PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	HSPA4	3	affinity chromatography technology	Choudhury NR (2017)	1
TGFBR1	2	BAMBI	3	pull down, affinity chromatography technology	Yan X (2009), Yan X (2009)	2
SMURF2	3	TRAF4	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Colland F (2004), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013)	8
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
MAP3K7	2	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Kimura N (2000), Yanagisawa M (2001)	2
MAPK14	0	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Edlund S (2003), Zhang S (2006)	2
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
TRIM25	5	MAPK14	0	affinity chromatography technology	Choudhury NR (2017)	1
ACVRL1	1	PEG10	2	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, imaging technique	Lux A (2005), Lux A (2005), Lux A (2005), Lux A (2005), Lux A (2005)	5
TGFBR2	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Krymskaya VP (1997), Huttlin EL (2015), Huttlin EL (2017)	3
SMAD7	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Asano Y (2004), Koinuma D (2003), Kavsak P (2000), Hayashi H (1997), Hayashi H (1997), Datta PK (2000), Wicks SJ (2005), Lallemand F (2005), Seong HA (2007), Yan X (2011), Cai Y (2012), Cai Y (2012), Seo SR (2004), Zhu L (2012), Zhu L (2012), Nakao A (1997), Yan X (2009), Kamiya Y (2010), Suzuki C (2002), Hsu HY (2014)	21
TRAF6	0	HSPA4	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Chen H (2006), Pridgeon JW (2004), Chen H (2006)	3
TGFBR1	2	CAV1	0	biochemical, affinity chromatography technology	Razani B (2001), Razani B (2001)	2
MAP3K7	2	ITCH	1	affinity chromatography technology	Kathania M (2015)	1
SMAD2	5	DAB2	1	pull down, affinity chromatography technology	Hocevar BA (2001), Hocevar BA (2001)	2
MAPK14	0	TOLLIP	3	affinity chromatography technology	Yagasaki Y (2004)	1
EP300	36	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kim RH (2000), Luciakova K (2008), Janknecht R (1998), Chung CL (2011), Shen X (1998), Dornan D (2003), Yang Y (2015)	7
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
TOLLIP	3	TRAF6	0	affinity chromatography technology	Lee JY (2009)	1
TRIM25	5	NOTCH1	25	affinity chromatography technology	Choudhury NR (2017)	1
STRAP	2	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Datta PK (1998), Datta PK (2000)	2
TGFBR1	2	PIK3R1	6	affinity chromatography technology	Krymskaya VP (1997)	1
EPHA2	3	AP2B1	3	affinity chromatography technology	Dutta D (2013)	1
MAP3K7	2	SKIL	3	affinity chromatography technology	Kajino T (2007)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
SMURF2	3	DAB2	1	two hybrid	Colland F (2004)	1
NOTCH1	25	USP15	4	affinity chromatography technology	Yatim A (2012)	1
SMAD7	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lallemand F (2005), Lallemand F (2005), Al-Salihi MA (2012), Gen Y (2017), Gen Y (2017)	5
NLGN3	3	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	TAB2	5	affinity chromatography technology	Gano JJ (2010)	1
OTUB1	0	SMAD4	9	affinity chromatography technology, pull down	Herhaus L (2013), Herhaus L (2013)	2
ELAVL1	0	APPL1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TGFBR1	2	OTUB1	0	enzymatic study, affinity chromatography technology	Herhaus L (2015), Herhaus L (2015)	2
TGFB1	2	FKBP1A	0	two hybrid, two hybrid	Cheng SY (2002), Li Y (2013)	2
SPTBN1	6	TPM1	0	affinity chromatography technology	Tang Y (2003)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
OCLN	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
ELAVL1	0	GOLT1B	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
CDC42	3	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
SMAD4	9	USP4	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhou F (2017), Zhou F (2017), Zhou F (2017), Zhou F (2017)	4
MYOC	1	TGFBR1	2	two hybrid	Fautsch MP (2006)	1
STRAP	2	SMAD2	5	affinity chromatography technology, affinity chromatography technology, genetic interference	Datta PK (2000), Datta PK (2000), Datta PK (2000)	3
TOLLIP	3	ITCH	1	affinity chromatography technology	Li S (2011)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
