PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF31	3	UBE2D1	0	pull down, pull down	Nakamura M (2006), Kirisako T (2006)	2
TRIM5	4	UBC	7	enzymatic study	Pertel T (2011)	1
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
UBC	7	RLIM	1	affinity chromatography technology	Matsumoto M (2005)	1
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
TRAF6	0	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Ling L (2000), Ling L (2000), Ling L (2000), Wang J (2011)	4
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
TNIP1	1	TBK1	1	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Gao L (2011)	2
NFKB1	2	TNFAIP3	3	affinity chromatography technology	Lapid D (2017)	1
TRAF6	0	IRAK2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Muzio M (1997), Keating SE (2007), Li S (2011), Li S (2011), Wang J (2011), Wang H (2015), Huttlin EL (2017)	8
ELAVL1	0	TNFAIP3	3	affinity chromatography technology	Balkhi MY (2013)	1
BIRC2	1	NFKB2	3	affinity chromatography technology	Goncharov T (2013)	1
TNFAIP3	3	TNIP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Van Huffel S (2001), Dong G (2011), Dong G (2011), Bohgaki M (2008), Klinkenberg M (2001)	5
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
ARRDC3	0	NEDD4L	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012), Huttlin EL (2017)	3
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
HSP90AA1	7	UBE2N	1	pull down	Zhang M (2005)	1
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
TNF	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	4
RIPK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fearns C (2006), Taipale M (2012)	2
IKBKB	1	TNFRSF1A	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang SQ (2000), Chaudhary PM (2000), Fan YH (2011), Park KJ (2002), Guan YJ (2011), Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008), Chen TC (2014)	9
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
TNFAIP3	3	PPP6R3	2	affinity chromatography technology	Sowa ME (2009)	1
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
TRIM23	3	UBE2D1	0	pull down, pull down	Vichi A (2005), Vichi A (2006)	2
YWHAZ	1	NEDD4L	3	two hybrid	Bandyopadhyay S (2010)	1
TNFAIP3	3	ARRDC3	0	two hybrid	Rolland T (2014)	1
RNF11	0	IKBKG	0	two hybrid	Colland F (2004)	1
IKBKG	0	TBK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Fenner BJ (2010), Li S (2011), Wang L (2012), Wang L (2012), Ran Y (2016), Huttlin EL (2017)	7
NXF1	0	MTOR	14	affinity chromatography technology	Castello A (2012)	1
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
IKBKE	2	BIRC2	1	affinity chromatography technology, enzymatic study	Zhou AY (2013), Zhou AY (2013)	2
ELAVL1	0	PPP6R3	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CHUK	5	RIPK1	2	biochemical	Poyet JL (2000)	1
CHUK	5	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
BIRC2	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Xu M (2009), Phu L (2011), Oberoi TK (2012), Bertrand MJ (2011), Guicciardi ME (2014), Takeda AN (2014), Wauer T (2015), Vu NT (2016)	11
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
TRAF1	0	RBCK1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Abdul-Sater AA (2017)	4
TRAF6	0	SRC	2	affinity chromatography technology, pull down	Wong BR (1999), Liu A (2012)	2
TRIM23	3	SNAI1	1	two hybrid	Rolland T (2014)	1
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
IKBKE	2	TRAF2	1	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Shen RR (2012), Shen RR (2012), Shen RR (2012), Zhang W (2010), Zhou AY (2013), Zhou AY (2013), So J (2015), Fang R (2017)	8
RNF166	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chen HW (2015), Chen HW (2015)	2
UBE2D1	0	RLIM	1	two hybrid, pull down, pull down, pull down	Markson G (2009), Gontan C (2012), Her YR (2009), Gao K (2016)	4
ARIH1	3	SHKBP1	4	affinity chromatography technology	Huttlin EL (2017)	1
NOD2	1	TNFAIP3	3	affinity chromatography technology	Draber P (2015)	1
SHARPIN	1	CHUK	5	affinity chromatography technology	Tokunaga F (2011)	1
IKBKB	1	TNFAIP3	3	enzymatic study, affinity chromatography technology	Zetoune FS (2001), Xiong Y (2011)	2
TNFAIP3	3	TBC1D24	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM23	3	TRAF1	0	two hybrid	Rolland T (2014)	1
TRAF1	0	TBK1	1	affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Huttlin EL (2017)	2
RIPK1	2	IKBKB	1	biochemical, pull down	Yang Y (2011), Poyet JL (2000)	2
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
TICAM1	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Piao W (2009), Sato S (2003), Sato S (2003), Hu YH (2015), Cai B (2017)	6
BECN1	2	TRAF6	0	affinity chromatography technology, enzymatic study	Shi CS (2010), Shi CS (2010)	2
