Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
TJP1 7082 GENISTEIN CHEMBL44 NCI 10330056
TJP1 7082 DEXAMETHASONE CHEMBL384467 NCI 8206910
TJP1 7082 ALCOHOL CHEMBL545 NCI 9952110

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
TJP1 rs785423 A risperidone efficacy yes The number of A alleles present in a patient was negatively associated with PGI score. Please note that this variant is in high linkage disequilibrium with rs711355 and rs813676. Allele A is associated with increased response to risperidone in people with Schizophrenia as compared to allele G. 23241943 1450815079
TJP1 rs813676 T risperidone efficacy yes The number of T alleles present in a patient was negatively associated with PGI score. Please note that this variant is in high linkage disequilibrium with rs711355 and rs785423. Allele T is associated with increased response to risperidone in people with Schizophrenia as compared to allele C. 23241943 1450815085
TJP1 rs711355 T risperidone efficacy yes The number of T alleles present in a patient was negatively associated with PGI score. Please note that this variant is in high linkage disequilibrium with rs785423 and rs813676. Allele T is associated with increased response to risperidone in people with Schizophrenia as compared to allele C. 23241943 1450815073