PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STX4	2	SNAP29	1	pull down	Steegmaier M (1998)	1
VAPA	1	VAPB	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishimura Y (1999), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
STX1A	2	VAPB	2	pull down, affinity chromatography technology	Li G (2003), Baron Y (2014)	2
STX1A	2	VAMP1	0	two hybrid	Perez-Branguli F (2002)	1
VAPA	1	VAMP1	0	pull down	Weir ML (1998)	1
VAMP1	0	VAPB	2	pull down	Nishimura Y (1999)	1
LMNA	2	STX4	2	two hybrid	Dittmer TA (2014)	1
VAMP1	0	SNAP29	1	two hybrid	Rolland T (2014)	1
VAMP1	0	STX4	2	two hybrid, two hybrid	Jagadish MN (1996), Rolland T (2014)	2
STX4	2	VAPB	2	pull down	Li G (2003)	1
ATP4A	6	VAMP1	0	affinity chromatography technology	Lapierre LA (2007)	1
LMNA	2	CCDC155	2	two hybrid	Dittmer TA (2014)	1
VAMP1	0	CCDC155	2	two hybrid	Rolland T (2014)	1
STX1A	2	SNAP29	1	pull down, two hybrid	Steegmaier M (1998), Corominas R (2014)	2
STX1B	2	VAPB	2	pull down, affinity chromatography technology	Li G (2003), Baron Y (2014)	2
STX1B	2	VAMP1	0	two hybrid	Perez-Branguli F (2002)	1
LMNA	2	VAMP1	0	two hybrid	Dittmer TA (2014)	1
CDKN2A	1	VAMP1	0	two hybrid	Daakour S (2016)	1