PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NCOA3	3	HNF1A	0	affinity chromatography technology, pull down	Soutoglou E (2000), Soutoglou E (2000)	2
CDX2	4	HNF1A	0	pull down	Mitchelmore C (2000)	1
VCP	6	YWHAE	0	affinity chromatography technology	Yu CC (2013)	1
ACTB	8	EP300	36	two hybrid	Wang J (2011)	1
HNF1A	0	YWHAG	5	affinity chromatography technology	Yu M (2008)	1
CREBBP	29	BCL6	6	enzymatic study	Pasqualucci L (2011)	1
HNF1A	0	RNF14	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Wu B (2013), Wu B (2013), Wu B (2013), Wu B (2013)	4
CREBBP	29	HNF1A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Soutoglou E (2000), Soutoglou E (2000), Dohda T (2004), Dohda T (2004)	4
HNF1A	0	CALM3	0	affinity chromatography technology	Ewing RM (2007)	1
VCP	6	YWHAG	5	affinity chromatography technology	Yu CC (2013)	1
CREBBP	29	FOS	0	pull down, affinity chromatography technology, two hybrid	Fan S (2002), Bossis G (2005), Patel D (1999)	3
SIRT1	3	HNF1A	0	pull down, affinity chromatography technology, affinity chromatography technology	Grimm AA (2011), Grimm AA (2011), Grimm AA (2011)	3
YWHAE	0	CBX3	1	biochemical	Havugimana PC (2012)	1
PCBD1	0	PCBD2	0	two hybrid	Ravasi T (2010)	1
YWHAZ	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down	Tzivion G (2000), Tzivion G (2000), Tzivion G (2000)	3
STAT3	0	ANXA2	0	affinity chromatography technology, affinity chromatography technology	Wang YQ (2012), Wang YQ (2012)	2
VCP	6	ANXA2	0	affinity chromatography technology	Yu CC (2013)	1
HNF1A	0	RHPN2	3	affinity chromatography technology	Ewing RM (2007)	1
NCOA1	6	STAT3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Giraud S (2002), Giraud S (2002), Zhang Y (2007), Zhang Y (2007)	4
HNF1A	0	ANXA2	0	affinity chromatography technology	Yu M (2008)	1
FOS	0	NCOA3	3	pull down, affinity chromatography technology	Fauquier L (2008), Fauquier L (2008)	2
CREBBP	29	HMGB1	0	enzymatic study	Pasheva E (2004)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
EP300	36	YWHAZ	1	enzymatic study	Mortenson JB (2015)	1
AES	2	HNF1A	0	two hybrid	Brantjes H (2001)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
HNF1A	0	RYR3	18	pull down	Miyamoto-Sato E (2010)	1
CREBBP	29	NCOA1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Sheppard HM (2001), Sheppard HM (2001), Sheppard HM (2001), Wu RC (2002), Torchia J (1997), Torchia J (1997), Matsuda S (2004), DiRenzo J (2000), Nakuci E (2006), Ruas JL (2005), Huang SM (2002)	11
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
NCOA1	6	NCOA3	3	affinity chromatography technology, affinity chromatography technology	Lodrini M (2008), Lodrini M (2008)	2
NCOA3	3	ANXA2	0	affinity chromatography technology	Jung SY (2005)	1
HNF1A	0	IGFBP7	1	affinity chromatography technology	Yu M (2008)	1
VCP	6	VIM	0	affinity chromatography technology	Yu CC (2013)	1
KAT2B	2	NCOA3	3	two hybrid, pull down	Korzus E (1998), Takeshita A (1997)	2
HNF1A	0	PCBD2	0	affinity chromatography technology	Ewing RM (2007)	1
SNRPA1	1	SRSF7	0	biochemical	Havugimana PC (2012)	1
HNF1A	0	VIM	0	affinity chromatography technology	Yu M (2008)	1
EP300	36	FOS	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang WM (2011), Pekarsky Y (2008), Wang C (2001)	3
HNF1A	0	STAT3	0	affinity chromatography technology	Leu JI (2001)	1
NCOA1	6	HNF1A	0	affinity chromatography technology, pull down	Soutoglou E (2000), Soutoglou E (2000)	2
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
HNF1A	0	HNF1B	3	pull down, pull down	Mendel DB (1991), Lindner TH (1999)	2
AES	2	HMGB1	0	pull down	Dintilhac A (2002)	1
AES	2	BCL6	6	two hybrid	Rolland T (2014)	1
HNF1A	0	SRSF7	0	affinity chromatography technology	Yu M (2008)	1
SIRT1	3	FOS	0	pull down, enzymatic study	Zhang R (2010), Zhang R (2010)	2
HNF1A	0	220885	0	affinity chromatography technology	Yu M (2008)	1
HNF1A	0	PEBP1	0	affinity chromatography technology	Yu M (2008)	1
HNF1A	0	CBX3	1	affinity chromatography technology	Yu M (2008)	1
EP300	36	BCL6	6	enzymatic study, affinity chromatography technology	Bereshchenko OR (2002), Bereshchenko OR (2002)	2
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
HNF1A	0	YWHAB	1	affinity chromatography technology	Yu M (2008)	1
HNF1A	0	VCP	6	affinity chromatography technology	Yu M (2008)	1
STAT3	0	PCBD2	0	two hybrid	Ravasi T (2010)	1
