PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIRT7	1	HIST2H2AC	1	pull down	Ford E (2006)	1
JUN	0	MTA3	3	affinity chromatography technology	Aguilera C (2011)	1
HIST2H2AC	1	HIST2H2BE	1	pull down	Long L (2014)	1
TRIM25	5	MAPK14	0	affinity chromatography technology	Choudhury NR (2017)	1
MTA3	3	HMG20A	0	affinity chromatography technology	Bantscheff M (2011)	1
USP7	14	HIST2H2BE	1	affinity chromatography technology	Lecona E (2015)	1
GATAD2B	15	CDK2AP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
NR3C1	2	JUN	0	pull down	Lerner L (2003)	1
USP7	14	HIST2H2AC	1	affinity chromatography technology, enzymatic study	Lecona E (2015), Yu M (2016)	2
TCF20	18	BRF1	6	affinity chromatography technology	Hein MY (2015)	1
TCF20	18	MTA2	1	affinity chromatography technology	Hein MY (2015)	1
OBSL1	9	MTA2	1	affinity chromatography technology	Hanson D (2014)	1
NANOG	0	TCF20	18	affinity chromatography technology	Oliviero G (2015)	1
TRIM25	5	GATAD2B	15	affinity chromatography technology	Choudhury NR (2017)	1
SIRT7	1	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Tsai YC (2012), Jiang L (2017), Jiang L (2017), Jiang L (2017), Jiang L (2017), Jiang L (2017)	6
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
HMG20A	0	RBBP7	1	affinity chromatography technology	Hein MY (2015)	1
CDK2AP1	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Spruijt CG (2010), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	5
HIST2H2AC	1	RBBP7	1	affinity chromatography technology	Verreault A (1998)	1
HMG20A	0	PHF14	6	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
HIST2H2AC	1	TCF20	18	pull down	Darvekar S (2012)	1
RBBP7	1	GATAD2B	15	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Feng Q (2002), Feng Q (2002), Gong Z (2006), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	6
TRIM25	5	ADARB1	5	affinity chromatography technology	Choudhury NR (2017)	1
GATAD2B	15	GATAD2A	3	biochemical	Wan C (2015)	1
TCF20	18	RNF4	1	two hybrid, pull down	Lyngso C (2000), Lyngso C (2000)	2
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
USP7	14	EWSR1	2	two hybrid	Lim J (2006)	1
HIST2H2AC	1	GATAD2A	3	pull down	Brackertz M (2006)	1
RBBP7	1	GATAD2A	3	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gong Z (2006), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	5
HIST2H2BE	1	GATAD2B	15	pull down	Brackertz M (2006)	1
HIST2H2BE	1	GATAD2A	3	pull down	Brackertz M (2006)	1
TCF20	18	RBBP7	1	affinity chromatography technology	Hein MY (2015)	1
HIST2H2AC	1	HIST1H2BA	0	pull down, pull down	Hoffmann A (1996), Boenisch C (2012)	2
MAPK14	0	HDAC1	4	biochemical	Wan C (2015)	1
POU5F1	0	CDK2AP1	1	affinity chromatography technology	Oliviero G (2015)	1
NR3C1	2	RAI1	16	bioid	Lempiaeinen JK (2017)	1
JUN	0	EWSR1	2	pull down, bioid	Fuchs B (2003), Elzi DJ (2014)	2
OBSL1	9	GATAD2A	3	affinity chromatography technology	Hanson D (2014)	1
MTA3	3	GATAD2B	15	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Bantscheff M (2011), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
HIST2H2AC	1	GATAD2B	15	pull down	Brackertz M (2006)	1
TRIM25	5	TCF20	18	affinity chromatography technology	Choudhury NR (2017)	1
FKBP9	1	TCF20	18	affinity chromatography technology	Huttlin EL (2017)	1
MAPK14	0	TCF20	18	two hybrid	Bandyopadhyay S (2010)	1
NANOG	0	USP7	14	affinity chromatography technology	Oliviero G (2015)	1
TRIM25	5	GATAD2A	3	affinity chromatography technology	Choudhury NR (2017)	1
MTA3	3	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
AR	3	RNF4	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Moilanen AM (1998), Poukka H (2000), Moilanen AM (1998), Moilanen AM (1998), Pero R (2002), Pero R (2002), Poukka H (2000)	7
JUN	0	TCF20	18	pull down	Kirstein M (1996)	1
MTA3	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Fujita N (2003), Kwintkiewicz J (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
TRIM27	2	GATAD2B	15	two hybrid	Rolland T (2014)	1
TCF20	18	ADARB1	5	affinity chromatography technology	Hein MY (2015)	1
