PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PZP	3	TGFB2	2	pull down	Philip A (1994)	1
TGFBR2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TGFB2	2	DCN	0	pull down	Schoenherr E (1998)	1
VASN	2	TGFB2	2	pull down	Ikeda Y (2004)	1
VTN	1	APP	1	pull down	Olah J (2011)	1
TGFBR2	0	TGFB2	2	affinity chromatography technology	Rotzer D (2001)	1
TGFB2	2	APP	1	imaging technique	Chen TC (2014)	1
VTN	1	TGFB2	2	pull down	Schoppet M (2002)	1
TGFB2	2	BMP2	2	imaging technique	Chen TC (2014)	1
CEBPA	0	TGFB2	2	affinity chromatography technology	Bararia D (2008)	1