PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
S100A11	1	TACC1	2	biochemical	Havugimana PC (2012)	1
VAPA	1	VAPB	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishimura Y (1999), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
TACC1	2	BAIAP2L1	1	affinity chromatography technology	Hein MY (2015)	1
TACC1	2	RNF41	2	affinity chromatography technology	Huttlin EL (2017)	1
ITSN2	7	KDM1A	2	two hybrid	Wong KA (2012)	1
HTT	14	TACC1	2	two hybrid	Suter B (2013)	1
TACC1	2	KDM1A	2	two hybrid	Weimann M (2013)	1
POC1B	2	TACC1	2	affinity chromatography technology	Huttlin EL (2017)	1
RPN2	0	TACC1	2	affinity chromatography technology	Huttlin EL (2017)	1
AURKA	1	BTRC	1	affinity chromatography technology	Irelan JT (2007)	1
VAPA	1	RPN2	0	biochemical	Wan C (2015)	1
BARD1	4	AURKB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ryser S (2009), Ryser S (2009), Bosse KR (2012)	3
TACC1	2	LYST	8	affinity chromatography technology	Hein MY (2015)	1
STAT2	2	TACC1	2	affinity chromatography technology	Huttlin EL (2017)	1
TACC1	2	KAT2A	1	pull down	Gangisetty O (2004)	1
C12orf57	2	PLXNB2	14	biochemical	Havugimana PC (2012)	1
RNF41	2	ITSN2	7	affinity chromatography technology	Hein MY (2015)	1
AURKA	1	STAT2	2	pull down	Kamran M (2017)	1
BARD1	4	AURKA	1	affinity chromatography technology	Bosse KR (2012)	1
TACC1	2	MEMO1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SNRPG	0	TACC1	2	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Conte N (2002), Conte N (2002), Conte N (2002), Conte N (2002)	4
VAPB	2	RPN2	0	affinity chromatography technology, affinity chromatography technology	Baron Y (2014), Baron Y (2014)	2
AURKB	2	AURKA	1	affinity chromatography technology	Fogeron ML (2013)	1
TACC2	4	KAT2A	1	pull down, two hybrid, affinity chromatography technology	Gangisetty O (2004), Gangisetty O (2004), Gangisetty O (2004)	3
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
PLXNB2	14	TACC1	2	biochemical	Havugimana PC (2012)	1
SLC9A3R1	2	TACC1	2	biochemical	Havugimana PC (2012)	1
VAPA	1	TACC1	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
ITSN2	7	TACC1	2	two hybrid	Wong KA (2012)	1
YEATS4	0	KDM1A	2	two hybrid, two hybrid, affinity chromatography technology	Piccinni E (2011), Piccinni E (2011), Boldt K (2016)	3
TACC1	2	RB1CC1	9	affinity chromatography technology	Hein MY (2015)	1
C12orf57	2	TACC1	2	biochemical	Havugimana PC (2012)	1
BTRC	1	CKAP5	2	bioid	Coyaud E (2015)	1
TACC1	2	CKAP5	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Conte N (2003), Conte N (2003), Conte N (2003), Conte N (2003), Lauffart B (2002), Hein MY (2015)	6
TACC1	2	KNSTRN	0	affinity chromatography technology	Huttlin EL (2017)	1
TACC1	2	BRD3	6	affinity chromatography technology	Hein MY (2015)	1
STX5	0	TACC1	2	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
NIF3L1	0	TACC1	2	biochemical	Havugimana PC (2012)	1
YEATS4	0	TACC2	4	affinity chromatography technology, pull down	Lauffart B (2003), Lauffart B (2003)	2
STX5	0	VAPB	2	pull down	Li G (2003)	1
TACC1	2	AURKA	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Delaval B (2004), Conte N (2003), Tien AC (2004)	3
VAPB	2	RB1CC1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKB	2	TACC1	2	affinity chromatography technology, affinity chromatography technology	Delaval B (2004), Delaval B (2004)	2
TACC1	2	TACC2	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
THAP12	0	TACC1	2	two hybrid	Rolland T (2014)	1
BARD1	4	TACC1	2	affinity chromatography technology, affinity chromatography technology	Ryser S (2009), Ryser S (2009)	2
TACC1	2	YEATS4	0	two hybrid, affinity chromatography technology	Lauffart B (2002), Lauffart B (2002)	2
FBXW11	2	TACC1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Low TY (2014), Huttlin EL (2017)	3
TACC1	2	SH2D4A	0	two hybrid	Rolland T (2014)	1
VAPB	2	TACC1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NIF3L1	0	PLXNB2	14	biochemical	Havugimana PC (2012)	1
CKAP5	2	TACC2	4	affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Hein MY (2015)	2
FBXW11	2	VAPA	1	affinity chromatography technology	Kim TY (2014)	1
TACC1	2	BTRC	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
TACC1	2	LSM7	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Conte N (2003), Conte N (2002), Conte N (2002), Conte N (2002), Conte N (2002)	5
VAPA	1	RB1CC1	9	affinity chromatography technology	Huttlin EL (2017)	1
DTNBP1	1	TACC1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DTNBP1	1	STX5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TACC1	2	TDRD7	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Conte N (2003), Conte N (2003), Conte N (2003), Conte N (2003)	4
BRD3	6	YEATS4	0	biochemical	Havugimana PC (2012)	1