PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCM7	5	FHL2	0	two hybrid	Chan KK (2000)	1
MCM7	5	SP2	3	two hybrid	Rolland T (2014)	1
FHL2	0	BANP	1	two hybrid	Rolland T (2014)	1
IRF1	0	SP2	3	affinity chromatography technology, affinity chromatography technology	Letourneur M (2009), Letourneur M (2009)	2
E2F1	0	SP2	3	affinity chromatography technology, pull down	Rotheneder H (1999), Rotheneder H (1999)	2
SOX2	4	SP2	3	affinity chromatography technology	Cox JL (2013)	1
FHL2	0	SP2	3	two hybrid	Rolland T (2014)	1
SP2	3	BANP	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
FHL2	0	APP	1	pull down	Olah J (2011)	1
ESR1	0	SP2	3	affinity chromatography technology	He S (2005)	1
MCM7	5	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
E2F1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology	Liu W (2012), Liu W (2012)	2
NR0B2	1	SP2	3	affinity chromatography technology, affinity chromatography technology	Das A (2006), Das A (2006)	2
HECW2	13	SP2	3	affinity chromatography technology	Lu L (2013)	1
ESR1	0	FHL2	0	two hybrid	Kobayashi S (2004)	1
NR0B2	1	ESR1	0	two hybrid, pull down, pull down	Seol W (1998), Seol W (1998), Klinge CM (2002)	3
E2F1	0	FHL2	0	two hybrid	Schlisio S (2002)	1
SP2	3	APP	1	pull down	Olah J (2011)	1
NKX3-1	2	SP2	3	two hybrid	Simmons SO (2006)	1
ZDHHC17	1	SP2	3	two hybrid	Butland SL (2014)	1