PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SSX2	0	RNF2	1	pull down	Barco R (2009)	1
SSX2	0	SMARCA5	4	affinity chromatography technology	Su L (2012)	1
SSX2	0	AMD1	2	affinity chromatography technology	Huttlin EL (2017)	1
RNF2	1	HDAC2	1	affinity chromatography technology	Cao Q (2014)	1
SSX2	0	EZH2	4	affinity chromatography technology, affinity chromatography technology	Su L (2012), Su L (2012)	2
SSX2IP	0	KRT40	0	two hybrid	Rolland T (2014)	1
SSX2	0	CUL7	4	affinity chromatography technology	Huttlin EL (2017)	1
SSX2	0	KIF3A	4	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	LYRM7	0	affinity chromatography technology	Fei T (2017)	1
EZH2	4	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	van der Vlag J (1999), van der Vlag J (1999), Caretti G (2004), Tong ZT (2012), Tong ZT (2012), Su L (2012), Su L (2012), Wan C (2015)	8
TLE1	6	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn JW (2009), Ahn JW (2009), Su L (2012), Su L (2012)	4
EED	1	RNF2	1	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014)	4
SSX2	0	CDK5RAP2	3	affinity chromatography technology	Huttlin EL (2017)	1
CDK5RAP2	3	AKAP9	13	affinity chromatography technology	Wang Z (2010)	1
SMARCA2	17	HDAC1	4	biochemical, affinity chromatography technology, affinity chromatography technology	Sif S (2001), Nakamura T (2002), Hein MY (2015)	3
SUZ12	0	SMARCA5	4	affinity chromatography technology	Cao Q (2014)	1
HNRNPL	3	SSX2	0	affinity chromatography technology	Fei T (2017)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
SSX2	0	ZBED1	0	two hybrid	Rolland T (2014)	1
CUL7	4	HNRNPL	3	affinity chromatography technology	Hanson D (2014)	1
SSX2	0	TAX1BP1	3	two hybrid	Rolland T (2014)	1
SSX3	0	SSX2B	0	affinity chromatography technology	Huttlin EL (2017)	1
EZH2	4	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	van der Vlag J (1999), van der Vlag J (1999), Tong ZT (2012), Tong ZT (2012), Wan C (2015)	5
PRKAR2B	1	AKAP9	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
HNRNPL	3	RAB3IP	0	affinity chromatography technology	Fei T (2017)	1
EED	1	SMARCA5	4	affinity chromatography technology	Cao Q (2014)	1
SSX2	0	AKAP9	13	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
SSX2	0	SSX3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EED	1	SMARCA2	17	affinity chromatography technology	Cao Q (2014)	1
SSX2	0	LYRM7	0	affinity chromatography technology	Huttlin EL (2017)	1
SUZ12	0	AKAP9	13	affinity chromatography technology	Cao Q (2014)	1
SSX2	0	SSX2IP	0	two hybrid	Rolland T (2014)	1
SSX2	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Su L (2012), Su L (2012)	2
SSX2	0	KRT40	0	two hybrid	Rolland T (2014)	1
SSX2	0	MAGEC2	0	two hybrid	Rolland T (2014)	1
SSX2	0	PRKAR2B	1	affinity chromatography technology	Huttlin EL (2017)	1
HDAC2	1	SUZ12	0	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Pasini D (2010), Wan C (2015)	3
EED	1	SUZ12	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Sarma K (2008), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Chan YS (2013), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	22
EED	1	HDAC2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Cao Q (2014)	6
SSX2	0	ZMIZ2	1	two hybrid	Rolland T (2014)	1
SSX2	0	SMARCA2	17	affinity chromatography technology, affinity chromatography technology	Nagai M (2001), Su L (2012)	2
HDAC1	4	SMARCA5	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
EZH2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su IH (2005), Aoto T (2008), Hansen KH (2008), Li G (2010), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Pasini D (2008), Sarma K (2008), Xu B (2011), Xu B (2011), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Lee ST (2011), Havugimana PC (2012), Sahasrabuddhe AA (2014), Wang L (2013), Wu L (2013), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Bhatnagar S (2014), Bhatnagar S (2014), Zhao R (2015), Wienken M (2016), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Mahara S (2016), Hauri S (2016), Hauri S (2016)	40
