PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHMP2A	3	TGFB3	0	two hybrid	Wang J (2011)	1
ENG	5	TGFB3	0	affinity chromatography technology	Cheifetz S (1992)	1
CCL20	0	TGFB3	0	two hybrid	Wang J (2011)	1
ELAVL1	0	TGFB3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	SDC4	0	affinity chromatography technology	Abdelmohsen K (2009)	1
VASN	2	TGFB3	0	pull down	Ikeda Y (2004)	1
TGFB3	0	TGFBR2	0	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	De Crescenzo G (2003), Hart PJ (2002), Barbara NP (1999), Rotzer D (2001)	4
SDC4	0	TGFB3	0	two hybrid	Wang J (2011)	1
TGFBR2	0	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Barbara NP (1999), Blanco FJ (2005)	6