PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IRF9	0	STAT2	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Horvath CM (1996), Horvath CM (1996), Martinez-Moczygemba M (1997), Martinez-Moczygemba M (1997), Li S (2011), Huttlin EL (2017)	6
STAT2	2	DPP9	4	affinity chromatography technology	Huttlin EL (2017)	1
PML	7	STAT1	1	affinity chromatography technology, affinity chromatography technology	Chen Y (2015), Kim YE (2015)	2
IFNAR2	1	IRF9	0	affinity chromatography technology	Tang X (2007)	1
STAT2	2	FBXO45	1	affinity chromatography technology	Huttlin EL (2017)	1
EP300	36	GAA	3	two hybrid	Wang J (2011)	1
STAT2	2	MYCBP2	11	affinity chromatography technology	Huttlin EL (2017)	1
STAT2	2	TRRAP	31	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	SMARCC1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
PML	7	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Matsuzaki K (2003), Doucas V (1999), Doucas V (1999), Zhong S (1999), Chen Y (2015)	7
SMARCA4	19	SMARCC1	5	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sif S (2001), Wang W (1996), Otsuki T (2001), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Inayoshi Y (2006), Inayoshi Y (2006), Pal S (2003), Pal S (2003), Bultman SJ (2005), Nagl NG (2005), Mahajan MC (2005), Trotter KW (2008), Dallas PB (1998), Tando T (2010), Tando T (2010), Bartlett C (2011), Bartlett C (2011), Oh J (2008), Oh J (2008), Havugimana PC (2012), Wan C (2015)	25
ZNF692	3	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
TRRAP	31	MED14	0	biochemical	Meyer KD (2008)	1
IFNAR1	4	STAT6	1	affinity chromatography technology	Gupta S (1999)	1
XPO1	8	INPPL1	6	affinity chromatography technology	Kirli K (2015)	1
SMARCA4	19	STAT2	2	affinity chromatography technology, pull down, affinity chromatography technology	Huang M (2002), Huang M (2002), Huang M (2002)	3
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
IFNAR2	1	STAT2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Li X (1997), Nguyen VP (2002), Nguyen VP (2002), Tang X (2007)	4
RCAN1	0	HSP90AA1	7	affinity chromatography technology	Lee JY (2009)	1
XPO1	8	IWS1	3	affinity chromatography technology	Kirli K (2015)	1
STAT2	2	TACC1	2	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	STAT1	1	unspecified method, affinity chromatography technology	Xu D (2012), Kirli K (2015)	2
SMARCA4	19	STAT1	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Ni Z (2005), Cheng MB (2010), Zhang Y (2010)	3
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
STAT2	2	EP300	36	pull down, pull down, pull down	Paulson M (1999), Matt T (2004), Zhang J (2008)	3
CDH1	4	EP300	36	affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005)	2
SMARCC2	9	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Nagl NG (2005), Mak AB (2010), Havugimana PC (2012), Wan C (2015), Dallas PB (1998), Huttlin EL (2017)	10
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
IARS2	2	STAT2	2	affinity chromatography technology	Huttlin EL (2017)	1
AURKA	1	STAT2	2	pull down	Kamran M (2017)	1
RCAN1	0	STAT2	2	affinity chromatography technology, affinity chromatography technology	Lee JW (2012), Lee JW (2012)	2
GAA	3	STAT2	2	two hybrid	Wang J (2011)	1
IWS1	3	STAT2	2	two hybrid	Wang J (2011)	1
STAT2	2	UBR4	15	affinity chromatography technology	Morrison J (2013)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
XPO1	8	SMARCE1	1	affinity chromatography technology	Kirli K (2015)	1
HSP90AA1	7	KLHL10	1	affinity chromatography technology	Taipale M (2012)	1
XPO1	8	STAT2	2	affinity chromatography technology	Kirli K (2015)	1
STAT2	2	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
STAT2	2	SMARCC2	9	affinity chromatography technology	Huang M (2002)	1
HSPB1	2	SMARCA4	19	two hybrid	Katsogiannou M (2014)	1
CDH1	4	INPPL1	6	bioid	Guo Z (2014)	1
HSP90AA1	7	IARS2	2	affinity chromatography technology	Falsone SF (2005)	1
HSPB1	2	XPO1	8	two hybrid	Katsogiannou M (2014)	1
HSPB1	2	IARS2	2	two hybrid	Katsogiannou M (2014)	1
ELAVL1	0	FBXO11	14	affinity chromatography technology	Abdelmohsen K (2009)	1
PML	7	EGFR	5	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Kuo HY (2013), Kuo HY (2013), Kuo HY (2013), Kuo HY (2013)	4
IRF9	0	STAT1	1	two hybrid, pull down	Horvath CM (1996), Horvath CM (1996)	2
EGFR	5	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Pesesse X (2001), Sanada F (2009)	2
STAT2	2	INPPL1	6	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	DOK4	3	unspecified method	Jones RB (2006)	1
ELAVL1	0	SMARCC2	9	affinity chromatography technology	Abdelmohsen K (2009)	1
HSPB1	2	HSP90AA1	7	two hybrid	Katsogiannou M (2014)	1
KLHL10	1	STAT2	2	affinity chromatography technology	Huttlin EL (2017)	1
IFNAR2	1	CREBBP	29	affinity chromatography technology	Tang X (2007)	1
EGFR	5	STAT2	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ELAVL1	0	IRF9	0	affinity chromatography technology	Abdelmohsen K (2009)	1
USP1	4	STAT2	2	affinity chromatography technology	Huttlin EL (2017)	1
STAT2	2	ZNF692	3	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
XPO1	8	AURKA	1	affinity chromatography technology	Kirli K (2015)	1
IFNAR2	1	STAT1	1	pull down, pull down	Li X (1997), Usacheva A (2001)	2