CUL7	4	SMARCA5	4	affinity chromatography technology	Hanson D (2014)	1
HNRNPL	3	AMD1	2	affinity chromatography technology	Fei T (2017)	1
SUZ12	0	RNF2	1	affinity chromatography technology	Cao Q (2014)	1
SSX3	0	SSX7	0	affinity chromatography technology	Huttlin EL (2017)	1
SUZ12	0	HDAC1	4	affinity chromatography technology, biochemical	Cao Q (2014), Wan C (2015)	2
SSX2	0	METTL18	4	affinity chromatography technology	Huttlin EL (2017)	1
SSX2	0	HDAC2	1	affinity chromatography technology	Su L (2012)	1
EZH2	4	TLE1	6	affinity chromatography technology, affinity chromatography technology	Su L (2012), Su L (2012)	2
RNF2	1	HNRNPL	3	affinity chromatography technology	Cao Q (2014)	1
SSX2	0	EED	1	affinity chromatography technology	Su L (2012)	1
BLZF1	0	AKAP9	13	two hybrid	Rolland T (2014)	1
EZH2	4	EED	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Lohuizen M (1998), van Lohuizen M (1998), van Lohuizen M (1998), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Pasini D (2004), Cao R (2004), Su IH (2005), Hansen KH (2008), Margueron R (2008), Margueron R (2008), Shen X (2008), Shen X (2008), Hernandez-Munoz I (2005), Sarma K (2008), Sarma K (2008), Han Z (2007), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Satijn DP (2001), Satijn DP (2001), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Wang L (2013), Wu L (2013), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Chan YS (2013), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	49
CUL7	4	HDAC2	1	affinity chromatography technology	Hanson D (2014)	1
SSX2	0	SSX2B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SSX2	0	SSX7	0	affinity chromatography technology	Huttlin EL (2017)	1
PRKAR2B	1	CDK5RAP2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
RNF2	1	SMARCA5	4	affinity chromatography technology	Cao Q (2014)	1
SSX3	0	SSX2IP	0	two hybrid	Rolland T (2014)	1
SSX2	0	SSX5	1	affinity chromatography technology	Huttlin EL (2017)	1
SSX2	0	RAB3IP	0	two hybrid	Rolland T (2014)	1
SSX2	0	SYCE1	0	two hybrid	Rolland T (2014)	1
SMARCA5	4	HDAC2	1	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, biochemical, biochemical	Hakimi MA (2002), Hakimi MA (2002), Zhou J (2005), Zhou J (2005), Zhou J (2005), Havugimana PC (2012), Wan C (2015)	7
SSX2	0	SUZ12	0	affinity chromatography technology	Su L (2012)	1
EED	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Hein MY (2015)	4
EED	1	HNRNPL	3	affinity chromatography technology	Cao Q (2014)	1
SSX2	0	BLZF1	0	two hybrid	Rolland T (2014)	1
SSX2	0	SESTD1	1	affinity chromatography technology	Huttlin EL (2017)	1
SSX2	0	TLE1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su L (2012), Su L (2012), Su L (2012)	3
SMARCA2	17	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology	Sif S (2001), Pal S (2003), Nakamura T (2002)	3
RNF2	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014)	2
SSX2	0	280657	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB3IP	0	KRT40	0	two hybrid	Rolland T (2014)	1
HNRNPL	3	SMARCA2	17	affinity chromatography technology	Fei T (2017)	1
TLE1	6	ATF2	1	affinity chromatography technology, affinity chromatography technology	Su L (2012), Su L (2012)	2
SUZ12	0	CDK5RAP2	3	affinity chromatography technology	Cao Q (2014)	1
SSX2	0	ATF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Su L (2012), Su L (2012), Su L (2012), Su L (2012)	4
RNF2	1	AKAP9	13	affinity chromatography technology	Cao Q (2014)	1