PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SOX2	4	TBX3	0	affinity chromatography technology	Cox JL (2013)	1
HNRNPLL	1	TBX3	0	affinity chromatography technology	Huttlin EL (2017)	1
TOLLIP	3	TBX3	0	two hybrid	Bandyopadhyay S (2010)	1
SOX2	4	HDAC2	1	affinity chromatography technology	Engelen E (2011)	1
KIF21B	2	TBX3	0	affinity chromatography technology	Hein MY (2015)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
TBX3	0	HDAC1	4	affinity chromatography technology	Yarosh W (2008)	1
HDAC1	4	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Khan MM (2001), Khan MM (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Morey L (2008), Kuo HY (2013), Kim YE (2015)	10
CDK8	1	TBX3	0	affinity chromatography technology	Hein MY (2015)	1
TBX3	0	HDAC2	1	affinity chromatography technology	Yarosh W (2008)	1
TBX3	0	HDAC5	4	affinity chromatography technology	Yarosh W (2008)	1
PML	7	HDAC3	5	affinity chromatography technology, pull down	Wu WS (2001), Wu WS (2001)	2
CA8	0	TBX3	0	two hybrid	Rolland T (2014)	1
PML	7	TBX3	0	affinity chromatography technology	Martin N (2012)	1
MAPK3	4	DCP1A	1	two hybrid	Corominas R (2014)	1
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HDAC2	1	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu WS (2001), Morey L (2008), Kraemer OH (2008), Kim YE (2015)	4
TBX3	0	PLEKHF2	1	two hybrid	Yu H (2011)	1
KIF21A	7	TBX3	0	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	TOLLIP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
DNAJC11	2	TBX3	0	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	AES	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPLL	1	HDAC3	5	affinity chromatography technology	Huttlin EL (2017)	1
SOX2	4	HDAC1	4	affinity chromatography technology	Engelen E (2011)	1
CDCA5	0	TBX3	0	affinity chromatography technology	Hein MY (2015)	1
HDAC5	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Zhang J (2002), Grozinger CM (2000), Greco TM (2011), Greco TM (2011)	6
ELAVL1	0	KIF21A	7	affinity chromatography technology	Abdelmohsen K (2009)	1
PML	7	MAPK3	4	affinity chromatography technology	Warren DT (2010)	1
ELAVL1	0	TBX3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TBX3	0	HDAC3	5	affinity chromatography technology	Yarosh W (2008)	1
HDAC5	4	HDAC1	4	affinity chromatography technology	Greco TM (2011)	1
SOX2	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
HDAC5	4	HNRNPLL	1	affinity chromatography technology	Greco TM (2011)	1
KIF21B	2	KIF21A	7	affinity chromatography technology	Hein MY (2015)	1
TBX3	0	TBX3	0	x-ray crystallography	Coll M (2002)	1
ELAVL1	0	PLEKHF2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
AES	2	TBX3	0	two hybrid	Rolland T (2014)	1
DCP1A	1	TBX3	0	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	TBX3	0	affinity chromatography technology	Hein MY (2015)	1