PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FOXH1	1	SMAD3	1	affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology	Liu B (1999), Cui Q (2005), Cui Q (2005), Yoon SJ (2011), Cui Q (2005)	5
TGIF1	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
JUN	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
TGIF1	1	SDAD1	1	affinity chromatography technology	Ewing RM (2007)	1
TGIF1	1	JUN	0	affinity chromatography technology, pull down	Pessah M (2001), Pessah M (2001)	2
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
AR	3	SMAD3	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Hayes SA (2001), Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002), Chipuk JE (2002)	12
TGIF1	1	A2M	8	two hybrid	Vinayagam A (2011)	1
SIN3A	13	TGIF1	1	two hybrid, affinity chromatography technology, pull down	Sharma M (2001), Sharma M (2001), Sharma M (2001)	3
MDFI	1	TGIF1	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
TGIF1	1	MKKS	1	affinity chromatography technology	Ewing RM (2007)	1
HDAC1	4	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Khan MM (2001), Khan MM (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Morey L (2008), Kuo HY (2013), Kim YE (2015)	10
ELAVL1	0	CTBP1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD3	1	JUN	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Verrecchia F (2000), Liberati NT (1999), Liberati NT (2001), Lee SY (2011)	7
SMAD2	5	TGIF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Wotton D (1999), Pessah M (2001)	4
HDAC1	4	TGIF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Melhuish TA (2000), Melhuish TA (2001), Lo RS (2001)	3
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
CTBP2	7	CTBP1	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sewalt RG (1999), Wang J (2011), Corominas R (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
ELAVL1	0	TGIF1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TGIF1	1	MED31	0	two hybrid	Stelzl U (2005)	1
TGIF1	1	PML	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Faresse N (2008), Seo SR (2006), Seo SR (2006), Seo SR (2006)	4
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
TGIF1	1	SMAD1	0	affinity chromatography technology	Wotton D (1999)	1
SMAD3	1	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
MOB3A	1	TGIF1	1	two hybrid	Yu H (2011)	1
FOXH1	1	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Liu B (1999), Liu F (1997), Liu F (1997), Dou C (2000), Chen X (1997), Chen X (1997), Prunier C (2003), Yoon SJ (2011), Seo SR (2006), Cui Q (2005)	11
MKKS	1	APP	1	pull down	Olah J (2011)	1
JUN	0	HDAC1	4	affinity chromatography technology	Tenbrock K (2006)	1
MOB3A	1	APP	1	pull down	Olah J (2011)	1
STK16	1	MKKS	1	affinity chromatography technology	Ewing RM (2007)	1
CTBP2	7	APP	1	pull down	Olah J (2011)	1
TGIF1	1	APP	1	pull down	Olah J (2011)	1
CTBP2	7	TGIF1	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
AR	3	TGIF1	1	pull down	Sharma M (2001)	1
TGIF1	1	STK16	1	affinity chromatography technology	Ewing RM (2007)	1
SMAD3	1	SIN3A	13	pull down	Liberati NT (2001)	1
TGIF1	1	EEF1A1	0	two hybrid	Stelzl U (2005)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
PML	7	SIN3A	13	pull down, affinity chromatography technology	Khan MM (2001), Khan MM (2001)	2
HDAC1	4	CTBP1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang CL (2001), Melhuish TA (2000), Sundqvist A (1998), Jin W (2008), Joshi P (2013)	5
SMAD1	0	AR	3	affinity chromatography technology, affinity chromatography technology, protein complementation assay, imaging technique, affinity chromatography technology	Qiu T (2007), Qiu T (2007), Qiu T (2007), Qiu T (2007), Li Y (2013)	5
SMAD2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Takeda M (2004), Lo RS (2001)	4
SMAD1	0	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	MOB3A	1	affinity chromatography technology	Abdelmohsen K (2009)	1
A2M	8	APP	1	two hybrid	Soler-Lopez M (2011)	1
TGIF1	1	CTBP1	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid	Melhuish TA (2000), Melhuish TA (2000), Merrill JC (2010), Rolland T (2014)	4
SMAD3	1	PML	7	affinity chromatography technology	Lin HK (2004)	1
FOXH1	1	TGIF1	1	affinity chromatography technology	Wotton D (1999)	1
PML	7	SMAD2	5	affinity chromatography technology	Lin HK (2004)	1
PML	7	JUN	0	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vallian S (1998), Yasuda S (1999), Salomoni P (2005), Salomoni P (2005), Seo SR (2006), Seo SR (2006), Seo SR (2006)	7
SMAD2	5	EEF1A1	0	two hybrid	Colland F (2004)	1
ELAVL1	0	SDAD1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
JUN	0	AR	3	affinity chromatography technology, affinity chromatography technology	Sato N (1997), Sato N (1997)	2
SMAD2	5	JUN	0	affinity chromatography technology, pull down	Pessah M (2001), Miyamoto-Sato E (2010)	2
AR	3	SIN3A	13	affinity chromatography technology	Zhu P (2006)	1
TGIF1	1	SMAD3	1	affinity chromatography technology, pull down	Melhuish TA (2001), Liberati NT (2001)	2
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4