (2016), Huttlin EL (2017)	20
TRPC4AP	4	TRPC4	3	affinity chromatography technology	Mace KE (2010)	1
AKT1	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yeh PY (2006), Yeh PY (2006), Yeh PY (2006)	3
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
ELAVL1	0	FBXO11	14	affinity chromatography technology	Abdelmohsen K (2009)	1
MSN	0	FADD	1	biochemical	Gajate C (2005)	1
TNFRSF1A	3	SCAI	2	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1B	4	TRAF2	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Song HY (1995), Song HY (1995), Takeuchi M (1996), Hostager BS (2002), Rothe M (1996), Marsters SA (1997), Carpentier I (2008), Rothe M (1995), Park YC (1999), Boucher LM (1997), Rothe M (1994), Rothe M (1994)	13
TRIM25	5	FOXK2	9	affinity chromatography technology	Choudhury NR (2017)	1
TNF	0	MAP3K7	2	affinity chromatography technology	Ea CK (2006)	1
TNFSF13	0	FAS	2	pull down	Kelly K (2000)	1
ELAVL1	0	TTYH3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
FAS	2	TRADD	0	affinity chromatography technology	Kumar A (2001)	1
PIK3R1	6	SH3KBP1	1	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Gout I (2000), Tossidou I (2010), Borthwick EB (2004), Borthwick EB (2004)	4
CASP8	1	TRADD	0	affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kolliputi N (2009)	2
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
CASP8	1	MAPK1	1	affinity chromatography technology	Yao Z (2007)	1
TRIM25	5	TNFRSF1A	3	affinity chromatography technology	Choudhury NR (2017)	1
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
TNFRSF1A	3	JPH1	0	affinity chromatography technology	Huttlin EL (2017)	1
MSN	0	CASP8	1	biochemical	Gajate C (2005)	1
STRN	1	FGFR1OP2	0	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	5
BIRC3	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
CFLAR	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kataoka T (2000), Chaudhary PM (2000), Rebe C (2007), Feoktistova M (2011), Ranjan K (2016), Ranjan K (2016)	6
TRAF2	1	USP2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Rolland T (2014), Mahul-Mellier AL (2012), Mahul-Mellier AL (2012)	7
FYN	1	CAV1	0	biochemical	Mastick CC (1997)	1
SHARPIN	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Verhelst K (2012), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Draber P (2015), Liu J (2017)	6
CBL	7	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006)	14
BABAM2	2	OPTN	1	biochemical	Kristensen AR (2012)	1
MAPK8	3	MAP3K7	2	affinity chromatography technology, pull down	Sanna MG (2002), Sanna MG (2002)	2
CYLD	2	UBQLN1	1	affinity chromatography technology	Elliott PR (2016)	1
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
IKBKG	0	MUC1	0	affinity chromatography technology	Ahmad R (2007)	1
MAPK8	3	HSPA8	4	two hybrid	Vinayagam A (2011)	1
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
UBB	4	UBQLN1	1	two hybrid	Rolland T (2014)	1
OPTN	1	CYLD	2	two hybrid, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Nagabhushana A (2011), Nagabhushana A (2011), Nagabhushana A (2011), Genin P (2015), Genin P (2015)	5
DAXX	5	MCRS1	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin DY (2002), Lin DY (2002), Lin DY (2002), Lin DY (2002), Xu M (2012)	5
SOS1	5	EGFR	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian X (2000), Qian X (1998), Buday L (1994), Tong J (2009), Kurada BR (2009), Tong J (2008), Foerster S (2013), Tong J (2014), Kapoor GS (2010)	9
ELAVL1	0	CDK6	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFRSF1A	3	BCL10	0	two hybrid	Costanzo A (1999)	1
EGFR	5	UCHL1	1	protein complementation assay	Deribe YL (2009)	1
TNF	0	OPTN	1	affinity chromatography technology	Klingseisen L (2012)	1
CYLD	2	HSPA8	4	affinity chromatography technology	Elliott PR (2016)	1
MAPK8	3	AKT1	1	enzymatic study	Xiao L (2010)	1
TRPC4AP	4	INTS14	5	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	NFKBIL1	3	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	UTP15	1	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
USP4	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fan YH (2011), Hou X (2013), Hou X (2013)	3
TRAF1	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Wong BR (1999), Narita T (2005)	2
TNFRSF1A	3	UTP20	5	affinity chromatography technology	Huttlin EL (2017)	1
PIK3CA	8	TNFSF13	0	two hybrid	Arroyo R (2015)	1
CASP10	1	TRAF1	0	enzymatic study	Leo E (2001)	1
TRAF2	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Kataoka T (2000), Kataoka T (2000)	3
BCL10	0	IKBKB	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Lobry C (2007), Lobry C (2007), Poyet JL (2001), Zhou H (2004), Bidere N (2009)	5
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
RBCK1	0	MAP3K7	2	affinity chromatography technology	Tian Y (2007)	1
RIPK1	2	DAB2IP	3	affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Zhang H (2004)	2
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
TRIM25	5	UTP20	5	affinity chromatography technology	Choudhury NR (2017)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
RHOA	0	TRPC1	0	affinity chromatography technology, pull down	Mehta D (2003), Mehta D (2003)	2
BIRC2	1	BCL10	0	affinity chromatography technology, affinity chromatography technology	Yoneda T (2000), Hu S (2006)	2
STRIP1	3	STRN3	3	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	5
TNF	0	CAV1	0	affinity chromatography technology	Legler DF (2003)	1
STAMBP	2	TNFRSF1A	3	enzymatic study	Fritsch J (2014)	1