IRAK1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Vig E (2001), Windheim M (2008)	2
RNF11	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
NFKB1	2	TNIP3	3	affinity chromatography technology	Bouwmeester T (2004)	1
TNFAIP3	3	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Shao L (2013), Shao L (2013)	2
MALT1	1	IKBKB	1	affinity chromatography technology	Bidere N (2009)	1
NXF1	0	NFKB2	3	affinity chromatography technology	Castello A (2012)	1
TNF	0	TNIP1	1	affinity chromatography technology	Haas TL (2009)	1
SHARPIN	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, biochemical	Verhelst K (2012), Keusekotten K (2013), Schaeffer V (2014), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), Draber P (2015), Draber P (2015), Draber P (2015), Stieglitz B (2012), Huttlin EL (2017), Elliott PR (2016), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017)	21
ELAVL1	0	YWHAG	5	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
NOD2	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
TNFAIP3	3	CCDC50	0	two hybrid, affinity chromatography technology	Bohgaki M (2008), Bohgaki M (2008)	2
HSP90AA1	7	IKBKE	2	affinity chromatography technology	Taipale M (2012)	1
TRAF6	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999), Mochida Y (2000), Fujino G (2007), Fujino G (2007)	5
TNFAIP3	3	LRRC47	1	affinity chromatography technology	Sowa ME (2009)	1
MALT1	1	TNFAIP3	3	affinity chromatography technology	Yang Y (2014)	1
TP53	0	TRIM8	6	affinity chromatography technology	Caratozzolo MF (2012)	1
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
NFKB1	2	NFKB2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Bouwmeester T (2004), Wang J (2011), Li X (2015)	4
TRIM3	2	UBE2D1	0	pull down	Raheja R (2014)	1
IKBKG	0	TRIM23	3	affinity chromatography technology, affinity chromatography technology	Arimoto K (2010), Arimoto K (2010)	2
RNF11	0	TNFRSF10B	1	affinity chromatography technology	Huttlin EL (2017)	1
TBK1	1	NFKB2	3	affinity chromatography technology	Bouwmeester T (2004)	1
TNFAIP3	3	LAMP1	0	biochemical	Li L (2008)	1
TNFAIP3	3	IRF7	2	affinity chromatography technology, affinity chromatography technology	Ning S (2010), Ning S (2010)	2
ARIH1	3	KCTD10	1	affinity chromatography technology	Huttlin EL (2017)	1
RIPK1	2	FADD	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Young JA (2011), Tenev T (2011), Ramakrishnan P (2011), Legarda-Addison D (2009), ODonnell MA (2012), Vanlangenakker N (2011), Biton S (2011), Biton S (2011), Lee EW (2012), Puliyappadamba VT (2013), Wu P (2014), Huttlin EL (2015), Baratchian M (2016), Moquin DM (2013), Ranjan K (2016), Pescatore A (2016), Zheng M (2016)	18
CHUK	5	SRC	2	affinity chromatography technology, affinity chromatography technology	Huang WC (2003), Funakoshi-Tago M (2005)	2
RARRES3	0	YWHAE	0	affinity chromatography technology	Liu HM (2012)	1
IRAK1	1	CHUK	5	affinity chromatography technology, affinity chromatography technology	Vig E (2001), Windheim M (2008)	2
UBE2N	1	RBCK1	0	two hybrid	Markson G (2009)	1
IKBKG	0	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Zhao T (2007), Zhou AY (2013)	2
YWHAG	5	TNFAIP3	3	two hybrid	Bandyopadhyay S (2010)	1
BIRC3	1	NFKB1	2	imaging technique	Chen TC (2014)	1
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
NEDD4L	3	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chandran S (2011), Ichimura T (2013)	2
RNF11	0	TNIP1	1	two hybrid	Colland F (2004)	1
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
TP53	0	CHUK	5	affinity chromatography technology	Huang WC (2007)	1
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
HSP90AA1	7	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang K (2006), Taipale M (2012), Liu XY (2010)	3
TNFSF10	2	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
TRAF6	0	IKBKE	2	affinity chromatography technology	Fang R (2017)	1
TNFRSF1A	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
TNF	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	5
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
TNF	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Yamaguchi N (2015)	2
YWHAZ	1	KIF11	5	affinity chromatography technology	Mortenson JB (2015)	1
TBK1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bouwmeester T (2004), Bonnard M (2000), Behrends C (2010), Li S (2011), Li S (2011), Shen RR (2012), Zhang W (2010), Huttlin EL (2017), Fang R (2017), Fang R (2017)	10
TICAM1	3	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Sasai M (2010), Sasai M (2010), Jiang Z (2004), Wang YY (2004), Sato S (2003), Sato S (2003), Sato S (2003), Takaki H (2009), Verstak B (2014), Hu YH (2015)	10
