PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CRK	0	FGFR1	2	imaging technique, affinity chromatography technology, pull down	Chen TC (2014), Larsson H (1999), Larsson H (1999)	3
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
SHC1	0	ANXA2	0	affinity chromatography technology	Brehme M (2009)	1
FGFR1	2	SHC1	0	pull down, affinity chromatography technology	Klint P (1995), Vecchione A (2007)	2
BCR	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Million RP (2000), Million RP (2004), Million RP (2004), Puil L (1994), Puil L (1994), Ma G (1997), Maru Y (1995), Maru Y (1995), Gaston I (2004), Gaston I (2004), Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	13
CBL	7	NCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Erdreich-Epstein A (1999), Miyoshi-Akiyama T (2001), Izadi KD (1998), Izadi KD (1998), Wunderlich L (1999), Shishido T (2000), Okabe S (2006), Adler CE (2000), Adler CE (2000), Buvall L (2013), Buvall L (2013), Buvall L (2013), Buvall L (2013)	13
EGFR	5	CRKL	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
SOS1	5	ABL1	9	affinity chromatography technology	Puil L (1994)	1
EPS8L2	1	ABI1	1	affinity chromatography technology	Offenhaeuser N (2004)	1
SOS1	5	SORBS1	2	affinity chromatography technology	Limpert AS (2007)	1
EPS8	1	GRB2	2	two hybrid	Rolland T (2014)	1
SH3KBP1	1	ABL1	9	affinity chromatography technology	Havrylov S (2009)	1
ABL1	9	PLCG1	6	pull down	Koch A (2000)	1
MUC1	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid, protein complementation assay, affinity chromatography technology, enzymatic study	Schroeder JA (2001), Li Y (2001), Li Y (2001), Pochampalli MR (2007), Merlin J (2011), Merlin J (2011), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Schroeder JA (2001)	10
CBL	7	ABL1	9	affinity chromatography technology, enzymatic study, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, far western blotting, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Soubeyran P (2003), Miyoshi-Akiyama T (2001), Miyoshi-Akiyama T (2001), Miyoshi-Akiyama T (2001), Patel H (2006), Johnson KJ (2009), Shishido T (2000), Shishido T (2000), Shishido T (2000), Gaston I (2004), Jain SK (1997), Reedquist KA (1996), Bhat A (1997), Bhat A (1997), Bhat A (1997), Grossmann AH (2004), Brehme M (2009), Brehme M (2009), Brehme M (2009), Nishihara T (2003), Tsukahara F (2010)	21
BCR	3	ABL1	9	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Ling X (2003), Pendergast AM (1991), Puil L (1994), Puil L (1994), Slupianek A (2011)	5
CSF1R	0	GRB2	2	two hybrid, pull down, affinity chromatography technology	Mancini A (1997), Mancini A (1997), Wang Y (1999)	3
PTPN6	0	LAT	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Matalon O (2016), Matalon O (2016), Matalon O (2016)	3
ABI1	1	SRRM1	2	two hybrid	Wang J (2011)	1
LCK	0	PIK3R1	6	pull down	Kapeller R (1994)	1
NCK2	2	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Chen M (1998), Braverman LE (1999), Tu Y (1998), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
LRRK1	12	BCR	3	affinity chromatography technology	Titz B (2010)	1
NCK2	2	TNIK	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SH3KBP1	1	CRK	0	affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000)	2
SORBS1	2	NCK2	2	affinity chromatography technology	Cowan CA (2001)	1
EPS8L2	1	SOS1	5	affinity chromatography technology	Offenhaeuser N (2004)	1
EGFR	5	PTPN6	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Tomic S (1995), Keilhack H (1998), Keilhack H (1998), Yao Z (2017)	4
TNFRSF1A	3	MUC1	0	affinity chromatography technology	Ahmad R (2007)	1
SOS1	5	LAT	0	imaging technique	Houtman JC (2006)	1
