PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PXN	1	MAPK1	1	imaging technique	Chen TC (2014)	1
ADAM17	2	MAPK1	1	pull down, enzymatic study, affinity chromatography technology	Diaz-Rodriguez E (2002), Diaz-Rodriguez E (2002), Diaz-Rodriguez E (2002)	3
MAD2L1	0	ADAM17	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Nelson KK (1999), Nelson KK (1999), Nelson KK (1999), Poghosyan Z (2002)	4
CDH1	4	ADAM17	2	bioid	Guo Z (2014)	1
ADAM17	2	TNFRSF1B	4	enzymatic study	Tellier E (2006)	1
ADAM17	2	TNFRSF1A	3	enzymatic study	Tellier E (2006)	1
CDH1	4	DLG1	2	bioid	Guo Z (2014)	1
CFTR	5	CDH1	4	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
TGFA	1	DLG1	2	pull down, two hybrid, affinity chromatography technology, imaging technique	Surena AL (2009), Surena AL (2009), Surena AL (2009), Surena AL (2009)	4
ADAM17	2	LRRC3	2	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	PXN	1	bioid	Guo Z (2014)	1
PXN	1	ADAM17	2	affinity chromatography technology, imaging technique	Lee JH (2013), Lee JH (2013)	2
PTCH1	8	ST8SIA4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TGFA	1	ADAM17	2	imaging technique, affinity chromatography technology	Chen TC (2014), Surena AL (2009)	2
PTCH1	8	ADAM17	2	affinity chromatography technology	Huttlin EL (2015)	1
CFTR	5	ADAM17	2	affinity chromatography technology	Pankow S (2015)	1
ADAM17	2	SDK2	4	affinity chromatography technology	Huttlin EL (2017)	1
ADAM17	2	DLG1	2	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Peiretti F (2003), Peiretti F (2003), Peiretti F (2003), Surena AL (2009), Surena AL (2009), Surena AL (2009), Surena AL (2009)	7
TIMP3	0	ADAM17	2	pull down	Lee MH (2002)	1
PDIA3	0	ADAM17	2	affinity chromatography technology	Jessop CE (2007)	1
MAPK1	1	TNFRSF1A	3	enzymatic study, affinity chromatography technology, pull down	Frankel SK (2001), Ibeas E (2009), Ibeas E (2009)	3
LMAN2L	0	ADAM17	2	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	PDIA3	0	affinity chromatography technology	Pankow S (2015)	1
TNFRSF1B	4	TNFRSF1A	3	affinity chromatography technology	Wicovsky A (2009)	1
ST8SIA4	0	ADAM17	2	affinity chromatography technology	Huttlin EL (2017)	1
EED	1	ADAM17	2	affinity chromatography technology	Lee JH (2013)	1
FBXO6	0	ADAM17	2	affinity chromatography technology	Liu B (2012)	1
INSL5	0	ADAM17	2	affinity chromatography technology	Huttlin EL (2017)	1