PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	HSPA4	3	affinity chromatography technology	Choudhury NR (2017)	1
CTBP2	7	STUB1	4	affinity chromatography technology, protein complementation assay	Lee JS (2013), Lee JS (2013)	2
YAP1	0	FASN	15	affinity chromatography technology	Hauri S (2013)	1
TRIM25	5	WWTR1	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PDHA1	7	affinity chromatography technology	Choudhury NR (2017)	1
E2F1	0	TEAD3	0	two hybrid	Giangrande PH (2003)	1
SUMO2	0	TEAD3	0	two hybrid	Wang J (2011)	1
E2F3	0	TEAD3	0	two hybrid	Giangrande PH (2003)	1
TEAD3	0	PDHA1	7	affinity chromatography technology	Hauri S (2013)	1
KIFC2	3	TEAD3	0	two hybrid	Wang J (2011)	1
PIDD1	5	TEAD3	0	two hybrid	Wang J (2011)	1
TRIM25	5	E2F3	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
VGLL4	1	TEAD3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDHA1	7	FASN	15	affinity chromatography technology	Malty RH (2017)	1
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
CTBP2	7	TEAD3	0	two hybrid	Rual JF (2005)	1
YAP1	0	PHB2	1	affinity chromatography technology	Enzo E (2015)	1
YAP1	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Enzo E (2015)	2
TEAD3	0	GTPBP8	1	affinity chromatography technology	Hauri S (2013)	1
YAP1	0	STUB1	4	affinity chromatography technology	Hauri S (2013)	1
AP4S1	0	TEAD3	0	two hybrid	Wang J (2011)	1
TEAD3	0	WWTR1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
YAP1	0	TEAD3	0	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Hauri S (2013), Enzo E (2015)	4
TRIM25	5	VGLL4	1	affinity chromatography technology	Choudhury NR (2017)	1
TEAD3	0	STUB1	4	affinity chromatography technology	Hauri S (2013)	1
TRIM25	5	TEAD3	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	CTBP2	7	affinity chromatography technology	Choudhury NR (2017)	1
TEAD3	0	MCMBP	3	affinity chromatography technology	Hauri S (2013)	1
YAP1	0	MCMBP	3	affinity chromatography technology	Hauri S (2013)	1
PHB2	1	TEAD3	0	two hybrid	Wang J (2011)	1
TEAD3	0	FASN	15	affinity chromatography technology	Hauri S (2013)	1
TEAD3	0	HSPA4	3	affinity chromatography technology	Hauri S (2013)	1
TEAD3	0	VGLL2	1	two hybrid	Rolland T (2014)	1
VGLL1	0	TEAD3	0	two hybrid	Vaudin P (1999)	1