PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBC	7	UBR1	3	affinity chromatography technology	Bish RA (2007)	1
UBC	7	TAC3	0	pull down	Nathan JA (2013)	1
TAC3	0	CCDC90B	2	two hybrid	Stelzl U (2005)	1
TAC3	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
TAC3	0	UBR1	3	two hybrid	Stelzl U (2005)	1
TAC3	0	ELP1	5	two hybrid	Stelzl U (2005)	1
TAC3	0	PTN	0	two hybrid	Stelzl U (2005)	1
PTN	0	FEZ1	0	two hybrid	Goehler H (2004)	1
TACR2	0	TAC3	0	pull down	Bhogal N (1994)	1
TAC3	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1