PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TERF2	2	PRMT5	3	affinity chromatography technology	Giannone RJ (2010)	1
TRIM25	5	UBXN6	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Choudhury NR (2017)	2
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
MYH9	19	PPP1CB	9	affinity chromatography technology	Hein MY (2015)	1
SMAD9	0	TERF1	1	two hybrid	Colland F (2004)	1
IQGAP1	1	DBN1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
DTNBP1	1	DCTN1	6	two hybrid	Camargo LM (2007)	1
ITGB4	11	ERBIN	5	two hybrid, pull down	Favre B (2001), Favre B (2001)	2
DYNLT1	3	ADD1	8	bioid	Gupta GD (2015)	1
ANLN	2	MYH9	19	affinity chromatography technology	Hein MY (2015)	1
SIRT7	1	G3BP1	4	affinity chromatography technology	Tsai YC (2012)	1
MED4	2	EXOC1	3	affinity chromatography technology	Lambert JP (2015)	1
MYO18A	7	DBN1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
DISC1	6	TNIK	4	two hybrid	Camargo LM (2007)	1
COPS7B	0	DST	13	affinity chromatography technology	Huttlin EL (2017)	1
MYH9	19	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
ANLN	2	DST	13	affinity chromatography technology	Hein MY (2015)	1
G3BP1	4	MAPRE1	0	affinity chromatography technology	Jain S (2016)	1
APC	5	ERBIN	5	two hybrid, unspecified method	Bandyopadhyay S (2010), Boisguerin P (2004)	2
LIMA1	4	IQGAP1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
OBSL1	9	MCM2	3	affinity chromatography technology	Hanson D (2014)	1
TERF1	1	MCM2	3	two hybrid	Lee OH (2011)	1
GAN	4	MYO18A	7	affinity chromatography technology	Johnson-Kerner BL (2015)	1
STK3	1	MOB1A	2	enzymatic study, affinity chromatography technology, bioid, affinity chromatography technology	Hirabayashi S (2008), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	4
STK3	1	MOB1B	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid	Bao Y (2009), Bao Y (2009), Couzens AL (2013), Couzens AL (2013)	4
ITSN2	7	DST	13	two hybrid	Wong KA (2012)	1
DST	13	ERBIN	5	two hybrid, pull down	Favre B (2001), Favre B (2001)	2
UNK	3	CALM1	0	affinity chromatography technology	Murn J (2015)	1
PPP1CB	9	PAK2	0	affinity chromatography technology	Zhang H (2013)	1
UNK	3	MAPRE1	0	affinity chromatography technology	Murn J (2015)	1
CDK2	0	PPP1CB	9	affinity chromatography technology	Hein MY (2015)	1
MMS19	5	ADD1	8	affinity chromatography technology	Stehling O (2012)	1
OBSL1	9	CDC5L	2	affinity chromatography technology	Hanson D (2014)	1
APC	5	DST	13	two hybrid	Bandyopadhyay S (2010)	1
PRKD2	3	DST	13	two hybrid	Colland F (2004)	1
G3BP1	4	PRMT5	3	affinity chromatography technology	Jain S (2016)	1
MED4	2	DST	13	bioid	Lambert JP (2015)	1
PPP1CB	9	CAPZA2	1	affinity chromatography technology	Hein MY (2015)	1
TMEM17	0	DST	13	bioid	Gupta GD (2015)	1
GAN	4	PRMT5	3	affinity chromatography technology	Johnson-Kerner BL (2015)	1
TRIM25	5	DST	13	affinity chromatography technology	Choudhury NR (2017)	1
ANLN	2	PPP1CB	9	affinity chromatography technology	Hein MY (2015)	1
MCM2	3	CAPZA2	1	affinity chromatography technology	Drissi R (2015)	1
TRIM25	5	DCTN1	6	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	DST	13	affinity chromatography technology	So J (2015)	1
SH3BP5	0	DST	13	two hybrid	Camargo LM (2007)	1
MAGEA1	0	DST	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC8	1	LIMA1	4	affinity chromatography technology	Hanson D (2014)	1
TRIM25	5	ANLN	2	affinity chromatography technology	Choudhury NR (2017)	1
MYO18A	7	MYH9	19	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
OBSL1	9	CAPZA2	1	affinity chromatography technology	Hanson D (2014)	1
GAN	4	CELSR3	16	affinity chromatography technology	Johnson-Kerner BL (2015)	1
ADD1	8	CALM1	0	genetic interference	Kuhlman PA (1996)	1
TMEM17	0	TNIK	4	bioid	Gupta GD (2015)	1
