PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TERF1	1	BTRC	1	affinity chromatography technology, affinity chromatography technology	Wang C (2013), Wang C (2013)	2
TERF2IP	1	POT1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Ye JZ (2004), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
TERF1	1	GNL3L	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009)	4
TERF1	1	KPNB1	3	pull down, affinity chromatography technology	Forwood JK (2002), Giannone RJ (2010)	2
BRCA1	7	KPNB1	3	affinity chromatography technology	Ertych N (2016)	1
ATM	9	TERF2	2	affinity chromatography technology, pull down	Karlseder J (2004), Karlseder J (2004)	2
TINF2	1	TERF1	1	affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Stelzl U (2005), Kim SH (1999), Kim SH (1999), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Tan R (2017)	18
TERF2	2	TERF2IP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	OConnor MS (2004), OConnor MS (2004), OConnor MS (2004), Li B (2000), Zhu XD (2000), Zhu XD (2000), Chen Y (2011), Chen Y (2011), Chen Y (2011), Chen Y (2011), Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Her YR (2009), Havugimana PC (2012), Her YR (2013), Wan C (2015), Hein MY (2015), Her J (2015), Arat N Oe (2012), Li JS (2017), Jeong YY (2016), Ilic A (2017), Ilic A (2017)	28
STUB1	4	ABL1	9	enzymatic study, affinity chromatography technology	Tsukahara F (2010), Huang H (2017)	2
FANCD2	3	BRCA1	7	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reuter TY (2003), Vandenberg CJ (2003), Garcia-Higuera I (2001), Garcia-Higuera I (2001), Loke J (2015)	5
YWHAG	5	TERF1	1	two hybrid, two hybrid	Bandyopadhyay S (2010), Lee OH (2011)	2
FANCD2	3	TNKS	12	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lyakhovich A (2011), Lyakhovich A (2011), Lyakhovich A (2011), Lyakhovich A (2011)	4
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
GNL3L	1	PSMD4	1	genetic interference	Horlbeck MA (2018)	1
TINF2	1	TERF2IP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	9
PINX1	0	TERF1	1	affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhou XZ (2001), Zhou XZ (2001), Lee OH (2011), Her YR (2009), Her YR (2009), Her YR (2009), Huttlin EL (2015), Jeong YY (2016), Huttlin EL (2017)	9
BTRC	1	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
TERF1	1	TERF1	1	pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down	Bianchi A (1997), Bianchi A (1997), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Lee OH (2011), Sommers JA (2014)	7
NUB1	2	PSMD4	1	pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kamitani T (2001), Rani N (2012), Rani N (2012), Rani N (2012), Tanji K (2005), Tanji K (2005), Jeong YY (2016), Jeong YY (2016)	8
TERF2IP	1	ACD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Hein MY (2015), Huttlin EL (2017)	3
ACD	1	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
TNKS2	6	TERF1	1	enzymatic study, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Cook BD (2002), Chi NW (2000), Sbodio JI (2002), Kaminker PG (2001), Huttlin EL (2015), Huttlin EL (2017)	6
POT1	2	TNKS	12	affinity chromatography technology	Loayza D (2003)	1
TERF1	1	PSMD4	1	affinity chromatography technology, affinity chromatography technology	Jeong YY (2016), Jeong YY (2016)	2
TERF1	1	FBXO4	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, two hybrid, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee TH (2006), Lee TH (2006), Lee TH (2006), Lee TH (2006), Zeng Z (2010), Zeng Z (2010), Zeng Z (2010), Li Y (2010), Li Y (2010), Zhu Q (2009), Lee EK (2013), Kim J (2014), Tan R (2017), Tan R (2017)	14
FANCD2	3	TERF1	1	enzymatic study, imaging technique	Lyakhovich A (2011), Fan Q (2009)	2
POT1	2	STUB1	4	two hybrid	Lee OH (2011)	1
BTRC	1	PSMD4	1	enzymatic study, enzymatic study	Uchiki T (2009), Kim HT (2012)	2
BRCA1	7	TERF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballal RD (2009), Ballal RD (2009), Hill SJ (2014)	3
TINF2	1	STUB1	4	two hybrid	Lee OH (2011)	1
TERF1	1	TNKS	12	two hybrid, affinity chromatography technology, enzymatic study, two hybrid, pull down, pull down, two hybrid, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cook BD (2002), Cook BD (2002), Cook BD (2002), Seimiya H (2002), Seimiya H (2002), Sbodio JI (2002), Smith S (1998), Smith S (1998), Sbodio JI (2002), Giannone RJ (2010), Bisht KK (2012), Wang C (2013), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	18
SALL1	2	TERF1	1	two hybrid, pull down	Netzer C (2001), Netzer C (2001)	2
