PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPN12	2	PTK2B	6	enzymatic study	Lyons PD (2001)	1
SLC6A3	6	TGFB1I1	2	two hybrid, pull down	Carneiro AM (2002), Carneiro AM (2002)	2
PXN	1	PTK2B	6	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hiregowdara D (1997), Hiregowdara D (1997), Matsuya M (1998), Matsuya M (1998), Anfosso F (2001), Ivankovic-Dikic I (2000)	6
NEDD4L	3	PTK2B	6	affinity chromatography technology	Verma N (2017)	1
GP6	0	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
TGFB1I1	2	HSPB2	1	affinity chromatography technology	Desai LP (2014)	1
XPO1	8	VCL	6	biochemical	Kristensen AR (2012)	1
TGFB1I1	2	NR3C1	2	two hybrid	Yang L (2000)	1
AR	3	SMAD3	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Hayes SA (2001), Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002), Chipuk JE (2002)	12
VHL	0	AR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen S (2013), Chen S (2013), Wang J (2014), Wang J (2014)	4
GP1BB	1	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
CBLB	3	TGFB1I1	2	two hybrid	Ryan PE (2012)	1
PTPN12	2	PXN	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, bioid, affinity chromatography technology	Shen Y (2000), Shen Y (2000), Shen Y (2000), Cote JF (1999), Cote JF (1999), Shen Y (1998), Shen Y (1998), St-Denis N (2016), Huttlin EL (2017)	9
GP1BB	1	NCF1	2	pull down, affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011), Arthur JF (2011)	3
PTK2	2	TGFB1I1	2	pull down, affinity chromatography technology, pull down, two hybrid	Matsuya M (1998), Nishiya N (2001), Thomas SM (1999), Vinayagam A (2011)	4
SMAD4	9	TGFB1I1	2	affinity chromatography technology	Wang H (2005)	1
SMAD3	1	NR3C1	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li G (2003), Li G (2003), Song CZ (1999), Song CZ (1999)	4
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
GP1BB	1	TRAF4	1	pull down, affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011), Arthur JF (2011)	3
CBLB	3	PTK2B	6	affinity chromatography technology	Fan Y (2014)	1
CBLC	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GP6	0	NCF1	2	affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011)	2
HSPB1	2	TES	1	biochemical, affinity chromatography technology	Wan C (2015), Sala S (2017)	2
PTK2	2	CCNA1	3	imaging technique	Chen TC (2014)	1
SMAD4	9	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lebrun JJ (1999), Moren A (2005), Moren A (2005), Moren A (2005), Zhang S (2007), Yan X (2016)	6
PLA2G3	0	TGFB1I1	2	two hybrid	Wang J (2011)	1
TES	1	NR3C1	2	affinity chromatography technology	Sala S (2017)	1
TRAF4	1	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
AR	3	HSPB2	1	affinity chromatography technology, affinity chromatography technology	Zoubeidi A (2007), Zoubeidi A (2007)	2
XPO1	8	NEDD4L	3	affinity chromatography technology	Kirli K (2015)	1
CSK	3	PTK2	2	affinity chromatography technology	Bergman M (1995)	1
NCF1	2	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
HSPB1	2	XPO1	8	two hybrid	Katsogiannou M (2014)	1
TGFB1I1	2	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wang H (2005), Wang H (2005), Wang H (2005), Shibanuma M (2004)	4
SMAD3	1	UBQLN4	2	two hybrid	Wang J (2011)	1
GP6	0	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
TES	1	TGFB1I1	2	affinity chromatography technology	Sala S (2017)	1
PXN	1	PTK2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovacic-Milivojevic B (2001), Matsuya M (1998), Turner CE (1999), Liu S (2002), Liu S (2002), Mazaki Y (1997), Zheng C (1998), Brown MC (1996), Fujita H (1998), Zhang Z (1999), Wang JF (2000), Ivankovic-Dikic I (2000)	12
CSK	3	TGFB1I1	2	pull down	Thomas SM (1999)	1
HIPK3	5	TGFB1I1	2	two hybrid	Colland F (2004)	1
SMAD7	1	NEDD4L	3	affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Al-Salihi MA (2012), Aragon E (2012), Aragon E (2012), Aragon E (2012)	4
TGFB1I1	2	PTK2B	6	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Matsuya M (1998), Wang X (2002), Wang X (2002), Wang X (2002), Wang X (2002), Matsuya M (1998), Matsuya M (1998), Thomas SM (1999)	8
AR	3	TGFB1I1	2	two hybrid, affinity chromatography technology, pull down, two hybrid, unspecified method	Wang X (2002), Wang X (2002), Wang X (2002), He B (2002), He B (2002)	5
HSPB1	2	TGFB1I1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jia Y (2001), Jia Y (2001), Jia Y (2001), Desai LP (2014)	4
CBLC	1	TGFB1I1	2	affinity chromatography technology, two hybrid, affinity chromatography technology	Ryan PE (2012), Ryan PE (2012), Desai LP (2014)	3
PTPN12	2	TGFB1I1	2	affinity chromatography technology, pull down, two hybrid	Nishiya N (1999), Nishiya N (1999), Nishiya N (1999)	3
PTPN12	2	CSK	3	bioid	St-Denis N (2016)	1
GP1BB	1	TGFB1I1	2	pull down, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011)	2
TGFB1I1	2	VCL	6	pull down	Thomas SM (1999)	1
CSK	3	PXN	1	affinity chromatography technology	Bergman M (1995)	1
CCNA1	3	TGFB1I1	2	affinity chromatography technology	Ewing RM (2007)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
UBQLN4	2	TGFB1I1	2	two hybrid	Lim J (2006)	1
NEDD4L	3	TGFB1I1	2	pull down	Persaud A (2009)	1
XPO1	8	PXN	1	unspecified method, affinity chromatography technology	Xu D (2012), Kirli K (2015)	2
GP6	0	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011)	2
NCF1	2	TRAF4	1	affinity chromatography technology, two hybrid	Xu YC (2002), Takeshita F (2005)	2
NEDD4L	3	NR3C1	2	pull down	Almloef T (1998)	1
CDKN2B	0	TGFB1I1	2	two hybrid	Wang J (2011)	1
XPO1	8	TGFB1I1	2	affinity chromatography technology	Kirli K (2015)	1
SMAD7	1	TGFB1I1	2	affinity chromatography technology, pull down	Wang H (2008), Wang H (2008)	2
PXN	1	VCL	6	pull down, pull down, pull down, biochemical	Turner CE (1999), Mazaki Y (1997), Brown MC (1996), Wan C (2015)	4
TRAF4	1	CBLC	1	two hybrid	Woodsmith J (2012)	1
TRAF4	1	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
XPO1	8	SMAD4	9	affinity chromatography technology	Kirli K (2015)	1
VHL	0	TGFB1I1	2	affinity chromatography technology	Ewing RM (2007)	1
TGFB1I1	2	PXN	1	affinity chromatography technology	Nishiya N (2001)	1
SMAD4	9	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002)	4
NEDD4L	3	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology	Gao S (2009), Gao S (2009), Aragon E (2012), Herhaus L (2013), Gao S (2009), Gao S (2009), Yan X (2016)	7