HDAC1	4	TRIM27	2	imaging technique, affinity chromatography technology	Kato T (2009), Shimono Y (2003)	2
HIST1H2BA	0	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology	Li X (2014), Huttlin EL (2015), Huttlin EL (2017)	3
SIRT7	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology	Tsai YC (2012), Mo Y (2017)	2
NOP9	1	TCF20	18	affinity chromatography technology	Hein MY (2015)	1
TCF20	18	MTA3	3	affinity chromatography technology	Hein MY (2015)	1
TCF20	18	PHF14	6	affinity chromatography technology	Hein MY (2015)	1
OBSL1	9	TCF20	18	affinity chromatography technology	Hanson D (2014)	1
TCF20	18	SLC39A10	2	affinity chromatography technology	Hein MY (2015)	1
OBSL1	9	NIPSNAP1	3	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	HIST2H2BE	1	affinity chromatography technology	Hanson D (2014)	1
SIRT7	1	COPB1	0	affinity chromatography technology	Tsai YC (2012)	1
TCF20	18	RAI1	16	affinity chromatography technology	Hein MY (2015)	1
JUN	0	NFE2L2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Venugopal R (1998), Venugopal R (1998), Levy S (2010), Lee AC (2010)	4
HMG20A	0	GATAD2A	3	affinity chromatography technology	Hein MY (2015)	1
HDAC1	4	TCF20	18	affinity chromatography technology	Hein MY (2015)	1
TCF20	18	COPB1	0	affinity chromatography technology	Hein MY (2015)	1
SIRT7	1	MTA2	1	affinity chromatography technology	Tsai YC (2012)	1
POU5F1	0	COPB1	0	affinity chromatography technology	Oliviero G (2015)	1
JUN	0	HDAC1	4	affinity chromatography technology	Tenbrock K (2006)	1
SIRT7	1	RAI1	16	affinity chromatography technology	Tsai YC (2012)	1
SIRT7	1	HIST2H2BE	1	pull down	Ford E (2006)	1
AR	3	TCF20	18	affinity chromatography technology, pull down, bioid	Elvenes J (2011), Elvenes J (2011), Lempiaeinen JK (2017)	3
EWSR1	2	TCF20	18	bioid	Elzi DJ (2014)	1
MTA3	3	CDK2AP1	1	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Hein MY (2015)	2
MTA3	3	GATAD2A	3	affinity chromatography technology, biochemical, affinity chromatography technology	Bantscheff M (2011), Wan C (2015), Huttlin EL (2017)	3
USP7	14	ACTL8	1	affinity chromatography technology	Hein MY (2015)	1
POU5F1	0	USP7	14	affinity chromatography technology	Oliviero G (2015)	1
NR3C1	2	MTA2	1	biochemical	Kristensen AR (2012)	1
POU5F1	0	TCF20	18	affinity chromatography technology	Oliviero G (2015)	1
GATAD2B	15	MTA2	1	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Feng Q (2002), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
CDK2AP1	1	RAI1	16	affinity chromatography technology	Hein MY (2015)	1
CDK2AP1	1	TCF20	18	affinity chromatography technology	Hein MY (2015)	1
HMG20A	0	MTA2	1	affinity chromatography technology	Hein MY (2015)	1
MAPK14	0	OBSL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
NR3C1	2	TCF20	18	bioid	Lempiaeinen JK (2017)	1
AR	3	RAI1	16	bioid	Lempiaeinen JK (2017)	1
NFE2L2	1	TCF20	18	imaging technique	Darvekar SR (2014)	1
HMG20A	0	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
TCF20	18	GATAD2B	15	affinity chromatography technology	Hein MY (2015)	1
SMAD1	0	AR	3	affinity chromatography technology, affinity chromatography technology, protein complementation assay, imaging technique, affinity chromatography technology	Qiu T (2007), Qiu T (2007), Qiu T (2007), Qiu T (2007), Li Y (2013)	5
TRIM25	5	USP7	14	affinity chromatography technology	Choudhury NR (2017)	1
USP7	14	TCF20	18	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
HMG20A	0	GATAD2B	15	affinity chromatography technology	Hein MY (2015)	1
RBBP7	1	SIN3A	13	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Kuzmichev A (2002), Nakamura T (2002), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	6
HDAC1	4	GATAD2A	3	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gong Z (2006), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	6
HIST1H2BA	0	PHF14	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	SLC39A10	2	affinity chromatography technology	Choudhury NR (2017)	1
AR	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Chen ST (2015), Chen ST (2015), Chen ST (2015), Chen ST (2015)	4
