Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SREBF2 rs2228314 GG simvastatin efficacy no No association was found between this SNP and response (change in total cholesterol, LDL-cholesterol, trigylcerides). Please note; variant was described as SREBF-2 1784A>G, no rsID was provided, and was genotyped using MspI restriction enzyme digest - this location maps to this rsID however it is a G>C change and the C abolishes a MspI enzyme site. Genotype GG is not associated with response to simvastatin in people with Hypercholesterolemia as compared to genotypes CC + CG. 16158080 982046193