CHUK	5	MTOR	14	affinity chromatography technology, affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008), Dan HC (2008)	3
TRAF1	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
BIRC3	1	IKBKE	2	enzymatic study	Zhou AY (2013)	1
TNF	0	CASP8	1	affinity chromatography technology	Fritsch J (2014)	1
BECN1	2	UBC	7	pull down	Shi CS (2010)	1
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
TRAF6	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Bidere N (2006), Bidere N (2006), He L (2006), He L (2006), Zinngrebe J (2016)	5
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
MALT1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
UBC	7	NDUFS1	4	affinity chromatography technology	Matsumoto M (2005)	1
BECN1	2	TP53	0	affinity chromatography technology	Verma N (2017)	1
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
UBE2D1	0	TRIM8	6	two hybrid	Markson G (2009)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
TNF	0	UBE2N	1	genetic interference, affinity chromatography technology	Deng L (2000), Fritsch J (2014)	2
TRAF1	0	TNIP1	1	affinity chromatography technology	Greenfeld H (2015)	1
UBC	7	TNIP1	1	affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down	Wagner S (2008), Wagner S (2008), Fenner BJ (2009), Verhelst K (2012), Zhang X (2017), Kliza K (2017)	6
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
TNFAIP3	3	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
TNFAIP3	3	SHKBP1	4	affinity chromatography technology	Huttlin EL (2017)	1
IKBKE	2	RNF11	0	affinity chromatography technology, affinity chromatography technology	Charoenthongtrakul S (2013), Charoenthongtrakul S (2013)	2
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
LAPTM5	3	LAMP1	0	imaging technique	Glowacka WK (2012)	1
TNFAIP3	3	MTOR	14	affinity chromatography technology, imaging technique	Matsuzawa Y (2015), Matsuzawa Y (2015)	2
MTOR	14	YWHAZ	1	affinity chromatography technology, genetic interference	Vander Haar E (2007), Srivas R (2016)	2
SHARPIN	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Verhelst K (2012), Verhelst K (2012)	2
TNFAIP3	3	KCTD10	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	NOD2	1	affinity chromatography technology	Park S (2013)	1
NEDD4L	3	UBE2D1	0	pull down, pull down, pull down, pull down	Schwarz SE (1998), Herhaus L (2013), Bosanac I (2011), Todaro DR (2017)	4
NFKB1	2	IKBKG	0	affinity chromatography technology, pull down	Bouwmeester T (2004), Smolle M (2004)	2
TNFAIP3	3	YWHAE	0	affinity chromatography technology, two hybrid	Vincenz C (1996), Wang J (2011)	2
HSP90AA1	7	FBXO3	0	affinity chromatography technology	Taipale M (2012)	1
YWHAQ	0	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
TICAM1	3	TRAF1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Jiang Z (2004), Su X (2006), Su X (2006), Su X (2006), Takaki H (2009)	5
TRIM23	3	UBE2N	1	pull down	Dawidziak DM (2017)	1
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
TNF	0	FADD	1	affinity chromatography technology	Fritsch J (2014)	1
NFKB1	2	YWHAQ	0	two hybrid	Wang J (2011)	1
NFKB1	2	TNIP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Lang V (2004), Lang V (2004), Lang V (2004), Lang V (2004), Wang J (2011), Li X (2015)	7
NOD2	1	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
IKBKG	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
NOD2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
IRAK1	1	IRAK2	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Li S (2011), Li S (2011), Ross K (2002), Ross K (2002)	4
IKBKG	0	TAX1BP1	3	two hybrid	Wang J (2011)	1
UBC	7	KCTD10	1	affinity chromatography technology	Matsumoto M (2005)	1
TP53	0	LAPTM5	3	genetic interference	Xie L (2013)	1
TNFAIP3	3	RNF114	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rodriguez MS (2014), Rodriguez MS (2014), Rodriguez MS (2014), Rodriguez MS (2014), Huttlin EL (2017)	5
YWHAB	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
TNIP2	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Leotoing L (2011), Leotoing L (2011)	2
TNFRSF1A	3	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
FADD	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Won M (2010), Saitoh Y (2016)	2
IKBKE	2	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Saitoh T (2005)	2
UBE2N	1	RIPK1	2	enzymatic study	Bohgaki M (2008)	1
BECN1	2	TRAF2	1	affinity chromatography technology, affinity chromatography technology, pull down	Liu H (2017), Liu H (2017), Liu H (2017)	3
TICAM1	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meylan E (2004), Meylan E (2004), Chang M (2009), Hu YH (2015)	4