FGFR1	2	PTPN11	20	affinity chromatography technology	Vecchione A (2007)	1
PTPN6	0	BCR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liedtke M (1998), Liedtke M (1998), Li X (2016)	3
SOS1	5	FRS2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foehr ED (2000), Wong A (2002), Kouhara H (1997), Lao DH (2006)	4
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
BCR	3	RAC1	7	pull down	Zhang B (1998)	1
SHC1	0	BCR	3	affinity chromatography technology	Brehme M (2009)	1
PLCG1	6	LAT	0	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Zhang W (1998), Paz PE (2001), Paz PE (2001), Zhang W (1998), Jiang Y (2007), Braiman A (2006), Braiman A (2006), Matalon O (2016), Matalon O (2016)	9
NTRK1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi Y (2011), Emdal KB (2015), Emdal KB (2015)	3
CRK	0	SOS1	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Okada S (1996), Okada S (1996), Okada S (1996), Ingham RJ (1996), Brehme M (2009), Chen TC (2014)	6
FGFR1	2	FRS2	0	pull down, affinity chromatography technology, two hybrid, pull down, two hybrid, x-ray crystallography, enzymatic study, affinity chromatography technology	Yan KS (2002), Ong SH (2000), Xu H (1998), Xu H (1998), Dhalluin C (2000), Dhalluin C (2000), Larsson H (1999), Vecchione A (2007)	8
FRS2	0	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ong SH (1996), Wong A (2002), Meakin SO (1999), Kouhara H (1997), Mason JM (2004), Liu BA (2012), Lao DH (2006), Bisson N (2011), Zhou L (2015)	9
LCK	0	SOS1	5	unspecified method	Tran T (2005)	1
EGFR	5	ITSN2	7	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ABI1	1	CBL	7	affinity chromatography technology	Tanos BE (2007)	1
PTPN6	0	PIK3R1	6	two hybrid	Sathish JG (2001)	1
FRS2	0	NTRK1	1	pull down, two hybrid	Meakin SO (1999), Meakin SO (1999)	2
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
SRRM1	2	SOS1	5	affinity chromatography technology	McCracken S (2005)	1
TNFRSF1A	3	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
NTRK1	1	ANXA2	0	affinity chromatography technology	Emdal KB (2015)	1
HRAS	2	CBL	7	affinity chromatography technology	Lito P (2008)	1
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
CRK	0	BCR	3	pull down, affinity chromatography technology	Ingham RJ (1996), Brehme M (2009)	2
PLCG1	6	SOS1	5	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim MJ (2000), Kim MJ (2000), Kim MJ (2000), Kim MJ (2000), Scholler JK (2000)	5
MET	7	SHC1	0	affinity chromatography technology	Liang Q (1998)	1
NTRK1	1	CRKL	1	affinity chromatography technology	Emdal KB (2015)	1
CBL	7	PLCG1	6	far western blotting, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Tvorogov D (2002), Tvorogov D (2002), Tvorogov D (2002), Graham LJ (1998), Singh AJ (2007), Rellahan BL (2003), Rellahan BL (2003), Okabe S (2006), Choi JH (2003), Choi JH (2003), Braiman A (2006), Braiman A (2006), Braiman A (2006), Chen TC (2014)	14
SOS1	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hadari YR (1998), Chin H (1997), Kapoor GS (2010), Yu WM (2006)	4
NTRK1	1	PLCG1	6	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Ohmichi M (1991), Qian X (1998), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	6
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
CRKL	1	SOS1	5	affinity chromatography technology	Hein MY (2015)	1
LAT	0	PIK3R1	6	affinity chromatography technology, pull down	Paz PE (2001), Paz PE (2001)	2
ITSN1	5	ITSN2	7	protein complementation assay	Wong KA (2012)	1
ABL1	9	SPTAN1	9	pull down, two hybrid	Ziemnicka-Kotula D (1998), Ziemnicka-Kotula D (1998)	2
PLCG1	6	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Matalon O (2016), Matalon O (2016)	2