SMAD3	1	USP15	4	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Inui M (2011), Inui M (2011), Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015)	5
PAK1	2	HSP90AA1	7	two hybrid	Bandyopadhyay S (2010)	1
PSEN1	11	NOTCH1	25	affinity chromatography technology	Ray WJ (1999)	1
OTUB1	0	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Herhaus L (2013), Herhaus L (2013), Herhaus L (2013)	3
PPP1R16B	2	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
MAPK14	0	PAK1	2	affinity chromatography technology	Chan PM (2008)	1
ITCH	1	NOTCH1	25	affinity chromatography technology	Puca L (2013)	1
CAV1	0	SMAD2	5	biochemical	Razani B (2001)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
MAP3K7	2	HSP90AA1	7	affinity chromatography technology	Liu XY (2008)	1
SMURF2	3	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhou F (2017), Zhou F (2017)	3
MYOC	1	HSPA4	3	affinity chromatography technology	Fautsch MP (2006)	1
APPL1	1	PIK3R2	3	two hybrid	Grossmann A (2015)	1
TOLLIP	3	PEG10	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
MAPK14	0	TAB2	5	affinity chromatography technology	Grimsey NJ (2015)	1
SMAD2	5	SMAD6	9	affinity chromatography technology	Topper JN (1997)	1
SKI	3	SKIL	3	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Cohen SB (1999), Cohen SB (1999), Tan R (2006), He J (2003), Ikeuchi Y (2014)	5
CD44	1	TGFBR1	2	pull down, affinity chromatography technology, affinity chromatography technology	Bourguignon LY (2002), Wakahara K (2005), Wakahara K (2005)	3
TGFBR2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Kim SI (2009), Kim SI (2009)	2
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
CD44	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	FBXO34	0	affinity chromatography technology	Taipale M (2012)	1
DAB2	1	TGFBR1	2	affinity chromatography technology	Hocevar BA (2001)	1
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
TOLLIP	3	CAV1	0	affinity chromatography technology	Ohnuma K (2005)	1
MAP3K7	2	SMAD3	1	imaging technique	Chen TC (2014)	1
SMAD3	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yan X (2009), Tang Y (2003), Tang Y (2003), Herhaus L (2015)	4
TRIM25	5	PPP1R16B	2	affinity chromatography technology	Choudhury NR (2017)	1
APPL1	1	TRAF6	0	affinity chromatography technology	Cheng KK (2013)	1
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
DAB2	1	AP2B1	3	affinity chromatography technology	Mulkearns EE (2012)	1
MYOC	1	TPM1	0	affinity chromatography technology	Fautsch MP (2006)	1
DAB2	1	TGFBR2	0	affinity chromatography technology	Hocevar BA (2001)	1
SMAD4	9	SKI	3	pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Wu JW (2002), Stroschein SL (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Takeda M (2004), Takeda M (2004), Ferrand N (2010), Wu K (2003), Wu K (2003), Barrios-Rodiles M (2005), Colland F (2004), He J (2003), He J (2003), Jinnin M (2007), Li X (2015), Rashidian J (2015), Rashidian J (2015), Zhou F (2017)	21
USP15	4	SMURF2	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Eichhorn PJ (2012), Iyengar PV (2015), Iyengar PV (2015)	3
TGFBR1	2	AP2B1	3	affinity chromatography technology	Yao D (2002)	1
TGFBR2	0	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhang L (2013)	2
ENG	5	TGFB1	2	affinity chromatography technology	Cheifetz S (1992)	1
SMAD7	1	TGFBR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Nakao A (1997), Hsu HY (2014)	3
TRIM25	5	TGFBR2	0	affinity chromatography technology	Choudhury NR (2017)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
FNTA	0	TGFBR1	2	two hybrid, pull down, enzymatic study	Kawabata M (1995), Kawabata M (1995), Kawabata M (1995)	3
TGFBR1	2	SMAD2	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Razani B (2001), Faresse N (2008), Bai Y (2004), Tang Y (2003), Tang Y (2003), Ding L (2009), Lu D (2013), Herhaus L (2015)	8
TSC22D1	1	OTUB1	0	two hybrid	Vinayagam A (2011)	1
PPP1R16B	2	USP11	3	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
SNX6	1	ACVRL1	1	affinity chromatography technology	Parks WT (2001)	1
PPP1R16B	2	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TGFBR1	2	TPM1	0	affinity chromatography technology	Tang Y (2003)	1
