PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
ASF1A	0	TFAP2A	1	imaging technique	Pchelintsev NA (2013)	1
TFAP2C	4	MYC	2	genetic interference, affinity chromatography technology, affinity chromatography technology, imaging technique	Wong PP (2012), Wong PP (2012), Wong PP (2012), Wong PP (2012)	4
TP53	0	ASF1A	0	affinity chromatography technology	Lunardi A (2010)	1
GPR22	0	TFAP2C	4	two hybrid	Wang J (2011)	1
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
ERBB4	5	TP53	0	affinity chromatography technology	Gilmore-Hebert M (2010)	1
NR1I2	5	TFAP2C	4	two hybrid	Wang J (2011)	1
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
TFAP2C	4	ERBB4	5	affinity chromatography technology, pull down	Sundvall M (2010), Sundvall M (2010)	2
TFAP2C	4	UBE2I	0	two hybrid	Eloranta JJ (2002)	1
HIRA	5	TFAP2C	4	imaging technique	Pchelintsev NA (2013)	1
UBN1	3	HIRA	5	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ray-Gallet D (2011), Tang Y (2012), Tang Y (2012), Tang Y (2012), Tang Y (2012), Tang Y (2012), Lee JS (2016), Lee JS (2016), Lee JS (2016), Pchelintsev NA (2013), Pchelintsev NA (2013)	11
TFAP2A	1	UBE2I	0	two hybrid	Eloranta JJ (2002)	1
UBN1	3	TFAP2C	4	imaging technique	Pchelintsev NA (2013)	1
CCNG1	1	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology	Zhao L (2003), Zhao L (2003), Ohtsuka T (2003)	3
UBN1	3	TFAP2A	1	imaging technique	Pchelintsev NA (2013)	1
TFAP2A	1	KCTD1	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Ding X (2009), Ding X (2009), Ding X (2009), Ding X (2009), Ding X (2009)	5
UBE2I	0	NR1I2	5	enzymatic study	Hu G (2010)	1
CITED4	0	TFAP2C	4	pull down	Braganca J (2002)	1
ELAVL1	0	HIRA	5	affinity chromatography technology	Abdelmohsen K (2009)	1
MYC	2	UBE2I	0	genetic interference	Toyoshima M (2012)	1
CCNG1	1	TFAP2C	4	two hybrid	Wang J (2011)	1
CITED2	0	TFAP2C	4	two hybrid, pull down	Braganca J (2003), Braganca J (2002)	2
TFAP2A	1	TFAP2C	4	affinity chromatography technology	Thewes V (2010)	1
MYC	2	TFAP2A	1	affinity chromatography technology, pull down	Gaubatz S (1995), Gaubatz S (1995)	2
ASF1A	0	TFAP2C	4	imaging technique	Pchelintsev NA (2013)	1
TFAP2A	1	ERBB4	5	affinity chromatography technology	Sundvall M (2010)	1
ELAVL1	0	CITED2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBN1	3	ASF1A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang Y (2012), Hein MY (2015), Huttlin EL (2017), Pchelintsev NA (2013), Pchelintsev NA (2013)	5
HIRA	5	TFAP2A	1	imaging technique	Pchelintsev NA (2013)	1
TFAP2A	1	TP53	0	imaging technique, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	McPherson LA (2002), McPherson LA (2002), McPherson LA (2002), McPherson LA (2002), Stabach PR (2006), Stabach PR (2006)	6
NR1I2	5	TP53	0	affinity chromatography technology, affinity chromatography technology	Elias A (2013), Elias A (2013)	2
IKBKB	1	TFAP2C	4	two hybrid	Wang J (2011)	1
ELAVL1	0	TFAP2A	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CITED2	0	TFAP2A	1	two hybrid, far western blotting, pull down	Braganca J (2003), Braganca J (2003), Braganca J (2002)	3
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
ZFAND4	0	TFAP2C	4	two hybrid	Wang J (2011)	1
IKBKB	1	TP53	0	enzymatic study	Xia Y (2009)	1
UBE2I	0	HIRA	5	enzymatic study	Gocke CB (2005)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
BRCA1	7	TFAP2C	4	affinity chromatography technology	Buckley NE (2011)	1
HIRA	5	MYC	2	imaging technique, affinity chromatography technology	Pchelintsev NA (2013), Pchelintsev NA (2013)	2
ASF1A	0	MYC	2	imaging technique	Pchelintsev NA (2013)	1
MYC	2	KDM5B	27	affinity chromatography technology, affinity chromatography technology	Wong PP (2012), Wong PP (2012)	2
UBN1	3	MYC	2	imaging technique	Pchelintsev NA (2013)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
BRCA1	7	TFAP2A	1	affinity chromatography technology	Buckley NE (2011)	1
ASF1A	0	HIRA	5	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang Y (2006), Tang Y (2006), Tang Y (2006), Zhang R (2005), Zhang R (2005), Galvani A (2008), Yang JH (2011), Zhang R (2007), Hein MY (2015), Huttlin EL (2017), Lee JS (2016), Lee JS (2016), Pchelintsev NA (2013), Pchelintsev NA (2013)	14
CITED4	0	TFAP2A	1	pull down	Braganca J (2002)	1
KCTD1	3	TFAP2C	4	affinity chromatography technology	Ding X (2009)	1
TFAP2C	4	KDM5B	27	genetic interference, affinity chromatography technology, affinity chromatography technology, imaging technique	Wong PP (2012), Wong PP (2012), Wong PP (2012), Wong PP (2012)	4
ELAVL1	0	TFAP2C	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	KDM5B	27	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2I	0	KCTD1	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TP53	0	TFAP2C	4	pull down	McPherson LA (2002)	1