ELAVL1	0	TNPO3	16	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFRSF1B	4	TRADD	0	affinity chromatography technology	Wicovsky A (2009)	1
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
FYN	1	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Taher TE (2002), Deckert M (1998), Deckert M (1998), Deckert M (1998), Ghosh AK (2004), Rellahan BL (2003), Boussiotis VA (1997), Andoniou CE (2000), Shishido T (2000), Okabe S (2006), Kaabeche K (2004), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tanaka S (1995), Reedquist KA (1996), Grossmann AH (2004), Panchamoorthy G (1996), Fukazawa T (1995), Fukazawa T (1995), Fukazawa T (1995), Nishio H (2002), Anderson SM (1997), Fukazawa T (1996), Grossmann A (2015)	27
CASP8	1	OPTN	1	affinity chromatography technology, affinity chromatography technology	Nakazawa S (2016), Nakazawa S (2016)	2
UBC	7	FANCD2	3	pull down, affinity chromatography technology	Rego MA (2012), Yamamoto KN (2011)	2
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	LMBR1	1	affinity chromatography technology	Yao Z (2017)	1
IKBKG	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Verhelst K (2012), Zak DE (2011), Tokunaga F (2011), Tokunaga F (2011), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017), Bal E (2017)	10
TNFRSF1A	3	CAV1	0	biochemical	Legler DF (2003)	1
TNFRSF1A	3	STAT1	1	affinity chromatography technology	Wang Y (2000)	1
RNF31	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	8
UBC	7	PSMD2	2	pull down	Zhang X (2017)	1
IKBKB	1	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li HY (2008), Mitsuhashi S (2008), Mitsuhashi S (2008)	3
BIRC2	1	CASP2	1	pull down	Cheung HH (2006)	1
TRPC4AP	4	TRPC5	5	affinity chromatography technology	Mace KE (2010)	1
VANGL2	2	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1B	4	UBQLN1	1	two hybrid	Wang J (2011)	1
STRIP1	3	MOB4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Glatter T (2009)	3
TRIM25	5	TNPO3	16	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CBL	7	TRAF2	1	affinity chromatography technology	Xu L (2017)	1
TNFRSF1A	3	TRPC5	5	affinity chromatography technology	Mace KE (2010)	1
ELAVL1	0	FANCD2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
BIRC2	1	CASP7	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Tenev T (2005), Eckelman BP (2006), Vucic D (2000)	6
SLMAP	3	STRN4	2	bioid, affinity chromatography technology, biochemical	Couzens AL (2013), Hauri S (2013), Wan C (2015)	3
UBE2I	0	CASP2	1	two hybrid	Shirakura H (2005)	1
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
CCND2	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CYLD	2	SYNCRIP	6	affinity chromatography technology	Elliott PR (2016)	1
STRIP1	3	FGFR1OP2	0	affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Hein MY (2015)	2
FAS	2	RIPK1	2	two hybrid	Stanger BZ (1995)	1
ELAVL1	0	PIP4K2C	7	affinity chromatography technology	Abdelmohsen K (2009)	1
CASP10	1	FADD	1	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, pull down, pull down	Gajate C (2005), Vincenz C (1997), Vincenz C (1997), Srinivasula SM (1997), Srinivasula SM (1997), Wang J (2001), McDonald ER (2004), Choi H (2011), Choi H (2011)	9
TNFRSF1A	3	SOS1	5	affinity chromatography technology	Kurada BR (2009)	1
TNFRSF1A	3	DOLK	1	affinity chromatography technology	Huttlin EL (2017)	1
RIPK2	0	RNF31	3	affinity chromatography technology	Damgaard RB (2012)	1
SIKE1	1	STRN4	2	affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Hein MY (2015)	2
ARHGDIA	3	CASP8	1	biochemical	Gajate C (2005)	1
IKBKB	1	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
CASP8	1	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
OPTN	1	TBC1D15	1	two hybrid	Rolland T (2014)	1
BID	1	FADD	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
ELAVL1	0	EZR	8	affinity chromatography technology	Abdelmohsen K (2009)	1
UBC	7	SYNCRIP	6	affinity chromatography technology	Matsumoto M (2005)	1
MYOC	1	TNFRSF1A	3	two hybrid	Fautsch MP (2006)	1
HRG	4	TNFRSF1A	3	two hybrid	Wang J (2011)	1
BID	1	CSNK1E	0	imaging technique	Chen TC (2014)	1
TRIM25	5	FBXO11	14	affinity chromatography technology	Choudhury NR (2017)	1
NSMAF	5	TNFRSF1A	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Adam-Klages S (1996), Adam-Klages S (1996), Schuetze S (1999)	3
TNFAIP3	3	CHUK	5	affinity chromatography technology	Zetoune FS (2001)	1
FAS	2	MSN	0	biochemical	Gajate C (2005)	1
TRADD	0	NOL3	0	genetic interference	Koseki T (1998)	1
CBL	7	SYK	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Lupher ML (1998), Lupher ML (1998), Bertagnolo V (2001), Melander F (2003), Macglashan D (2004), Rao N (2001), Rao N (2001), Yankee TM (1999), Saci A (2000), Moon KD (2005), Lottin-Divoux S (2006), Grossmann AH (2004), Ota S (2000), Ota S (2000), Panchamoorthy G (1996), Marcilla A (1995), Justa-Schuch D (2016)	17
PRKCB	4	RBCK1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tatematsu K (2008), Vallentin A (2007), Vallentin A (2007), Nakamura M (2006), Gustafsson Sheppard N (2012)	5
DPH1	7	UBC	7	pull down	Gyrd-Hansen M (2008)	1
TNFRSF1B	4	FANCD2	3	affinity chromatography technology	Bouwmeester T (2004)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
TNFRSF10B	1	TRADD	0	affinity chromatography technology	Chaudhary PM (1997)	1
TBC1D15	1	UTP15	1	affinity chromatography technology	Huttlin EL (2017)	1
