PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
MLX	0	ZBTB32	0	two hybrid	Rolland T (2014)	1
MLX	0	GABARAPL2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MLX	0	SNX5	3	affinity chromatography technology	Huttlin EL (2017)	1
EWSR1	2	MLX	0	bioid	Elzi DJ (2014)	1
AES	2	MLX	0	two hybrid	Rolland T (2014)	1
MLXIP	1	MLX	0	far western blotting, imaging technique, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Billin AN (2000), Eilers AL (2002), Eilers AL (2002), Eilers AL (2002), Eilers AL (2002), Yu FX (2009), Huttlin EL (2017)	7
MLX	0	SAP30BP	2	two hybrid	Gao J (2008)	1
MLX	0	RBM39	2	two hybrid	Rolland T (2014)	1
MXD1	2	APP	1	pull down	Olah J (2011)	1
SNX1	2	APP	1	pull down	Olah J (2011)	1
MNT	2	MLX	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Cairo S (2001), Meroni G (2000), Meroni G (2000), Meroni G (2000), Meroni G (2000)	5
MXD1	2	MLX	0	two hybrid, two hybrid	Cairo S (2001), Meroni G (2000)	2
NXF1	0	MLX	0	affinity chromatography technology	Castello A (2012)	1
SNX1	2	SNX5	3	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
MLX	0	CSNK2B	5	affinity chromatography technology	Huttlin EL (2017)	1
MLX	0	MGA	9	affinity chromatography technology	Huttlin EL (2017)	1
MLX	0	CSPG5	2	affinity chromatography technology	Huttlin EL (2017)	1
MLX	0	AMPD2	7	affinity chromatography technology	Huttlin EL (2017)	1
MLX	0	BACH1	3	affinity chromatography technology	Huttlin EL (2017)	1
MLX	0	MLX	0	two hybrid, two hybrid, affinity chromatography technology, pull down	Cairo S (2001), Meroni G (2000), Meroni G (2000), Meroni G (2000)	4
CSNK2A1	15	NXF1	0	enzymatic study	Zhang M (2011)	1
MLX	0	MXD4	3	two hybrid, two hybrid	Billin AN (2000), Billin AN (1999)	2
MXD1	2	MNT	2	affinity chromatography technology	Cheng J (2017)	1
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
CSNK2A1	15	SAP30BP	2	enzymatic study	Zhang M (2011)	1
MLX	0	SNX1	2	affinity chromatography technology	Huttlin EL (2017)	1
NXF1	0	SNX1	2	affinity chromatography technology	Castello A (2012)	1
MLX	0	MLXIPL	3	two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cairo S (2001), Cairo S (2001), Cairo S (2001), Cairo S (2001), Zhang P (2010), Huttlin EL (2017)	6
NXF1	0	CSNK2B	5	affinity chromatography technology	Castello A (2012)	1
EWSR1	2	SAP30BP	2	biochemical, bioid	Havugimana PC (2012), Elzi DJ (2014)	2
MLX	0	APP	1	pull down	Olah J (2011)	1
RBM39	2	SAP30BP	2	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
MLX	0	ID3	0	two hybrid	Gao J (2008)	1
CSNK2B	5	AMPD2	7	biochemical	Kristensen AR (2012)	1
MLX	0	CSNK2A1	15	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A2	1	SAP30BP	2	affinity chromatography technology	Varjosalo M (2013)	1
MXD1	2	MGA	9	affinity chromatography technology	Cheng J (2017)	1
GABARAPL2	0	APP	1	pull down	Olah J (2011)	1
CSNK2A1	15	APP	1	pull down	Olah J (2011)	1
CSNK2B	5	CSNK2A2	1	two hybrid, affinity chromatography technology, far western blotting, two hybrid, enzymatic study, biochemical, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lehner B (2004), Kim MS (1998), Marin O (1997), Bosc DG (2000), Watabe M (2011), Havugimana PC (2012), Wang J (2011), Kristensen AR (2012), Varjosalo M (2013), Wallach T (2013), Hein MY (2015), Goetz C (1999), Hauri S (2016)	13
MLX	0	CSNK2A2	1	affinity chromatography technology	Huttlin EL (2017)	1
NXF1	0	SAP30BP	2	affinity chromatography technology	Castello A (2012)	1
MXD1	2	MXD4	3	affinity chromatography technology	Cheng J (2017)	1
NXF1	0	BACH1	3	affinity chromatography technology	Castello A (2012)	1
NXF1	0	RBM39	2	affinity chromatography technology	Castello A (2012)	1
RBM39	2	APP	1	pull down	Olah J (2011)	1