PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	HIF1AN	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PAFAH1B2	2	ZFP36L1	1	two hybrid	Stelzl U (2005)	1
AKT1	1	ZFP36L1	1	enzymatic study	Benjamin D (2006)	1
TINF2	1	TERF1	1	affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Stelzl U (2005), Kim SH (1999), Kim SH (1999), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Tan R (2017)	18
ZFP36L1	1	DCP2	0	affinity chromatography technology	Maitra S (2008)	1
ZFP36L1	1	MAPK14	0	two hybrid, affinity chromatography technology, enzymatic study	Rual JF (2005), Rual JF (2005), Benjamin D (2006)	3
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
XPO1	8	HIF1AN	0	affinity chromatography technology	Kirli K (2015)	1
HIF1AN	0	ZFP36L1	1	affinity chromatography technology	Rodriguez J (2016)	1
ACD	1	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
RBM8A	2	ZFP36L1	1	affinity chromatography technology	Yamashita A (2009)	1
ELAVL1	0	MAPKAPK2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
AKT1	1	MAPK14	0	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Rane MJ (2001), Rane MJ (2001), Hartman AD (2006), Rane MJ (2001), Rane MJ (2001), Ivanov AA (2017)	6
ELAVL1	0	CNOT6	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	CNOT6	2	affinity chromatography technology	Rodriguez J (2016)	1
YWHAB	1	PAFAH1B2	2	biochemical	Kristensen AR (2012)	1
XPO1	8	ZFP36L1	1	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	ACD	1	affinity chromatography technology	Kirli K (2015)	1
EGLN3	0	ACD	1	affinity chromatography technology	Rodriguez J (2016)	1
ELAVL1	0	YWHAB	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TINF2	1	ZFP36L1	1	two hybrid	Lee OH (2011)	1
POT1	2	ACD	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Liu J (2015), Hein MY (2015), Huttlin EL (2017)	12
ELAVL1	0	DCP2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPKAPK2	1	MAPK14	0	affinity chromatography technology, protein complementation assay, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Rane MJ (2001), Srivastav RK (2011), Wang J (2011), Varjosalo M (2013), Rane MJ (2001), White A (2007), ter Haar E (2007), Varjosalo M (2013), Gum RJ (1999), Gum RJ (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Smith JA (2000), Huttlin EL (2017)	16
EGLN3	0	DCP2	0	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	MAPKAPK2	1	affinity chromatography technology	Kirli K (2015)	1
EGLN3	0	ZFP36L1	1	affinity chromatography technology	Rodriguez J (2016)	1
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
TERF1	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
TERF1	1	ZFP36L1	1	two hybrid	Lee OH (2011)	1
ELAVL1	0	ZFP36L1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
EGLN3	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
AKT1	1	MAPKAPK2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, imaging technique	Rane MJ (2001), Rane MJ (2001), Rane MJ (2001), Rane MJ (2001), Wu R (2007), Wu R (2007), Chen TC (2014)	7
POT1	2	ZFP36L1	1	two hybrid	Lee OH (2011)	1
ZFP36L1	1	CNOT6	2	affinity chromatography technology	Maitra S (2008)	1
ACD	1	ZFP36L1	1	two hybrid	Lee OH (2011)	1
ZFP36L1	1	YWHAB	1	pull down	Benjamin D (2006)	1
ZFP36L1	1	EXOSC2	2	affinity chromatography technology	Maitra S (2008)	1
TINF2	1	ACD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	11
MAPKAPK2	1	ZFP36L1	1	enzymatic study, enzymatic study	Benjamin D (2006), Maitra S (2008)	2