STAMBP	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Bremm A (2010), Komander D (2009), McCullough J (2006), Nakasone MA (2013), Davies CW (2013), Trang VH (2014), Wauer T (2015), Michel MA (2015), Bueno AN (2015), Baiady N (2016), Baiady N (2016), Castaneda CA (2016), Kliza K (2017)	13
TNFRSF1A	3	JAK1	6	pull down, affinity chromatography technology	Guo D (1998), Miscia S (2002)	2
ARHGDIA	3	BID	1	biochemical	Gajate C (2005)	1
SYNCRIP	6	PPP1CA	3	biochemical	Havugimana PC (2012)	1
UBE2I	0	STAT1	1	enzymatic study	Wu PY (2003)	1
TNFRSF1A	3	KHDRBS1	1	affinity chromatography technology	Pincheira R (2008)	1
RABGEF1	1	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF1	0	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
FYN	1	TNF	0	pull down	Simms HH (1997)	1
TNFRSF1A	3	C1orf112	0	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	TPCN1	3	affinity chromatography technology	Huttlin EL (2017)	1
STRIP1	3	STRN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	6
RHOA	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
AKT1	1	HSPA8	4	affinity chromatography technology	Klein JB (2005)	1
SUMO1	0	PSMD2	2	biochemical	Wan C (2015)	1
ATF6	3	TNFRSF1A	3	two hybrid	Wang J (2011)	1
TNFRSF1A	3	MFSD5	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8	3	TNFRSF1A	3	biochemical	Gajate C (2005)	1
FADD	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Chaudhary PM (1997), Kim Y (2002), Guo F (2005), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017)	8
TRAF6	0	TNFRSF1B	4	affinity chromatography technology	Khursigara G (1999)	1
MAGEH1	0	TNFRSF1A	3	pull down	Selimovic D (2012)	1
TRIM25	5	EZR	8	affinity chromatography technology	Choudhury NR (2017)	1
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
CHUK	5	PRKCD	2	pull down, affinity chromatography technology, affinity chromatography technology	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	3
PRKCB	4	CHUK	5	imaging technique	Chen TC (2014)	1
RIPK1	2	CRADD	0	pull down, pull down	Ahmad M (1997), Duan H (1997)	2
ELAVL1	0	CSNK1E	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SYK	3	TRAF3	1	affinity chromatography technology	Lin YC (2013)	1
RHOA	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
UCHL1	1	TNFRSF1A	3	enzymatic study	Fritsch J (2014)	1
TRAF1	0	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
EZR	8	FASLG	0	biochemical, affinity chromatography technology	Gajate C (2005), Parlato S (2000)	2
CASP7	1	CASP2	1	enzymatic study	Paroni G (2001)	1
TNFRSF1B	4	CSNK1A1L	1	pull down, enzymatic study	Darnay BG (1994), Darnay BG (1994)	2
TNF	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
EGFR	5	THADA	6	affinity chromatography technology	Foerster S (2013)	1
PRDX3	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC3	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
RHOA	0	FASLG	0	biochemical	Gajate C (2005)	1
INTS14	5	TNFRSF1A	3	affinity chromatography technology	Hein MY (2015)	1
UBC	7	SH3KBP1	1	pull down, x-ray crystallography, pull down, x-ray crystallography, pull down, x-ray crystallography	Bezsonova I (2008), Korzhnev DM (2009), Ortega Roldan JL (2013), Ortega Roldan JL (2013), Stamenova SD (2007), Bezsonova I (2008)	6
TNFRSF1A	3	PRKCD	2	affinity chromatography technology, enzymatic study	Kilpatrick LE (2000), Kilpatrick LE (2000)	2
FAS	2	NOL3	0	genetic interference	Koseki T (1998)	1
HNRNPD	3	HSPA8	4	affinity chromatography technology, affinity chromatography technology, biochemical	Sinsimer KS (2008), Laroia G (1999), Wan C (2015)	3
ATR	6	FANCD2	3	enzymatic study, imaging technique, enzymatic study	Ho GP (2006), Pichierri P (2004), Shigechi T (2012)	3
TNFRSF1A	3	XPR1	3	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF10B	1	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
CAV1	0	SRC	2	pull down	Li S (1996)	1
CDK6	0	CDC6	0	enzymatic study	Anders L (2011)	1
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
CHUK	5	TNFRSF1A	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008)	3
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
LTA	1	TNFRSF1B	4	pull down, pull down	Higuchi M (1992), Chaturvedi MM (1994)	2
CDK6	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
TNFRSF1A	3	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRIM25	5	XPR1	3	affinity chromatography technology	Choudhury NR (2017)	1
UBE2I	0	RIPK2	0	two hybrid	Rual JF (2005)	1
TNFRSF1A	3	FOXK1	5	affinity chromatography technology	Huttlin EL (2017)	1
SIKE1	1	SLMAP	3	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	4
GRB2	2	HNRNPD	3	affinity chromatography technology	Brehme M (2009)	1
FAS	2	TNFRSF1A	3	biochemical	Gajate C (2005)	1
SHARPIN	1	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Keusekotten K (2013), Nakazawa S (2016)	2
PPP1CA	3	PRKCB	4	enzymatic study	Keranen LM (1995)	1
FAS	2	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Shu HB (1997), MacFarlane M (1997), Huttlin EL (2015), Jeong M (2017), Huttlin EL (2017), Kleber S (2008)	7
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
CDK6	0	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Sweeney KJ (1997), Varjosalo M (2013), Ivanov AA (2017)	4
CSNK1E	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
STK11	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
HNRNPD	3	SYNCRIP	6	two hybrid, pull down, affinity chromatography technology	Moraes KC (2003), Moraes KC (2003), Hein MY (2015)	3
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
TNFRSF1A	3	FYN	1	biochemical	Legler DF (2003)	1