ELAVL1	0	FKBP1A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PARD6A	0	CDC42	3	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Joberty G (2000), Qiu RG (2000), Qiu RG (2000), Noda Y (2001), Noda Y (2001), Brajenovic M (2004)	6
TGFBR2	0	AP2B1	3	affinity chromatography technology, two hybrid	Yao D (2002), Yao D (2002)	2
KCNK18	0	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
TGFBR1	2	TSC22D1	1	two hybrid, affinity chromatography technology, pull down	Yan X (2011), Yan X (2011), Yan X (2011)	3
FBXO34	0	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
ELAVL1	0	SH3KBP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
SMAD2	5	HSPA4	3	affinity chromatography technology	Brown KA (2008)	1
SMAD4	9	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lebrun JJ (1999), Moren A (2005), Moren A (2005), Moren A (2005), Zhang S (2007), Yan X (2016)	6
RASSF1	3	ITCH	1	affinity chromatography technology	Pefani DE (2016)	1
STRAP	2	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Datta PK (1998), Datta PK (2000)	2
TGFBR2	0	SH3KBP1	1	affinity chromatography technology	Yakymovych I (2015)	1
GOLT1B	0	CAV1	0	affinity chromatography technology	Hein MY (2015)	1
SMAD4	9	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Moren A (2005)	2
TGFBRAP1	2	SMAD4	9	pull down, affinity chromatography technology	Wurthner JU (2001), Wurthner JU (2001)	2
ELAVL1	0	OXSR1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TGFBR1	2	HMMR	1	affinity chromatography technology	Park D (2012)	1
SMAD6	9	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
CDC42	3	ARHGEF6	0	affinity chromatography technology, imaging technique	Feng Q (2004), Chen TC (2014)	2
ELAVL1	0	SNX6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	SKI	3	affinity chromatography technology	Choudhury NR (2017)	1
SMAD7	1	MAP3K7	2	affinity chromatography technology	Edlund S (2003)	1
USP4	3	MAP3K7	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Fan YH (2011), Fan YH (2011), Fan YH (2011)	3
OXSR1	2	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
OCLN	1	ITCH	1	affinity chromatography technology	Murakami T (2009)	1
TRIM25	5	TGFBRAP1	2	affinity chromatography technology	Choudhury NR (2017)	1
CDC42	3	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
PAK1	2	TGFBR2	0	pull down, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
USP4	3	USP15	4	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang L (2012), Loch CM (2012), Das T (2017)	3
EPHA2	3	TGFBR1	2	affinity chromatography technology	Hein MY (2015)	1
TGFBR1	2	TGFBRAP1	2	affinity chromatography technology	Wurthner JU (2001)	1
TRIM25	5	USP11	3	affinity chromatography technology	Choudhury NR (2017)	1
PAK1	2	CDC42	3	pull down, pull down, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Seoh ML (2003), Zhang B (1998), Bandyopadhyay S (2010), Mott HR (1999), Owen D (2000), Morreale A (2000), Wells CD (2006), Marivin A (2013), Varjosalo M (2013), Shen Y (2008), Gonzalez-Martinez D (2004)	11
APPL1	1	PIK3R1	6	affinity chromatography technology, two hybrid	Yang L (2003), Grossmann A (2015)	2
SMAD2	5	SMURF1	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Ito I (2010), Colland F (2004)	3
NOTCH1	25	PPP2R2A	0	affinity chromatography technology	Yatim A (2012)	1
SMAD2	5	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Luo K (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Inoue Y (2011), Ferrand N (2010), Chen W (2007), Brown KA (2008), He J (2003), Rashidian J (2015), Zhou F (2017)	15
TRIM25	5	CD44	1	affinity chromatography technology	Choudhury NR (2017)	1
SMAD7	1	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Yan X (2011), Yan X (2011)	2
TGFBR1	2	PIK3R2	3	affinity chromatography technology	Krymskaya VP (1997)	1
NLGN3	3	FKBP1A	0	two hybrid	Shen C (2015)	1
SH3KBP1	1	DAB2	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Havrylov S (2009), Kowanetz K (2003), Kowanetz K (2003)	3
GOLT1B	0	TGFBR1	2	affinity chromatography technology	Hein MY (2015)	1
SPTBN1	6	SMAD2	5	affinity chromatography technology	Tang Y (2003)	1
STRAP	2	SMAD3	1	affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference	Datta PK (2000), Datta PK (2000), Datta PK (2000), Datta PK (2000)	4
