PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	CNTN2	4	protein complementation assay	Deribe YL (2009)	1
CNTN2	4	CNTN1	4	pull down	Pavlou O (2002)	1
CNTN2	4	L1CAM	3	pull down	Pavlou O (2002)	1
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
CNTN2	4	CNTNAP2	5	affinity chromatography technology, affinity chromatography technology	Traka M (2003), Traka M (2003)	2
L1CAM	3	NCAN	4	pull down	Friedlander DR (1994)	1
L1CAM	3	EGFR	5	affinity chromatography technology	Donier E (2012)	1
CNTN2	4	NCAN	4	pull down	Milev P (1996)	1
CNTN2	4	NRCAM	1	pull down	Pavlou O (2002)	1
IKBKG	0	CNTN2	4	affinity chromatography technology, affinity chromatography technology	Zhao T (2009), Hai T (2006)	2