TNFRSF1A	3	BAG4	2	affinity chromatography technology, pull down	Jiang Y (1999), Miki K (2002)	2
TNFRSF1A	3	DAPK1	6	affinity chromatography technology	Henshall DC (2003)	1
UBE2I	0	TRAF3	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Miliara S (2013), Miliara S (2013), Miliara S (2013), Miliara S (2013)	4
FAS	2	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
DAB2IP	3	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xie D (2009), Xie D (2009), Dai X (2014)	3
SYNCRIP	6	TNFRSF1A	3	affinity chromatography technology	Hein MY (2015)	1
IKBKG	0	RHOA	0	pull down	Kim HJ (2014)	1
AKT1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Vandermoere F (2005), Vandermoere F (2005), Chen TC (2014), Busch F (2012)	4
TNFRSF1A	3	RNF8	2	affinity chromatography technology, affinity chromatography technology	Fritsch J (2014), Fritsch J (2014)	2
TRPC1	0	CAV1	0	affinity chromatography technology, affinity chromatography technology	Singh BB (2000), Sundivakkam PC (2009)	2
UBC	7	TBC1D15	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
TNFRSF1A	3	RBCK1	0	affinity chromatography technology	Nakazawa S (2016)	1
MOB4	0	SIKE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Glatter T (2009), Hein MY (2015)	4
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
TNFRSF1B	4	TNF	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Bouwmeester T (2004), Kuai J (2004), Montaldo PG (1994), Liu LS (1998), Zhang L (1994), Higuchi M (1992), Chaturvedi MM (1994), Chainy GB (1996), Nielsen FS (2004), Ameloot P (2001)	10
TNF	0	CHUK	5	affinity chromatography technology, genetic interference	Haas TL (2009), Sahu I (2014)	2
TNFRSF1A	3	TRPC4AP	4	affinity chromatography technology, pull down, affinity chromatography technology	Soond SM (2003), Soond SM (2003), Mace KE (2010)	3
CFLAR	1	FADD	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Han DK (1997), Kerr E (2012), Rebe C (2007), Choi H (2011), Feoktistova M (2011), Ranjan K (2016), Jeong M (2017)	13
TRAF6	0	USP4	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Xiao N (2011), Xiao N (2011), Xiao N (2011), Xiao N (2011), Zhou F (2012), Zhou F (2012)	6
FADD	1	TRADD	0	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henshall DC (2003), Hsu H (1996), Hsu H (1996), Thomas LR (2002), Guan YJ (2011), Park KJ (2003), Qi Z (2014)	7
TRIM25	5	RNF8	2	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	JPH1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PIK3CA	8	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sattler M (1997), Sattler M (1997), Chernock RD (2001), Chernock RD (2001), Brehme M (2009)	5
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
EGFR	5	HSPA8	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Yao Z (2017)	8
MSN	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CAV1	0	BID	1	affinity chromatography technology, affinity chromatography technology	Zhang M (2011), Zhang M (2011)	2
IKBKG	0	FADD	1	affinity chromatography technology	Biton S (2011)	1
SRC	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Narita T (2005), Schroeder B (2012)	2
TNFRSF1A	3	RABGEF1	1	affinity chromatography technology	Huttlin EL (2017)	1
SUMO1	0	FAS	2	two hybrid, pull down	Okura T (1996), Okura T (1996)	2
MOB4	0	STRN4	2	affinity chromatography technology, affinity chromatography technology, biochemical	Goudreault M (2009), Glatter T (2009), Wan C (2015)	3
CASP10	1	CASP7	1	enzymatic study	Srinivasula SM (1996)	1
CYLD	2	JAK1	6	affinity chromatography technology	Elliott PR (2016)	1
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
ELAVL1	0	XPR1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
AKT1	1	FANCD2	3	affinity chromatography technology	Zhang X (2016)	1
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
CBL	7	SOS1	5	affinity chromatography technology	Wang Y (1999)	1
TNFRSF1A	3	VANGL1	2	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	PIP4K2C	7	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	DAB2IP	3	affinity chromatography technology	Zhang H (2004)	1
RIPK3	2	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu PW (1999), Yu PW (1999), Li S (2011), Lee EW (2012), Petersen SL (2015), Moquin DM (2013), Moriwaki K (2016)	7
CHUK	5	RIPK2	0	enzymatic study	Marinis JM (2012)	1
RIPK2	0	UBC	7	affinity chromatography technology	Park S (2013)	1
SRC	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Funakoshi-Tago M (2005), Funakoshi-Tago M (2005), Lee SH (2012)	3
CASP7	1	STAT1	1	enzymatic study	Walsh JG (2008)	1
UBC	7	KHDRBS1	1	pull down	Zhang X (2017)	1
TRAF1	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Wicovsky A (2009), Henkler F (2003)	2
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
TNFRSF1A	3	PIK3R1	6	affinity chromatography technology	Pincheira R (2008)	1
FADD	1	DAXX	5	affinity chromatography technology	Meinecke I (2007)	1
FADD	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011), Chen TC (2014)	5
DAXX	5	RIPK3	2	pull down, pull down, affinity chromatography technology, enzymatic study	Lee YS (2013), Lee YS (2013), Lee YS (2013), Lee YS (2013)	4
FASLG	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
MSN	0	CASP10	1	biochemical	Gajate C (2005)	1
PIK3R1	6	SOS1	5	imaging technique	Chen TC (2014)	1
TNFRSF1A	3	CBL	7	affinity chromatography technology	Narita T (2005)	1
RIPK3	2	TNFRSF1A	3	affinity chromatography technology	Yu PW (1999)	1
