PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TAL2	1	PCBD2	0	two hybrid	Ravasi T (2010)	1
TCF4	26	CBFA2T2	3	affinity chromatography technology	Li X (2015)	1
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TAL2	1	TCF12	14	two hybrid	Ravasi T (2010)	1
RUNX1T1	1	PCBD2	0	two hybrid	Ravasi T (2010)	1
TAL2	1	CBFA2T2	3	two hybrid	Ravasi T (2010)	1
RUNX1T1	1	TCF12	14	affinity chromatography technology, pull down	Zhang J (2004), Zhang J (2004)	2
TCF4	26	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TAL2	1	LMO1	0	two hybrid	Wadman I (1994)	1
RUNX1T1	1	CBFA2T2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Lindberg SR (2003), Hoogeveen AT (2002), Zhang J (2004)	4
RUNX1T1	1	TAL2	1	two hybrid	Ravasi T (2010)	1
TAL2	1	LMO2	2	two hybrid	Wadman I (1994)	1
TCF4	26	TAL2	1	two hybrid, two hybrid	Langlands K (1997), Rolland T (2014)	2
LMO1	0	TCF4	26	two hybrid	Rolland T (2014)	1