PIK3R1	6	SH3KBP1	1	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Gout I (2000), Tossidou I (2010), Borthwick EB (2004), Borthwick EB (2004)	4
CDC42	3	MAP3K20	1	affinity chromatography technology	Hein MY (2015)	1
PIK3R1	6	EPHA2	3	pull down, affinity chromatography technology, two hybrid	Pandey A (1994), Pandey A (1994), Pandey A (1994)	3
SMAD7	1	TAB2	5	affinity chromatography technology, affinity chromatography technology	Hong S (2007), Hong S (2007)	2
SKI	3	RANBP9	5	affinity chromatography technology	Rashidian J (2015)	1
PARD6A	0	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Ozdamar B (2005), Ozdamar B (2005)	2
ACVRL1	1	TGFB1	2	affinity chromatography technology, affinity chromatography technology	Oh SP (2000), Attisano L (1993)	2
ELAVL1	0	ITCH	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPK14	0	SPTBN1	6	two hybrid	Bandyopadhyay S (2010)	1
ELAVL1	0	TPM1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
SPTBN1	6	ANK1	8	affinity chromatography technology	Tang Y (2003)	1
STRAP	2	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Datta PK (2000), Datta PK (2000), Datta PK (2000), Seong HA (2007)	4
ELAVL1	0	CDC42	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ARHGEF6	0	PAK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013), Huttlin EL (2017)	3
TGFBR1	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Yakymovych I (2015), Yakymovych I (2015)	2
SMAD6	9	USP11	3	affinity chromatography technology, affinity chromatography technology	Herhaus L (2014), Herhaus L (2014)	2
TGFBR1	2	NOTCH1	25	affinity chromatography technology, affinity chromatography technology	Gudey SK (2014), Gudey SK (2014)	2
SMURF2	3	SKIL	3	affinity chromatography technology	Bonni S (2001)	1
TRIM25	5	TGFBR1	2	affinity chromatography technology	Choudhury NR (2017)	1
SMAD6	9	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Hata A (1998), Kamiya Y (2010)	2
TGFBR1	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koinuma D (2003), Ebisawa T (2001), Murakami G (2003)	3
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
TGFBR1	2	MAPK14	0	affinity chromatography technology	Sorrentino A (2008)	1
SMAD3	1	DAB2	1	pull down, affinity chromatography technology	Hocevar BA (2001), Hocevar BA (2001)	2
SMAD6	9	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
SNX6	1	TGFBR1	2	affinity chromatography technology	Parks WT (2001)	1
SMAD6	9	STRAP	2	affinity chromatography technology, affinity chromatography technology	Datta PK (2000), Datta PK (2000)	2
SPTBN1	6	SMAD4	9	affinity chromatography technology, affinity chromatography technology	Tang Y (2003), Tang Y (2003)	2
SMURF2	3	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Hsu HY (2014)	2
SMURF2	3	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Yan X (2011), Cai Y (2012), Cai Y (2012), Zhang L (2013), Chandhoke AS (2015), Hsu HY (2014)	7
TGFBR1	2	TGFB1	2	affinity chromatography technology, affinity chromatography technology, pull down	Ebner R (1993), Oh SP (2000), Wakahara K (2005)	3
TGFBR2	0	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
BMPR2	1	TGFBR1	2	two hybrid, two hybrid	Liu F (1995), Kawabata M (1995)	2
SMAD4	9	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
FBXO34	0	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TOLLIP	3	SMAD7	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Zhu L (2012), Zhu L (2012), Zhu L (2012)	3
SMURF1	4	SPTBN1	6	affinity chromatography technology	Xie Y (2013)	1
ELAVL1	0	TOLLIP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD3	1	SMURF1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017)	4
TGFBR2	0	TGFB1	2	affinity chromatography technology, affinity chromatography technology	Rotzer D (2001), Attisano L (1993)	2
OXSR1	2	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
SMAD7	1	USP15	4	affinity chromatography technology	Eichhorn PJ (2012)	1
TGFBR1	2	ANK1	8	affinity chromatography technology	Tang Y (2003)	1
SMAD4	9	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (1999), Stroschein SL (1999), Barrios-Rodiles M (2005), Colland F (2004), Colland F (2004), He J (2003), He J (2003), Ikeuchi Y (2014), Jinnin M (2007), Li X (2015)	10