UBC	7	UCHL1	1	two hybrid, enzymatic study, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, pull down, pull down	Stelzl U (2005), Bremm A (2010), Boudreaux D (2012), Boudreaux DA (2010), Boudreaux DA (2010), Phillips AH (2013), Larsen CN (1998), Duerksen-Hughes PJ (1989), Flierman D (2016), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	13
TRPC4AP	4	TRADD	0	affinity chromatography technology	Soond SM (2003)	1
FAS	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), MacFarlane M (1997), Jeong M (2017)	3
AKT1	1	CHUK	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Ozes ON (1999), Ozes ON (1999), Romashkova JA (1999), Lu Y (2005), Chen TC (2014), Takada Y (2005), Koul D (2001)	7
TNFRSF1A	3	CSNK1E	0	affinity chromatography technology	Huttlin EL (2017)	1
CASP10	1	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Vincenz C (1997)	2
UBC	7	UBQLN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Ko HS (2004), Ko HS (2004), Sokratous K (2012), Raasi S (2005), Raasi S (2005), Massey LK (2004), Ko HS (2004), Ko HS (2004), Rolland T (2014), Castaneda CA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Kristariyanto YA (2015), Kurlawala Z (2017)	16
UBC	7	BABAM2	2	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2009), Zhang X (2017)	3
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
TNFRSF1A	3	RRP12	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF3	1	SRC	2	affinity chromatography technology, affinity chromatography technology	Wong BR (1999), Johnsen IB (2009)	2
SLMAP	3	RABGEF1	1	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Huttlin EL (2017)	3
ELAVL1	0	TNFRSF1A	3	affinity chromatography technology	Abdelmohsen K (2009)	1
AKT1	1	USP4	3	pull down, affinity chromatography technology, enzymatic study	Zhang L (2012), Zhang L (2012), Zhang L (2012)	3
FYN	1	TNFRSF10B	1	affinity chromatography technology	Huttlin EL (2017)	1
FADD	1	DAPK1	6	affinity chromatography technology, affinity chromatography technology, imaging technique	Henshall DC (2003), Henshall DC (2004), Chen TC (2014)	3
LTA	1	LTB	1	pull down, pull down, affinity chromatography technology, pull down	Williams-Abbott L (1997), Browning JL (1997), Browning JL (1995), Browning JL (1995)	4
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
GRB2	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Hildt E (1999), Kurada BR (2009)	2
FADD	1	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology	Ramakrishnan P (2011), Ramakrishnan P (2011)	2
TRPC4AP	4	IKBKG	0	affinity chromatography technology	Soond SM (2003)	1
ELAVL1	0	GRB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
RHOA	0	EZR	8	biochemical	Gajate C (2005)	1
HNRNPD	3	FANCD2	3	affinity chromatography technology	Hein MY (2015)	1
MAPK8	3	FADD	1	biochemical	Gajate C (2005)	1
DAPK1	6	MAPK1	1	two hybrid, pull down, affinity chromatography technology, enzymatic study	Chen CH (2005), Chen CH (2005), Chen CH (2005), Chen CH (2005)	4
TNFRSF1A	3	RNF138	0	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	CASP2	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
CDK6	0	CDKN2B	0	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Mo XL (2015), Huttlin EL (2017), Ivanov AA (2017)	8
IKBKB	1	MUC1	0	affinity chromatography technology, biochemical	Ahmad R (2007), Ahmad R (2007)	2
SYK	3	MAP3K7	2	affinity chromatography technology	Lin YC (2013)	1
TRIM25	5	HNRNPD	3	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	ATR	6	affinity chromatography technology	Foerster S (2013)	1
OPTN	1	UBC	7	affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down	Wild P (2011), Fenner BJ (2009), Zhu G (2007), Zhu G (2007), Wagner S (2008), Gleason CE (2011), Nagabhushana A (2011), Korac J (2012), Wild P (2011), Tumbarello DA (2015), Heo JM (2015), Ordureau A (2015), Richter B (2016), Richter B (2016), Nakazawa S (2016), Zhang X (2017), Kliza K (2017), Bansal M (2018)	18
ARHGDIA	3	TNFRSF1A	3	biochemical	Gajate C (2005)	1
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
AKT1	1	PRKCB	4	two hybrid, enzymatic study	Arroyo R (2015), Wu D (2009)	2
MUC1	0	SRC	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Li Y (2001), Li Y (2001), Li Y (2001), Li Y (2001), Li Y (2001), Bernier AJ (2011)	6
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
FADD	1	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
JAK2	1	STAT1	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Cheng MB (2010), Cheng MB (2010), Manea A (2010), Andl CD (2004), Chang YJ (2004)	5
TNFRSF1A	3	GRK6	3	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
PIK3R1	6	KHDRBS1	1	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Sanchez-Margalet V (2001), Shen Z (1999), Shen Z (1999), Asbach B (2012), Asbach B (2012), Asbach B (2012), Sung CK (1994), Sung CK (1994)	8
CASP8	1	RIPK3	2	affinity chromatography technology	Lee EW (2012)	1
GRB2	2	HSPA8	4	affinity chromatography technology	Brehme M (2009)	1
TNFAIP3	3	SRC	2	affinity chromatography technology	Huttlin EL (2017)	1
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
PRKCD	2	ELAVL1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Doller A (2007), Doller A (2008), Doller A (2008), Doller A (2011), Doller A (2011), Doller A (2010)	6
TNFRSF1A	3	STRN3	3	affinity chromatography technology	Huttlin EL (2017)	1
JAK2	1	TRAF6	0	two hybrid	Wang J (2011)	1
EGFR	5	TNFRSF10B	1	affinity chromatography technology	Tong J (2014)	1
RHOA	0	MSN	0	biochemical	Gajate C (2005)	1
