PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TFE3	4	ACLY	3	affinity chromatography technology	Ewing RM (2007)	1
XPO1	8	TFEB	6	affinity chromatography technology	Kirli K (2015)	1
TFE3	4	TFE3	4	pull down	Beckmann H (1991)	1
RPA3	2	CLTC	12	affinity chromatography technology	Marechal A (2014)	1
TFE3	4	PHB2	1	affinity chromatography technology	Ewing RM (2007)	1
CLTC	12	PHB2	1	biochemical	Wan C (2015)	1
CUL2	3	ACLY	3	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	MITF	3	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	SMARCE1	1	affinity chromatography technology	Kirli K (2015)	1
TFE3	4	RPA3	2	affinity chromatography technology	Ewing RM (2007)	1
TFE3	4	MITF	3	genetic interference, affinity chromatography technology, affinity chromatography technology	Steingrimsson E (2002), Mansky KC (2002), Huttlin EL (2017)	3
CUL2	3	CLTC	12	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	TFE3	4	affinity chromatography technology	Kirli K (2015)	1
TFE3	4	CLTC	12	affinity chromatography technology	Ewing RM (2007)	1
TFE3	4	EIF3A	4	affinity chromatography technology	Ewing RM (2007)	1
NEDD8	0	CLTC	12	affinity chromatography technology	Bennett EJ (2010)	1
EWSR1	2	SMARCE1	1	bioid	Elzi DJ (2014)	1
MITF	3	TFEC	0	affinity chromatography technology	Mansky KC (2002)	1
TFE3	4	NEDD8	0	affinity chromatography technology	Ewing RM (2007)	1
EWSR1	2	SMAD4	9	two hybrid	Rual JF (2005)	1
RPA3	2	TRIM28	1	affinity chromatography technology	Marechal A (2014)	1
E2F3	0	TFE3	4	two hybrid, pull down, affinity chromatography technology	Giangrande PH (2003), Giangrande PH (2003), Giangrande PH (2003)	3
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
TFEC	0	TFE3	4	pull down	Chung MC (2001)	1
SMAD4	9	TFE3	4	pull down, pull down	Grinberg AV (2003), Hua X (1999)	2
TFE3	4	RPL38	0	affinity chromatography technology	Ewing RM (2007)	1
CUL2	3	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
TFE3	4	CUL2	3	affinity chromatography technology	Ewing RM (2007)	1
RPA3	2	EPRS	2	affinity chromatography technology	Marechal A (2014)	1
TARDBP	4	TFE3	4	affinity chromatography technology	Davis SA (2018)	1
CUL2	3	RPL38	0	affinity chromatography technology	Bennett EJ (2010)	1
TFEB	6	TFE3	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
RPA3	2	EWSR1	2	affinity chromatography technology	Marechal A (2014)	1
SMAD3	1	TFE3	4	pull down, pull down	Grinberg AV (2003), Hua X (1999)	2
TRIM28	1	E2F3	0	affinity chromatography technology, affinity chromatography technology	Chen L (2012), Chen L (2012)	2
TARDBP	4	EIF3A	4	affinity chromatography technology	Freibaum BD (2010)	1
TFEB	6	TFEC	0	affinity chromatography technology	Huttlin EL (2017)	1
RPA3	2	TARDBP	4	affinity chromatography technology	Marechal A (2014)	1
CUL2	3	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
EPRS	2	XPO1	8	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TARDBP	4	TRIM28	1	affinity chromatography technology	Freibaum BD (2010)	1
TARDBP	4	PHB2	1	affinity chromatography technology, affinity chromatography technology	Davis SA (2018), Davis SA (2018)	2
TFE3	4	PFAS	3	affinity chromatography technology	Ewing RM (2007)	1
NEDD8	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
TFE3	4	AKR1B1	0	affinity chromatography technology	Ewing RM (2007)	1
TFEB	6	MITF	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
TFE3	4	VARS	5	affinity chromatography technology	Ewing RM (2007)	1
TFE3	4	SMARCE1	1	pull down	Kadam S (2000)	1
TFE3	4	EPRS	2	affinity chromatography technology	Ewing RM (2007)	1
EWSR1	2	TFE3	4	bioid	Elzi DJ (2014)	1
TFE3	4	TRIM28	1	affinity chromatography technology	Ewing RM (2007)	1
TARDBP	4	CUL2	3	affinity chromatography technology, affinity chromatography technology	Uchida T (2016), Uchida T (2016)	2
XPO1	8	SMAD4	9	affinity chromatography technology	Kirli K (2015)	1