TRIM25	5	HMG20A	0	affinity chromatography technology	Choudhury NR (2017)	1
OBSL1	9	EWSR1	2	affinity chromatography technology	Hanson D (2014)	1
TCF20	18	CLTB	0	affinity chromatography technology	Hein MY (2015)	1
NANOG	0	MTA3	3	affinity chromatography technology	Oliviero G (2015)	1
MTA2	1	RBBP7	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Yao YL (2003), Zhang Y (1999), Feng Q (2001), Wang Y (2009), Fu J (2011), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017), Brasen C (2017), Brasen C (2017), Hauri S (2016)	11
NIPSNAP1	3	TCF20	18	affinity chromatography technology	Hein MY (2015)	1
HMG20A	0	RAI1	16	affinity chromatography technology	Hein MY (2015)	1
NANOG	0	CDK2AP1	1	affinity chromatography technology	Oliviero G (2015)	1
MTA3	3	MTA2	1	affinity chromatography technology, biochemical	Bantscheff M (2011), Wan C (2015)	2
TCF20	18	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
HMG20A	0	TCF20	18	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
TRIM25	5	RNF4	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	SIN3A	13	affinity chromatography technology	Choudhury NR (2017)	1
HIST2H2BE	1	TCF20	18	pull down	Darvekar S (2012)	1
TCF20	18	ACTL8	1	affinity chromatography technology	Hein MY (2015)	1
NANOG	0	SIN3A	13	affinity chromatography technology	Oliviero G (2015)	1
POU5F1	0	SIN3A	13	affinity chromatography technology	Oliviero G (2015)	1
CDK2AP1	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Spruijt CG (2010), Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	6
HDAC1	4	PHF14	6	affinity chromatography technology	Hein MY (2015)	1
CDK2AP1	1	MTA2	1	affinity chromatography technology	Hein MY (2015)	1
TCF20	18	GATAD2A	3	affinity chromatography technology	Hein MY (2015)	1
TCF20	18	SIN3A	13	affinity chromatography technology	Hein MY (2015)	1
RNF4	1	NFE2L2	1	affinity chromatography technology	Malloy MT (2013)	1
NANOG	0	MTA2	1	affinity chromatography technology	Oliviero G (2015)	1
HIST1H2BA	0	HMG20A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC1	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Ng HH (1999), Zhang Y (1999), Zhang Y (1997), Banach-Orlowska M (2009), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Yeh HH (2015), Yeh HH (2015), Huttlin EL (2017), Hauri S (2016)	19
NFE2L2	1	HDAC1	4	affinity chromatography technology	Lee DY (2012)	1
HDAC1	4	MTA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Yao YL (2003), You A (2001), Zhang Y (1999), Zhang Y (1999), Yasui D (2002), Banach-Orlowska M (2009), Banach-Orlowska M (2009), Cui Y (2006), Pflum MK (2001), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Zhang Y (1998), Terhune SS (2010), Opsahl JA (2010), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	27
HIST1H2BA	0	TCF20	18	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP7	14	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Hein MY (2015), Zaman MM (2013), Zaman MM (2013)	4
SIRT7	1	EWSR1	2	affinity chromatography technology	Tsai YC (2012)	1
NR3C1	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe, pull down	Qiu Y (2006), Jee YK (2005), Kristensen AR (2012), Qiu Y (2011), Qiu Y (2011)	5
CDK2AP1	1	PHF14	6	affinity chromatography technology	Hein MY (2015)	1
JUN	0	AR	3	affinity chromatography technology, affinity chromatography technology	Sato N (1997), Sato N (1997)	2
SMAD1	0	TCF20	18	two hybrid	Ravasi T (2010)	1
MTA2	1	GATAD2A	3	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
MAPK14	0	JUN	0	enzymatic study	Thakur N (2014)	1
GATAD2B	15	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Feng Q (2002), Gong Z (2006), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
AR	3	SIN3A	13	affinity chromatography technology	Zhu P (2006)	1
MTA2	1	SIN3A	13	affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Pflum MK (2001)	2
HDAC1	4	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
CDK2AP1	1	HMG20A	0	affinity chromatography technology	Hein MY (2015)	1
CDK2AP1	1	GATAD2A	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
SIRT7	1	TCF20	18	affinity chromatography technology	Tsai YC (2012)	1