TNFRSF1B	4	RIPK1	2	affinity chromatography technology	Wicovsky A (2009)	1
TNFRSF1A	3	SRC	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Narita T (2005), Pincheira R (2008), Darnay BG (1997)	3
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
FYN	1	PIK3R1	6	pull down	Kapeller R (1994)	1
TRAF3	1	BIRC3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mao AP (2010), de Jong SJ (2013), Goncharov T (2013)	3
XPR1	3	KIDINS220	4	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	CAV1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, pull down, biochemical	Couet J (1997), Couet J (1997), Khan EM (2006), Feldman R (2009), Hua H (2003), Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Park WY (2000), Abulrob A (2004), Abulrob A (2004)	12
FYN	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
TNFRSF1A	3	DAXX	5	two hybrid, pull down	Yang X (1997), Yang X (1997)	2
UBE2I	0	ARHGDIA	3	enzymatic study	Kuhlmann N (2016)	1
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
MAP3K7	2	USP2	0	affinity chromatography technology	Li Y (2013)	1
PRDX3	3	TNFRSF1A	3	two hybrid	Wang J (2011)	1
TRAF6	0	FYN	1	pull down	Liu A (2012)	1
PIK3R1	6	EZR	8	affinity chromatography technology, pull down	Gautreau A (1999), Gautreau A (1999)	2
FAS	2	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
MUC1	0	PRKCD	2	affinity chromatography technology, pull down, enzymatic study	Ren J (2002), Ren J (2002), Ren J (2002)	3
GRB2	2	SYK	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Saci A (2002), de Castro RO (2012), de Castro RO (2012)	4
TRPC5	5	TRPC1	0	affinity chromatography technology, fluorescent resonance energy transfe	Struebing C (2003), Hofmann T (2002)	2
PRKCB	4	RNF31	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Nakamura M (2006), Nakamura M (2006), Nakamura M (2006)	3
CBL	7	MAPK8	3	affinity chromatography technology, enzymatic study	Miao H (2002), Miao H (2002)	2
SOS1	5	FYN	1	pull down	Park C (1998)	1
ELAVL1	0	BCL10	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFRSF1A	3	LMBR1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	TRPC4AP	4	affinity chromatography technology	Choudhury NR (2017)	1
BCL10	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
TNFRSF1A	3	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BID	1	MAPK8	3	biochemical	Gajate C (2005)	1
DAXX	5	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Kim YY (2003), Kim YY (2003)	2
FYN	1	FAS	2	affinity chromatography technology	Atkinson EA (1996)	1
SRC	2	MAPK1	1	affinity chromatography technology	Lee J (2013)	1
CDKN2B	0	TRAF1	0	two hybrid	Rolland T (2014)	1
STRIP1	3	SIKE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Hein MY (2015)	3
TNFRSF1A	3	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TNFRSF1A	3	PIK3CA	8	affinity chromatography technology	Narita T (2005)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
STAMBP	2	GRB2	2	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bandyopadhyay S (2010), Sierra MI (2010), Sierra MI (2010), Sierra MI (2010), Kikuchi K (2003), Tsang HT (2006), Bisson N (2011), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	11
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
NOL3	0	DAXX	5	affinity chromatography technology, affinity chromatography technology	Donath S (2016), Donath S (2016)	2
EZR	8	FADD	1	biochemical, affinity chromatography technology, imaging technique	Gajate C (2005), Young JA (2011), Chen TC (2014)	3
FADD	1	TNFRSF1A	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Hsu H (1996), Kumar A (2001), Zheng L (2006)	4
CASP8	1	NOL3	0	genetic interference, affinity chromatography technology	Koseki T (1998), Koseki T (1998)	2
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
TNFRSF1A	3	UBQLN1	1	two hybrid	Wang J (2011)	1
RABGEF1	1	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	SGTA	1	affinity chromatography technology	Matsumoto M (2005)	1
MAPK8	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CSNK1A1L	1	TNFRSF1A	3	enzymatic study	Darnay BG (1994)	1
CHUK	5	BCL10	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Poyet JL (2001), Poyet JL (2001), Marinis JM (2012), Zhou H (2004)	4
EGFR	5	UTP15	1	affinity chromatography technology, affinity chromatography technology	Tong J (2014), Yao Z (2017)	2
UCHL1	1	UBE2I	0	two hybrid	Caballero OL (2002)	1
FGFR1OP2	0	CAV1	0	affinity chromatography technology	Hein MY (2015)	1
PRKCD	2	FYN	1	imaging technique	Chen TC (2014)	1
FGFR1OP2	0	STRN4	2	affinity chromatography technology	Hein MY (2015)	1
TRAF3	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang PX (2016), Wang PX (2016), Wang PX (2016)	3
SGTA	1	TNFRSF1A	3	two hybrid	Wang J (2011)	1
TNFRSF1A	3	ATR	6	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	STRN4	2	affinity chromatography technology	Huttlin EL (2017)	1
TRAF1	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shu HB (1997), Kataoka T (2000), Kataoka T (2000), Rolland T (2014)	4
ARHGDIA	3	CASP10	1	biochemical	Gajate C (2005)	1
FAS	2	RHOA	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
JAK1	6	STAT1	1	affinity chromatography technology, affinity chromatography technology	Andl CD (2004), Chang YJ (2004)	2
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
MOB4	0	STRN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, biochemical, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Goudreault M (2009), Glatter T (2009), Couzens AL (2013), Hauri S (2013), Wan C (2015), Hein MY (2015)	8