SOS1	5	BCR	3	affinity chromatography technology, affinity chromatography technology	Puil L (1994), Maru Y (1995)	2
SOS1	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000)	2
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
LAT	0	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Paz PE (2001), Zhang W (1998), Perez-Villar JJ (2002), Motto DG (1994), Houtman JC (2006)	5
ABL1	9	PTPN6	0	affinity chromatography technology	Kharbanda S (1996)	1
LRRK1	12	SHC1	0	affinity chromatography technology	Titz B (2010)	1
NTRK1	1	SHC1	0	two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Qian X (1998), Borrello MG (1994), Nakamura T (2002), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	7
KRAS	1	GRB2	2	genetic interference	Hart T (2015)	1
EGFR	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soubeyran P (2002), Szymkiewicz I (2002), Schmidt MH (2004), Schmidt MH (2003), Ronning SB (2011), Ronning SB (2011), Yang S (2006), Schmidt MH (2003)	8
KRAS	1	SHC1	0	genetic interference	Hart T (2015)	1
NTRK1	1	SPTAN1	9	affinity chromatography technology	Emdal KB (2015)	1
SH3KBP1	1	SRRM1	2	affinity chromatography technology	Havrylov S (2009)	1
LCK	0	LAT	0	biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology	Munoz P (2003), Munoz P (2003), Jiang Y (2007), Jiang Y (2007)	4
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
MUC1	0	GRB2	2	pull down, affinity chromatography technology, two hybrid	Pandey P (1995), Pandey P (1995), Bandyopadhyay S (2010)	3
SOS1	5	SPTAN1	9	two hybrid	Bandyopadhyay S (2010)	1
SHC1	0	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Puil L (1994), Brehme M (2009), Brehme M (2009), Brehme M (2009)	5
NCK2	2	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Buvall L (2013), Buvall L (2013), Huttlin EL (2015), Huttlin EL (2017)	4
PIK3R1	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang S (1999), Takahashi Y (1999), Craddock BL (1997), Wu CJ (2000), Wu CJ (2001), Yu WM (2006)	6
CRKL	1	PTPN11	20	affinity chromatography technology	Chin H (1997)	1
NTRK1	1	SRRM1	2	affinity chromatography technology	Emdal KB (2015)	1
CRKL	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down	Gesbert F (1998), Gelkop S (2001), Ren SY (2005)	3
MUC1	0	SOS1	5	affinity chromatography technology, affinity chromatography technology	Pandey P (1995), Schroeder JA (2001)	2
EPS8L1	6	SOS1	5	affinity chromatography technology	Offenhaeuser N (2004)	1
FYN	1	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Tang H (1999), Chernock RD (2001)	2
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
ABI1	1	ABL1	9	pull down, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology	Tani K (2003), Biesova Z (1997), Yamamoto A (2001), Xiong X (2008), Xiong X (2008), Xiong X (2008)	6
EGFR	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010)	29
NCK1	0	PIK3R1	6	affinity chromatography technology	Gelkop S (2001)	1
FGFR1	2	NCK2	2	two hybrid	Hu Y (2004)	1
CSF1R	0	SOS1	5	affinity chromatography technology, affinity chromatography technology	Wang Y (1999), Wang Y (1999)	2
SOS1	5	ITSN1	5	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Tong XK (2000), Tong XK (2000), Bandyopadhyay S (2010), Tsyba L (2008), Wang JB (2005)	5
FGFR1	2	SOS1	5	imaging technique	Chen TC (2014)	1
GRB2	2	PTPN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Kon-Kozlowski M (1996), Saci A (2002)	3
CBL	7	PTPN6	0	affinity chromatography technology	Kant AM (2002)	1
LAT	0	CBL	7	affinity chromatography technology	Jiang Y (2007)	1
ITSN1	5	PIK3R1	6	two hybrid	Wong KA (2012)	1
LRRK1	12	ABL1	9	affinity chromatography technology	Titz B (2010)	1