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TNFSF10	2	RIPK1	2	affinity chromatography technology	Bellail AC (2012)	1
TRAF1	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017), Abdul-Sater AA (2017)	4
MALT1	1	UBE2N	1	pull down	Zhou H (2004)	1
CASP8	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
NOD2	1	UBC	7	x-ray crystallography	Ver Heul AM (2013)	1
RNF31	3	RIPK1	2	affinity chromatography technology	Draber P (2015)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
HSP90AA1	7	TRIM2	1	affinity chromatography technology	Taipale M (2012)	1
TNIP1	1	NFKB1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Cohen S (2009), Cohen S (2009), Wang J (2011), Li X (2015)	4
TNFAIP3	3	TRIM5	4	two hybrid	Hayes SD (2012)	1
ELAVL1	0	CHUK	5	affinity chromatography technology	Chu PC (2012)	1
NOD2	1	BIRC3	1	affinity chromatography technology	Damgaard RB (2012)	1
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
YWHAG	5	MAP3K5	1	affinity chromatography technology	Wang H (2015)	1
TAX1BP1	3	TBK1	1	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Goodwin JM (2017)	2
MAP3K5	1	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Zhang L (1999), So J (2015)	2
GIT2	2	TNIP1	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
TNFAIP3	3	RNF5	0	two hybrid	Hayes SD (2012)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
ELAVL1	0	NEDD4L	3	affinity chromatography technology	Abdelmohsen K (2009)	1
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
UBE2D1	0	RNF14	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
ELAVL1	0	KIF11	5	affinity chromatography technology	Abdelmohsen K (2009)	1
SHARPIN	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Verhelst K (2012), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Draber P (2015), Liu J (2017)	6
TNFAIP3	3	RLIM	1	two hybrid	Hayes SD (2012)	1
ARIH1	3	UBC	7	pull down, x-ray crystallography	Dove KK (2017), Dove KK (2017)	2
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
TNFAIP3	3	AIDA	1	affinity chromatography technology	Huttlin EL (2017)	1
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
NEDD4L	3	MAP3K5	1	enzymatic study	Persaud A (2009)	1
RNF11	0	NEDD4L	3	two hybrid	Colland F (2004)	1
UBE2D1	0	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
NEDD4L	3	YWHAB	1	affinity chromatography technology	Pavlov TS (2010)	1
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
UBE2D1	0	RNF114	0	two hybrid, pull down, enzymatic study	Markson G (2009), Bijlmakers MJ (2011), Lin B (2017)	3
TRAF1	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Wong BR (1999), Narita T (2005)	2
TNFAIP3	3	OCLN	1	affinity chromatography technology, enzymatic study	Kolodziej LE (2011), Kolodziej LE (2011)	2
NXF1	0	TNFAIP3	3	affinity chromatography technology	Castello A (2012)	1
TP53	0	SNAI1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim SO (2010), Lim SO (2010), Liu T (2017)	3
HSP90AA1	7	TNFAIP3	3	affinity chromatography technology	Taipale M (2012)	1
TRIM23	3	UBC	7	enzymatic study	Dawidziak DM (2017)	1
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
YWHAE	0	TBK1	1	affinity chromatography technology, affinity chromatography technology	Zuo S (2010), Zuo S (2010)	2
RNF11	0	YWHAQ	0	affinity chromatography technology	Connor MK (2005)	1
NOD2	1	BIRC2	1	affinity chromatography technology	Damgaard RB (2012)	1
HSP90AA1	7	CHUK	5	affinity chromatography technology, affinity chromatography technology	Qu X (2012), Gano JJ (2010)	2
RIPK1	2	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2008)	2
ELAVL1	0	YWHAB	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFSF10	2	CASP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Gonzalvez F (2012), Jennewein C (2012), Li Y (2013), Xu J (2015)	6
TRIM5	4	IKBKG	0	affinity chromatography technology	Pertel T (2011)	1
ARRDC3	0	TNFRSF10B	1	affinity chromatography technology	Huttlin EL (2017)	1
IKBKG	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Verhelst K (2012), Zak DE (2011), Tokunaga F (2011), Tokunaga F (2011), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017), Bal E (2017)	10
NXF1	0	YWHAZ	1	affinity chromatography technology	Castello A (2012)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBE2N	1	RNF11	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Scheper J (2009), Colland F (2004), Poulsen SL (2013)	5
ELAVL1	0	UBE2N	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ARIH1	3	UBE2D1	0	pull down	Capili AD (2004)	1
TNFAIP3	3	NFKB2	3	affinity chromatography technology	Yamaguchi N (2013)	1
TNFAIP3	3	MCM6	5	affinity chromatography technology	Sowa ME (2009)	1
TNIP1	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Gao L (2011), Gao L (2011), Rolland T (2014)	3