EGFR	5	BABAM2	2	affinity chromatography technology	Liccardi G (2014)	1
RIPK2	0	TNFRSF1A	3	affinity chromatography technology	McCarthy JV (1998)	1
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
MSN	0	EZR	8	biochemical, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Gary R (1995), Gary R (1993), Gary R (1993), Hein MY (2015)	5
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
PIK3CA	8	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
PHAX	0	TNFRSF1A	3	affinity chromatography technology	Hein MY (2015)	1
RIPK2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	McCarthy JV (1998), Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	8
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
TRIM25	5	CDK6	0	affinity chromatography technology	Choudhury NR (2017)	1
IKBKG	0	JAK2	1	pull down	Fenner BJ (2010)	1
UBC	7	CHUK	5	pull down	Zhang X (2017)	1
ELAVL1	0	MSN	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFRSF1A	3	UTP6	2	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
IKBKB	1	PRDX3	3	affinity chromatography technology	Masaki M (2003)	1
KHDRBS1	1	RIPK1	2	pull down, affinity chromatography technology	Ramakrishnan P (2011), Ramakrishnan P (2011)	2
RBCK1	0	RIPK1	2	affinity chromatography technology	Tian Y (2007)	1
RABGEF1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Penengo L (2006), Yao Z (2017)	2
TRADD	0	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
PIK3CA	8	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
MSN	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
CYLD	2	BIRC2	1	affinity chromatography technology	Elliott PR (2016)	1
TNFRSF1B	4	TRAF1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Marsters SA (1997), Mosialos G (1995), Mosialos G (1995), Boucher LM (1997), Rothe M (1994), Kato T (2008)	6
MAPK1	1	TNFRSF1A	3	enzymatic study, affinity chromatography technology, pull down	Frankel SK (2001), Ibeas E (2009), Ibeas E (2009)	3
KIF2C	1	RRP12	1	affinity chromatography technology	Hein MY (2015)	1
FYN	1	JAK2	1	affinity chromatography technology, pull down	Sayeski PP (1999), Sayeski PP (1999)	2
TRAF2	1	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
TNFRSF1A	3	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TNFRSF1A	3	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
PPP1CA	3	GYS2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF1A	3	LTA	1	x-ray crystallography, pull down, pull down, pull down	Banner DW (1993), Crowe PD (1994), Higuchi M (1992), Chaturvedi MM (1994)	4
IKBKB	1	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Huang WC (2003), Huang WC (2003), Funakoshi-Tago M (2005), Chang YJ (2004)	4
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
TNFRSF1A	3	FOXK2	9	affinity chromatography technology	Huttlin EL (2017)	1
KHDRBS1	1	CASP8	1	affinity chromatography technology	Ramakrishnan P (2011)	1
MSN	0	MAPK8	3	biochemical	Gajate C (2005)	1
TNFRSF1A	3	NOL3	0	genetic interference	Koseki T (1998)	1
TNFRSF1A	3	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	KIF14	8	affinity chromatography technology	Huttlin EL (2017)	1
PIK3CA	8	EGFR	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRIM25	5	PSMD2	2	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	MAPK8	3	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
OPTN	1	TRADD	0	affinity chromatography technology	Zhu G (2007)	1
CASP7	1	TNFRSF1A	3	enzymatic study	Ethell DW (2001)	1
PIK3CA	8	AKT1	1	affinity chromatography technology, protein complementation assay, affinity chromatography technology, enzymatic study	Mitra S (2011), Miao B (2010), Xiong Y (2009), Akil H (2015)	4
EGFR	5	SYK	3	unspecified method	Jones RB (2006)	1
BIRC3	1	SUMO1	0	two hybrid	Wang J (2011)	1
FADD	1	NOL3	0	genetic interference	Koseki T (1998)	1
FYN	1	IKBKG	0	affinity chromatography technology	Lee SH (2012)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
PPP1CA	3	CSNK1E	0	enzymatic study	Luo W (2007)	1
FASLG	0	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Legler DF (2003)	2
FAS	2	FASLG	0	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Starling GC (1997), Schneider P (1997), Legler DF (2003), Tao RH (2011), Chen TC (2014)	7
TNFRSF1A	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahmad R (2007), Fan YH (2011), Cusson-Hermance N (2005), Blonska M (2005), Mitsuhashi S (2008)	5
BIRC3	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Yoneda T (2000), Hu S (2006), Yui D (2001), Hu S (2006), Hu S (2006), Hu S (2006), Hu S (2006)	7
OPTN	1	TNFRSF1A	3	affinity chromatography technology	Klingseisen L (2012)	1
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
OPTN	1	RIPK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nagabhushana A (2011), Zhu G (2007), Zhu G (2007), Klingseisen L (2012), Nakazawa S (2016)	5
ELAVL1	0	TNF	0	affinity chromatography technology	Xin H (2011)	1
CDC6	0	ATR	6	pull down, affinity chromatography technology	Yoshida K (2010), Yoshida K (2010)	2
MOB4	0	FGFR1OP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Glatter T (2009), Hein MY (2015)	3
TNFRSF1B	4	TNFRSF1A	3	affinity chromatography technology	Wicovsky A (2009)	1
OPTN	1	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Mankouri J (2010), Mankouri J (2010)	2
MOB4	0	FADD	1	two hybrid	Stelzl U (2005)	1
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