SIRT7	1	DST	13	affinity chromatography technology	Tsai YC (2012)	1
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
CDH1	4	LIMA1	4	bioid	Guo Z (2014)	1
CELSR3	16	DST	13	two hybrid	Nakayama M (2002)	1
CDK2	0	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
MED4	2	TRIM25	5	bioid	Lambert JP (2015)	1
MOB1A	2	DST	13	bioid	Couzens AL (2013)	1
CDH1	4	ADD1	8	bioid	Guo Z (2014)	1
DBN1	1	ERBIN	5	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	CAPZA2	1	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	MYH9	19	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Hein MY (2015)	2
TERF1	1	MYH9	19	affinity chromatography technology	Giannone RJ (2010)	1
OBSL1	9	DST	13	affinity chromatography technology	Hanson D (2014)	1
TRIM25	5	PPP1CB	9	affinity chromatography technology	Choudhury NR (2017)	1
MAPK6	1	DBN1	1	two hybrid	Vinayagam A (2011)	1
TMEM17	0	ERBIN	5	bioid	Gupta GD (2015)	1
IQGAP1	1	CAPZA2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
UBXN6	1	LIMA1	4	affinity chromatography technology	Haines DS (2012)	1
ANLN	2	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
CCDC8	1	DST	13	affinity chromatography technology	Hanson D (2014)	1
DBN1	1	DST	13	affinity chromatography technology	Hein MY (2015)	1
CDC5L	2	MYH9	19	affinity chromatography technology	Lleres D (2010)	1
MCM2	3	DST	13	affinity chromatography technology	Drissi R (2015)	1
TERF2	2	MYH9	19	affinity chromatography technology	Giannone RJ (2010)	1
MYO18A	7	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
G3BP1	4	CDC5L	2	affinity chromatography technology	Jain S (2016)	1
DCTN1	6	MAPRE1	0	bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Hein MY (2015), Boldt K (2016)	3
UNK	3	DST	13	affinity chromatography technology	Murn J (2015)	1
CDH1	4	MAPRE1	0	bioid	Guo Z (2014)	1
ANLN	2	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
MAPRE1	0	DBN1	1	affinity chromatography technology	Hein MY (2015)	1
CDK2	0	NFYC	0	affinity chromatography technology	Yun J (2003)	1
TERF2	2	DST	13	affinity chromatography technology	Giannone RJ (2010)	1
COL17A1	3	DST	13	imaging technique, two hybrid, two hybrid	Koster J (2003), Koster J (2003), Hopkinson SB (2000)	3
MCM2	3	CALM1	0	affinity chromatography technology	Drissi R (2015)	1
DISC1	6	CDC5L	2	two hybrid	Camargo LM (2007)	1
SIRT7	1	KIAA0368	0	affinity chromatography technology	Tsai YC (2012)	1
TRIM25	5	KIAA1549	10	affinity chromatography technology	Choudhury NR (2017)	1
CAPZA2	1	DCTN1	6	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Hein MY (2015), Huttlin EL (2017)	4
CDC5L	2	DST	13	two hybrid	Camargo LM (2007)	1
LIMA1	4	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
DISC1	6	DST	13	two hybrid	Camargo LM (2007)	1
MCM2	3	G3BP1	4	affinity chromatography technology	Drissi R (2015)	1
SIRT7	1	MYH9	19	affinity chromatography technology	Tsai YC (2012)	1
DTNBP1	1	DST	13	two hybrid	Camargo LM (2007)	1
MOB1B	0	DST	13	bioid	Couzens AL (2013)	1
EXOC1	3	SH3BP5	0	two hybrid	Camargo LM (2007)	1
CDH1	4	ERBIN	5	bioid	Guo Z (2014)	1
CDK2	0	IQGAP1	1	affinity chromatography technology	Neganova I (2011)	1
CDH1	4	COL17A1	3	bioid	Guo Z (2014)	1
LIMA1	4	SH3BP5	0	affinity chromatography technology	Hein MY (2015)	1
UBXN6	1	DST	13	affinity chromatography technology	Haines DS (2012)	1
TERF1	1	PRMT5	3	affinity chromatography technology	Giannone RJ (2010)	1
MAPK6	1	KIAA0368	0	affinity chromatography technology	Rodriguez J (2016)	1
DST	13	DCTN1	6	two hybrid, affinity chromatography technology	Liu JJ (2003), Liu JJ (2003)	2
MAPK6	1	DST	13	two hybrid	Bandyopadhyay S (2010)	1
CEP63	2	DST	13	two hybrid	Camargo LM (2007)	1
SMAD9	0	DST	13	two hybrid	Colland F (2004)	1
MOB1B	0	MOB1A	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