RARRES3	0	TNFAIP3	3	affinity chromatography technology	Lin R (2006)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
YWHAZ	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
TP53	0	UBE2N	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009)	5
TNFAIP3	3	KIF11	5	affinity chromatography technology	Sowa ME (2009)	1
TRIM23	3	TNFAIP3	3	two hybrid	Rolland T (2014)	1
FADD	1	IRF7	2	affinity chromatography technology	Young JA (2011)	1
IKBKB	1	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
TNFAIP3	3	YWHAH	0	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	De Valck D (1997), De Valck D (1997), Vincenz C (1996), Vincenz C (1996), Vincenz C (1996), Sowa ME (2009)	6
NFKB1	2	TBK1	1	affinity chromatography technology	Bouwmeester T (2004)	1
TNIP2	1	CHUK	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Leotoing L (2011), Leotoing L (2011), Leotoing L (2011)	3
TNFAIP3	3	CHUK	5	affinity chromatography technology	Zetoune FS (2001)	1
IKBKB	1	NEDD4L	3	enzymatic study	Edinger RS (2009)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
TNFAIP3	3	ANKRD13D	4	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	TRIM2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBC	7	TAX1BP1	3	pull down, x-ray crystallography, pull down, pull down	Fenner BJ (2009), Tumbarello DA (2015), Tumbarello DA (2015), Zhang X (2017)	4
HSP90AA1	7	BECN1	2	affinity chromatography technology	Xu C (2011)	1
TNFAIP3	3	OTUD5	2	affinity chromatography technology	Huttlin EL (2017)	1
NFKB2	3	TNIP2	1	affinity chromatography technology	Bouwmeester T (2004)	1
RNF31	3	IRF7	2	affinity chromatography technology	Wang L (2017)	1
LAPTM5	3	NEDD4L	3	two hybrid	Colland F (2004)	1
NFKB2	3	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Liang C (2006), Xiao G (2004), Qing G (2007), Nadiminty N (2006)	4
SRC	2	TP53	0	enzymatic study	Huang YF (2014)	1
FADD	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Chaudhary PM (1997), Kim Y (2002), Guo F (2005), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017)	8
UBE2N	1	TRIM5	4	two hybrid, pull down, x-ray crystallography	Markson G (2009), Yudina Z (2015), Yudina Z (2015)	3
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
RNF11	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shembade N (2009), Pranski EL (2012), Kelly C (2012), Colland F (2004)	4
TBK1	1	IRF7	2	pull down	Ikeda F (2007)	1
RNF11	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2009)	2
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
RNF5	0	UBC	7	enzymatic study	Didier C (2003)	1
YWHAB	1	SHKBP1	4	affinity chromatography technology	Couzens AL (2013)	1
ELAVL1	0	LAMP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
TNF	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
MAP3K5	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Won M (2010), Won M (2010)	2
GIT2	2	IKBKG	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TNFRSF10B	1	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
NXF1	0	UBC	7	affinity chromatography technology	Castello A (2012)	1
CHUK	5	TNFRSF1A	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008)	3
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
YWHAQ	0	MTOR	14	pull down	Meek SE (2004)	1
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
TAX1BP1	3	TNIP3	3	two hybrid	Rolland T (2014)	1
YWHAQ	0	MAP3K5	1	pull down	Zhang H (2007)	1
SHARPIN	1	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Keusekotten K (2013), Nakazawa S (2016)	2
TNFAIP3	3	ALDH9A1	2	affinity chromatography technology	Sowa ME (2009)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
TNFAIP3	3	PPP2R1B	4	affinity chromatography technology	Sowa ME (2009)	1
TP53	0	TBC1D24	1	genetic interference	Xie L (2013)	1
BECN1	2	TNFAIP3	3	affinity chromatography technology	Shi CS (2010)	1
YWHAZ	1	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology	Waterman MJ (1998), Waterman MJ (1998), Gu YM (2006)	3
RNF166	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
YWHAB	1	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
TNFAIP3	3	YWHAQ	0	two hybrid	Rodriguez MS (2014)	1
UBC	7	CCDC50	0	pull down, two hybrid, pull down, pull down	Fenner BJ (2009), Bohgaki M (2008), Bohgaki M (2008), Zhang X (2017)	4
TNFRSF1A	3	RBCK1	0	affinity chromatography technology	Nakazawa S (2016)	1
TNIP2	1	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, two hybrid	Liu WK (2004), Liu WK (2004), Liu WK (2004), Liu WK (2004), Liu WK (2004), Wang J (2011)	6
TNFAIP3	3	TNIP1	1	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Heyninck K (1999), Heyninck K (1999), Bohgaki M (2008), Klinkenberg M (2001), Heyninck K (2003), Wang J (2011), Rodriguez MS (2014), Rolland T (2014)	8
