PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SULT1E1	0	COPS6	0	two hybrid	Stelzl U (2005)	1
SULT1E1	0	RBM48	1	two hybrid	Stelzl U (2005)	1
SULT1E1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
SULT1E1	0	AGL	4	biochemical	Wan C (2015)	1
SULT1E1	0	ENOX1	3	two hybrid	Rual JF (2005)	1
UNC119	4	PDE9A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	EEF1A1	0	affinity chromatography technology	Fogeron ML (2013)	1
SULT1E1	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
SULT1E1	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
SULT1E1	0	EEF1A1	0	two hybrid	Stelzl U (2005)	1
SULT1E1	0	GK	0	biochemical	Wan C (2015)	1
SULT1E1	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
SULT1E1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
SULT1E1	0	SULT2B1	0	two hybrid	Rual JF (2005)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
SULT1E1	0	TP53	0	two hybrid	Stelzl U (2005)	1
PDE9A	4	SULT1E1	0	two hybrid	Rolland T (2014)	1