CAPZA2	1	ADD1	8	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	ADD1	8	affinity chromatography technology	Choudhury NR (2017)	1
DST	13	ITGB4	11	two hybrid	Hopkinson SB (2000)	1
CAPZA2	1	DST	13	affinity chromatography technology	Hein MY (2015)	1
KIAA1549	10	ITSN2	7	two hybrid	Nakayama M (2002)	1
TRIM25	5	MAPK6	1	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
MYH9	19	DBN1	1	affinity chromatography technology	Hein MY (2015)	1
DYNLT1	3	DST	13	bioid	Gupta GD (2015)	1
ANLN	2	MYO18A	7	affinity chromatography technology	Hein MY (2015)	1
IQGAP1	1	DST	13	affinity chromatography technology	Hein MY (2015)	1
KIAA0368	0	DCTN1	6	imaging technique	Gorbea C (2010)	1
IQGAP1	1	PPP1CB	9	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
STK3	1	DST	13	affinity chromatography technology	Varjosalo M (2013)	1
ANLN	2	DBN1	1	affinity chromatography technology	Hein MY (2015)	1
DISC1	6	SH3BP5	0	two hybrid	Camargo LM (2007)	1
MYH9	19	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
MYO18A	7	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
MYO18A	7	DST	13	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	DBN1	1	bioid	Guo Z (2014)	1
CDK2	0	MAPRE1	0	affinity chromatography technology	Neganova I (2011)	1
TRIM25	5	IQGAP1	1	affinity chromatography technology	Choudhury NR (2017)	1
CALM1	0	CDC5L	2	pull down, affinity chromatography technology	Shen X (2005), Shen X (2005)	2
MCM2	3	MYH9	19	affinity chromatography technology	Drissi R (2015)	1
CDC5L	2	EXOC1	3	two hybrid, two hybrid	Camargo LM (2007), Camargo LM (2007)	2
TNIK	4	DST	13	two hybrid	Camargo LM (2007)	1
TRAF3IP1	3	EXOC1	3	two hybrid	Camargo LM (2007)	1
DISC1	6	TRAF3IP1	3	two hybrid, affinity chromatography technology, two hybrid	Morris JA (2003), Morris JA (2003), Camargo LM (2007)	3
IQGAP1	1	ADD1	8	affinity chromatography technology	Hein MY (2015)	1
SIRT7	1	PPP1CB	9	affinity chromatography technology	Tsai YC (2012)	1
CDC5L	2	ANLN	2	affinity chromatography technology	Lleres D (2010)	1
ANLN	2	CAPZA2	1	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	PAK2	0	bioid	Guo Z (2014)	1
G3BP1	4	DST	13	affinity chromatography technology	Jain S (2016)	1
MYH9	19	DST	13	affinity chromatography technology	Hein MY (2015)	1
APC	5	MAPRE1	0	pull down, pull down, affinity chromatography technology	Askham JM (2002), Xia P (2012), Hein MY (2015)	3
MMS19	5	DST	13	affinity chromatography technology	Stehling O (2012)	1
PRMT5	3	DST	13	biochemical	Havugimana PC (2012)	1
OBSL1	9	IQGAP1	1	affinity chromatography technology	Hanson D (2014)	1
MYH9	19	CAPZA2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
SIRT7	1	IQGAP1	1	affinity chromatography technology	Tsai YC (2012)	1
CDH1	4	DST	13	bioid	Guo Z (2014)	1
CALM1	0	DST	13	pull down	Shen X (2005)	1
IQGAP1	1	MYO18A	7	affinity chromatography technology	Hein MY (2015)	1
TRAF3IP1	3	DST	13	two hybrid	Camargo LM (2007)	1
CDK2	0	CDC5L	2	enzymatic study	Boudrez A (2000)	1
GAN	4	DST	13	affinity chromatography technology	Johnson-Kerner BL (2015)	1
DISC1	6	DCTN1	6	two hybrid	Camargo LM (2007)	1
CAPZA2	1	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
CALM1	0	IQGAP1	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Z (2003), Briggs MW (2002), Ren JG (2008), Hein MY (2015), Boldt K (2016)	5
OBSL1	9	LIMA1	4	affinity chromatography technology	Hanson D (2014)	1
CDC5L	2	IQGAP1	1	affinity chromatography technology	Lleres D (2010)	1
MAPRE1	0	ADD1	8	affinity chromatography technology	Hein MY (2015)	1
PRKAB2	0	DST	13	two hybrid	Moreno D (2009)	1
KIAA1549	10	DST	13	two hybrid	Nakayama M (2002)	1
MED4	2	ERBIN	5	bioid	Lambert JP (2015)	1
PPP1CB	9	DST	13	affinity chromatography technology	Hein MY (2015)	1
DBN1	1	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