TRAF6	0	MTOR	14	affinity chromatography technology, enzymatic study	Linares JF (2013), Linares JF (2013)	2
AXIN1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down	Li Q (2011), Li Q (2011), He Y (2013), He Y (2013), He Y (2013), He Y (2013)	6
TNFSF10	2	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	4
AXIN1	1	UBC	7	affinity chromatography technology	Li VS (2012)	1
TNF	0	CHUK	5	affinity chromatography technology, genetic interference	Haas TL (2009), Sahu I (2014)	2
UBC	7	RNF114	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Capon F (2008), Fenner BJ (2009), Fenner BJ (2009)	4
UBC	7	TNIP2	1	unspecified method, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down	Laplantine E (2009), Wagner S (2008), Fenner BJ (2009), Komander D (2009), Lin SM (2017), Lin SM (2017)	6
YWHAZ	1	YWHAH	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	4
RNF5	0	UBE2N	1	pull down	Tcherpakov M (2009)	1
NOD2	1	IKBKG	0	affinity chromatography technology	Damgaard RB (2012)	1
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
IKBKG	0	FADD	1	affinity chromatography technology	Biton S (2011)	1
IRAK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	3
NEDD4L	3	UBE2N	1	pull down	Herhaus L (2013)	1
TAX1BP1	3	IKBKE	2	affinity chromatography technology	Gao L (2011)	1
YWHAG	5	UBC	7	affinity chromatography technology	Jin J (2004)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
TNF	0	TBK1	1	affinity chromatography technology	Kuai J (2004)	1
TBK1	1	SRC	2	affinity chromatography technology	Johnsen IB (2009)	1
TNFAIP3	3	PCDHB5	0	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
UBE2D1	0	TRIM5	4	two hybrid	Markson G (2009)	1
SRC	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Funakoshi-Tago M (2005), Funakoshi-Tago M (2005), Lee SH (2012)	3
ELAVL1	0	LRRC47	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TNIP1	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Gao L (2011)	2
TRAF1	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Wicovsky A (2009), Henkler F (2003)	2
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
TICAM1	3	TRAF2	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Sasai M (2010), Sasai M (2010), Sasai M (2010), Jiang Z (2004), Takaki H (2009)	5
HSP90AA1	7	IRAK2	3	affinity chromatography technology	Taipale M (2012)	1
OTUD5	2	TP53	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique, pull down	Sowa ME (2009), Luo J (2013), Luo J (2013), Luo J (2013), Luo J (2013), Luo J (2013), Park SY (2015), Park SY (2015), Park SY (2015)	9
NOD2	1	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
OCLN	1	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Raikwar NS (2010), Huttlin EL (2017)	2
TNFAIP3	3	YWHAB	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Vincenz C (1996), Vincenz C (1996), Vincenz C (1996), Sowa ME (2009), Bohgaki M (2008)	5
TNFAIP3	3	TNIP3	3	affinity chromatography technology, two hybrid	Wullaert A (2007), Rolland T (2014)	2
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
IKBKB	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008), Dan HC (2008)	3
ELAVL1	0	TNFRSF1A	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CASP8	1	MTOR	14	genetic interference	Shen JP (2017)	1
IRAK1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
IKBKB	1	HSP90AA1	7	affinity chromatography technology	Xue J (2010)	1
TNFAIP3	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang M (2013), Wang M (2013), Liu J (2013), Liu J (2013)	4
IKBKB	1	TP53	0	enzymatic study	Xia Y (2009)	1
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
RBCK1	0	UBE2D1	0	pull down	Kirisako T (2006)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
TNFAIP3	3	RNF166	0	affinity chromatography technology	Huttlin EL (2017)	1
TNFAIP3	3	SNAI1	1	affinity chromatography technology, enzymatic study	Lee JH (2017), Lee JH (2017)	2
TNFAIP3	3	SRC	2	affinity chromatography technology	Huttlin EL (2017)	1
IKBKG	0	MALT1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Duewel M (2009), Gyrd-Hansen M (2008), Oeckinghaus A (2007), Karim ZA (2015)	4
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
TNFAIP3	3	YWHAZ	1	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid	De Valck D (1997), Vincenz C (1996), Vincenz C (1996), Vincenz C (1996), Bandyopadhyay S (2010), Wang J (2011)	6
IRAK2	3	TNFAIP3	3	affinity chromatography technology	Xiong Y (2011)	1
TRAF6	0	IRF7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawai T (2004), Young JA (2011), Hu Y (2011), Ning S (2008), Ning S (2008), Naiki Y (2015), Naiki Y (2015)	7
TNFRSF1A	3	SRC	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Narita T (2005), Pincheira R (2008), Darnay BG (1997)	3
