PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AURKC	0	3323	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKC	0	C12orf43	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
730211	0	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
AURKC	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKB	2	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	3
HSP90AA1	7	USP19	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Gano JJ (2010), Lee JG (2014), Lee JG (2014), Lee JG (2014), He WT (2016), He WT (2016), He WT (2016)	7
AURKB	2	INCENP	4	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Gassmann R (2004), Xu Z (2009), Xu Z (2009), Katayama H (2008), Kaitna S (2000), Maerki S (2009), Vader G (2006), Honda R (2003), Ban R (2011), Sun L (2008), Nozawa RS (2010), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Fu J (2009), Fu J (2009), Li X (2004), Gomez V (2010)	18
730211	0	HSP90AB1	2	biochemical	Havugimana PC (2012)	1
AURKC	0	DHX38	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4L	3	CDK5	0	enzymatic study	Persaud A (2009)	1
HSP90AA1	7	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Johnson N (2013), Johnson N (2013), Ertych N (2016)	3
BRCA1	7	TUBB8	2	affinity chromatography technology	Ertych N (2016)	1
CDK5	0	HSP90AA1	7	affinity chromatography technology	Varjosalo M (2013)	1
NEDD4	2	CDK5	0	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
CDC37	0	USP19	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
AURKC	0	CDK5	0	affinity chromatography technology	Huttlin EL (2017)	1
FKBP5	0	AURKB	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37	0	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
NEDD4	2	AURKC	0	pull down	Persaud A (2009)	1
AURKC	0	MYH4	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H3A	3	INCENP	4	bioid	Lambert JP (2015)	1
AURKC	0	USP19	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LNX1	7	AURKC	0	pull down	Wolting CD (2011)	1
HSP90AA1	7	SRPK1	2	affinity chromatography technology	Taipale M (2012)	1
CDC37	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
SRPK1	2	AURKC	0	enzymatic study	Varjosalo M (2013)	1
AURKC	0	CDC37	0	affinity chromatography technology	Huttlin EL (2015)	1
LNX1	7	AURKB	2	pull down	Wolting CD (2011)	1
HSP90AA1	7	AURKC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2015), Huttlin EL (2017)	3
HSP90AA1	7	LNX1	7	affinity chromatography technology	Taipale M (2012)	1
FKBP5	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
BRCA1	7	CDC37	0	affinity chromatography technology	Ertych N (2016)	1
AURKB	2	CENPA	0	enzymatic study, enzymatic study, enzymatic study	Fernandez-Miranda G (2010), Sun L (2010), Zeitlin SG (2001)	3
BIRC5	1	AURKB	2	two hybrid, pull down, genetic interference, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wheatley SP (2001), Chen J (2003), Chen J (2003), Wheatley SP (2001), Xu Z (2009), Maerki S (2009), Knauer SK (2006), Knauer SK (2006), Ban R (2011), Sun L (2008), Noton EA (2006), Noton EA (2006), Fu J (2009), Gomez V (2010)	14
AURKC	0	CENPA	0	enzymatic study	Fernandez-Miranda G (2010)	1
3327	0	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
CDC37	0	AURKB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Huttlin EL (2015)	3
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
HSP90AB1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erazo T (2013), Erazo T (2013), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Li J (2013), Karras GI (2017), Synoradzki K (2015)	10
INCENP	4	AURKC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2004), Huttlin EL (2015), Huttlin EL (2017)	3
AURKB	2	3323	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AA1	7	BIRC5	1	affinity chromatography technology	Plescia J (2005)	1
BRCA1	7	AURKC	0	two hybrid	Woods NT (2012)	1
NEDD4L	3	AURKC	0	enzymatic study	Persaud A (2009)	1
HSP90AA1	7	AURKB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012), Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	5
AURKC	0	730211	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FKBP5	0	HSP90AA1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nair SC (1997), Nair SC (1997), Li J (2011), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Ni L (2010), Luo K (2017)	13
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
AURKC	0	HIST1H3A	3	enzymatic study	Li X (2004)	1
AURKC	0	3327	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKC	0	MYH1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKB	2	AURKC	0	affinity chromatography technology, biochemical	Li X (2004), Li X (2004)	2
BIRC5	1	INCENP	4	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Wheatley SP (2001), Wheatley SP (2001), Xu Z (2009), Vader G (2006), Knauer SK (2006), Knauer SK (2006), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Klein UR (2006), Huttlin EL (2017)	11
AURKB	2	HIST1H3A	3	pull down, enzymatic study, enzymatic study, enzymatic study	Han A (2011), Han A (2011), Sun L (2008), Zeitlin SG (2001)	4
AURKC	0	BIRC5	1	two hybrid	Wang J (2011)	1
AURKC	0	TACC2	4	two hybrid	Tien AC (2004)	1
AURKC	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK5	0	HSP90AB1	2	affinity chromatography technology	Varjosalo M (2013)	1
AURKC	0	TUBB8	2	affinity chromatography technology	Huttlin EL (2015)	1
AURKC	0	MYH8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	HSP90AB1	2	affinity chromatography technology	Ertych N (2016)	1
AURKB	2	730211	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2