SIRT7	1	PRMT5	3	affinity chromatography technology	Tsai YC (2012)	1
DYNLT1	3	DCTN1	6	bioid	Gupta GD (2015)	1
ADD1	8	DST	13	affinity chromatography technology	Hein MY (2015)	1
MYO18A	7	CAPZA2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
G3BP1	4	CAPZA2	1	affinity chromatography technology	Jain S (2016)	1
PPP1CB	9	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
CEP63	2	MED4	2	bioid	Gupta GD (2015)	1
TRIM25	5	G3BP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017), Jain S (2016)	3
OBSL1	9	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2011), Hanson D (2011), Hanson D (2014), Nie J (2015)	4
440915	0	DST	13	biochemical	Havugimana PC (2012)	1
NFYC	0	DST	13	two hybrid	Bandyopadhyay S (2010)	1
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
UNK	3	PPP1CB	9	affinity chromatography technology	Murn J (2015)	1
LIMA1	4	DBN1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CCDC8	1	TRIM25	5	affinity chromatography technology	Hanson D (2014)	1
CCDC8	1	CAPZA2	1	affinity chromatography technology	Hanson D (2014)	1
MYH9	19	IQGAP1	1	affinity chromatography technology	Hein MY (2015)	1
TMEM17	0	KIAA1549	10	bioid	Gupta GD (2015)	1
CCDC8	1	G3BP1	4	affinity chromatography technology	Hanson D (2014)	1
DTNBP1	1	EXOC1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DTNBP1	1	TRAF3IP1	3	two hybrid, affinity chromatography technology	Camargo LM (2007), Boldt K (2016)	2
COL17A1	3	ITGB4	11	two hybrid, affinity chromatography technology	Aho S (1998), Schaapveld RQ (1998)	2
MAPRE1	0	TERF1	1	pull down, affinity chromatography technology, genetic interference	Nakamura M (2002), Nakamura M (2002), Nakamura M (2002)	3
MAPRE1	0	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	MYH9	19	bioid	Guo Z (2014)	1
MCM2	3	MMS19	5	affinity chromatography technology	Drissi R (2015)	1
MAPRE1	0	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
TERF1	1	DBN1	1	two hybrid	Lee OH (2011)	1
TRAF3IP1	3	CDC5L	2	two hybrid	Camargo LM (2007)	1
CEP63	2	TNIK	4	bioid	Firat-Karalar EN (2014)	1
TRAF3IP1	3	MYH9	19	affinity chromatography technology	Guo CW (2010)	1
MTNR1B	1	DST	13	two hybrid	Benleulmi-Chaachoua A (2016)	1
PPP1CB	9	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
DST	13	KIAA0368	0	two hybrid	Gorbea C (2010)	1
TERF1	1	DST	13	affinity chromatography technology	Giannone RJ (2010)	1
IQGAP1	1	CDH1	4	affinity chromatography technology, pull down, bioid	Li Z (1999), Li Z (1999), Guo Z (2014)	3
PAK2	0	DST	13	two hybrid	Bandyopadhyay S (2010)	1
CDH1	4	ANLN	2	bioid	Guo Z (2014)	1
EXOC1	3	DST	13	two hybrid	Camargo LM (2007)	1
APC	5	TRIM25	5	two hybrid	Arroyo R (2015)	1
MCM2	3	IQGAP1	1	affinity chromatography technology	Drissi R (2015)	1
DISC1	6	CEP63	2	two hybrid, affinity chromatography technology, two hybrid	Morris JA (2003), Morris JA (2003), Camargo LM (2007)	3
PPP1CB	9	DBN1	1	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	MYH9	19	affinity chromatography technology	Choudhury NR (2017)	1
MAPRE1	0	DST	13	affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Buey RM (2012), Buey RM (2012), Hein MY (2015), Huttlin EL (2017)	5
CCDC8	1	MCM2	3	affinity chromatography technology	Hanson D (2014)	1
DISC1	6	EXOC1	3	two hybrid	Camargo LM (2007)	1
CCDC8	1	IQGAP1	1	affinity chromatography technology	Hanson D (2014)	1
CDC5L	2	SH3BP5	0	two hybrid	Camargo LM (2007)	1
CDK2	0	MYO18A	7	affinity chromatography technology	Hein MY (2015)	1
MYO18A	7	PPP1CB	9	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CDK2	0	DBN1	1	affinity chromatography technology	Hein MY (2015)	1
LIMA1	4	DST	13	affinity chromatography technology	Hein MY (2015)	1
DBN1	1	CAPZA2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2