TGFBR1	2	USP11	3	affinity chromatography technology	Al-Salihi MA (2012)	1
SMAD3	1	NOTCH1	25	pull down, affinity chromatography technology	Blokzijl A (2003), Blokzijl A (2003)	2
CDC42	3	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EP300	36	SMAD7	1	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Groenroos E (2002), Groenroos E (2002), Groenroos E (2002), Groenroos E (2002)	4
SMAD3	1	HSPA4	3	affinity chromatography technology	Brown KA (2008)	1
SKI	3	SMURF2	3	affinity chromatography technology	Zhou F (2017)	1
TRIM25	5	AP2B1	3	affinity chromatography technology	Choudhury NR (2017)	1
TGFBR1	2	TGFBR2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Kawabata M (1995), Razani B (2001), Yan X (2011), Yan X (2009), Kim SI (2009), Kim SI (2009), Datta PK (2000), Perlman R (2001), Cho W (2015)	9
RANBP9	5	USP11	3	two hybrid, pull down, affinity chromatography technology	Ideguchi H (2002), Ideguchi H (2002), Ideguchi H (2002)	3
ARHGEF6	0	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TGFBR2	0	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yamashita M (2008), Yamashita M (2008), Yamashita M (2008), Cao Q (2016)	4
SMAD6	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Ebisawa T (2001), Sangadala S (2007), Lee YS (2011), Lee YS (2011)	5
ELAVL1	0	PPP2R2A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PSEN1	11	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Gudey SK (2014), Gudey SK (2014), Gudey SK (2014)	3
CLU	1	TGFBR2	0	two hybrid, pull down, affinity chromatography technology	Reddy KB (1996), Reddy KB (1996), Reddy KB (1996)	3
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
USP15	4	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhang L (2013)	2
EP300	36	STRAP	2	affinity chromatography technology	Xu D (2008)	1
TRAF6	0	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique	Sorrentino A (2008), Yamashita M (2008), Yamashita M (2008), Yamashita M (2008), Zhang J (2014), Cao Q (2016), Sundar R (2015), Sundar R (2015), Sundar R (2015)	9
ACVRL1	1	BAMBI	3	pull down	Yan X (2009)	1
TGFBR1	2	EP300	36	affinity chromatography technology, affinity chromatography technology	Mu Y (2011), Mu Y (2011)	2
CD44	1	CAV1	0	imaging technique	Su YJ (2011)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
TRAF6	0	USP4	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Xiao N (2011), Xiao N (2011), Xiao N (2011), Xiao N (2011), Zhou F (2012), Zhou F (2012)	6
RASSF1	3	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Lee MG (2016), Lee MG (2016), Lee MG (2016)	3
SMAD6	9	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
TRAF6	0	TRAF4	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Takeshita F (2005), Takeshita F (2005), Chen TC (2014)	3
PAK1	2	SH3KBP1	1	affinity chromatography technology	Schmidt MH (2006)	1
HSP90AA1	7	TGFBR1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wrighton KH (2008), Wrighton KH (2008), Wrighton KH (2008), Zhang K (2012), Zhang K (2012), Antonov AS (2012)	6
SMURF1	4	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Ebisawa T (2001), Johansson E (2016)	2
SMAD6	9	ITCH	1	affinity chromatography technology	Herhaus L (2014)	1
KCNK18	0	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
TGFBR1	2	HSPA4	3	affinity chromatography technology	Yun CH (2010)	1
ELAVL1	0	TGFBR1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF6	0	PSEN1	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Powell JC (2009), Elzinga BM (2009), Elzinga BM (2009), Yan R (2013), Yan R (2013), Gudey SK (2014), Gudey SK (2014)	7
RASSF1	3	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SKI	3	TGFBR1	2	affinity chromatography technology, pull down	Ferrand N (2010), Ferrand N (2010)	2
NLGN3	3	TGFBR1	2	affinity chromatography technology	Hein MY (2015)	1
HSP90AA1	7	EPHA2	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
PIK3R2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
MAPK14	0	USP11	3	affinity chromatography technology	Varjosalo M (2013)	1
SMAD3	1	RANBP9	5	two hybrid	Colland F (2004)	1
TRAF6	0	ITCH	1	affinity chromatography technology	Shembade N (2008)	1