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
CSF1R	0	SHC1	0	affinity chromatography technology	Wang Y (1999)	1
NF2	1	EGFR	5	affinity chromatography technology, fluorescent resonance energy transfe	Guerrero PA (2015), Ivanov AA (2017)	2
PIK3R1	6	HRAS	2	affinity chromatography technology, pull down, imaging technique	Hanna AN (1999), Rodriguez-Viciana P (1997), Chen TC (2014)	3
KRAS	1	SOS1	5	genetic interference	Hart T (2015)	1
CBL	7	CSF1R	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mancini A (2002), Mancini A (2002), Mancini A (2002), Wilhelmsen K (2002), Wilhelmsen K (2002), Wang Y (1999), Wang Y (1999), Tanaka S (1995), Ota J (2000), Ota J (2000)	10
SOS1	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian X (2000), Foehr ED (2000), Park RK (1999), Chin H (1997), Wang Y (1999), Brehme M (2009), Brizzi MF (1996), Yu WM (2006), Klint P (1995)	9
BIN1	2	SOS1	5	pull down	Leprince C (1997)	1
NCK2	2	NCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EPS8	1	SOS1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Offenhaeuser N (2004), Scita G (1999), Jeganathan N (2016)	3
ITSN2	7	SH3KBP1	1	two hybrid	Wong KA (2012)	1
SOS1	5	ANXA2	0	pull down	Buday L (1994)	1
MUC1	0	ABL1	9	affinity chromatography technology, enzymatic study	Raina D (2006), Raina D (2006)	2
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
ABI1	1	NCK1	0	pull down, affinity chromatography technology	Yamamoto A (2001), Cowan CA (2001)	2
PIK3R1	6	SH3KBP1	1	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Gout I (2000), Tossidou I (2010), Borthwick EB (2004), Borthwick EB (2004)	4
CBL	7	SPTAN1	9	affinity chromatography technology	Brehme M (2009)	1
SOS1	5	RIT2	1	affinity chromatography technology	Hoshino M (2002)	1
ABL1	9	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, two hybrid, enzymatic study	Brehme M (2009), Brehme M (2009), Brehme M (2009), Peterson ME (2008), Yoshida K (2005), Chen C (2008), Feller SM (1994), Feller SM (1994), Bai RY (1998), Ren J (2002)	10
EGFR	5	EPS8	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Burke P (2001), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
SOS1	5	EGFR	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian X (2000), Qian X (1998), Buday L (1994), Tong J (2009), Kurada BR (2009), Tong J (2008), Foerster S (2013), Tong J (2014), Kapoor GS (2010)	9
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
ABL1	9	EGFR	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
SOS1	5	RAC1	7	affinity chromatography technology	Jeganathan N (2016)	1
EGFR	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology, enzymatic study	Schulze WX (2006), Tomic S (1995), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Kapoor GS (2010), Vogel W (1996)	7
SH3KBP1	1	MET	7	affinity chromatography technology	Petrelli A (2002)	1
FYN	1	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Taher TE (2002), Deckert M (1998), Deckert M (1998), Deckert M (1998), Ghosh AK (2004), Rellahan BL (2003), Boussiotis VA (1997), Andoniou CE (2000), Shishido T (2000), Okabe S (2006), Kaabeche K (2004), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tanaka S (1995), Reedquist KA (1996), Grossmann AH (2004), Panchamoorthy G (1996), Fukazawa T (1995), Fukazawa T (1995), Fukazawa T (1995), Nishio H (2002), Anderson SM (1997), Fukazawa T (1996), Grossmann A (2015)	27
NF2	1	MET	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NTRK1	1	PIK3R1	6	affinity chromatography technology	Emdal KB (2015)	1
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
CRKL	1	SHC1	0	affinity chromatography technology	Chin H (1997)	1