STAT6	1	STAT2	2	affinity chromatography technology	Gupta S (1999)	1
DOK4	3	STAT2	2	two hybrid	Grossmann A (2015)	1
CDH1	4	STAT1	1	bioid	Guo Z (2014)	1
ELAVL1	0	STAT2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SMARCE1	1	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Lai D (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Mak AB (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
FAM196A	1	STAT2	2	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	STAT2	2	bioid	Guo Z (2014)	1
TACC1	2	AURKA	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Delaval B (2004), Conte N (2003), Tien AC (2004)	3
MED14	0	STAT2	2	affinity chromatography technology, pull down	Lau JF (2003), Lau JF (2003)	2
SMARCA4	19	CREBBP	29	genetic interference	DiRenzo J (2000)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
HSP90AA1	7	STAT2	2	affinity chromatography technology	Taipale M (2012)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
EP300	36	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Paulson M (1999), Hiroi M (2003), Ray S (2002), Strassheim D (2009), Liu X (2008), Ghosh AK (2001), Yang WS (2005), Zhang Y (2015), Kotla S (2015), Kotla S (2015)	10
STAT2	2	EP400	19	affinity chromatography technology	Huttlin EL (2017)	1
LIPT1	1	STAT2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STAT2	2	SELENOO	4	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005)	2
SMARCA4	19	EP400	19	biochemical	Wan C (2015)	1
PML	7	STAT2	2	affinity chromatography technology	Kim YE (2015)	1
PML	7	AURKA	1	affinity chromatography technology, affinity chromatography technology	Xu ZX (2005), Xu ZX (2005)	2
USP1	4	HSPB1	2	affinity chromatography technology	Sowa ME (2009)	1
GYPA	0	STAT2	2	affinity chromatography technology	Huttlin EL (2017)	1
AURKA	1	TRRAP	31	pull down	Kamran M (2017)	1
SMARCA4	19	SMARCE1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Wang W (1996), Zhao K (1998), Zhao K (1998), Hu K (2006), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Bultman SJ (2005), Battaglioli E (2002), ONeill DW (2000), Tando T (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	18
CREBBP	29	STAT2	2	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Bhattacharya S (1996), Bhattacharya S (1996), Bhattacharya S (1996), Bhattacharya S (1996), Huttlin EL (2017), Lindstroem I (2017)	6
CREBBP	29	STAT1	1	pull down, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Zhang JJ (1996), Zhang JJ (1996), Horvai AE (1997), Horvai AE (1997), Ma Z (2005), Vaelineva T (2005), Strassheim D (2009), Kraemer OH (2006), Kraemer OH (2006), Jansma AL (2014), Chen Y (2015)	11
CDH1	4	HSP90AA1	7	affinity chromatography technology	Catimel B (2005)	1
SMARCA4	19	PML	7	imaging technique	Chuang YS (2011)	1
HSPB1	2	STAT2	2	affinity chromatography technology	Gibert B (2012)	1
CREBBP	29	IRF9	0	affinity chromatography technology	Tang X (2007)	1
TRRAP	31	EP400	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fuchs M (2001), Fuchs M (2001), Fuchs M (2001), Hein MY (2015), Cheng J (2017)	5
STAT1	1	STAT2	2	biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (1996), Dumler I (1999), Dumler I (1999), Dumler I (1999), Fagerlund R (2002), Tang X (2007), Gupta S (1999), Liu B (1998), Huttlin EL (2017)	9
STAT2	2	SMARCE1	1	affinity chromatography technology	Huang M (2002)	1
EGFR	5	UBR4	15	affinity chromatography technology	Tong J (2014)	1
AURKA	1	HSP90AA1	7	affinity chromatography technology	Fogeron ML (2013)	1
SMARCE1	1	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Chen J (2005), Keppler BR (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	15
STAT6	1	EP300	36	genetic interference, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	McDonald C (1999), McDonald C (1999), Cui X (2007), Cui X (2007), Qiu R (2013), Qiu R (2013), Qiu R (2013), Qiu R (2013)	8
EGFR	5	HSPB1	2	affinity chromatography technology	Li J (2013)	1
STAT6	1	CREBBP	29	pull down, genetic interference, affinity chromatography technology	Litterst CM (2001), McDonald C (1999), Vaelineva T (2005)	3
FBXO45	1	MYCBP2	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saiga T (2009), Saiga T (2009), Chen X (2014), Chen X (2014), Chen X (2014), Chung FZ (2014), Chung FZ (2014), Chung FZ (2014), Boldt K (2016)	9
STAT2	2	SMARCC1	5	affinity chromatography technology	Huang M (2002)	1
IFNAR1	4	IFNAR2	1	imaging technique, affinity chromatography technology	Wilmes S (2015), Zheng H (2013)	2
ELAVL1	0	DOK4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SMARCA4	19	SMARCC2	9	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wang W (1996), Otsuki T (2001), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Trotter KW (2008), Tando T (2010), Mak AB (2010), Nishimoto N (2012), Nishimoto N (2012), Havugimana PC (2012), Wan C (2015), Dallas PB (1998), Huttlin EL (2017)	15
EGFR	5	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Olayioye MA (1999), Xia L (2002), Andl CD (2004), Foerster S (2013), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	8
FNTA	0	STAT2	2	two hybrid	Wang J (2011)	1
IFNAR1	4	STAT2	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Li X (1997), Uddin S (1995), Yan H (1996), Fagerlie SR (2004)	4