TGFBR1	2	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Eichhorn PJ (2012), Zhang L (2013), Herhaus L (2014)	3
SKIL	3	TGFBR1	2	affinity chromatography technology	Ferrand N (2010)	1
TGFBR2	0	TGFBRAP1	2	affinity chromatography technology	Wurthner JU (2001)	1
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
CLU	1	TGFBR1	2	two hybrid, pull down, affinity chromatography technology	Reddy KB (1996), Reddy KB (1996), Reddy KB (1996)	3
PARD6A	0	MAP3K20	1	affinity chromatography technology	Hein MY (2015)	1
TGFBR1	2	RANBP9	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Zhang J (2014), Zhang J (2014), Zhang J (2014), Zhang J (2014)	4
USP4	3	TGFBR1	2	pull down, affinity chromatography technology, enzymatic study	Zhang L (2012), Zhang L (2012), Zhang L (2012)	3
TGFBR1	2	TAB2	5	affinity chromatography technology	Kim SI (2009)	1
TGFBR1	2	APPL1	1	affinity chromatography technology, pull down, imaging technique	Song J (2016), Song J (2016), Song J (2016)	3
SMAD2	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015)	3
ARHGEF6	0	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
ACVRL1	1	FKBP1A	0	two hybrid	Lee NY (2009)	1
USP11	3	USP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Zhang L (2012)	3
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
SMAD7	1	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
TGFBR1	2	PPP2R2A	0	pull down, affinity chromatography technology	Griswold-Prenner I (1998), Griswold-Prenner I (1998)	2
SMURF1	4	PARD6A	0	affinity chromatography technology, affinity chromatography technology	Cheng PL (2011), Ozdamar B (2005)	2
TGFBR1	2	TOLLIP	3	affinity chromatography technology, affinity chromatography technology	Zhu L (2012), Zhu L (2012)	2
TGFBR2	0	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Krymskaya VP (1997), Huttlin EL (2015), Huttlin EL (2017)	3
FKBP1A	0	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Yamaguchi T (2006), Yamaguchi T (2006)	2
TGFB1	2	FNTA	0	two hybrid	Wang T (1996)	1
NRP1	2	TGFBR1	2	affinity chromatography technology, pull down, affinity chromatography technology	Cao Y (2010), Glinka Y (2011), Glinka Y (2011)	3
CD44	1	EP300	36	affinity chromatography technology	Su YJ (2011)	1
OTUB1	0	HSPA4	3	affinity chromatography technology	Scholz CC (2016)	1
ELAVL1	0	EPHA2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SKIL	3	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (1999), Tan R (2006), Mizuide M (2003), Brown KA (2008), Colland F (2004), Colland F (2004), He J (2003), Ikeuchi Y (2014)	9
SMURF1	4	PPP2R2A	0	affinity chromatography technology	Xie Y (2013)	1
TGFBR1	2	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Blanco FJ (2008), Blanco FJ (2008), Blanco FJ (2005)	7
SPTBN1	6	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Tang Y (2003), Tang Y (2003)	2
EP300	36	NOTCH1	25	affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Hao L (2010), Popko-Scibor AE (2011), Popko-Scibor AE (2011), Popko-Scibor AE (2011)	4
ITCH	1	SMAD2	5	enzymatic study, affinity chromatography technology	Bai Y (2004), Bai Y (2004)	2
ELAVL1	0	CD44	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD3	1	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (2001), Stroschein SL (1999), Liberati NT (2001), Tan R (2006), Mizuide M (2003), Colland F (2004), He J (2003), Jinnin M (2007), Jinnin M (2007)	10
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
MAPK14	0	EP300	36	pull down, enzymatic study, affinity chromatography technology	Pillai VB (2011), Pillai VB (2011), Saha RN (2007)	3
ANK1	8	CD44	1	unspecified method	Zhu D (1998)	1
ELAVL1	0	SMAD6	9	affinity chromatography technology	Abdelmohsen K (2009)	1
USP15	4	USP11	3	affinity chromatography technology	Sowa ME (2009)	1
TGFBR1	2	SMAD4	9	biochemical, affinity chromatography technology	Razani B (2001), Barrios-Rodiles M (2005)	2
TRAF6	0	RANBP9	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Wang L (2011), Wang L (2011), Wang L (2011), Wang L (2011), Wang L (2011), Zhang J (2014)	6
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
HSP90AA1	7	CAV1	0	affinity chromatography technology	Ji Y (2007)	1
OCLN	1	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