EGFR	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tvorogov D (2002), Bedrin MS (1997), Crovello CS (1998), Choi JH (2003), Jones RB (2006), Tong J (2014), Egan JE (2002), Wu D (2009), Wu D (2009)	9
LRRK1	12	PTPN11	20	affinity chromatography technology	Titz B (2010)	1
SH3BP5	0	SOS1	5	two hybrid	Camargo LM (2007)	1
TNFRSF1A	3	SOS1	5	affinity chromatography technology	Kurada BR (2009)	1
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
FGFR1	2	PLCG1	6	two hybrid, imaging technique, two hybrid, pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Xu H (1998), Chen TC (2014), Hu Y (2004), Shi E (1993), Shi E (1993), Bae JH (2009), Bae JH (2009), Bae JH (2009), Browaeys-Poly E (2010), Browaeys-Poly E (2010), Vecchione A (2007)	11
NF2	1	SOS1	5	affinity chromatography technology	Qian X (2000)	1
LRRK1	12	GRB2	2	affinity chromatography technology, affinity chromatography technology	Titz B (2010), Brehme M (2009)	2
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
SOS1	5	ITSN2	7	two hybrid, two hybrid	Bandyopadhyay S (2010), Wong KA (2012)	2
GRAP	0	SOS1	5	biochemical	Feng GS (1996)	1
SHC1	0	PIK3R1	6	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harrison-Findik D (1995), Ren SY (2005), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Lee DY (2010)	6
CRK	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	Gelkop S (2001), Gelkop S (2001), Garcia-Guzman M (2000), Brehme M (2009), Grossmann A (2015), Chen TC (2014)	6
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
LCK	0	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
LCK	0	CBL	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Rao N (2002), Tsygankov AY (1996), Reedquist KA (1996), Nervi S (2005)	4
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
SOS1	5	ABI1	1	pull down, affinity chromatography technology	Scita G (1999), Scita G (1999)	2
CRK	0	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Larsson H (1999)	2
NTRK1	1	PTPN11	20	affinity chromatography technology	Emdal KB (2015)	1
HRAS	2	SH3KBP1	1	affinity chromatography technology	Lito P (2008)	1
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
TNFRSF1A	3	FYN	1	biochemical	Legler DF (2003)	1
TNIK	4	SOS1	5	two hybrid	Camargo LM (2007)	1
CSF1R	0	PIK3R1	6	affinity chromatography technology, imaging technique	Wang Y (1999), Chen TC (2014)	2
FGFR1	2	CRKL	1	affinity chromatography technology	Seo JH (2009)	1
LAT	0	GRAP	0	affinity chromatography technology, pull down	Zhang W (1998), Perez-Villar JJ (2002)	2
NTRK1	1	ABL1	9	two hybrid, affinity chromatography technology, pull down	Koch A (2000), Yano H (2000), Koch A (2000)	3
EGFR	5	LRRK1	12	affinity chromatography technology	Yao Z (2017)	1
SOS1	5	PTPN6	0	affinity chromatography technology	Kon-Kozlowski M (1996)	1
PTPN6	0	LCK	0	enzymatic study, enzymatic study, pull down	Yu CL (2000), Chiang GG (2001), Lorenz U (1994)	3
NCK1	0	SOS1	5	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Wunderlich L (1999), Hu Q (1995), Hu Q (1995), Okada S (1996), Okada S (1996), Braverman LE (1999)	6
CBL	7	SOS1	5	affinity chromatography technology	Wang Y (1999)	1
ITSN1	5	SH3KBP1	1	affinity chromatography technology	Nikolaienko O (2009)	1
ABL1	9	GRB2	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warmuth M (1997), Ren R (1994), Ren R (1994), Patel H (2006), Johnson KJ (2009), Gaston I (2004), Gaston I (2004), Brehme M (2009), Brehme M (2009), Chen R (2013), Feller SM (1994)	11
TNFRSF1A	3	PIK3R1	6	affinity chromatography technology	Pincheira R (2008)	1
PIK3R1	6	SOS1	5	imaging technique	Chen TC (2014)	1
TNFRSF1A	3	CBL	7	affinity chromatography technology	Narita T (2005)	1
