PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TAC1	TACR1	2	pull down, pull down	Tian Y (1996), Bellucci F (2002)	2
TACR2	TAC1	0	pull down, pull down	Bhogal N (1994), Bellucci F (2002)	2
TAC1	XRCC6	3	two hybrid	Vinayagam A (2011)	1
TAC1	CENPB	0	two hybrid	Vinayagam A (2011)	1
TAC1	TACR3	0	pull down	Tian Y (1996)	1
TAC1	BAG6	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2