TNFAIP3	3	TNFAIP3	3	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, two hybrid, two hybrid	Song HY (1996), De Valck D (1996), De Valck D (1996), Klinkenberg M (2001), Yamaguchi N (2013), Rodriguez MS (2014), Rodriguez MS (2014), Wertz IE (2004), Rolland T (2014), Schimmack G (2017)	10
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
TNFSF10	2	TRAF2	1	affinity chromatography technology	Bellail AC (2012)	1
IRAK1	1	TNFAIP3	3	affinity chromatography technology	Xiong Y (2011)	1
BIRC3	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Hu S (2006), Guicciardi ME (2014)	6
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
TRAF2	1	UBE2D1	0	pull down	Alvarez SE (2010)	1
TP53	0	UBB	4	affinity chromatography technology	Fogeron ML (2013)	1
TNFAIP3	3	TRIM3	2	two hybrid	Hayes SD (2012)	1
ELAVL1	0	TRIM8	6	affinity chromatography technology	Abdelmohsen K (2009)	1
BIRC2	1	UBE2N	1	two hybrid	Schimmack G (2017)	1
TRIM2	1	TRIM3	2	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	MTOR	14	imaging technique	Chen TC (2014)	1
NXF1	0	IRAK1	1	affinity chromatography technology	Castello A (2012)	1
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
RARRES3	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Matsumiya T (2009), Matsumiya T (2009)	2
IKBKB	1	NFKB1	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Heissmeyer V (2001), Heissmeyer V (1999), Beinke S (2002), Beinke S (2002), Beinke S (2002), Chen TC (2014)	6
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
TNFAIP3	3	TRIM2	1	two hybrid	Hayes SD (2012)	1
FADD	1	TNFRSF1A	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Hsu H (1996), Kumar A (2001), Zheng L (2006)	4
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
TRIM23	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sparrer KMJ (2017), Sparrer KMJ (2017), Sparrer KMJ (2017), Sparrer KMJ (2017)	4
TNFAIP3	3	TRIM8	6	two hybrid	Hayes SD (2012)	1
YWHAG	5	NEDD4L	3	two hybrid	Bandyopadhyay S (2010)	1
IKBKG	0	PPP2R1B	4	affinity chromatography technology	Griffiths DA (2013)	1
IKBKB	1	IKBKE	2	enzymatic study, affinity chromatography technology	Heilker R (1999), Zhou AY (2013)	2
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
TRIM8	6	TRIM2	1	two hybrid	Woodsmith J (2012)	1
UBE2N	1	CHUK	5	enzymatic study	Deng L (2000)	1
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
IKBKG	0	IRAK1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Conze DB (2008), Conze DB (2008), Windheim M (2008), Windheim M (2008), Ordureau A (2008), Xiong Y (2011), Jeon J (2014), Emmerich CH (2013)	8
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
TNFAIP3	3	RNF14	2	two hybrid	Hayes SD (2012)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
YWHAQ	0	TNF	0	unspecified method	Stoecklin G (2004)	1
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
MALT1	1	TRAF2	1	pull down, affinity chromatography technology	Sun L (2004), Garrison JB (2009)	2
UBC	7	CHUK	5	pull down	Zhang X (2017)	1
IRF7	2	IRAK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Li S (2011), Li S (2011), Uematsu S (2005), Uematsu S (2005), Uematsu S (2005), Uematsu S (2005)	6
MALT1	1	RBCK1	0	enzymatic study	Klein T (2015)	1
MALT1	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2004), Sun L (2004), Garrison JB (2009), Li Y (2013), Oeckinghaus A (2007), Oeckinghaus A (2007), Nie Z (2015), Liu Y (2012), Liu Y (2012)	9
TNFAIP3	3	FBXO3	0	affinity chromatography technology	Sowa ME (2009)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
NFKB1	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Heissmeyer V (1999), Beinke S (2002), Beinke S (2002), Beinke S (2002)	4
RBCK1	0	RIPK1	2	affinity chromatography technology	Tian Y (2007)	1
YWHAB	1	TP53	0	affinity chromatography technology	Lee MK (2007)	1
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
UBE2D1	0	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
ELAVL1	0	YWHAH	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFAIP3	3	NDUFS1	4	affinity chromatography technology	Sowa ME (2009)	1
TRAF2	1	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
IKBKB	1	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Huang WC (2003), Huang WC (2003), Funakoshi-Tago M (2005), Chang YJ (2004)	4
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
TRIM5	4	UBB	4	two hybrid	Lukic Z (2011)	1
OTUD5	2	UBC	7	pull down, enzymatic study, enzymatic study, pull down, pull down	Kayagaki N (2007), Huang OW (2012), Mevissen TE (2013), Zhang X (2017), Kwasna D (2018)	5
TRAF1	0	MAP3K5	1	affinity chromatography technology	Nishitoh H (1998)	1