FGFR1	2	NCK1	0	unspecified method	Liu BA (2012)	1
SOS1	5	HRAS	2	x-ray crystallography, x-ray crystallography, affinity chromatography technology	Margarit SM (2003), Boriack-Sjodin PA (1998), Ji H (2016)	3
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
PTPN11	20	PTPN6	0	affinity chromatography technology	Li X (2016)	1
CBL	7	ITSN1	5	far western blotting, two hybrid, affinity chromatography technology, affinity chromatography technology	Martin NP (2006), Thalappilly S (2008), Dergai M (2011), Tsyba L (2008)	4
BCR	3	CRKL	1	affinity chromatography technology, two hybrid, two hybrid, far western blotting, affinity chromatography technology	Heaney C (1997), Heaney C (1997), Kolibaba KS (1999), Kolibaba KS (1999), Million RP (2004)	5
GRB2	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Hildt E (1999), Kurada BR (2009)	2
NCK1	0	ABL1	9	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Miyoshi-Akiyama T (2001), Ren R (1994), Ren R (1994), Wunderlich L (1999), Adler CE (2000)	5
EGFR	5	LAT	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
FRS2	0	SORBS1	2	two hybrid, pull down, affinity chromatography technology	Tomasovic A (2012), Tomasovic A (2012), Tomasovic A (2012)	3
EPS8	1	SHC1	0	affinity chromatography technology, pull down	Matoskova B (1995), Matoskova B (1995)	2
MET	7	CRK	0	affinity chromatography technology	Oh YM (2014)	1
CBL	7	BCR	3	pull down, pull down, affinity chromatography technology, enzymatic study	Gaston I (2004), Panchamoorthy G (1996), Brehme M (2009), Tsukahara F (2010)	4
FYN	1	LAT	0	enzymatic study	Jiang Y (2007)	1
ABL1	9	PIK3R1	6	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Kapeller R (1994), Ren SY (2005), Ren SY (2005), Ren SY (2005), Brehme M (2009)	5
KRAS	1	EGFR	5	genetic interference	Hart T (2015)	1
NCK1	0	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay	Tang J (1997), Li W (1992), Braverman LE (1999), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	6
EPS8L1	6	ABI1	1	affinity chromatography technology	Offenhaeuser N (2004)	1
SORBS1	2	ABL1	9	affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin WH (2001), Fernow I (2009), Fernow I (2009)	3
SOS1	5	HDLBP	9	two hybrid	Bandyopadhyay S (2010)	1
FYN	1	PIK3R1	6	pull down	Kapeller R (1994)	1
FYN	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
EGFR	5	TNIK	4	affinity chromatography technology	Yao Z (2017)	1
SOS1	5	FYN	1	pull down	Park C (1998)	1
ABI1	1	PIK3R1	6	unspecified method, affinity chromatography technology	Dubielecka PM (2010), Dubielecka PM (2010)	2
NTRK1	1	HDLBP	9	affinity chromatography technology	Emdal KB (2015)	1
ITSN2	7	CBL	7	two hybrid	Wong KA (2012)	1
CRKL	1	ABL1	9	affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heaney C (1997), Heaney C (1997), Heaney C (1997), Ren R (1994), Ren R (1994), Kyono WT (1998), Ren R (1994), Patel H (2006), Johnson KJ (2009), Ribon V (1996), Senechal K (1998), Nishihara T (2003), Peterson ME (2008)	13
CBL	7	MET	7	enzymatic study, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, far western blotting, imaging technique	Petrelli A (2002), Ng C (2008), Ng C (2008), Kong-Beltran M (2006), Kong-Beltran M (2006), Peschard P (2004), Peschard P (2004), Deheuninck J (2009), Goldoni S (2009), Hill KS (2011), Sun Q (2011), Sun Q (2011), Sun Q (2011), Peschard P (2004), Chen TC (2014)	15
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
FYN	1	CSF1R	0	pull down, pull down, affinity chromatography technology	Courtneidge SA (1993), Courtneidge SA (1993), Courtneidge SA (1993)	3
FRS2	0	CBL	7	affinity chromatography technology, pull down, affinity chromatography technology	Wong A (2002), Wong A (2002), Belleudi F (2007)	3