STRN	1	STRN3	3	affinity chromatography technology, affinity chromatography technology, biochemical, bioid, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Havugimana PC (2012), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	9
TNF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Tokunaga F (2012), Verhelst K (2012), Keusekotten K (2013), Fu J (2013), Schaeffer V (2014), Draber P (2015)	7
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
SYNCRIP	6	PSMD2	2	affinity chromatography technology	Hein MY (2015)	1
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
TRPC4AP	4	RIPK1	2	affinity chromatography technology	Soond SM (2003)	1
UBC	7	SHARPIN	1	pull down	Zhang X (2017)	1
MAP3K7	2	BCL10	0	affinity chromatography technology	Blonska M (2007)	1
TRIM25	5	ATF6	3	affinity chromatography technology	Choudhury NR (2017)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
CAV1	0	TRADD	0	affinity chromatography technology	Feng X (2001)	1
SHARPIN	1	IKBKB	1	affinity chromatography technology	Tokunaga F (2011)	1
TRADD	0	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Hsu H (1996), Ea CK (2006), Guan YJ (2011), Jeon J (2014), Lin B (2016)	7
GRB2	2	SYNCRIP	6	pull down	Fu C (1997)	1
TRAF3	1	RIPK1	2	affinity chromatography technology	Hsu H (1996)	1
BABAM2	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Li Q (2004), Li Q (2004)	2
BIRC3	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
USP4	3	IKBKB	1	affinity chromatography technology	Fan YH (2011)	1
GRB2	2	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	3
GRB2	2	SOS1	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Liu SK (1998), Oneyama C (2002), Puil L (1994), Robinson A (1996), Li N (1993), Wong A (2002), Wong A (2002), Reif K (1994), DAngelo G (1999), Nel AE (1995), Pandey P (1995), Buday L (1994), Tong XK (2000), Park RK (1999), Okada S (1996), Okada S (1996), Okada S (1996), Germani A (1999), Park RK (1999), Chin H (1997), Saci A (2002), Sastry L (1997), Spivak-Kroizman T (1994), Ingham RJ (1996), Wang Y (1999), Chu J (1998), Brehme M (2009), Houtman JC (2006), Lao DH (2006), Bisson N (2011), Wang J (2011), Ng MY (2017), Huttlin EL (2017), Kapoor GS (2010), Saito T (2004), Klint P (1995)	37
TNFRSF10B	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Bellail AC (2012), Gonzalvez F (2012)	2
CASP2	1	CRADD	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, two hybrid	Tinel A (2004), Droin N (2000), Droin N (2000), Duan H (1997), Duan H (1997), Duan H (1997), Jeong WJ (2012), Rolland T (2014)	8
TRIM25	5	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
MAP3K7	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Koga T (2008), Elliott PR (2016)	2
CDK6	0	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
TNFAIP3	3	RBCK1	0	affinity chromatography technology, two hybrid	Verhelst K (2012), Hayes SD (2012)	2
IKBKB	1	TRAF1	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid	Sughra K (2010), Sughra K (2010), Sughra K (2010), Henkler F (2003)	4
EGFR	5	PSMD2	2	affinity chromatography technology	Foerster S (2013)	1
CASP10	1	NFKBIL1	3	two hybrid	Wang J (2011)	1
CASP10	1	CFLAR	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Micheau O (2003), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Feoktistova M (2011), Chen TC (2014)	7
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
TNFRSF10B	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Gonzalvez F (2012)	4
CDKN2B	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RABGEF1	1	RBCK1	0	affinity chromatography technology	Huttlin EL (2017)	1
VANGL2	2	VANGL1	2	affinity chromatography technology	Puvirajesinghe TM (2016)	1
EZR	8	TNFRSF10B	1	biochemical	Gajate C (2005)	1
EGFR	5	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Olayioye MA (1999), Xia L (2002), Andl CD (2004), Foerster S (2013), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	8
ARHGDIA	3	FASLG	0	biochemical	Gajate C (2005)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
ELAVL1	0	TRPC1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TNF	0	RNF8	2	affinity chromatography technology	Fritsch J (2014)	1
EZR	8	BID	1	biochemical	Gajate C (2005)	1
CAV1	0	FAS	2	affinity chromatography technology, affinity chromatography technology	Zhang M (2011), Zhang M (2011)	2
EGFR	5	JAK1	6	affinity chromatography technology	Tong J (2008)	1
FASLG	0	PIK3CA	8	unspecified method	Voss M (2009)	1
TRIM25	5	JPH1	0	affinity chromatography technology	Choudhury NR (2017)	1
TNFRSF1A	3	KHNYN	1	affinity chromatography technology	Huttlin EL (2017)	1
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
TNFRSF1A	3	KIF2C	1	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Oshima S (2009), Saitoh Y (2016)	2
TNFRSF1A	3	PRKCB	4	affinity chromatography technology	Kilpatrick LE (2000)	1
ELAVL1	0	RNF138	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CCND2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARHGDIA	3	FADD	1	biochemical	Gajate C (2005)	1
PPP1CA	3	CAV1	0	affinity chromatography technology, affinity chromatography technology, pull down	Li L (2003), Li L (2003), Li L (2003)	3
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
IKBKG	0	DAPK1	6	pull down	Fenner BJ (2010)	1
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
BIRC2	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
TNFRSF1A	3	SIKE1	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF8	2	BCL10	0	affinity chromatography technology	Zhao H (2014)	1