PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TROVE2	4	TEP1	10	biochemical	Havugimana PC (2012)	1
BLM	2	TERF2	2	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Opresko PL (2002), Bhattacharyya S (2009), Lillard-Wetherell K (2004), Lillard-Wetherell K (2004)	4
TEP1	10	100144435	0	affinity chromatography technology	Kickhoefer VA (1999)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
TP53	0	BLM	2	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Sengupta S (2004), Sengupta S (2004), Sengupta S (2004), Wang XW (2001), Wang XW (2001), Wang XW (2001), Wang XW (2001), Garkavtsev IV (2001), Garkavtsev IV (2001), Yang Q (2002), Yang Q (2002), Wang J (2013)	12
BLM	2	TEP1	10	affinity chromatography technology, affinity chromatography technology	Bhattacharyya S (2009), Bhattacharyya S (2009)	2
TP53	0	TERT	7	genetic interference, genetic interference	Xie L (2013), Xie L (2013)	2
TEP1	10	TP53	0	pull down	Li H (1999)	1
TEP1	10	VTRNA1-2	0	affinity chromatography technology	Kickhoefer VA (1999)	1
ATN1	2	TEP1	10	two hybrid	Lim J (2006)	1
PARP4	3	TEP1	10	affinity chromatography technology	Liu Y (2004)	1
MVP	1	TEP1	10	biochemical, affinity chromatography technology	Kickhoefer VA (1999), Kickhoefer VA (1999)	2
TIRAP	1	TEP1	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TERF2	2	ATN1	2	affinity chromatography technology	Giannone RJ (2010)	1
TEP1	10	TERT	7	affinity chromatography technology	Beattie TL (2000)	1
TEP1	10	VTRNA1-1	0	affinity chromatography technology	Kickhoefer VA (1999)	1
NEUROG3	3	TEP1	10	affinity chromatography technology	Huttlin EL (2017)	1
TERF2	2	TEP1	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bhattacharyya S (2009), Bhattacharyya S (2009), Bhattacharyya S (2009)	3
MVP	1	TP53	0	two hybrid	Corominas R (2014)	1
PARP4	3	MVP	1	two hybrid, two hybrid, pull down, affinity chromatography technology	van Zon A (2002), Kickhoefer VA (1999), Kickhoefer VA (1999), Huttlin EL (2017)	4
HNRNPL	3	TEP1	10	affinity chromatography technology	Fei T (2017)	1