TERF1	1	GNL3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhu Q (2006), Zhu Q (2009), Zhu Q (2009)	3
TERF1	1	ATM	9	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down	Kishi S (2001), Kishi S (2001), Kishi S (2001), Takai H (2007), Karlseder J (2004)	5
ATM	9	FANCD2	3	pull down, affinity chromatography technology, two hybrid, enzymatic study	Taniguchi T (2002), Taniguchi T (2002), Reuter TY (2003), Taniguchi T (2002)	4
ATM	9	BRCA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Gatei M (2000), Gatei M (2000), Kim ST (1999), Cortez D (1999), Cortez D (1999), Tibbetts RS (2000), Wang Y (2000), Mu JJ (2007), Tsai WB (2008), Gatei M (2000), Gatei M (2000), Gatei M (2000)	12
BRCA1	7	TERF1	1	affinity chromatography technology, affinity chromatography technology	Ballal RD (2009), Ballal RD (2009)	2
ACD	1	TERF2	2	affinity chromatography technology	Liu D (2004)	1
NEK7	0	TERF1	1	protein complementation assay, pull down, affinity chromatography technology, enzymatic study	Tan R (2017), Tan R (2017), Tan R (2017), Tan R (2017)	4
BRCA1	7	NME1	0	affinity chromatography technology	Ertych N (2016)	1
TINF2	1	YWHAG	5	two hybrid	Lee OH (2011)	1
POT1	2	ACD	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Liu J (2015), Hein MY (2015), Huttlin EL (2017)	12
TERF1	1	ABL1	9	affinity chromatography technology, affinity chromatography technology	Kishi S (2001), Kishi S (2001)	2
TERF2	2	STUB1	4	affinity chromatography technology	Giannone RJ (2010)	1
TERF1	1	NUB1	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Jeong YY (2016), Jeong YY (2016), Jeong YY (2016), Jeong YY (2016), Jeong YY (2016)	5
TERF2	2	TNKS	12	affinity chromatography technology	Giannone RJ (2010)	1
TERF1	1	STUB1	4	affinity chromatography technology, two hybrid	Giannone RJ (2010), Lee OH (2011)	2
TERF1	1	TERF2IP	1	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015)	6
TERF2	2	U2AF2	7	affinity chromatography technology	Giannone RJ (2010)	1
TERF1	1	NME1	0	two hybrid, pull down	Nosaka K (1998), Nosaka K (1998)	2
BRCA1	7	PSMD4	1	affinity chromatography technology	Ertych N (2016)	1
ATM	9	ABL1	9	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study	Shafman T (1997), Chen G (1999), Chen G (1999), Kishi S (2001), Kishi S (2001), Shafman T (1997), Shafman T (1997), Hunt CR (2007), Wang X (2011), Baskaran R (1997)	10
TERF2	2	POT1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Giannone RJ (2010), Giannone RJ (2010), Liu D (2004), Liu D (2004), Liu D (2004), Hein MY (2015), Huttlin EL (2017)	7
PSMD4	1	ABL1	9	biochemical	Liu X (2006)	1
ABL1	9	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, fluorescent resonance energy transfe	Foray N (2002), Foray N (2002), Foray N (2002), Foray N (2002), Foray N (2002), Morell M (2007)	6
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
TINF2	1	TERF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, far western blotting, imaging technique, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Giannone RJ (2010), Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Her YR (2013), Her YR (2013), Hein MY (2015), Huttlin EL (2017)	15
YWHAG	5	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
AKTIP	3	TERF1	1	pull down, affinity chromatography technology	Burla R (2015), Burla R (2015)	2
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
ACD	1	STUB1	4	two hybrid	Lee OH (2011)	1
U2AF2	7	MAPRE1	0	affinity chromatography technology	Whisenant TC (2015)	1
MAPRE1	0	TERF1	1	pull down, affinity chromatography technology, genetic interference	Nakamura M (2002), Nakamura M (2002), Nakamura M (2002)	3
AKTIP	3	TERF2	2	pull down, affinity chromatography technology	Burla R (2015), Burla R (2015)	2
BRCA1	7	GNL3L	1	affinity chromatography technology	Hill SJ (2014)	1
RLIM	1	TERF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Her YR (2009), Her YR (2009), Her YR (2009), Her YR (2009)	4
U2AF2	7	KPNB1	3	affinity chromatography technology	Whisenant TC (2015)	1
TINF2	1	ACD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	11
POT1	2	YWHAG	5	two hybrid	Lee OH (2011)	1
TERF2	2	KPNB1	3	affinity chromatography technology	Giannone RJ (2010)	1
PSMD4	1	STUB1	4	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, biochemical	Connell P (2001), Scaglione KM (2011), Uchiki T (2009), Kim HT (2012), Connell P (2001), Wan C (2015)	6
TNKS	12	TINF2	1	biochemical, affinity chromatography technology	Ye JZ (2004), Huttlin EL (2017)	2
TERF1	1	U2AF2	7	pull down, affinity chromatography technology, affinity chromatography technology	Kim J (2014), Kim J (2014), Kim J (2014)	3