HNF1A	0	HIST2H2AB	1	affinity chromatography technology	Yu M (2008)	1
HNF1A	0	SNX14	5	affinity chromatography technology	Yu M (2008)	1
VCP	6	ACTB	8	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
HNF1A	0	YWHAE	0	affinity chromatography technology	Yu M (2008)	1
HNF1A	0	PCBD1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid	Ewing RM (2007), Sourdive DJ (1997), Sourdive DJ (1997), Sourdive DJ (1997), Rho H (2010), Wang J (2011)	6
SIRT1	3	HIST2H2AB	1	affinity chromatography technology	Law IK (2009)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
CDX2	4	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology	Hussain MA (1999), Hussain MA (1999), Hussain MA (1999)	3
EP300	36	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Bouras T (2005), Bourguignon LY (2009)	2
HNF1A	0	SNRPA1	1	affinity chromatography technology	Ewing RM (2007)	1
YWHAE	0	SRSF7	0	affinity chromatography technology	Choudhary C (2009)	1
HNF1A	0	ACTB	8	affinity chromatography technology	Yu M (2008)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
HNF1A	0	RANBP1	0	affinity chromatography technology	Yu M (2008)	1
NCOA1	6	FOS	0	pull down, two hybrid, pull down, pull down, affinity chromatography technology	Lee SK (2000), Lee SK (1998), Lee SK (1998), Fauquier L (2008), Fauquier L (2008)	5
EP300	36	HIST2H2AB	1	enzymatic study, enzymatic study	Bordoli L (2001), Kim MY (2001)	2
NCOA1	6	KAT2B	2	pull down, two hybrid, affinity chromatography technology, two hybrid, pull down	Spencer TE (1997), Spencer TE (1997), Korzus E (1998), Korzus E (1998), Jenster G (1997)	5
BCL6	6	HNF1A	0	affinity chromatography technology	Miles RR (2005)	1
EP300	36	ANXA2	0	affinity chromatography technology	Jung SY (2005)	1
VCP	6	YWHAB	1	affinity chromatography technology	Yu CC (2013)	1
SIRT1	3	KAT2B	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Pediconi N (2009), Pediconi N (2009), Pediconi N (2009)	3
HNF1A	0	HMGB1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu M (2008), Yu M (2008), Yu M (2008)	3
HNF1A	0	HNF1A	0	pull down, affinity chromatography technology	Mendel DB (1991), Yu M (2008)	2
KAT2B	2	ACTB	8	affinity chromatography technology, affinity chromatography technology	Obrdlik A (2008), Obrdlik A (2008)	2
MYOG	1	HNF1A	0	pull down	Funk WD (1992)	1
PCBD1	0	HNF1B	3	two hybrid	Ravasi T (2010)	1
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
HNF1A	0	YWHAZ	1	affinity chromatography technology	Yu M (2008)	1
CREBBP	29	STAT3	0	affinity chromatography technology, enzymatic study	Sun Y (2001), Yuan ZL (2005)	2
NCOA1	6	VCP	6	affinity chromatography technology	Jung SY (2005)	1
NCOA3	3	CREBBP	29	two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Naltner A (2000), Wu RC (2002), Wu RC (2002), Kamei Y (1996), Naeem H (2007), Naeem H (2007), Torchia J (1997), Torchia J (1997), Torchia J (1997), Torchia J (1997), Takeshita A (1997), Wu RC (2004), Corkery D (2011), Yi P (2005), Ceschin DG (2011)	15
HNF1A	0	LDHA	2	affinity chromatography technology	Yu M (2008)	1
SIRT1	3	STAT3	0	affinity chromatography technology	Lin Z (2012)	1
STAT3	0	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima K (1999), Nakashima K (1999), Ray S (2002), Ray S (2002), Yuan ZL (2005), Yuan ZL (2005), Gupta M (2011), Wang R (2005), Gray MJ (2005), Hou T (2008), Kotla S (2015)	11
VCP	6	YWHAZ	1	affinity chromatography technology, two hybrid	Yu CC (2013), Wang J (2011)	2
KAT2B	2	HNF1A	0	affinity chromatography technology, pull down	Soutoglou E (2000), Soutoglou E (2000)	2
NCOA3	3	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, imaging technique, two hybrid, enzymatic study, affinity chromatography technology, pull down	Pao GM (2000), Feng Q (2006), Demarest SJ (2002), Demarest SJ (2002), Arimura A (2004), Font de Mora J (2000), Wang F (2010), Yi P (2005), Chen H (1999), Yi P (2015), Yi P (2015)	11
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
NCOA1	6	EP300	36	affinity chromatography technology, imaging technique, pull down, pull down	Matsuda S (2004), Wang F (2010), Kino T (2002), Nasrin N (2000)	4
YWHAG	5	VIM	0	affinity chromatography technology	Jin J (2004)	1
HNF1A	0	FOS	0	affinity chromatography technology	Leu JI (2001)	1
EP300	36	HNF1A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ban N (2002), Ban N (2002), Dohda T (2004), Dohda T (2004)	4