IKBKG	0	TNIP1	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Ashida H (2010), Wagner S (2008), Wang J (2011)	3
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
TP53	0	IRF7	2	two hybrid	Chen J (2008)	1
RNF11	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Shembade N (2009), Colland F (2004)	2
UBE2D1	0	RNF166	0	two hybrid	Markson G (2009)	1
GIT2	2	TRAF1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
TP53	0	YWHAE	0	affinity chromatography technology	Fogeron ML (2013)	1
ELAVL1	0	TNF	0	affinity chromatography technology	Xin H (2011)	1
TNFAIP3	3	NEDD4L	3	affinity chromatography technology	Huttlin EL (2017)	1
TNFAIP3	3	ARIH1	3	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Yao Z (2007), Yao Z (2007)	2
TNFSF10	2	TNFRSF10B	1	pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaptein A (2000), Walczak H (1997), Hymowitz SG (1999), Hymowitz SG (1999), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	7
TNFAIP3	3	GLDC	2	affinity chromatography technology	Sowa ME (2009)	1
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
CHUK	5	IKBKE	2	enzymatic study	Heilker R (1999)	1
HSP90AA1	7	MAP3K5	1	affinity chromatography technology	Taipale M (2012)	1
TNF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Tokunaga F (2012), Verhelst K (2012), Keusekotten K (2013), Fu J (2013), Schaeffer V (2014), Draber P (2015)	7
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
TNIP1	1	TNIP3	3	two hybrid	Rolland T (2014)	1
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
CCDC50	0	RIPK1	2	affinity chromatography technology	Bohgaki M (2008)	1
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
ANKRD13D	4	UBC	7	pull down, pull down	Tanno H (2012), Zhang X (2017)	2
UBC	7	SHARPIN	1	pull down	Zhang X (2017)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
TNFAIP3	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gao L (2011), Saitoh T (2005)	3
SHARPIN	1	IKBKB	1	affinity chromatography technology	Tokunaga F (2011)	1
GIT2	2	TNFAIP3	3	two hybrid	Wang J (2011)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
UBC	7	LAPTM5	3	pull down	Pak Y (2006)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
TNFAIP3	3	CNKSR2	5	affinity chromatography technology	Sowa ME (2009)	1
TNFRSF10B	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Bellail AC (2012), Gonzalvez F (2012)	2
UBC	7	TNIP3	3	affinity chromatography technology, two hybrid	Wagner S (2008), Wagner S (2008)	2
TBK1	1	RNF11	0	affinity chromatography technology, affinity chromatography technology	Charoenthongtrakul S (2013), Charoenthongtrakul S (2013)	2
TICAM1	3	TNFAIP3	3	affinity chromatography technology	Wang YY (2004)	1
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
UBE2D1	0	TRIM2	1	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
TNFAIP3	3	RBCK1	0	affinity chromatography technology, two hybrid	Verhelst K (2012), Hayes SD (2012)	2
IKBKB	1	TRAF1	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid	Sughra K (2010), Sughra K (2010), Sughra K (2010), Henkler F (2003)	4
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
PPP6R3	2	HSP90AA1	7	biochemical	Kristensen AR (2012)	1
TNFAIP3	3	LAPTM5	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, two hybrid	Glowacka WK (2012), Glowacka WK (2012), Glowacka WK (2012), Glowacka WK (2012), Colland F (2004)	5
NXF1	0	HSP90AA1	7	affinity chromatography technology	Castello A (2012)	1
TRAF2	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Nishitoh H (1998), Hoeflich KP (1999), Gan B (2006), Kolliputi N (2009), Fujino G (2007), Fujino G (2007), Wu Y (2006), Zhang H (2004), Hwang SG (2014), Yoon KW (2009), Yoon KW (2009)	11
TNFAIP3	3	RNH1	8	affinity chromatography technology	Sowa ME (2009)	1
UBE2N	1	ARIH1	3	affinity chromatography technology	Lim GG (2013)	1
MTOR	14	IKBKG	0	affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008)	2
NEDD4L	3	YWHAH	0	affinity chromatography technology	Nagaki K (2006)	1
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
RNF114	0	HSP90AA1	7	biochemical	Bijlmakers MJ (2011)	1
CASP8	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Oshima S (2009), Saitoh Y (2016)	2
RBCK1	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013)	2
NFKB2	3	IKBKG	0	affinity chromatography technology	Bouwmeester T (2004)	1
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
YWHAG	5	YWHAH	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
MTOR	14	TP53	0	affinity chromatography technology, genetic interference	Su WC (2009), Ye H (2016)	2
TNFAIP3	3	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	De Valck D (1999), De Valck D (1999), Klinkenberg M (2001), Kelly C (2012), Huttlin EL (2017)	5