PAK1	2	TGFBR1	2	pull down, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
NRP1	2	TGFBR2	0	affinity chromatography technology, pull down, affinity chromatography technology	Cao Y (2010), Glinka Y (2011), Glinka Y (2011)	3
ITCH	1	CAV1	0	affinity chromatography technology	Malik R (2012)	1
PIK3R2	3	SPTBN1	6	affinity chromatography technology	Brehme M (2009)	1
SMAD7	1	BAMBI	3	affinity chromatography technology, affinity chromatography technology	Yan X (2009), Yan X (2009)	2
TRIM25	5	SMAD4	9	affinity chromatography technology	Choudhury NR (2017)	1
TGFBR2	0	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Barbara NP (1999), Blanco FJ (2005)	6
SMAD2	5	RANBP9	5	two hybrid	Colland F (2004)	1
TRIM25	5	TGFB1	2	affinity chromatography technology	Choudhury NR (2017)	1
SMAD6	9	BAMBI	3	affinity chromatography technology	Yan X (2009)	1
TRIM25	5	SPTBN1	6	affinity chromatography technology	Choudhury NR (2017)	1
PIK3R1	6	EP300	36	affinity chromatography technology	Song L (2011)	1
GOLT1B	0	CDC42	3	affinity chromatography technology	Hein MY (2015)	1
ACVRL1	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Attisano L (1993), Attisano L (1993)	2
RASSF1	3	TGFBR2	0	affinity chromatography technology	Pefani DE (2016)	1
NOTCH1	25	USP11	3	affinity chromatography technology	Yatim A (2012)	1
TGFBR1	2	MAP3K20	1	affinity chromatography technology	Huang CY (2004)	1
ACVRL1	1	HSP90AA1	7	affinity chromatography technology	Antonov AS (2012)	1
SMAD6	9	SMURF2	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Komuro A (2004), Colland F (2004), Herhaus L (2014)	3
MAPK14	0	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ELAVL1	0	MAP3K20	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TGFBR1	2	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhang L (2013)	2
FKBP1A	0	TGFBR1	2	two hybrid, two hybrid, affinity chromatography technology	Wang T (1994), Liu F (1995), Wang T (1994)	3
TGFBR1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sorrentino A (2008), Kim SI (2009), Kim SI (2009), Zhang L (2013)	4
ACVRL1	1	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
ENG	5	ACVRL1	1	affinity chromatography technology, affinity chromatography technology	Blanco FJ (2005), Blanco FJ (2005)	2
SMAD3	1	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Ueki N (2003), Tabata T (2009), Prunier C (2003), Liberati NT (2001), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Mizuide M (2003), Wu K (2003), Chen W (2007), Band AM (2009), Qin BY (2002), He J (2003), He J (2003), Jinnin M (2007), Jinnin M (2007), Rashidian J (2015)	19
PEG10	2	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
BMPR2	1	CAV1	0	affinity chromatography technology	Nohe A (2005)	1
OTUB1	0	SMAD2	5	affinity chromatography technology, affinity chromatography technology, pull down	Herhaus L (2013), Herhaus L (2013), Herhaus L (2013)	3
ITCH	1	SMAD3	1	pull down	Feng L (2004)	1
SMAD4	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Moren A (2005), Zhang L (2013)	2
TGFBR1	2	ITCH	1	affinity chromatography technology	Bai Y (2004)	1
SMAD7	1	USP11	3	affinity chromatography technology, biochemical, affinity chromatography technology	Al-Salihi MA (2012), Al-Salihi MA (2012), Herhaus L (2014)	3
SMURF1	4	TRAF4	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, genetic interference, enzymatic study	Li S (2010), Li S (2010), Li S (2010), Li S (2010), Li S (2010), Zhang L (2013)	6
TRAF4	1	MAP3K7	2	affinity chromatography technology	Zhang L (2013)	1
SNX6	1	TGFBR2	0	affinity chromatography technology	Parks WT (2001)	1
TRIM25	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pauli EK (2014), Pauli EK (2014), Pauli EK (2014), Pauli EK (2014)	4
RASSF1	3	TGFBR1	2	affinity chromatography technology	Pefani DE (2016)	1
HSP90AA1	7	TGFBR2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wrighton KH (2008), Wrighton KH (2008), Wrighton KH (2008), Zhang K (2012), Zhang K (2012)	5
PEG10	2	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
SPTBN1	6	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Tang Y (2003), Tang Y (2003)	2
NOTCH1	25	RANBP9	5	affinity chromatography technology	Yatim A (2012)	1