SORBS1	2	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Haglund K (2004), Vandenbroere I (2003), Limpert AS (2007)	4
FGFR1	2	PIK3R1	6	imaging technique, two hybrid, pull down	Chen TC (2014), Hu Y (2004), Shi E (1993)	3
LRRK1	12	SOS1	5	affinity chromatography technology	Titz B (2010)	1
NTRK1	1	SOS1	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	BCR	3	affinity chromatography technology	Emdal KB (2015)	1
FRS2	0	PTPN11	20	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, unspecified method, affinity chromatography technology	Delahaye L (2000), Delahaye L (2000), Kurokawa K (2001), Hadari YR (1998), Hadari YR (1998), Liu BA (2012), Zhou L (2015)	7
EPS8	1	ABI1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Offenhaeuser N (2004), Biesova Z (1997), Biesova Z (1997), Biesova Z (1997), Lanzetti L (2000)	5
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
SHC1	0	SPTAN1	9	affinity chromatography technology	Brehme M (2009)	1
CBL	7	CRKL	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Alsayed Y (2000), Alsayed Y (2000), Kyono WT (1998), Lin H (2001), Park RK (1998), Taher TE (2002), Sattler M (1997), Erdreich-Epstein A (1999), Erdreich-Epstein A (1999), Sattler M (1997), Sattler M (1997), Gesbert F (1998), Chin H (1997), Feshchenko EA (2004), Izadi KD (1998), de Jong R (1995), de Jong R (1995), Boussiotis VA (1997), Boussiotis VA (1997), Barber DL (1997), Uemura N (1999), Okabe S (2006), Alsayed Y (2000), Alsayed Y (2000), Brenner B (2001), van Leeuwen JE (1999), Ribon V (1996), Bhat A (1997), Bhat A (1997), Huang JY (2000), Chernock RD (2001), Chernock RD (2001), Grossmann AH (2004), Sakamoto H (2004), Nishihara T (2003), Peterson ME (2008), Fukazawa T (1996), Martelli MP (2001), Joshi S (2014), Grossmann A (2015)	40
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
GRB2	2	ANXA2	0	affinity chromatography technology, affinity chromatography technology	Buday L (1994), Brehme M (2009)	2
NCK2	2	SOS1	5	affinity chromatography technology	Braverman LE (1999)	1
BCR	3	PIK3R1	6	far western blotting	Weinger JG (2008)	1
GRB2	2	SOS1	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Liu SK (1998), Oneyama C (2002), Puil L (1994), Robinson A (1996), Li N (1993), Wong A (2002), Wong A (2002), Reif K (1994), DAngelo G (1999), Nel AE (1995), Pandey P (1995), Buday L (1994), Tong XK (2000), Park RK (1999), Okada S (1996), Okada S (1996), Okada S (1996), Germani A (1999), Park RK (1999), Chin H (1997), Saci A (2002), Sastry L (1997), Spivak-Kroizman T (1994), Ingham RJ (1996), Wang Y (1999), Chu J (1998), Brehme M (2009), Houtman JC (2006), Lao DH (2006), Bisson N (2011), Wang J (2011), Ng MY (2017), Huttlin EL (2017), Kapoor GS (2010), Saito T (2004), Klint P (1995)	37
MET	7	GRB2	2	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Ponzetto C (1996), Liang Q (1998), Goldoni S (2009), Hill KS (2011)	4
EGFR	5	SRRM1	2	affinity chromatography technology	Yao Z (2017)	1
EPS8	1	CBL	7	two hybrid, affinity chromatography technology	Grossmann A (2015), Jeganathan N (2016)	2
CRK	0	FRS2	0	pull down	Meakin SO (1999)	1
NTRK1	1	SORBS1	2	affinity chromatography technology	Limpert AS (2007)	1
RAC1	7	GRB2	2	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	CRKL	1	affinity chromatography technology	Park RK (1999)	1
ABI1	1	NCK2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cowan CA (2001), Huttlin EL (2015), Huttlin EL (2017)	3
MET	7	SOS1	5	affinity chromatography technology	Liang Q (1998)	1
EGFR	5	MET	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li J (2013), Li L (2015), Liu X (2011)	3