PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
GRB7	1	TMSB4X	0	two hybrid	Vinayagam A (2011)	1
RAD21	3	TMSB4X	0	two hybrid	Panigrahi AK (2011)	1
TK1	0	ALAS1	2	two hybrid	Vinayagam A (2011)	1
TMSB4X	0	PNMA1	0	two hybrid	Rolland T (2014)	1
TK1	0	TMSB4X	0	two hybrid	Vinayagam A (2011)	1
TMSB4X	0	KRT40	0	two hybrid	Rolland T (2014)	1
TRIM27	2	TMSB4X	0	two hybrid	Rolland T (2014)	1
MLH1	6	TRIM23	3	two hybrid	Brieger A (2010)	1
CDKN1A	1	TMSB4X	0	two hybrid	Vinayagam A (2011)	1
ACTA1	1	TRIP6	2	imaging technique	Xu J (2004)	1
TRIM23	3	TMSB4X	0	two hybrid	Rolland T (2014)	1
ALAS1	2	TMSB4X	0	two hybrid	Rolland T (2014)	1
TAF1D	0	TMSB4X	0	two hybrid	Vinayagam A (2011)	1
HSF2	2	TMSB4X	0	affinity chromatography technology	Hein MY (2015)	1
SCHIP1	0	TMSB4X	0	pull down	Miyamoto-Sato E (2010)	1
FAM118B	0	TMSB4X	0	two hybrid	Vinayagam A (2011)	1
MLH1	6	ACTG1	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Brieger A (2010), Brieger A (2010), Brieger A (2010)	3
ACTG1	5	ACTA1	1	biochemical	Kristensen AR (2012)	1
ACTG1	5	TMSB4X	0	x-ray crystallography, pull down	Hertzog M (2004), Van Troys M (1996)	2
MYH6	12	TMSB4X	0	affinity chromatography technology	Hein MY (2015)	1
KRT13	2	TMSB4X	0	two hybrid	Rolland T (2014)	1
KRT31	0	TMSB4X	0	two hybrid	Rolland T (2014)	1
TMSB4X	0	RBPMS	0	two hybrid	Rolland T (2014)	1
TMSB4X	0	ACTA1	1	pull down, pull down	Ballweber E (2002), Safer D (1997)	2
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
TMSB4X	0	TRIP6	2	two hybrid	Rolland T (2014)	1
MLH1	6	TMSB4X	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Brieger A (2010), Brieger A (2010), Brieger A (2010)	3
CDKN1A	1	KRT31	0	two hybrid	Rolland T (2014)	1
SMN1	0	TMSB4X	0	two hybrid	Vinayagam A (2011)	1
ZNF526	1	TMSB4X	0	affinity chromatography technology	Hein MY (2015)	1
KRT15	2	TMSB4X	0	two hybrid	Rolland T (2014)	1
ANXA7	0	TMSB4X	0	two hybrid	Vinayagam A (2011)	1
CDKN1A	1	ALAS1	2	two hybrid	Vinayagam A (2011)	1